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Shy-Drager Syndrome (0):
Recent article
Shy-Drager Syndrome
Casopis lekaru ceskych (149)5 2010
Abstract
Shy-Drager syndrome is a rare neurological disease with a poor prognosis causing a generalised autonomy dysfunction. The disorder is also known as multiple system atrophy, the orthostatic hypotension syndrome or Shy-McGee-Drager syndrome. Patients have mainly dysautonomic symptoms. Patients suffer f...
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PMID: 20629342
PDF is available here.
PDF is available here.
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Neurologist (15)4 2009
Abstract
Pediatric Neurosurgery (45)5 2009
Abstract
In this short series, surgical decompression of CM1 has a high success rate (70%) for patients with Chiari drop attacks. Tilt table testing has poor predictive value in judging the clinical response to surgical decompression and is not a useful test to guide surgical decision- making.
Copyright 200...
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PMID: 19940537
PDF is available here.
PDF is available here.
Diabetic Medicine (25)11 2008
Abstract
The new squatting test indices provide useful information for assessing autonomic neuropathy and for identifying diabetic patients at high risk of cardiovascular events....
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PMID: 19046221
PDF is available here.
PDF is available here.
Abstract
Movement Disorders (23)8 2008
Abstract
We propose a combination of two out of six red flag categories as additional diagnostic criteria for probable MSA-P.
(c) 2008 Movement Disorder Society...
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PMID: 18442131
PDF is available here.
PDF is available here.
Circulation (117)21 2008
Abstract
Deutsche Medizinische Wochenschrift (133 Suppl 1) 2008
Abstract
Magnetic resonance imaging (MRI) plays an important role in differentiating idiopathic Parkinson's disease (PD) from its atypical forms. Causes like chronic vascular disease and normal-pressure hydrocephalus are easily visualized. Furthermore, specific atrophy patterns can be found with multi-system...
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PMID: 18437637
PDF is available here.
PDF is available here.
Seminars in Neurology (28)2 2008
Abstract
Autonomic nervous system dysfunction may manifest with a variety of symptoms, with orthostatic intolerance (including orthostatic hypotension or tachycardia) and sweating abnormalities (increased or decreased sweating) being common problems requiring medical evaluation and treatment. Determination o...
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PMID: 18351521
PDF is available here.
PDF is available here.
Abstract
We assessed the clinical features of autonomic dysfunction and the central cardiovascular control circuits in two MSA patients who had LAP as a cardinal symptom in the early stages. Development of autonomic dysfunction was preceded or followed by LAP. The autonomic symptom occurring predominantly in...
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PMID: 17826894
PDF is available here.
PDF is available here.
Movement Disorders (22 Suppl 17)s17 2007
Abstract
Nonmotor symptoms have recently become a focus of renewed clinical interest and research in Parkinson's disease (PD). Autonomic and cognitive dysfunction are among the most prevalent of these nonmotor aspects of the disease. Although exact clinico-pathological correlations have not been established,...
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PMID: 18175399
PDF is available here.
PDF is available here.
Abstract
Abstract
Journal of Neurology (254)6 2007
Abstract
We measured seated, standing and postprandial BP in the morning without and with ingestion of 350 ml tap water at 07.30 hours for seven successive days. The changes from the basal BP level at 07.30 hours (DeltaBP) were assessed as an index of the effect of water drinking. RESULTS : Water drinking el...
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PMID: 17420927
PDF is available here.
PDF is available here.
Neuroscience Letters (415)3 2007
Abstract
Orthostatic hypotension commonly occurs in persons with spinal cord injury (SCI), limiting rehabilitation and independence. Findings of increased production of nitric oxide (NO) by inducible nitric oxide synthase (iNOS) after exposure to simulated microgravity suggest that increased iNOS expression...
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PMID: 17287083
PDF is available here.
PDF is available here.
Movement Disorders (22)4 2007
Abstract
The objective of this study was to investigate cardiovascular autonomic function in patients with parkin disease. Ten patients with a genetically confirmed diagnosis were compared to 11 healthy controls. Symptoms related to autonomic dysfunction were collected by structured interviews. Cardiovascula...
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PMID: 17230469
PDF is available here.
PDF is available here.
Journal of the Neurological Sciences (254)1-2 2007
Abstract
We assessed CA in PD patients and the potential influence of dopaminergic agents. CA was determined by means of transcranial Doppler (TCD) monitoring of the middle cerebral artery (MCA) at rest and during a thigh cuff release test inducing a systemic blood pressure (BP) drop. Fourteen patients were...
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PMID: 17275849
PDF is available here.
PDF is available here.
Abstract
We conclude that OH is frequent in PDD and should be addressed therapeutically since it may exacerbate attentional dysfunction....
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PMID: 17195917
PDF is available here.
PDF is available here.
Abstract
Shy-Drager syndrome, one type of multisystem atrophy, is considered a Parkinson's-plus syndrome. Survival time is less than a decade from the onset of symptoms, and patients usually become physically dependent and wheelchair bound years before death. Ethical dilemmas are very common in health care....
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PMID: 17233508
PDF is available here.
PDF is available here.
Abstract
STN stimulation of patients with PD increases peripheral vasoconstriction and BRS and stabilizes BP, thereby improving postural hypotension in patients with PD. The results indicate that STN stimulation not only alleviates motor deficits but also influences autonomic regulation in patients with PD....
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PMID: 17130410
PDF is available here.
PDF is available here.
Abstract
The pupils are often affected in autonomic neuropathy, although this is not always apparent either to the patient or to their doctors. Considerable care is needed not only to detect these abnormalities but also to interpret correctly the results of pupil tests in this group of patients....
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PMID: 16754691
PDF is available here.
PDF is available here.
Abstract
Patients with autonomic failure suffer severe postural hypotension that may be associated with symptoms of cerebral hypoperfusion. This study utilized near-infrared spectroscopy (NIRS) to measure changes in cerebral oxygenation and haemodynamics during the head-up tilt table test in 18 patients with...
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PMID: 16868345
PDF is available here.
PDF is available here.
Journal of the Neurological Sciences (243)1-2 2006
Abstract
We measured blood flow velocity (BFV) in the middle cerebral artery (MCA) and vertebral artery (VA) in patients with these disorders and investigated whether cerebral vasomotor reactivity (VMR) differs in these three disorders. Twenty-four patients (9 with PD, 10 with MSA and 5 with PAF) were studie...
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PMID: 16438986
PDF is available here.
PDF is available here.
Archives of Neurology (63)4 2006
Abstract
Pyridostigmine significantly improves standing BP in patients with OH without worsening supine hypertension. The greatest effect is on diastolic BP, suggesting that the improvement is due to increased total peripheral resistance....
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PMID: 16476804
PDF is available here.
PDF is available here.
Medizinische Klinik (101 Suppl 1) 2006
Abstract
Various disorders of autonomic circulatory control are characterized by symptoms of orthostatic intolerance and syncope. Since the introduction of tilt-table testing as a cardiac diagnostic tool by Kenny et al., definition of these disorders has changed significantly. This review summarizes the curr...
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PMID: 16802526
PDF is available here.
PDF is available here.
Abstract
Physical abuse directly affects maternal and fetal/infant health, with documented reports of higher rates of pregnancy termination, neonatal death, and lower birth weights. Although the Centers for Disease Control and Prevention recommend repeated interviews of women of childbearing age to screen fo...
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PMID: 16552948
PDF is available here.
PDF is available here.
Abstract
We reveal unexpected origins of age induced departure from 1/f-type temporal scaling in healthy human heart rate. Contrary to the widely established view, we provide evidence that age induced dynamical imbalance in the autonomic control is not due to the emergent functional dominance of the sympathe...
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PMID: 16402607
PDF is available here.
PDF is available here.
Abstract
Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder that affects adults. It is characterised by autonomic failure affecting many systems; cardiovascular, urinary, sexual, gastrointestinal and sudomotor, amongst others. In addition there are motor deficits, resulting in both parkin...
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PMID: 17017551
PDF is available here.
PDF is available here.
Abstract
The PD + OH resembles PAF and differs from MSA in hemodynamic responses to drugs that alter NE release from sympathetic nerves. The results fit with sympathetic noradrenergic denervation in PD + OH and PAF but not in MSA....
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PMID: 16772807
PDF is available here.
PDF is available here.
The Lancet (366 Suppl 1) 2005
Abstract
Abstract
Pressure recovery time is a valuable index of adrenergic failure. It extends the value of the Valsalva maneuver by providing a quantitative index that is measurable in patients with severe adrenergic failure....
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PMID: 16301478
PDF is available here.
PDF is available here.
Journal of Nuclear Medicine (46)11 2005
Abstract
Desipramine treatment was associated with decreased 6-(18)F-fluorodopamine-derived radioactivity in the heart, renal cortex, and thyroid gland but not in the liver, spleen, renal pelvis, or salivary glands. Both the PD+OH group and the PAF group had decreased 6-(18)F-fluorodopamine-derived radioacti...
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PMID: 16269589
PDF is available here.
PDF is available here.
Abstract
We review this report and propose that the Lewis family may represent an unusual form of autosomal dominant cerebellar ataxia type I, which might be categorized either as SCA3 (Machado-Joseph disease) or a new SCA subtype. There remains no conclusive evidence to support the notion of hereditary MSA....
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PMID: 16103001
PDF is available here.
PDF is available here.
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 8) 2005
Abstract
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 8) 2005
Abstract
Abstract
We assessed fludrocortisone's efficacy in treating postural hypotension, and its effect on survival and secondary long-term FD problems. For 341 FD patients we obtained demographic data and clinical information from the last Center evaluation (most current or prior to death) including mean blood pre...
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PMID: 16032383
PDF is available here.
PDF is available here.
Abstract
Abstract
A 61-year-old man with Shy-Drager Syndrome underwent partial pulmonary lobectomy under general anesthesia combined with thoracic epidural anesthesia. The blood pressure decreased from 140/ 100 mmHg to 80/50 mmHg after thoracic epidural anesthesia. It increased after intravenous ephedrine. The blood...
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PMID: 16026063
PDF is available here.
PDF is available here.
Abstract
Mutations in the PINK1 gene cause autosomal recessive parkinsonism characterized by early onset and a variable phenotypic presentation. A patient homozygous for the Ala168Pro mutation has been fully characterized clinically. Apart from onset at age 39 years and the excellent and sustained response t...
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PMID: 15955954
PDF is available here.
PDF is available here.
Nippon rinsho. Japanese journal of clinical medicine (63 Suppl 6) 2005
Abstract
Abstract
In most of non-diabetic functional renal transplant patients, there is an absence of an orthostatic decline in blood pressure. Thus, it could be considered that there is no real dysautonomia in this specific population....
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PMID: 15812257
PDF is available here.
PDF is available here.
Psychosomatics (46)1 2005
Abstract
New England Journal of Medicine (351)27 2004
Abstract
Abstract
Water is thus beneficial in improving standing BP in AF, acting within 15 minutes in both MSA and PAF. The earlier onset of the pressor effect in PAF may reflect the differing lesion site and underlying pathophysiology between these conditions....
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PMID: 15548493
PDF is available here.
PDF is available here.
Abstract
Physical Review E (70)5 Pt 1 2004
Abstract
We present systematic evidence for the origins of 1/f -type temporal scaling in human heart rate. The heart rate is regulated by the activity of two branches of the autonomic nervous system: the parasympathetic (PNS) and the sympathetic (SNS) nervous systems. We examine alterations in the scaling pr...
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PMID: 15600582
PDF is available here.
PDF is available here.
Abstract
A 64 year-old woman developed Raynaud's phenomenon and dry eyes/mouth. Laboratory examination revealed positive Schirmer's test, rheumatoid factor and anti-nuclear antibody, and lymphocytic sialoadenitis on salivary gland biopsy. These features strongly suggested the diagnosis of primary Sjogren's s...
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PMID: 15379743
PDF is available here.
PDF is available here.
Abstract
Abstract
Movement Disorders (19)1 2004
Abstract
In cases of multiple system atrophy (MSA), glial cytoplasmic inclusions (GCI) were distributed randomly or present in large diffuse clusters (>1,600 microm in diameter) in most areas studied. These spatial patterns contrast with those reported for filamentous neuronal inclusions in the tauopathies a...
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PMID: 14743371
PDF is available here.
PDF is available here.
Abstract
Abstract
Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by parkinsonism and cerebellar, autonomic, urinary, and/or pyramidal dysfunction. Urinary and erectile dysfunction (ED) symptoms are prominent early features in men with MSA. Autonomic failure, considered until re...
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PMID: 12934060
PDF is available here.
PDF is available here.
Abstract
A 58-year-old woman with a 40-year history of very slowly progressive Multiple System Atrophy is described.
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PMID: 12822045
PDF is available here.
PDF is available here.
Abstract
PAF involves generalized loss of sympathoadrenomedullary cells, MSA + NOH intact sympathoadrenomedullary cells, and PD + NOH intact adrenomedullary cells but organ-selective sympathetic denervation, especially in the heart....
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PMID: 12707437
PDF is available here.
PDF is available here.
Abstract
We evaluated SSwRs and SVRs to deep inspiration, mental arithmetic, exercise, and tactile stimulation in 40 MSA patients and 15 healthy controls. We also conducted head-up tilt tests and R-R interval variation tests (CV(R-R)). SSwRs were present in all controls, but absent in 19 (47.5 %) of the MSA...
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PMID: 12720092
PDF is available here.
PDF is available here.
Abstract
In recent years increased interest has focused on the nature and pathophysiology of orthostatic intolerance and syndromes associated with autonomic disorders. Understanding the pathophysiology underlying these syndromes has led to the recognition of several distinct clinical entities with overlappin...
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PMID: 12696403
PDF is available here.
PDF is available here.
European Neurology (49)1 2003
Abstract
Muscle & Nerve (26)5 2002
Abstract
Quantitative cardiovascular autonomic function tests (AFTs) and sympathetic skin response (SSR) were performed in 12 patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Parasympathetic autonomic function was examined by Valsalva ratio and R-R interval variation during res...
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PMID: 12402289
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (144)43 2002
Abstract
Patients with non-specific symptoms that manifest when standing, are commonly seen in the doctor's office. The suspected diagnosis orthostatic dysregulation, can be established on the basis of a careful history, physical examination and a standing test. Frequent symptoms of orthostatic dysregulation...
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PMID: 12534013
PDF is available here.
PDF is available here.
Circulation (106)17 2002
Abstract
Autonomic blockade prolongs QT interval in normal subjects to a similar duration as in PAF patients. Furthermore, blocking residual autonomic tone in PAF patients is associated with a further increase in QT interval length. Patients with MSA have greater residual sympathetic tone and greater prolong...
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PMID: 12390954
PDF is available here.
PDF is available here.