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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Blood-Air Barrier (0):
Recent article
Blood-Air Barrier
Abstract
The following are the proceedings of a symposium held at the Second International Congress for Respiratory Science in Bad Honnef, Germany. The goals of the symposium were to delineate the blood-gas barrier phenotype across vertebrate species; to delineate the interrelationship betwee...
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PMID: 20096383
PDF is available here.
PDF is available here.
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Abstract
We describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. This bioinspired microdevice reproduces complex integrated organ-level responses to bacteria and inflammatory cytokines introduced into the alveolar space. In nanotoxicolog...
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PMID: 20576885
PDF is available here.
PDF is available here.
Abstract
We could demonstrate that a high concentration of Ca(2+) could prevent the barrier-disrupting effect of Cd(2+). In conclusion, the exposure of Cd(2+) to cocultures of lung cells caused a decrease in TER, major morphological changes, a reduction of cell viability and an increase of cytokine release,...
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PMID: 20399800
PDF is available here.
PDF is available here.
Abstract
In this review, a case is made that asthma has its primary origin in the airways that involves defective behaviour of the epithelium in relation to environmental exposures. These include defects in barrier function and an impaired innate immunity to provide the substrate upon which allergic sensitiz...
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PMID: 19915457
PDF is available here.
PDF is available here.
Pulmonary tissue engineering using dual-compartment polymer scaffolds with integrated vascular tree.
Abstract
The microcarriers evenly distributed MLE-12 cells on the parenchymal compartment surface. Confluent cell layers were confirmed by fluorescent and electron microscopy. Adequate proliferation of MLE-12 cells within the construct was monitored via the DNA content. Viability of the cells was maintained...
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PMID: 19943231
PDF is available here.
PDF is available here.
Acta Oto-Laryngologica (129)7 2009
Abstract
Consistent with expectations for transTM gas exchange, ECP + EC O(2) decreased and CO(2) increased during the experiments. CO(2) increase was faster after application of epinephrine to the TM. The ratio of O(2)/CO(2) conductances was not consistent with the gas exchange through a primarily water or...
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PMID: 18728916
PDF is available here.
PDF is available here.
Pneumologie (63)6 2009
Abstract
The extremely thin blood-gas barrier, the high blood perfusion rate and the deformability of the lung required for ventilation call for safety measures in order to keep the peripheral airspaces dry. The protective factors are provided in part by the particular structural organization of the lung, in...
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PMID: 19259918
PDF is available here.
PDF is available here.
Journal of Perinatology (29 Suppl 2) 2009
Abstract
Surfactant treatment in preterm infants and term newborns with (acute respiratory distress syndrome) ARDS-like severe respiratory failure has become part of an individualized treatment strategy in many intensive care units around the world. These babies constitute heterogeneous groups of gestational...
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PMID: 19399004
PDF is available here.
PDF is available here.
Abstract
Inhalation Toxicology (21)1 2009
Abstract
Particulate air pollution is associated with increased risk of pulmonary diseases and detrimental outcomes related to the cardiovascular system, including altered vessel functions. This study's objective was too evaluate the effects of ambient particle exposure on the blood-gas permeability, lung fu...
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PMID: 18752169
PDF is available here.
PDF is available here.
Alcohol and Alcoholism (44)1 2009
Abstract
These observations provide further evidence that alcohol abuse affects the normal permeability of the alveolar-capillary barrier and thereby may contribute to the development of the acute respiratory distress syndrome in individuals with alcohol abuse....
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PMID: 18567916
PDF is available here.
PDF is available here.
Abstract
We have observed a remarkable consistency of the normalized baseline K(f) values between species with widely varying body weights from mice to sheep. Uniformity of K(f) values can be attributed to the thin alveolar capillary barrier required for gas exchange and the conserved matching of lung vascul...
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PMID: 18502816
PDF is available here.
PDF is available here.
Abstract
We addressed the in vivo role of Cdc42 activity in mediating endothelial barrier protection in lungs by generating mice expressing the dominant active mutant V12Cdc42 protein in vascular endothelial cells targeted via the VE-cadherin promoter. These mice developed normally and exhibited constitutive...
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PMID: 18515405
PDF is available here.
PDF is available here.
Abstract
We have recently shown that chronic exposure of mice or humans to arsenic (10-50 ppb) in drinking water alters bronchiolar lavage or sputum proteins consistent with reduced epithelial cell migration and wound repair in the airway. In this report, we used an in vitro model to examine effects of acute...
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PMID: 18539681
PDF is available here.
PDF is available here.
Abstract
We linked ANP-mediated protective effects to the activation of Epac/Rap and PKA signaling cascades, which dramatically inhibited the Rho pathway of thrombin-induced EC hyper-permeability. These results suggest a novel mechanism of ANP protective effects against agonist-induced pulmonary EC barrier d...
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PMID: 18064650
PDF is available here.
PDF is available here.
Georgian medical news ()159 2008
Abstract
I alveolocytes. Type II alveolocytes, basic membrane and elastic fibers in interstitial tissue were more stabile. The investigation showed that blood-air barrier directly reacts on environmental factors, decreasing the partial pressure of oxygen in the inspired air....
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PMID: 18633152
PDF is available here.
PDF is available here.
Abstract
We found that the prevalence and mean values for the serum IgM levels directed against nitro-BSA were significantly greater in patients with partial CFS, CFS and MDD than in normal controls, and significantly greater in CFS than in those with partial CFS and MDD. We found significant and positive co...
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PMID: 18580855
PDF is available here.
PDF is available here.
Abstract
The Australian Brush Turkey Alectura lathami is a member of the Megapodiidae, the mound-building birds that produce totally independent, "superprecocial" hatchlings. This study examined the post-hatching development of resting and maximal metabolic rates, and the morphometrically determined changes...
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PMID: 16714130
PDF is available here.
PDF is available here.
Journal of Surgical Research (146)1 2008
Abstract
Systemic TNF-alpha increased and cardiac index decreased at 8 h after CPB in PLA (P < 0.05 versus pre-CPB), but not in MP (P < 0.05 versus PLA). In both groups, at 8 h after CPB, PaO2 and PaO2/FiO2 were decreased and arterio-alveolar oxygen difference and pulmonary vascular resistance were increased...
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PMID: 17583746
PDF is available here.
PDF is available here.
Microvascular Research (75)3 2008
Abstract
We examined lung microvascular and artery endothelial cells to gain insight into mechanisms for segment-specific barrier functions. Transendothelial electrical resistance was significantly higher in microvascular barriers, and a 50% reduction in barrier function required 5-fold higher concentration...
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PMID: 18068735
PDF is available here.
PDF is available here.
Intensive Care Medicine (34)4 2008
Abstract
Intensive Care Medicine (34)4 2008
Abstract
Terbutaline reduces protein fluxes across the alveolar epithelial and pulmonary microvascular barriers during high-volume ventilation in vivo. The route of administration may be important....
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PMID: 18097649
PDF is available here.
PDF is available here.
Intensive Care Medicine (34)4 2008
Abstract
Pulmonary gas exchange critically depends upon the hydration state and the thinness of the interstitial tissue layer within the alveolo-capillary membrane. In the interstitium, fluid freely moving within the fibrous extracellular matrix (ECM) equilibrates with water chemically bound to hyaluronic ac...
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PMID: 18264693
PDF is available here.
PDF is available here.
Abstract
We measured diffusing capacity (DLCO), alveolar membrane properties (D (m)), capillary lung volume (V (c)), and alveolar volume (V (A) ) in 20 healthy subjects (12 males; age 32.4 +/- 13 (SD); BMI 21.7 +/- 3; non smokers) at total lung capacity (TLC) and at approximately 80, 60, and 40% TLC. In all...
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PMID: 18060560
PDF is available here.
PDF is available here.
Abstract
In acute myocardial infarction (AMI), alveolar interstitium edema is generally attributed to a hydrostatic imbalance. However, inflammatory burden and/or neural/hormonal/hemodynamic stimulation might injure the microvascular endothelium, eliciting interstitial overflow and altering alveolar-capillar...
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PMID: 18192218
PDF is available here.
PDF is available here.
Abstract
During its development that begins in intrauterine life, the lung is transformed from a simple epithelial lined sac that emerges from the foregut into a complex arrangement of blood vessels, airways, and alveoli that make up the mature lung structure. This remarkable transformation that continues fo...
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PMID: 18203035
PDF is available here.
PDF is available here.
Abstract
We previously described ATP-induced endothelial cell (EC) barrier enhancement via a complex cell signaling and hypothesized endothelial purinoreceptors activation to exert anti-inflammatory barrier-protective effects. To test this hypothesis, we used a murine model of ALI induced by intratracheal ad...
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PMID: 17993588
PDF is available here.
PDF is available here.
Thrombin enhances the barrier function of rat microvascular endothelium in a PAR-1-dependent manner.
Abstract
We questioned whether thrombin may have segmentally differentiated effects on pulmonary endothelium. In cultured rat endothelial cells, rat thrombin (10 U/ml) recapitulated the previously reported decrease in transmonolayer electrical resistance (TER), F-actin stress fiber formation, paracellular ga...
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PMID: 18083763
PDF is available here.
PDF is available here.
Abstract
Ten lobectomies and eight wedge resection were performed. Using the paired t-test with each patient's pre-operative A/C permeability as his own control data, the postoperative A/C permeability of the ipsilateral non-diseased lobe(s) was found to be significantly increased. The degree of increase in...
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PMID: 18027471
PDF is available here.
PDF is available here.
Abstract
99mTc-DTPA radioaerosol inhalation lung imaging may serve as a useful adjunct and supportive method to chest CT scanning for detecting mild pulmonary contusion....
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PMID: 17876552
PDF is available here.
PDF is available here.
Abstract
We start with an overview of noise and impedance analyses that have been applied to various epithelial barriers. Noise analysis yields specific information about ion channels and their regulation in epithelial and endothelial barriers. Impedance analysis can yield information about apical and basola...
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PMID: 17601795
PDF is available here.
PDF is available here.
Abstract
We studied alveolar epithelial (A549) and microvascular endothelial (HMEC-1) cells within varying microfluidic environments as a first step towards building a microfluidic analog of the gas-exchange interface. We fabricated polydimethylsiloxane (PDMS) microdevices for parallel studies of cell growth...
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PMID: 17694441
PDF is available here.
PDF is available here.
Experimental Cell Research (313)11 2007
Abstract
We studied involvement of cAMP-dependent kinase (PKA), cAMP-Epac-Rap1 pathway, and small GTPase Rac in the PGs-induced EC barrier protective effects and cytoskeletal remodeling. PGE(2) and PGI(2) synthetic analog beraprost increased transendothelial electrical resistance and decreased dextran permea...
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PMID: 17493609
PDF is available here.
PDF is available here.
Journal of Anatomy (211)1 2007
Abstract
I cells occurred through cell broadening and lamellar body extrusion. Superfluous cuboidal cells were lost through apoptosis and subsequent clearance by alveolar macrophages. The establishment of the thin blood-gas barrier was established through apposition of the incipient capillaries to the format...
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PMID: 17553103
PDF is available here.
PDF is available here.
Circulation Research (101)1 2007
Abstract
We addressed the in vivo role of RhoGDI-1 in regulating pulmonary microvascular permeability using RhoGDI-1(-/-) mice. We observed that basal endothelial permeability in lungs of RhoGDI-1(-/-) mice was 2-fold greater than wild-type mice. This was the result of opening of interendothelial junctions i...
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PMID: 17525371
PDF is available here.
PDF is available here.
Abstract
Our study showed that sidestream cigarette smoke (SCS), a major component of second-hand smoke, was able to disrupt endothelial junctions and increase endothelial permeability. Sidestream cigarette smoke stimulated the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and myosin light c...
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PMID: 17652909
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of TNF through its individual p55 and p75 receptors on early pulmonary edema formation during high stretch ventilation, before neutrophil infiltration. Anesthetized wild-type or TNF receptor single/double knockout mice were ventilated with high tidal volume ( approximatel...
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PMID: 17435079
PDF is available here.
PDF is available here.
Abstract
We developed a new perfused human lung preparation. We measured AFC in 20 human lungs rejected for transplantation and determined the contribution of AFC to lung fluid balance. AFC was then compared with air space and perfusate levels of a biological marker of epithelial injury. The majority of huma...
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PMID: 17351061
PDF is available here.
PDF is available here.
Toxicological Sciences (98)1 2007
Abstract
The capability of physiologically based pharmacokinetic models to incorporate age-appropriate physiological and chemical-specific parameters was utilized to predict changes in internal dosimetry for six volatile organic compounds (VOCs) across different ages of rats. Typical 6-h animal inhalation ex...
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PMID: 17426107
PDF is available here.
PDF is available here.
Abstract
We have previously described barrier-protective effects of oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) on human pulmonary endothelial cells (EC) mediated by small GTPases Rac and Cdc42. This work examined OxPAPC-induced focal adhesion (FA) and adherens junction (AJ) remo...
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PMID: 17513457
PDF is available here.
PDF is available here.
Inhalation Toxicology (19)8 2007
Abstract
We tested a recently established in vitro coculture model of the alveolo-capillary barrier for its applicability to investigate acute toxic effects of SM at the human respiratory unit. The epithelial compartment of cocultures was exposed to varying concentrations of SM (0-1000 microM; t = 30 min). F...
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PMID: 17510838
PDF is available here.
PDF is available here.
Abstract
We measured the arithmetic mean thickness of the different components (endothelium, interstitium, and epithelium) of the BGB in the domestic chicken lung and compared the results with three mammals. Morphometric analysis showed that the total BGB of the chicken lung was significantly thinner than th...
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PMID: 17114279
PDF is available here.
PDF is available here.
Abstract
We found that a function-blocking antibody against the integrin alphavbeta5 prevented development of lung vascular permeability in two different models of ALI: ischemia-reperfusion in rats (mediated by vascular endothelial growth factor [VEGF]) and ventilation-induced lung injury (VILI) in mice (med...
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PMID: 17079779
PDF is available here.
PDF is available here.
Abstract
We hypothesized that 2ME, similar to other MT inhibitors, disrupts endothelial barrier properties. We show that 2ME decreases transendothelial electrical resistance and increases FITC-dextran leakage across human pulmonary artery endothelial monolayer, which correlates with 2ME-induced MT depolymeri...
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PMID: 17012370
PDF is available here.
PDF is available here.
Cell and Tissue Research (327)1 2007
Abstract
We describe previously unknown expression patterns and the localisation and molecular characteristics of alpha-DB isoforms in non-muscle mouse tissues. We demonstrate a highly specific sub-cellular distribution of alpha-DB in organs forming blood-tissue barriers. We show alpha-DB expression and loca...
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PMID: 16868787
PDF is available here.
PDF is available here.
Respiratory Research (8)1 2007
Abstract
We used tumor necrosis factor-R1 knock out mice (TNF-alpha R1KO) to understand the roles of TNF-alpha on epithelial function in models of carrageenan-induced acute lung inflammation. In order to elucidate whether the observed anti-inflammatory status is related to the inhibition of TNF-alpha, we als...
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PMID: 17971210
PDF is available here.
PDF is available here.
Abstract
During acute lung injury (ALI), the alveolar-capillary barrier is damaged, resulting in the accumulation of fluid and protein in the alveolar space characteristic of the acute respiratory distress syndrome (ARDS). Disordered epithelial repair may contribute to the development of fibrosis and worsen...
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PMID: 17085253
PDF is available here.
PDF is available here.
Microcirculation (13)8 2006
Abstract
Phenotypic heterogeneity in pulmonary vascular endothelial cells extends to regulation of endothelial permeability, a process which often depends upon Ca2 + entry from the extracellular space. Scanning electron microscopy of vascular corrosion casts has documented distinct patterns of barrier disrup...
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PMID: 17085430
PDF is available here.
PDF is available here.
Abstract
Among the air-breathing vertebrates, the avian respiratory apparatus, the lung-air sac system, is the most structurally complex and functionally efficient. After intricate morphogenesis, elaborate pulmonary vascular and airway (bronchial) architectures are formed. The crosscurrent, countercurrent, a...
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PMID: 17038201
PDF is available here.
PDF is available here.
Circulation Research (99)9 2006
Abstract
Circulation Research (99)9 2006
Abstract
We hypothesized that activation of the vanilloid transient receptor potential channel TRPV4 disrupts the alveolar septal barrier. Expression of TRPV4 was confirmed via immunohistochemistry in the alveolar septal wall in human, rat, and mouse lung. In isolated rat lung, the TRPV4 activators 4alpha-ph...
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PMID: 17008604
PDF is available here.
PDF is available here.
Abstract
Cardiovascular Research (71)4 2006
Abstract
Life Sciences (79)12 2006
Abstract
The purpose of the present study was to examine the effects of astragaloside IV, a saponin isolated from Astragalus membranaceus (Fisch) Bge, on the impairment of barrier function induced by acute high glucose in cultured human vein endothelial cells. High glucose (27.8 mM) induced a decrease in tra...
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PMID: 16650877
PDF is available here.
PDF is available here.
Abstract
Our recently published data suggested the involvement of protein phosphatase 2A (PP2A) in endothelial cell (EC) barrier regulation (Tar et al. [2004] J Cell Biochem 92:534-546). In order to further elucidate the role of PP2A in the regulation of EC cytoskeleton and permeability, PP2A catalytic (PP2A...
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PMID: 16475161
PDF is available here.
PDF is available here.
Journal of Perinatology (26 Suppl 1) 2006
Abstract
Various pre- and postnatal risk factors, which act additively or synergistically induce an injurious inflammatory response in the airways and the pulmonary interstitium of preterm infants with bronchopulmonary dysplasia. This inflammatory response is characterized by an accumulation of neutrophils a...
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PMID: 16625227
PDF is available here.
PDF is available here.
Journal of Physiology (570)Pt 2 2006
Abstract
We present a simple method to calculate transpulmonary fluid fluxes in different species, which can be used to elucidate mechanisms of lung fluid balance in vivo....
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PMID: 16269434
PDF is available here.
PDF is available here.
Abstract
The authors conducted light optical and electron microscopic studies of caseum-free resected lung parenchymal portions from 11 patients with caseous pneumonia. All cases were found to have severe vascular bed permeability impairments, developed extensive intraalveolar edema, destruction of both type...
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PMID: 17139832
PDF is available here.
PDF is available here.
Toxicologic Pathology (34)7 2006
Abstract
We examined the translocation pathway of the intratracheally instilled ultrafine carbon black (UFCB) from the lung into the blood circulation in mouse. Electron microscopy demonstrated accumulation of intratracheally instilled UFCB in the large-sized gaps developing between the cytoplasmic processes...
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PMID: 17178695
PDF is available here.
PDF is available here.
Respiratory Medicine (100)1 2006
Abstract
Almost all patients with asthma have a normal DL(CO), most patients in the other groups do not have the expected pattern of diffusion disturbance, especially in the group with DPLD a bad match is observed. CONCLUSION: In this study the pattern of diffusion disturbance is of limited use in establishi...
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PMID: 15946833
PDF is available here.
PDF is available here.