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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Thrombosis (4):
Recent article
Thrombosis
New England Journal of Medicine (365)19 2011
Abstract
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New England Journal of Medicine (365)19 2011
Abstract
Autoimmunity Reviews (10)11 2011
Abstract
Anti-phospholipid syndrome (APS) is an autoimmune prothrombotic disorder characterised by the predisposition to venous and/or arterial thrombosis and obstetric morbidity. Management of APS centres on attenuating the procoagulant state whilst balancing the risks of anticoagulant thera...
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PMID: 21558021
PDF is available here.
PDF is available here.
Abstract
Cancer-associated thrombosis and enduring inflammation are strongly associated with cancer progression and metastasis. Heparin is the mostly clinically used anticoagulant/antithrombotic drug, and has recently been shown to exhibit antimetastatic and anti-inflammatory activities that...
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PMID: 21676168
PDF is available here.
PDF is available here.
Circulation Research (109)5 2011
Abstract
Membrane-shed submicron microparticles (MPs) are released after cell activation or apoptosis. High levels of MPs circulate in the blood of patients with atherothrombotic diseases, where they could serve as a useful biomarker of vascular injury and a potential predictor of cardiovascu...
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PMID: 21852557
PDF is available here.
PDF is available here.
Circulation (123)12 2011
Abstract
Circulation (123)10 2011
Abstract
Abstract
Abstract
Patients with rheumatoid arthritis (RA) are at high risk of cardiovascular events. Platelet biomarkers are involved in inflammation, atherosclerosis and thrombosis. Cardiovascular and RA-associated factors can alter the structure and function of platelets, starting from megakaryocyto...
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PMID: 20390282
PDF is available here.
PDF is available here.
Thrombosis Research (127 Suppl 3) 2011
Abstract
Abstract
Abstract
Thrombosis and Haemostasis (105)4 2011
Abstract
Abstract
It has been demonstrated that the occurrence of ischemic stroke is more prevalent in AF patients, when increased levels of inflammatory markers are present.
The aim of this study was to evaluate the effect of intensive cholesterol lowering therapy on inflammatory mark...
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PMID: 21784372
PDF is available here.
PDF is available here.
Abstract
Atherosclerosis is characterized by endothelial inflammation and dysfunction. Adipose tissue has increasingly been recognized as an active endocrine organ secreting so-called adipokines. Among these, resistin--recently described, but not yet extensively studied--has been defined as a novel inflammat...
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PMID: 20628259
PDF is available here.
PDF is available here.
Journal of Trauma (70)1 2011
Abstract
Experiments were designed to investigate the effects of ethyl pyruvate (EP) in a murine model of hind-limb ischemia-reperfusion (IR) injury.
C57BL6 mice underwent 90 minutes of unilateral ischemia followed by 24 hours of reperfusion using two treatment protocols. For the preischemic treatment (pre-I...
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PMID: 21217488
PDF is available here.
PDF is available here.
Cardiology in the Young (20)6 2010
Abstract
British Journal of Nutrition (104)12 2010
Abstract
Abstract
We tested PRT-060318 (PRT318), a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 completely inhibited HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets. Transgenic HIT model mice were treated with KKO, a mouse monocl...
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PMID: 21088136
PDF is available here.
PDF is available here.
Abstract
The administration of dual antiplatelet therapy with aspirin and a thienopyridine for the prevention of thrombosis in patients with acute coronary syndrome undergoing percutaneous coronary intervention is proven to reduce mortality. The original thienopyridine, ticlopidine, has largely been displace...
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PMID: 20839914
PDF is available here.
PDF is available here.
Abstract
We report a case of a 70-year-old Chinese male patient with extramedullary relapse of MM. After treatment with bortezomib and dexamethasone he developed a nonfatal thrombotic stroke. Administration of bortezomib and dexamethasone was then discontinued and he obtained partial remission....
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PMID: 20979938
PDF is available here.
PDF is available here.
Hämostaseologie (30 Suppl 1) 2010
Abstract
A significant positive correlation was seen between endogenous thrombin potential (ETP) (p = 0.012), time to peak (TTP) (p = 0.033) start tail (p = 0.007) and carotid IMT in the group of healthy volunteers younger than 45 years. Conclusion: We demonstrated that in adults younger than 45 years withou...
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PMID: 21042684
PDF is available here.
PDF is available here.
American Surgeon (76)11 2010
Abstract
Since the first reported case in 1994, a small but significant number of patients have developed major mesenteric arterial and venous thromboses after laparoscopy, usually with catastrophic outcomes. The basic science data in both animal and human models suggest that these events were due in part to...
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PMID: 21140681
PDF is available here.
PDF is available here.
Abstract
Circulation Journal (74)11 2010
Abstract
The optimal duration of dual antiplatelet therapy remains controversial.
Between December 2006 and March 2008, 823 patients were enrolled in a prospective multicenter registry for 3-month dual antiplatelet therapy (aspirin 100-200mg+clopidogrel 75 mg daily) followed by aspirin mono-therapy after zot...
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PMID: 20938098
PDF is available here.
PDF is available here.
Circulation Journal (74)11 2010
Abstract
Limited data exists regarding long-term clinical results and predictors of adverse outcomes after drug-eluting stents (DES) implantation for coronary bifurcation lesions in a real-world practice.
A total of 1,691 non-left main bifurcation lesions with side branches ≥2.0mm in 1,668 patients undergo...
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PMID: 20890049
PDF is available here.
PDF is available here.
Circulation Journal (74)11 2010
Abstract
Approximately 15% of acute coronary syndrome (ACS) cases have no significant coronary stenosis. Mechanisms underlying the attacks are, however, unknown.
The clinical study had 254 patients with ACS; 38 patients (31 females and 7 males; aged 51.0 ± 8.0 years) had no significant coronary stenosis on...
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PMID: 20827027
PDF is available here.
PDF is available here.
Circulation Journal (74)11 2010
Abstract
These results might affect the mid-term clinical outcomes of re-intervention with SES....
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PMID: 20890050
PDF is available here.
PDF is available here.
New England Journal of Medicine (363)17 2010
Abstract
We randomly assigned 2922 patients who were taking warfarin because of mechanical heart valves or atrial fibrillation and who were competent in the use of point-of-care INR devices to either weekly self-testing at home or monthly high-quality testing in a clinic. The primary end point was the time t...
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PMID: 20961244
PDF is available here.
PDF is available here.
Abstract
We examined the roles of thrombin receptors (protease-activated receptors, PARs) and the ADP receptor P2RY12 (purinergic receptor P2Y G protein-coupled 12) in human and mouse platelets ex vivo and in mouse models. Par3(-/-) and Par4(+/-) mouse platelets showed partially decreased responses to thromb...
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PMID: 20930120
PDF is available here.
PDF is available here.
Abstract
We present the first case of upper arm ischaemia associated with non-Hodgkin's lymphoma. A brief literature review of this rare phenomenon is also accompanied with it....
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PMID: 18696175
PDF is available here.
PDF is available here.
Abstract
Abstract
To provide a contemporary estimate of the economic burden of atherothrombosis in Canada, annual cardiovascular-related hospitalizations, medication use and associated costs across the entire spectrum of atherothrombotic disease were examined.
The REduction of Atherothrombosis for Continued Health (R...
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PMID: 20931098
PDF is available here.
PDF is available here.
Abstract
Abstract
To explore the best method for prevention and treatment of thrombosis and its mechanism.
Forty SD rats were randomly divided into a blank group, a model group, an electroacupuncture group and a crude herb moxibustion group. In the electroacupuncture group and the crude herb moxibustion group. "Zusan...
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PMID: 21058484
PDF is available here.
PDF is available here.
Abstract
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent arterial or venous thrombosis and/or pregnancy losses, in the presence of persistently elevated levels of anticardiolipin antibodies (aCL) and/or evidence of circulating lupus anticoagulant (LA). The kidney is a maj...
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PMID: 20587422
PDF is available here.
PDF is available here.
Pediatric Emergency Care (26)10 2010
Abstract
Abstract
Antithrombotic/antiplatelet therapy after coronary stent implantation is recommended with a high level of evidence in international guidelines. However, antithrombotic/antiplatelet treatment in patients after coronary stent implantation and in addition with an indication for oral anticoagulation is...
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PMID: 20925012
PDF is available here.
PDF is available here.
American Surgeon (76)10 2010
Abstract
Our objective was to study the effects of intraoperatively administered heparin on 30-day patency and postoperative bleeding complications in patients undergoing autogenous arteriovenous (AV) fistula surgery. A prospective, double-blinded, randomized controlled study was performed on 48 patients und...
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PMID: 21105622
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)4 2010
Abstract
Thrombosis and Haemostasis (104)4 2010
Abstract
Portal vein thromboses are frequent in cirrhotic patients and may be favoured by hypercoagulability in the splanchnic venous system. The coagulation balance and thrombin generation (TG) were evaluated in platelet-free plasma obtained from portal and systemic blood samples in 28 cirrhotic patients whi...
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PMID: 20806106
PDF is available here.
PDF is available here.
La Revue du praticien (60)7 2010
Abstract
Circulation (122)12 2010
Abstract
Abstract
I clinical trials, M-118 demonstrated potent activity against thrombin and Factor Xa, which could be reversed with protamine; M-118 also demonstrated a high and predictable bioavailability, and a short half-life. Promising results were observed in a phase II clinical trial in patients undergoing cor...
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PMID: 20730701
PDF is available here.
PDF is available here.
Abstract
Conducted research has shown that the life quality of patients who were treated with low-molecular-weight heparin changed for better in higher degree than patients who were treated with oral antithrombotic medicine....
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PMID: 20931823
PDF is available here.
PDF is available here.
Abstract
Abstract
This review discusses the current status of individual thrombosis risk assessment as an alternative to applying prophylaxis to broad groups in an attempt to simplify the process. Complete assessment is necessary in order to provide the proper type, duration, and intensity of prophylaxis, especially...
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PMID: 20592595
PDF is available here.
PDF is available here.
Abstract
We review: the current knowledge on the clinical and genetic determinants of warfarin dosing and summarize how such determinants have been incorporated in clinical practice; the main pharmacogenetics-based predictive models and their performance; and the potential clinical role of recently developed...
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PMID: 20473166
PDF is available here.
PDF is available here.
Abstract
Hereditary and acquired risk factors contribute to the development of venous thromboembolism (VTE). Relatives of patients who have a hereditary predisposition to thrombosis ('hereditary thrombophilia') will have a heightened risk of VTE if they share the same thrombophilic abnormality. However, if p...
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PMID: 20592597
PDF is available here.
PDF is available here.
Abstract
Abstract
PT+ patients were more frequently women with viral hepatitis, and TIPS was performed more often for bleeding indications. The TIPS success rate was significantly lower in the PT+ group (79%) than in the PT- group (99.5%) (P<10). Presence of a cavernoma decreased the success rate to 63%. TIPS was alw...
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PMID: 20308910
PDF is available here.
PDF is available here.
Abstract
A 27-year-old male with a six-year history of hypereosinophilic syndrome (HES) presented with a native mitral valve thrombus, despite therapeutic oral anticoagulation. The thrombus was removed, the mitral valve replaced, and subsequent oral anticoagulation maintained at a higher level (INR 3.5). The...
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PMID: 21053738
PDF is available here.
PDF is available here.
Atherosclerosis (212)1 2010
Abstract
We evaluated neutrophil elastase activity with the enzymatic assay. Concentrations of active matrix metalloproteinase-9 (MMP-9), total matrix metalloproteinase-8 (MMP-8), and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) were measured by ELISA. Biochemical parameters were compared with th...
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PMID: 20537648
PDF is available here.
PDF is available here.
Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukrainy, Naukove tovarystvo khirurhiv Ukrainy ()9 2010
Abstract
An optimal tactics of treatment of patients, suffering the upper extremities (UE) ischemia, caused by arterial thrombosis, occurred due to subclavian artery damage in those patients, who apply crutches for a long period of time, was elaborated. In modern medicine in patients with the UE arterial bed...
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PMID: 21105270
PDF is available here.
PDF is available here.
Abstract
We describe the placental characteristics that are most frequently listed in stillbirth case series, including entities associated with maternal diseases. First, we describe how macroscopic placental, cord, and membrane findings can provide answers to midwives and physicians at the time of delivery...
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PMID: 20661050
PDF is available here.
PDF is available here.
Anesthesia & Analgesia (111)3 2010
Abstract
We report a case of a large thrombus forming in the venous reservoir while using bivalirudin. We suggest that blood stasis associated with the full venous reservoir maintained in this case led to formation of a large thrombus at the top of the venous canister. Furthermore, activated clotting times m...
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PMID: 20686010
PDF is available here.
PDF is available here.
Vnitrni lekarstvi (56)9 2010
Abstract
Prevention and treatment of thrombosis represent some of the most common medical interventions in the clinical area that remains among the most common causes of mortality and morbidity. At present, heparins, pentasaccharides and warfarin are used to prevent thromboembolic events. Nevertheless, these...
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PMID: 21137179
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)3 2010
Abstract
Large randomised trials support the use of a variety of antithrombotic drugs for treatment of atherothrombotic disease processes leading to cardiovascular disease. The heterogeneous case-mix of patients enrolled in these trials, however, hamper the attempt to generalise their findings to subgroups w...
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PMID: 20664898
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)3 2010
Abstract
Clopidogrel is a prodrug that is converted via the hepatic cytochrome P450 system into its active thiol metabolite. Evidence is accumulating that proton pump inhibitors (PPIs) inhibit this enzymatic pathway and may therefore attenuate the antiplatelet effect of clopidogrel. The objective of this stu...
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PMID: 20664905
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)3 2010
Abstract
Shear stress has an established effect on mature endothelial cells, but less is known about how shear stress regulates endothelial progenitor cells (EPCs). In vitro expanded EPCs isolated from adult human blood represent a novel tool in regenerative vessel therapy. However, in vitro culturing may ge...
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PMID: 20664910
PDF is available here.
PDF is available here.