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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Cardiovascular System (8):
Recent article
Cardiovascular System
Abstract
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Abstract
We provide a comprehensive review of the actions of BAs on cardiovascular function. In the heart and the systemic circulation, BAs interact with plasma membrane G-protein-coupled receptors, for example, TGR5 and muscarinic receptors, and nuclear receptors, for example, the farnesoid (FXR) and pregna...
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PMID: 21707953
PDF is available here.
PDF is available here.
Abstract
Hydrogen sulfide (H2S), the colorless gas with the smell of rotten eggs, has been regarded as a novel gaseous signaling molecule. Although H2S has been proved been involved into the cardiovascular functions, the cardiovascular functions of H2S within the nucleus tractus solitarii (NT...
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PMID: 21612157
PDF is available here.
PDF is available here.
Abstract
Largely on the basis of the first publication of findings of net harm with menopausal hormone treatment in the Women's Health Initiative (WHI) hormone trials, current Food and Drug Administration recommendations limit menopausal hormone treatment to the "…shortest duration consistent with treatment...
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PMID: 21396500
PDF is available here.
PDF is available here.
Abstract
A pediatric assessment is now a required component of every New Drug Application in North America or Marketing Authorization Application in Europe, unless a waiver has been granted previously. Nonclinical juvenile toxicity studies are usually required as part of this assessment. The protocols for ju...
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PMID: 20972745
PDF is available here.
PDF is available here.
Hastings Center Report (41)2 2011
Abstract
Clinical calcium (20)11 2010
Abstract
Atherosclerotic vascular damage associated with aging manifest several features, namely atherosis, sclerosis and calcified change, finally leading to cardiovascular (CV) events. Accumulating recent reports show the importance of cellular senescence in atherosclerogenesis; however, few reports have a...
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PMID: 21037384
PDF is available here.
PDF is available here.
Harvard Heart Letter (21)3 2010
Abstract
Pediatric Research (68)5 2010
Abstract
In complicated labor, neonatal outcome may depend not only on the extent of fetal asphyxia and acidosis but also on the effects on the fetal cardiovascular system of reactive oxygen species (ROS) generated during the ischemia-reperfusion (I/R) associated with repeated compressions of the umbilical c...
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PMID: 20613682
PDF is available here.
PDF is available here.
Circulation Journal (74)11 2010
Abstract
Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellu...
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PMID: 20962430
PDF is available here.
PDF is available here.
Irish Journal of Medical Science (179)S10 2010
Abstract
Abstract
Hypertension and type 2 diabetes mellitus (T2DM) are powerful risk factors for cardiovascular disease (CVD) and chronic kidney disease (CKD), both of which are leading causes of morbidity and mortality worldwide. Research into the pathophysiology of CVD and CKD risk factors has ident...
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PMID: 20697411
PDF is available here.
PDF is available here.
Vnitrni lekarstvi (56)10 2010
Abstract
Obesity is an independent risk factor for the development and progression of hypertension, cardiovascular disease and chronic kidney disease. There is growing evidence that obesity and associated metabolic abnormalities may induce and accelerate renal complications in essential hypertension. The clu...
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PMID: 21105455
PDF is available here.
PDF is available here.
Abstract
I and II clinical trials performed with cinaciguat so far, however, are insufficient to provide convincing evidence on the efficacy and safety of the drug. Thus, caution should be exerted before extrapolating the present preliminary data to the clinical practice....
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PMID: 20730699
PDF is available here.
PDF is available here.
Future Oncology (6)9 2010
Abstract
Abstract
Vitamins D and K are lipid-phase nutrients that are pleiotropic - endowed with versatile homeostatic capacities at the organ, tissue, and cellular levels. Their metabolic and physiologic roles overlap considerably, as evidenced in the bone and cardiovascular systems. Vitamin D₃ (cholecalciferol, D...
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PMID: 21155624
PDF is available here.
PDF is available here.
European Heart Journal (31 Suppl 1) 2010
Abstract
Abstract
Lung, cardiovascular system, liver and kidney are some examples for organs that develop ramified three-dimensional networks of epithelial tubes. The tube morphology affects flow rates of transported materials, such as liquids and gases. Therefore, it is important to understand how tu...
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PMID: 20403463
PDF is available here.
PDF is available here.
Kardiologia polska (68)8 2010
Abstract
Our data showed the significant associations between the Trp64Arg polymorphism in the beta₃-AR gene and some CV parameters such as serum HDL-cholesterol and glucose levels in athletes. However, further studies of the precise mechanism behind these associations are needed....
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PMID: 20730725
PDF is available here.
PDF is available here.
Kardiologia polska (68)8 2010
Abstract
Brain research (1344) 2010
Abstract
It has been reported that L-glutamate (L-glu) microinjection into the hypothalamic paraventricular nucleus (PVN) evokes pressor and tachycardiac responses in unanesthetized rats. In the present study the hypothesis was tested that a local nitric oxide (NO)-guanylate cyclase interaction mediates card...
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PMID: 20478280
PDF is available here.
PDF is available here.
Abstract
Abstract
We were particularly struck by the limited availability of immunohistochemical markers for sheep tissue, despite sheep being the FDA-approved animal for heart valve testing. This paper, therefore, aims to compile the available knowledge and extend the marker list with antibodies cross-reacting with...
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PMID: 20090513
PDF is available here.
PDF is available here.
Abstract
We investigated the relation between MetS and left ventricle (LV) geometry and function, carotid intima-media thickness (IMT) and arterial stiffness in a community-based cohort of 702 adult subjects. Subjects were categorized into three groups according to the number of MetS components present, as d...
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PMID: 20592897
PDF is available here.
PDF is available here.
Biomedical Engineering (12)1 2010
Abstract
microRNAs (miRNAs) are small RNAs 18 to 24 nucleotides in length that serve the pivotal function of regulating gene expression. Instead of being translated into proteins, the mature single-stranded miRNA binds to messenger RNAs (mRNAs) to interfere with the translational process. It...
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PMID: 20415587
PDF is available here.
PDF is available here.
FASEB Journal (24)7 2010
Abstract
We evaluated the tissue selectivity of the ER alpha-selective agonist propyl pyrazole triol (PPT) compared with 17beta-estradiol (E2) in vivo. Four weeks postovariectomy, equimolar doses of PPT and E2 were administered to rats in subcutaneous implants for 5 d. Both treatments restored rapid vasorela...
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PMID: 20203089
PDF is available here.
PDF is available here.
Abstract
We demonstrate an inhibition of brown adipose tissue (BAT) thermogenesis evoked by activation of neurons in the VLM, as well as by neurons in the intermediate NTS, of chloralose/urethane-anesthetized, artificially ventilated rats. Activation of neurons in either rostral VLM or caudal VLM with N-meth...
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PMID: 20410479
PDF is available here.
PDF is available here.
Circulation Research (106)12 2010
Abstract
We provide evidence that the subdivision into canonical and noncanonical Wnt signaling pathways solely based on the identity of Wnt ligands or Frizzled receptors is not appropriate anymore. We thereby deliver a solid base for further upcoming articles of a review series focusing on the role of Wnt p...
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PMID: 20576942
PDF is available here.
PDF is available here.
The Aging Male (13)2 2010
Abstract
Soy- or red clover- derived products containing isoflavones have been amply studied in climacteric and postmenopausal women, and confusing contradicting results have been published. The beneficial effects on climacteric complaints, cholesterol and the development of osteoporosis are marginally at be...
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PMID: 19951012
PDF is available here.
PDF is available here.
Journal of Vascular Surgery (51)6 Suppl 2010
Abstract
Journal of Critical Care (25)2 2010
Abstract
The risk of abnormal aEEG is high in sick neonates with PPHN or complex CHD. Prospective evaluation of the relationship between aEEG recordings in these disorders and acute cardiorespiratory physiology, comprehensive neuroimaging, and long-term patient outcomes is needed.
Crown Copyright (c) 2010....
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PMID: 19327328
PDF is available here.
PDF is available here.
Mayo Clinic Proceedings (85)6 2010
Abstract
The role of the general internist in the care of breast cancer survivors is increasing as the number of women living with breast cancer continues to rise. Most breast cancers occurring in women older than 50 years are estrogen receptor- and/or progesterone receptor-positive, and adjuvant endocrine t...
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PMID: 20511486
PDF is available here.
PDF is available here.
Circulation (121)21 2010
Abstract
Circulation (121)20 2010
Abstract
Chronic kidney disease is a common comorbidity among patients admitted with acute severe hypertension, and AKI is a frequent form of acute target organ dysfunction, particularly in those with baseline chronic kidney disease. Any degree of AKI is associated with a greater risk of morbidity and mortal...
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PMID: 20458014
PDF is available here.
PDF is available here.
Circulation (121)20 2010
Abstract
These findings suggest that a proportion of PPCM/PACM cases results from a genetic cause....
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PMID: 20458009
PDF is available here.
PDF is available here.
Drug Discovery Today (15)9-10 2010
Abstract
Angiotensin-converting enzyme (ACE) is a major target in the treatment of cardiovascular diseases (CVDs). In addition to ACE, ACE2 - which is a homolog of ACE and promotes the degradation of angiotensin II (Ang II) to Ang (1-7) - has been recognized recently as a potential therapeutic target in the...
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PMID: 20170743
PDF is available here.
PDF is available here.
Matrix Biology (29)4 2010
Abstract
We demonstrate that ADAMTS9, a highly conserved versican-degrading protease, is required for correct cardiovascular development and adult homeostasis. Analysis of Adamts9(+/LacZ) adult mice revealed anomalies in the aortic wall, valvulosinus and valve leaflets. Abnormal myocardial projections and 's...
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PMID: 20096780
PDF is available here.
PDF is available here.
Abstract
We demonstrate the application of this technology for visualization of cardiovascular structures in developing mouse embryos using Lugol solution (aqueous potassium iodide plus iodine).
We show the optimization of this method to obtain ex vivo micro-CT images of embryonic and neonata...
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PMID: 20190279
PDF is available here.
PDF is available here.
Abstract
Depressive symptoms and verbal aggression may interact to promote exaggerated blood pressure responses to stressors, a possible marker for mechanisms that contribute to heart disease....
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PMID: 20379807
PDF is available here.
PDF is available here.
Abstract
Although the potential for some residual confounding by smoking could not be eliminated, these data suggest that CRF is inversely associated with lung cancer mortality in men. Continued study of CRF in relation to lung cancer, particularly among smokers, may further our understanding of disease etio...
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PMID: 19996990
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to determine the effects of a reduced whole body blood volume on the kinetic response of VO(2) during moderate and heavy intensity exercise. Six males and four females (age, 21+/-2 yrs; height, 175.2+/-5.1 cm; weight, 66.4+/-2.8 kg; VO(2)max, 53.0+/-4.1 ml x kg (-1) x m...
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PMID: 20180178
PDF is available here.
PDF is available here.
Kidney International (77)9 2010
Abstract
We studied 3364 patients from a community-based cohort of elderly individuals of whom 724 had CKD defined as creatinine clearances of stage 3 or less. The contribution of systolic blood pressure was evaluated in four ranges (<120, 120-129, 130-139, and > or = 140 mm Hg). All multiple linear regressi...
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PMID: 20130527
PDF is available here.
PDF is available here.
Kidney International (77)9 2010
Abstract
Patients with chronic kidney disease (CKD) have an inordinate risk of cardiovascular disease. In addition to the metabolic state of uremia, the CKD-associated risk is partly explainable by unique cofactors such as dyslipidemia, systemic inflammation, and exposures that occur during renal replacement...
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PMID: 20393488
PDF is available here.
PDF is available here.
Abstract
We discuss the roles of miRNAs as regulators of cardiac form and function, unresolved questions in the field, and issues for the future.
Copyright 2010 Elsevier Inc. All rights reserved....
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PMID: 20412767
PDF is available here.
PDF is available here.
Methods in Molecular Biology (616)616 2010
Abstract
We have begun to dissect the role of T lymphocytes in atherosclerosis in real time in vivo. Here, we provide step-by-step guides to the various stages involved in visualising the migration of T cells within a lymph node and their infiltration into inflamed tissues such as atherosclerotic arteries. T...
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PMID: 20379877
PDF is available here.
PDF is available here.
Abstract
Sumoylation is a covalent modification, which is mediated by small ubiquitin-like modifier (SUMO) polypeptides. A growing body of evidence has shown that sumoylation affects the functional properties of many substrates in the regulation of cellular processes. Recent reports indicate the crucial role...
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PMID: 20079693
PDF is available here.
PDF is available here.
Abstract
Epoxyeicosatrienoic acids (EETs) build a family consisting of four arachidonic acid derived regioisomers that are generated by P450 epoxygenases. In the past years, growing interest in influencing EET level arose since EETs possess numerous beneficial effects in the cardiovascular system, for exampl...
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PMID: 20079692
PDF is available here.
PDF is available here.
Abstract
Rac1 GTPase is an established master regulator of cell motility through cortical actin re-organization and of reactive oxygen species generation through regulation of NADPH oxidase activity. Numerous molecular and cellular studies have implicated Rac1 in various cardiovascular pathologies: vascular...
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PMID: 20060361
PDF is available here.
PDF is available here.
Abstract
The family of NADPH oxidases consists of seven members that are all producing reactive oxygen species (ROS). In the cardiovascular systems three NADPH oxidases are expressed: Nox1, Nox2 and Nox4, which all exhibit different physiological functions such as regulating blood pressure, mediating growth...
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PMID: 20149739
PDF is available here.
PDF is available here.
Abstract
The sarco/endoplasmic reticulum calcium ATPase (SERCA) is essential for the control of intracellular free Ca(2+) levels. Although the importance for this enzyme in cardiac myocytes is well recognized, it is only recently that SERCA has been identified as an important effector of nitric oxide (NO) ac...
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PMID: 20045379
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (99 Suppl 1) 2010
Abstract
Abstract
Clinical experience and literature evidence suggest that peritoneal dialysis (PD) is a safe and effective treatment in short term (3 to 5 years) for stage 5 chronic kidney disease patients. A major limitation to long-term PD has been peritoneal membrane structural and functional alterations over tim...
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PMID: 20093342
PDF is available here.
PDF is available here.
Abstract
We compared FBS with human platelet-lysate (PL) in media for in vitro cell culture. A threefold increase in duplication rate was found when human, saphenous vein-derived myofibroblasts were cultured in PL, whereas expression of marker proteins (alpha-smooth muscle actin, vimentin, desmin, and nonmus...
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PMID: 19908968
PDF is available here.
PDF is available here.
Pediatric Research (67)4 2010
Abstract
We studied cardiovascular rhythms by Fourier analysis of 24-h ambulatory blood pressure (BP) measurement profiles in 129 hypertensive children, 54 children with WCH, and 146 age-, height-, and gender-matched healthy subjects. The day/night mean arterial pressure ratio was lower in hypertensive and p...
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PMID: 20032814
PDF is available here.
PDF is available here.
Psychosomatic Medicine (72)3 2010
Abstract
We recorded heart rate (HR) and HRV during 301 working shifts. Participants provided salivary cortisol samples at the beginning of their work shift and every 2 hours thereafter. Samples were collected during three investigation periods spread over 9 months. Change scores for cortisol were calculated...
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PMID: 20190125
PDF is available here.
PDF is available here.
Pediatric Cardiology (31)3 2010
Abstract
Hypertension (55)4 2010
Abstract
Hypertension (55)4 2010
Abstract
We searched general bibliographic databases, PsycINFO, Web of Science, and PubMed, up to December 2009. Two reviewers independently extracted data on study characteristics, quality, and estimates of associations. There were 169 associations (36 articles) of stress reactivity and 30 associations (5 a...
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PMID: 20194301
PDF is available here.
PDF is available here.
Abstract
The nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most often prescribed drugs in the world. This heterogeneous class of drugs includes aspirin and several other selective or non-selective cyclooxygenase (COX) inhibitors. The non-selective NSAIDs are the oldest ones and are called tradi...
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PMID: 20498929
PDF is available here.
PDF is available here.
Circulation Research (106)4 2010
Abstract
We review the basic biochemistry of S-nitrosylation (and denitrosylation), discuss the role of S-nitrosylation in the vascular and cardiac functions of NO, and identify current and potential clinical applications....
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PMID: 20203313
PDF is available here.
PDF is available here.