Abstract
We retrospectively ascertained demographic characteristics (age, sex, and ethnicity), presentation (history and examination findings), investigations undertaken, features of angle-closure or occludable angles (symptoms, method of diagnosis, and treatment), and outcome (intraocular pressure (IOP) and...
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PMID: 20179618
PDF is available here.
Abstract
Baseline OCT morphology of macular edema (ME) due to branch (BRVO) or central retinal vein occlusion (CRVO) was evaluated with respect to response to bevacizumab treatment.
Sixty-five patients (33 CRVO, 32 BRVO) were treated with intravitreal injections of 2.5 mg bevacizumab. Reinjections were only...
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PMID: 20596719
PDF is available here.
Abstract
To investigate the effect of l-Arginine on the retinal arteriolar diameter following acute branch retinal vein occlusion (BRVO) in minipigs. Under general anesthesia, 10 eyes of 10 minipigs were evaluated. Two hours after BRVO, an intravitreal juxta-arteriolar micro-injection of 30 microl l-Arginine...
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PMID: 20457153
PDF is available here.
Abstract
Intravitreal bevacizumab seems to be an effective primary treatment option for macular oedema due to retinal occlusions. Its main drawback is that multiple injections are necessary to maintain visual and anatomic improvements....
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PMID: 20679089
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Abstract
Mean age of CRVO-fellow eye was higher than controls, 59.7 +/- 10.3 vs. 46.4 +/- 5.8 years, (p < 0.001). Males were more prevalent in CRVO-fellow eye than in the controls, 47.4% vs. 25%, (p = 0.001). In CRVO-fellow eye group, systemic diseases were more prevalent. Glaucoma and ocular hypertension we...
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PMID: 20718171
PDF is available here.
Abstract
We summarize the pathogenesis and the treatment strategy for macular edema in patients with branch retinal vein occlusion (BRVO), focusing on the role of the cytokines. Various cytokines are involved in the pathogenesis of macular edema associated with BRVO. When BRVO occurs, it leads to retinal isc...
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PMID: 20681253
PDF is available here.
Abstract
We report one case that developed from optic disc vasculitis to frosted branch angiitis associated with retinal vein occlusion. CASE: A 39 year old male. Fever, abdominal pain and chest pain were continued from childhood. In 2006, an idiopathic fever was reported with a renal disorder. Based on the...
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PMID: 20681258
PDF is available here.
Abstract
A 60-year-old woman who had experienced two episodes of amaurosis fugax in her right eye presented with vision loss. Two weeks earlier, at a private clinic, she was diagnosed with impending central retinal vein occlusion (CRVO) of the right eye and received an intravitreal injection of bevacizumab....
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PMID: 20532147
PDF is available here.
Abstract
Chorioretinal venous anastomosis was created in 76.4% of eyes with nonischemic CRVO in this study. Eyes that developed an anastomosis had a significant improvement (11.7 letters) in final visual acuity after 18 months, compared with eyes in the control group (P = 0.004). Complications were managed s...
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PMID: 20163872
PDF is available here.
Abstract
Central retinal vein occlusion (CRVO) is one of the common causes of visual loss. The main reasons for decreased vision are development of macular edema, macular ischemia and neovascular glaucoma. The introduction of anti-vascular endothelial growth factor (VEGF) drugs for CRVO in 2005 demonstrated...
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PMID: 20812499
PDF is available here.
Abstract
Central retinal vein occlusion (CRVO) remains one of the most common retinal vascular disorders that may lead to blindness. The etiology is unknown, however, predisposing factors such as hypertension, diabetes, atherosclerosis and hypercoagulable states have all been described. Local ophthalmic illn...
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PMID: 20812500
PDF is available here.
Abstract
The cases of impending central retinal vein occlusion that we observed seemed to primarily affect young patients with generally good prognoses. However, in some cases, the degrees of obstruction and hemorrhage increased as time progressed. This suggests that impending central retinal vein occlusion...
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PMID: 20379457
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Abstract
The combination of CAO and CRVO comprises a discrete clinical entity. In both our cases, FA did not show full obstruction of the cilioretinal artery. Even though many hypotheses have been postulated about this entity, it seems that it ensues from the increased intraluminal pressure in the retinal ca...
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PMID: 20408080
PDF is available here.
Abstract
We report a patient who had simultaneous bilateral CRVO as the initial presentation of acute myeloid leukemia. Thorough examination should be carefully conducted because ocular manifestations may be the initial presentation of life-threatening illness. A prompt search for the underlying systemic ill...
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PMID: 20186040
PDF is available here.
Abstract
The mean age of the patients was 68.1 +/- 11.8 and the mean follow up was 6.5 +/- 2.6 months. The mean baseline BVCA (logMAR) and CMT were 0.79 +/- 0.45 and 699 +/- 194 microm, respectively. After treatment, the mean BVCA improved significantly at 1 week (0.52 +/- 0.46, p<0.001), 1 month (0.48 +/- 0...
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PMID: 20432959
PDF is available here.
Abstract
FV Leiden is significantly more frequent among RVO patients without acquired risk factors. Thrombophilia plays a much more important role in the pathogenesis of RVO in patients without acquired risk factors. Screening for thrombophilia is thus indicated only for patients in whom these factors have b...
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PMID: 20379305
PDF is available here.
Abstract
We report a case of a 69-year-old male patient who came to our attention for macular edema in hemiretinal vein occlusion. Fluorescein angiogram showed presence of venous collaterals, but the pattern of the edema was atypical; optical coherence tomography (OCT) and indocyanine green angiography (ICG)...
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PMID: 19430731
PDF is available here.
Abstract
The results of this study show that the arterial stiffness indices (large arterial elasticity index and aortic distensibility) are abnormal in patients with BRVO compared to the healthy and hypertensive controls. Arterial stiffness may play a role in the onset or progression of BRVO. Further studies...
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PMID: 20084390
PDF is available here.
Abstract
Mean age and number of injections were 72.9 +/- 11.99 years, and 2 +/- 0.81 respectively. In eight patients with CRVO, initial visual acuity was logMAR 1.09 +/- 0.67 and mean visual acuity at 1, 3 and 6 months was logMAR 0.98 +/- 0.55 (p = 0.59), 1.33 +/- 1.05 (p = 0.4) and 1.4 +/- 1.2 (p = 0.34) re...
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PMID: 19898827
PDF is available here.
Abstract
PPV may improve perifoveal microcirculation and the visual prognosis in BRVO patients with macular edema....
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PMID: 19956967
PDF is available here.
Abstract
Unilateral (n = 19) and bilateral (n = 3) central retinal vein occlusions were identified in a total of 22 patients (25 eyes), with a mean follow-up time of 37 months. Hypercholesterolemia (65%), hypertriglyceridemia (64%), and hyperhomocysteinemia (42%) were all identified as risk factors. Three pa...
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PMID: 20010454
PDF is available here.
Abstract
The purpose of this study was to determine the morphologic patterns of angiographic macular edema using simultaneous colocalization of fluorescein angiography and spectral-domain optical coherence tomography (SD-OCT) images in diabetes, epiretinal membrane, uveitic and pseudophakic cystoid macular e...
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PMID: 20216291
PDF is available here.
Abstract
Of the 19 eyes, 14 showed moderate to severe ocular inflammation immediately after injection. Cultures of aqueous humor and vitreous from 5 eyes were negative for bacteria and fungi. Eyes with moderate inflammation received topical or systemic antibiotics and steroid treatment. Five eyes with severe...
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PMID: 19952993
PDF is available here.
Abstract
Occlusive retinal diseases are associated with vascular risk factors, but the association is specific for each entity.
Copyright 2008 Elsevier España, S.L. All rights reserved....
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PMID: 19942235
PDF is available here.
Abstract
In eyes with retinal vein occlusion, a small pointed RD initially developed just beneath the fovea, but subsequently changed into a dome-shaped RD. Based on the findings by OCT, we hypothesize that the foveal architecture, especially that of the Müller cell cone, is involved in the formation of s...
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PMID: 20103055
PDF is available here.
Abstract
Optimal management of retinal vein occlusion (RVO) is still a matter of debate. Antithrombotic and fibrinolytic drugs have been investigated after demonstration of a role of thrombosis in the complex pathogenesis of the disease. Aim of our study was to systematically summarise best available evidenc...
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PMID: 20126837
PDF is available here.
Abstract
Our results indicate that thrombophilic disorders are associated with the development of retinal vein occlusion in patients < or =45 years by the time of the RVO or a previous thromboembolic event, in patients with a family history of thromboembolism, or in patients without cardiovascular risk facto...
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PMID: 20126828
PDF is available here.
Abstract
MAs can develop during the course of RVO and DR. ICGA and HR-OCT improves the identification of capillary and venous MAs, and may thus be of interest to better identify sites of blood-retinal barrier rupture during chronic macular edema due to RVO or DR....
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PMID: 19701812
PDF is available here.
Abstract
Visual acuity and retinal thickness improved in 10/13 (77%) patients after surgery at 1-year follow-up. Adequate retinal reperfusion was achieved in ten of the 13 eyes. Acute reperfusion occurred in six eyes within 2 weeks of surgery and a shunt vessel at the optic disk developed in four eyes within...
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PMID: 19756692
PDF is available here.
Abstract
In CRVO patients, central retinal thickness (CRT) and patients' age are prognostic predictors in bevacizumab therapy. Age of CRVO patients differed significantly between groups 1 and 2 after first injection, while CRT only showed a strong trend to thinner CRT. At last visit, age and CRT differed sta...
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PMID: 19763601
PDF is available here.
Abstract
Interocular comparison of amplitude is a good solution for avoiding the variability of ERG. An interocular amplitude ratio of flicker ERG of 60% is a succinct, useful parameter in clinical practices for differentiating ischemic from nonischemic CRVO....
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PMID: 19813018
PDF is available here.
Abstract
Hematocrit decreased significantly by 23.7%, 19.8%, and 16.1% in the first hour, on the first day, and the seventh day after hemodilution, respectively (P < 0.001). The ocular perfusion pressure of the healthy eye and the eye with retinal vein occlusion decreased by 7.7% and 7.2% after 1 hour and by...
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PMID: 20175271
PDF is available here.
Abstract
The incidence of major branch retinal vein occlusion was higher in the SRD group (38 of 46, 83%) than in the CME group (32 of 56, 66%, P = 0.01). The incidences of ischemic vein occlusion and macular ischemia was similar between the SRD group (18 of 46 and 20 of 46) and the CME group (20 of 56 and 2...
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PMID: 19881397
PDF is available here.
Abstract
We described ocular changes following hepatitis C. The most common ophthalmic findings in hepatitis C patients treated with interferon--involve keratoconjunctivitis, scleritis, dry eye syndrome, uveitis, retinopathy, retinal hemorrhages, anterior ischemic optic neuropathy, retinal vascular changes a...
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PMID: 21121130
PDF is available here.
Abstract
Monoclonal antibodies have been developed to optimize treatment effects in various malignant and nonmalignant conditions, by selectively targeting key components of the underlying pathophysiologic processes. Rituximab, a chimeric anti-CD20 antibody has revolutionized treatment of malignant lymphomas...
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PMID: 19538160
PDF is available here.
Abstract
At 18 months of follow-up, visual acuity remained stable, intraocular pressure was in the normal range, but retinal tomography indicated an increase in glaucomatous optic damage to the nerve fiber layer in almost the complete temporal-inferior sector of the left eye, but without visual field defects...
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PMID: 20068371
PDF is available here.
Abstract
MCTD may be associated with bilateral vasculopathy that is refractory to systemic steroid, intravitreal steroid, and immunosuppressant treatment....
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PMID: 20128643
PDF is available here.
Abstract
Our results suggest that aqueous levels of VEGF and IL-6 may reflect the vitreous levels of these molecules. Measurement of VEGF and IL-6 in the aqueous humor may be clinically useful to assess the severity of macular edema in patients with CRVO....
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PMID: 19967679
PDF is available here.
Abstract
The initial short-term VA gain after bevacizumab treatment was not always maintained over a 2-year period despite repeated injections. Patients with low baseline VA and good response to the first injection seemed to benefit most from repeated bevacizumab injections....
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PMID: 19927266
PDF is available here.
Abstract
Intravitreal bevacizumab is a comparatively simple treatment method that can effectively improve BCVA and reduce CMT without ocular and systemic complications. Consequently, intravitreal bevacizumab injections may be useful as both an alternative and primary treatment for macular edema secondary to...
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PMID: 20046685
PDF is available here.
Abstract
To evaluate the incidence of intravitreal silicone oil (SO) droplets associated with intravitreal injections using a staked-on vs luer cone syringe design in the SCORE (Standard Care vs COrticosteroid in REtinal Vein Occlusion) Study.
Prospective, randomized, phase III clinical trial.
The incidence...
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PMID: 19674727
PDF is available here.
Abstract
We present three cases id combined vascular occlusion that were diagnosed at our department from 2003 until 2008. Our patients, all productive age, had undergone complete clinical examinations and investigations to determine the cause of this condition. One patient had been diagnosed to have heteroz...
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PMID: 20052822
PDF is available here.
Abstract
Our results indicate that thrombophilic disorders are associated with the development of retinal vein occlusion. Selective screening of young patients, patients with a personal or family history of thromboembolism, and patients without cardiovascular risk factors may be helpful in identifying retina...
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PMID: 19399710
PDF is available here.
Abstract
Bevacizumab is a full-length humanized murine monoclonal anti-VEGF (vascular endothelial growth factor) IgG1 antibody that was approved by the U.S. Food and Drug Administration in 2004 for the treatment of metastatic colorectal cancer. The intravenous formulation of bevacizumab was first injected int...
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PMID: 19412873
PDF is available here.
Abstract
Mean age was 65 years. In controls, pre-vitrectomy, the mean PO(2) adjacent to the retina (15.0 mmHg S.D.5.7) was significantly less than mid-cavity (33.7 mmHg S.D.12.8). Similarly in CRVO, the pre-vitrectomy pre-retinal PO(2) (8.1 mmHg S.D. 3.5), was significantly less than mid-cavity (19.8 mmHg S....
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PMID: 19347349
PDF is available here.
Abstract
To study the effect of intravitreal bevacizumab on macular edema secondary to branch retinal vein occlusion (BRVO).
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PMID: 19606809
PDF is available here.
Abstract
To date, no report shows retinal vascular occlusion as the primary symptom leading to the diagnosis PNH. This article describes, for the first time, that this rare disease needs to be considered in the differential diagnosis of retinal vascular occlusions....
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PMID: 18437293
PDF is available here.
Abstract
Following treatment with intravenous corticosteroids, macular star appeared 1 week after treatment. On the 2nd week, a focus of retinitis appeared, and the patient was started on antitoxoplasma treatment. This was poorly tolerated, and the patient was injected with intravitreal clindamycin. Inflamma...
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PMID: 18297246
PDF is available here.