Abstract
We investigated the effects of Tan IIA on cardiac hypertrophy and fibrosis in two-kidney, two-clip (2K2C) hypertensive rats and by which, if any, mechanisms. Administration of 2K2C hypertensive rats with Tan IIA attenuated cardiac dysfunction and fibrosis. However Tan IIA treatment had no effects on...
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PMID: 21812327
PDF is available here.
Abstract
We review the possible mechanisms of PSC-derived cardiomyocytes rejection, summarize the current knowledge pertaining to immunogenicity of such cells and describe the existing controversies. Myocardial graft rejection can be reduced by modifying PSCs prior to their differentiation into cardiomyocyte...
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PMID: 21086071
PDF is available here.
Abstract
We considered age, sex, diabetes, renal insufficiency, anemia, chronic obstructive pulmonary disease, hypertension, atrial fibrillation, beta-blocker therapy, left ventricular ejection fraction (LVEF), E/E', indexed left atrial volume (iLAV), type of surgery, and plasma BNP levels as potential predi...
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PMID: 21178638
PDF is available here.
Abstract
These results suggest that the Gal-PHEA-DOX conjugate has great potential for use in hepatocellular carcinoma chemotherapy because of its enhanced antitumor effect with reduced systemic toxicity including hepatotoxicity....
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PMID: 20966743
PDF is available here.
Abstract
The advanced practice nurse (APN) is critical to continuity of patient care, particularly in an innovative and research-intensive environment. The intensity of the environment, steep learning curve, and lack of a structured orientation can lead to difficulties in role assimilation and feelings of di...
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PMID: 21157242
PDF is available here.
Abstract
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking t...
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PMID: 21569277
PDF is available here.
Abstract
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking t...
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PMID: 21569277
PDF is available here.
Abstract
We compared AN and USW heart disease mortality rates during the 27-year period from 1981 through 2007.
We compared AN and USW heart disease mortality rates overall and by gender, age, and disease subtype. We calculated age-adjusted rates for AN people for three nine-year periods from...
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PMID: 21337932
PDF is available here.
Abstract
Detectable levels of cardiac troponin T (cTnT) are strongly associated with structural heart disease and increased risk of death and adverse cardiovascular events; however, cTnT is rarely detectable in the general population using standard assays.
To determine the prevalence and determinants of dete...
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PMID: 21139111
PDF is available here.
Abstract
We present several novel metrics proposed to serve this purpose. We use reclassification tables constructed on the basis of clinically meaningful disease risk categories to discuss the concepts of calibration, risk separation, risk discrimination, and risk classification accuracy. We discuss the not...
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PMID: 20716010
PDF is available here.
Alina M Robert,
Robert S Kramer,
Lawrence J Dacey,
David C Charlesworth,
Bruce J Leavitt,
Robert E Helm,
Felix Hernandez,
Gerald L Sardella,
Carmine Frumiento,
Donald S Likosky,
Jeremiah R Brown and
Northern New England Cardiovascular Disease Study Group
Abstract
We sought to estimate the ability of both the RIFLE and and AKIN criteria to predict the risk of in-hospital mortality in the setting of cardiac surgery.
Data were collected on 25,086 patients undergoing cardiac surgery in Northern New England from January 2001 to December 2007, excluding 339 patien...
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PMID: 21095340
PDF is available here.
Abstract
We used a protocol based on dynamic insulin administration targeted to achieve moderately tight glycemic control and tested its impact on clinical outcomes after cardiac surgery.
Patients with diabetes mellitus or random blood glucose greater than 150 mg/dL were treated in the intensive care unit wi...
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PMID: 21095319
PDF is available here.
Abstract
We sought to determine the frequency of this complication in the STS (Society of Thoracic Surgeons) database as well as the outcomes of patients who suffer intraoperative aortic dissection. We then developed a model to identify preoperative characteristics and intraoperative factors associated with...
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PMID: 21095316
PDF is available here.
Abstract
Maintenance of appropriate capillary blood glucose in cardiovascular surgery patients has been associated with improved outcomes, including lower mortality. Interpatient variability in insulin resistance can make management difficult, leading to unexpected episodes of hypoglycemia and hyperglycemia....
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PMID: 21095317
PDF is available here.
Abstract
The treatment goal of patients with arterial hypertension is to reduce the blood pressure below 140/90 mmHg with the aim to lower the risk of subsequent cardiovascular diseases and to prolong patient's longevity. There are five main classes for blood pressure treatment: ACE-inhibitors, angiotensin I...
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PMID: 21189521
PDF is available here.
Abstract
Sudden cardiac death in competing athletes is usually caused by unsuspected heart disease, and pre-participation screening may reduce the incidence of this tragic event. Although the cost-effectiveness of screening programs is unclear, international sports associations are currently implementing man...
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PMID: 21118665
PDF is available here.
Abstract
Hierarchical linear modelling was used to evaluate the influence of nurse staffing, work environment, and nurse and patient variables on system outcomes based on data collected in Canadian cardiac and cardiovascular inpatient units. Staffing utilization levels below 80% at the unit l...
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PMID: 21319641
PDF is available here.
Abstract
Myocardial perfusion imaging (MPI) is the single medical test with the highest radiation burden to the US population. Although many patients undergoing MPI receive repeat MPI testing, or additional procedures involving ionizing radiation, no data are available characterizing their total longitudinal...
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PMID: 21078807
PDF is available here.
Abstract
Patients with liver cirrhosis suffer various degrees of cardiac dysfunction which may be crucial in determining the outcome of surgery. The aim of this study was to determine the role of natriuretic peptides on the assessment of cardiac dysfunction in patients with liver cirrhosis.
Prospective longi...
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PMID: 20729741
PDF is available here.
Abstract
Sarcoidosis is a multi-systemic inflammatory disease of unknown etiology, histologically characterized by the presence of non caseating granulomas. The diagnostic suspicion relies on clinical, epidemiological, biological and radiological elements. It is confirmed by an evocative histology and by the...
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PMID: 21140958
PDF is available here.
Abstract
Telecardiology allows for the remote specialist interpretation of electrocardiographic recordings via telephone transmission. It has the potential to change the way cardiac care is being delivered in the primary care setting. This review discusses the current status of cardiac care in the community,...
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PMID: 20959351
PDF is available here.
Abstract
Cardial diseases are common causes of neurological emergencies. On the other hand, acute neurological disorders go along with systemic abnormalities, in particular they show cardial and pulmonary complications. This review is focused on the cardial consequences of cerebral lesions. Independent on th...
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PMID: 21082525
PDF is available here.
Abstract
Our data suggests that physicians caring for patients with PH should pay close attention to cardiac status, especially if renal function is impaired....
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PMID: 20921818
PDF is available here.
Abstract
We provide preliminary clinical data that support the potentiality of this new but fundamental approach of curing patients according to their genetic expression and/or protein activation that influence personalized development and the management of cardiovascular diseases....
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PMID: 21246777
PDF is available here.
Abstract
We examined all the patients referred for chest pain to the Emergency Department (ED) of "Civile-M. P. Arezzo" Hospital during a period of 6 months (from January 1st 2008 to June 30th 2008). As much as 857 patients were studied. The results of our study show that musculoskeletal chest pain is the mo...
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PMID: 20449691
PDF is available here.
Author(s) unavailable
Abstract
A study conducted by researchers at Wake Forest University Baptist Medical Center showed that using a cardiac MRI in the ED's observation unit enabled providers to manage most patients without admitting them, resulting in lower cost at the hospital of about $588 per patient. It also allowed diagnosi...
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PMID: 20957858
PDF is available here.
Abstract
Genetic testing for rare heart conditions might someday expand to more common cardiac ailments. Already there are signs testing is dramatically changing how some conditions are treated and doctors' definition of who a patient is. Stephen Strauss reports.
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PMID: 20944580
PDF is available here.
Abstract
This study was undertaken to determine the prevalence of periodontal bone loss and to assess the prevalence of self-reported medical conditions in patients with and without periodontal bone loss in Saudi Arabia.
A total of 2103 dental records with complete data from patients > or = 18 years of age a...
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PMID: 21128528
PDF is available here.
Abstract
We evaluated 980 consecutive patients undergoing urgent PCI for UA/NSTEMI who were treated with either bivalirudin or UFH plus GP IIb/IIIa inhibitor. We excluded patients who were on chronic clopidogrel therapy or received clopidogrel pretreatment prior to angiography. All patients received a clopid...
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PMID: 20882655
PDF is available here.
Abstract
Primary care clinicians need to move beyond first-line therapy for major depression. While initial treatment is ineffective in about two-thirds of patients, patients who have not responded to such initial treatments can be managed effectively. The severity of depression is as high in primary care as...
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PMID: 20977873
PDF is available here.
Abstract
In 2005, more than 10 million people in the United States were cancer survivors, and that number is expected to grow as therapies for cancer improve and the population ages. Although survival is something to be celebrated, it can be accompanied by a number of health problems secondary to the initial...
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PMID: 21140761
PDF is available here.
Abstract
Patients with the modified metabolic syndrome who are super obese had a 2-fold increased risk of death (adjusted odds ratio [AOR] 1.99; 95% CI 1.41-2.80). As stratified by body mass index, patients with the modified metabolic syndrome had a 2- to 2.5-fold higher risk of cardiac adverse events (CAE)...
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PMID: 20808207
PDF is available here.
Abstract
Heart failure is the common and final pathway of all the cardiovascular diseases. Its pathophysiology has progressed during the last 20 years; although the inotropy was the main target in the 80', new paradigms have emerged such as remodelling, neurohormonal activation, and more recently desynchroni...
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PMID: 21033483
PDF is available here.
Abstract
These results indicate that spontaneous activation of both Smad and non-Smad transforming growth factor-β signaling may contribute to profibrotic responses in aged PAI-1-deficient mice hearts and establish a possible link between endothelial-to-mesenchymal transition and cardiac fibrosis in PAI-1-d...
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PMID: 20823384
PDF is available here.
Abstract
A dead whooper swan was found in an area of cropland near a stream and was submitted to the National Veterinary Research and Quarantine Service (NVRQS) in Korea. The affected animal was in relatively good condition. Grossly, the heart was enlarged and had pale and dark red stripes. A white, elongate...
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PMID: 20431254
PDF is available here.
Abstract
In patients without prior coronary artery disease, routine follow-up SPECT scans are performed infrequently but well before the end of the patient's warranty period. Routine follow-up scans are performed more commonly in patients with prior coronary artery disease but generally after the end of the...
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PMID: 20631033
PDF is available here.
Philipp S PS Wild,
Christoph R CR Sinning,
Alexander A Roth,
Sandra S Wilde,
Renate B RB Schnabel,
Edith E Lubos,
Tanja T Zeller,
Till T Keller,
Karl J KJ Lackner,
Maria M Blettner,
Ramachandran S RS Vasan,
Thomas T Münzel and
Stefan S Blankenberg
Abstract
The rapidly evolving echocardiographic technology with persistent improvements in image quality and new measurement conventions require the evaluation of new reference limits for left ventricular metrics. The present investigation formulates reference limits and nomograms from state-of-the-art techn...
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PMID: 20643817
PDF is available here.
Abstract
Nuclear medicine techniques have the capacity to investigate neuronal dysfunction at the synapse level. For instance, metaiodobenzylguanidine (MIBG) shows a similar uptake, storage and release as norepinephrine. Intravenously injected radiolabeled MIBG is able to reflect neuronal damage induced by i...
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PMID: 20592600
PDF is available here.
Abstract
We recently assessed the prevalence of heart diseases in 11.236 consecutive patients older than 60 years discharged from Venetian hospitals with a diagnosis of pulmonary embolism. We observed a higher prevalence of all-cause heart diseases (odds ratio 1.26; 95% confidence interval, 1.13-1.40) in pat...
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PMID: 20531195
PDF is available here.