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Blood-Aqueous Barrier (0):
Recent article
Blood-Aqueous Barrier
Molecular Vision (16) 2010
Abstract
This study investigates the inflammation in the anterior chamber in eyes with primary angle closure glaucoma (PACG) and evaluates the effect of intraocular pressure (IOP) elevation on the blood-aqueous barrier (BAB).
Thirty-five patients (35 eyes) with acute primary angle closure glaucoma (APACG), 4...
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PMID: 21042429
PDF is available here.
PDF is available here.
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Current Eye Research (34)1 2009
Abstract
The radio-chemical purity of labeled ofloxacin was found to be 90-95% with the labeling efficiency of 90%. The static anterior planar images of verapamil pre-treated group showed marginal increase in the uptake of labeled ofloxacin, and dynamic images showed less systemic pool as compared to its con...
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PMID: 19172473
PDF is available here.
PDF is available here.
Contact Dermatitis (59)5 2008
Abstract
Transepidermal water loss assessments showed significantly higher measurements on the maximum outcome of the nasal cold compared with the time-point when the symptoms of the cold had disappeared. This was in accordance with skin colour chroma a* measurements and the visually assessed skin erythema a...
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PMID: 18976380
PDF is available here.
PDF is available here.
Ugeskrift for laeger (170)38 2008
Abstract
The special relationship between the eye and the immune system rests on a number of anatomical, physiological and immunological mechanisms. These mechanisms prevent the delicate structures of the eye from potentially damaging immunogenic inflammation while protecting against pathogens. Rather than i...
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PMID: 18808747
PDF is available here.
PDF is available here.
Abstract
The objective of this study was to synthesize and evaluate novel enzymatically stable dipeptide prodrugs for improved absorption of acyclovir. l-Valine-l-valine-acyclovir (LLACV), l-valine-d-valine-acyclovir (LDACV), d-valine-l-valine-acyclovir (DLACV) and d-valine-d-valine-acyclovir (DDACV) were su...
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PMID: 18573320
PDF is available here.
PDF is available here.
Abstract
The lesions on the corneal epithelium elicit proliferation of the iris vascular cells, mainly its endothelium, as well as an early breakdown of the blood-aqueous barrier. The daughter cells resulting from the damage to the eye surface were detected up to 21 days after a single injection of (3)H-TdR,...
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PMID: 18431590
PDF is available here.
PDF is available here.
Der Ophthalmologe (105)5 2008
Abstract
Glaucoma, a common and potentially devastating complication of intraocular inflammation, remains a considerable therapeutic challenge. During uveitis, breakdown of the blood-ocular barrier occurs with subsequent influx of proteins as well as inflammatory and immunocompetent cells. These mediators, i...
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PMID: 18461335
PDF is available here.
PDF is available here.
Abstract
Mean +/- s.d. enrofloxacin concentration in the aqueous humour 1 h post administration on Day 3 was 0.32 +/- 0.10 mg/l (range 0.18-0.47); and aqueous humour enrofloxacin, total protein and aqueous humour:plasma enrofloxacin ratios were higher on Day 4 than Day 3. CONCLUSIONS AND POTENTIAL RELEVANCE:...
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PMID: 18089468
PDF is available here.
PDF is available here.
Nippon Ganka Gakkai zasshi (112)3 2008
Abstract
We studied using a nonphysiological substance, fluorescein, ECCE was confirmed to be physiologically superior to ICCE. The transport mechanism of both physiological and nonphysiological substances from intraocular fluids (such as vitreous and aqueous humor) is believed to be related to the pathogene...
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PMID: 18411712
PDF is available here.
PDF is available here.
Abstract
Our study shows that recurrent VKH patients displayed a more striking and long-lasting breakdown of the BAB and more severe inflammation than initial-onset VKH patients. Our study also indicates that the disruption of BAB lasted longer than aqueous cells either in initial-onset or in recurrent VKH p...
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PMID: 17965105
PDF is available here.
PDF is available here.
Abstract
Latanoprost, travoprost, and bimatoprost had no statistically significant effect on the blood-aqueous barrier of phakic patients with POAG or OHT. Bimatoprost may be associated with a clinically irrelevant reduction in mean CCT....
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PMID: 16936646
PDF is available here.
PDF is available here.
Klinika oczna (110)4-6 2008
Abstract
The eyes which received TA-assisted PPV showed significantly less breakdown of the blood-ocular barrier than those with routine PPV. Intraoperative administration TA facilitates postoperative recovery after surgery lowering the inflammatory reaction....
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PMID: 18655452
PDF is available here.
PDF is available here.
Veterinary Ophthalmology (11)3 2008
Abstract
The results of this study show that topical latanoprost may cause BAB disruption in normal dogs while topical dorzolamide/timolol may have no effect on the BAB in normal dogs....
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PMID: 18435656
PDF is available here.
PDF is available here.
Abstract
Qualitatively, the AC, the PC or the vitreous did not show immediate contrast enhancement on the first and the second set of post-contrast T1WIs. However, the AC and the PC showed delayed contrast enhancement for both groups of cats on the second pre-contrast T1WIs. No enhancement or minimally delay...
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PMID: 18525222
PDF is available here.
PDF is available here.
Abstract
The hydrophilic acrylic IOLs (Hydroview H60M) had significantly higher amounts of calcified deposits than IOLs of other materials, indicating that hydrophilic acrylic IOLs easily accumulate calcified deposits in the body when the concentrations of calcium, phosphate, and albumin in the aqueous humor...
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PMID: 18165086
PDF is available here.
PDF is available here.
Abstract
Diclofenac was more effective than betamethasone in preventing angiographic CME and BAB disruption after small-incision cataract surgery. Thus, nonsteroidal antiinflammatory agents should be considered for routine treatment of eyes having cataract surgery....
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PMID: 18165082
PDF is available here.
PDF is available here.
Abstract
The effects of STA and its time course on CME or ME correlated well with those on BAB disruption. Since there is the close correlation between the BAB and blood-retinal barrier function, the effects of medical treatment on ME associated with BRVO or CRVO can be evaluated by means of the BAB function...
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PMID: 18001246
PDF is available here.
PDF is available here.
Abstract
Reduction of ChBFlow, disruption of the blood-aqueous barrier, and incidence of CME in early postsurgical pseudophakic eyes were more effectively prevented chronologically in eyes treated with diclofenac than in those treated with fluorometholone....
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PMID: 18055815
PDF is available here.
PDF is available here.
Abstract
We examined the effect of clinical P falciparum isolates on barrier function of primary dermal and lung microvascular endothelium in vitro. We showed that parasite sonicates but not intact infected erythrocytes disrupted endothelial barrier function in a Src-family kinase-dependent manner. The abnor...
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PMID: 17693580
PDF is available here.
PDF is available here.
Abstract
Research into treatment modalities affecting vision is rapidly progressing due to the high incidence of diseases such as diabetic macular edema, proliferative vitreoretinopathy, wet and dry age-related macular degeneration and cytomegalovirus retinitis. The unique anatomy and physiol...
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PMID: 17683251
PDF is available here.
PDF is available here.
Abstract
A laser flare-cell meter was used to examine blood-aqueous barrier function in a 57-year-old male patient who had typical reticular dystrophy of the retinal pigment epithelium with a bilateral hyperpigmented reticular pattern at the posterior pole in both eyes. Fluorescein angiography showed hypoflu...
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PMID: 17588843
PDF is available here.
PDF is available here.
Vestnik oftalmologii (123)6 2007
Abstract
Analysis of intraocular fluid and the vitreous body in 7 rabbits (14 eyes) by high performance liquid chromatography reveals histochrom metabolic products and, possibly, histrochrom itself during intravenous and subconjunctival injections and retrobulbar administration of histochrom through the irri...
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PMID: 18225525
PDF is available here.
PDF is available here.
Abstract
We concluded that EP1 receptor has no modulatory effect on EP2 receptors but there is definitely cross-talk between EP1 and EP4 receptors....
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PMID: 17052707
PDF is available here.
PDF is available here.
Abstract
Isolated porcine ciliary epithelial preparations transport fluid in the blood-to-aqueous direction, indicating that measurements of volumetric fluid flow across this preparation may serve as a suitable model for future studies directed toward the pharmacological control of secretion....
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PMID: 17197549
PDF is available here.
PDF is available here.
Abstract
These findings are consistent with the existence of an anterior diffusional pathway in the human eye. The model warrants further testing....
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PMID: 17122097
PDF is available here.
PDF is available here.
Abstract
Modern biological research has produced increasing number of promising therapeutic possibilities for medical treatment. These include for example growth factors, monoclonal antibodies, gene knockdown methods, gene therapy, surgical transplantations and tissue engineering. Ocular application of these...
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PMID: 17097758
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
The results of the present experiments suggest that EP2 and EP4 receptors partly mediate the disruption of the blood-aqueous barrier and leukocyte infiltration induced by prostaglandin E2, SDF-1, RANTES, and lipopolysaccharides....
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PMID: 16766399
PDF is available here.
PDF is available here.
Abstract
0.7% dexamethasone-cyclodextrin eye drops applied once daily is a more effective postoperative anti-inflammatory medication than 0.1% dexamethasone sodium phosphate applied three times a day. In both groups, 3 weeks after the operation the mean visual acuity was normal and intraocular pressure signi...
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PMID: 16217662
PDF is available here.
PDF is available here.
Abstract
The purpose of this research was to reassess the effects of topical pilocarpine on the integrity of the blood-aqueous barrier, using high resolution, magnetic resonance imaging, and the standard intravenous contrast agent gadolinium dimeglumine. It has long been known that topical pilocarpine gives...
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PMID: 16169551
PDF is available here.
PDF is available here.
Current Eye Research (31)7-8 2006
Abstract
Polyvinylalcohol (PVA) hydrogel cross-linked by gamma irradiation was assessed as a possible vitreous substitute. From a series of experiments, rise of intraocular pressure and inflammatory changes in the vitreous cavity after operation were observed in some cases. Crab-eating macaques were used for...
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PMID: 16877268
PDF is available here.
PDF is available here.
Abstract
An intact FP receptor gene is critical to the IOP response to bimatoprost in the mouse eye....
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PMID: 16303950
PDF is available here.
PDF is available here.
Abstract
We used a laser flare-cell meter to examine blood-aqueous barrier function in a 35-year-old male patient who had typical combined hamartomas of the retina and retinal pigment epithelium characterized by an ill-defined, slightly elevated, grey-white epipapillary lesion with overlying glial proliferat...
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PMID: 16091829
PDF is available here.
PDF is available here.
Abstract
This work demonstrates that isolated ciliary epithelial preparations transport fluid in the blood-to-aqueous direction. The present observations suggest that mounting arrangements for measuring volumetric fluid flow across the ciliary epithelium is suitable for future studies directed toward the pha...
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PMID: 15728551
PDF is available here.
PDF is available here.
Archives of Ophthalmology (123)2 2005
Abstract
Mean flare values were significantly higher in the bimatoprost, latanoprost, and travoprost groups throughout follow-up (P < .02). Four latanoprost-treated eyes, 1 bimatoprost-treated eye, and 1 travoprost-treated eye developed cystoid macular edema; all cases resolved after discontinuation of the p...
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PMID: 15710814
PDF is available here.
PDF is available here.
Abstract
Trabeculectomy can breakdown blood-aqueous barrier permanently while phacoemulsification damage the blood-aqueous barrier transiently. Phacoemulsification combined with a previous trabeculectomy can enhance this damage....
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PMID: 15840339
PDF is available here.
PDF is available here.
Abstract
VEGF injected intravitreally induced a time and dose-dependent breakdown of the blood-retinal and blood-aqueous barriers. Maximal vascular leakage was measured at 48 hr after intravitreal injection with a dose of 500 ng VEGF. Other effects of VEGF included prominent retinal vasodilation, vessel tort...
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PMID: 15670803
PDF is available here.
PDF is available here.
Ophthalmologica (219)1 2005
Abstract
BAB breakdown following phacoemulsification with posterior chamber lens implantation is relatively mild in eyes with FHU and the BAB appears to be fully reestablished to preoperative levels 6 weeks postoperatively, explaining the usually good outcome of cataract surgery in this condition.
Copyright...
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PMID: 15627823
PDF is available here.
PDF is available here.
Abstract
We conducted a series of surgical studies (n=155) to find out the possible utility of the Dutch Belted rabbits as an ocular test model. Following either vitrectomy (n=59) or lensectomy (n=96) studies using either BSS or BSS Plus, we characterized the corresponding magnitude and duration of inflammat...
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PMID: 15642327
PDF is available here.
PDF is available here.
Abstract
At all postoperative visits the mean increase in flare was greater for group 1 (intravenous steroid). Patients with posterior synechiae had greater blood-aqueous barrier damage (BAB) postoperatively. There were no statistically significant differences in logMAR visual acuity and incidences of CMO be...
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PMID: 15317700
PDF is available here.
PDF is available here.
Abstract
A total of 112 patients were divided into three groups: patients without diabetic mellitus as normal control (n=56), diabetic patients without diabetic retinopathy (n=2), with nonproliferation diabetic retinopathy (NPDR) (n=37), and diabetic patients with proliferation diabetic retinopathy (PDR) (n=...
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PMID: 15017379
PDF is available here.
PDF is available here.
Abstract
Because homocysteine induces vascular injury and alterations of extracellular matrix, high aqueous homocysteine may trigger the abnormal matrix accumulation characteristic. It may reflect the proposed impairment of the blood-aqueous barrier of pseudoexfoliation open-angle glaucoma and be involved in...
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PMID: 15234308
PDF is available here.
PDF is available here.
Abstract
Abstract
The purposes of this study were to provide functional evidence for the presence of a peptide transporter on blood-ocular barriers and to elucidate the mechanism of a dipeptide transport across these barriers following systemic administration. Glycylsarcosine was chosen as a model dipeptide and [(3)H...
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PMID: 15037116
PDF is available here.
PDF is available here.
Abstract
Mean aqueous flare values before treatment were 15.7 (+/-8.2) photon counts/ms; mean cell count was 9.8 (+/-14.8) cells/0.5 mm(3). One day after retinal cryocoagulation flare values had increased statistically significantly to a mean of 39.2 (+/-85.8) photon counts/ms, while the increase in mean cel...
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PMID: 14658072
PDF is available here.
PDF is available here.
Abstract
Blood-aqueous barrier after phacoemulsification with implantation of intraocular lens can be measured quantitatively by the laser flare cell meter. The blood-aqueous barrier disorders can be recovered shortly after phacoemulsification....
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PMID: 14989956
PDF is available here.
PDF is available here.
Ophthalmologica (218)5 2004
Abstract
The flare meter analysis shows that the eyes treated with bimatoprost and travoprost have a less significantly broken blood-aqueous barrier and their anterior chamber is also significantly less inflamed.
Copyright 2004 S. Karger AG, Basel...
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PMID: 15334011
PDF is available here.
PDF is available here.
Ophthalmic Research (36)6 2004
Abstract
FR122047, FR188582 and diclofenac sodium (15 micromol/kg each) injected intravenously 30 min before PGE2 application inhibited 29 +/- 5, 40 +/- 12 and 50 +/- 9% of aqueous flare elevation, respectively. Simultaneous injection of FR122047 (15 micromol/kg) and FR188582 (15 micromol/kg) 30 min before P...
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PMID: 15627832
PDF is available here.
PDF is available here.
Abstract
Normal function of the BAB (albumin equivalents 1mg/ml and less was found in 8 eyes (73%) independently on underlying disease, early postoperative reaction after pars plana vitrectomy with SO implantation, degree of SOE and late postoperative complications. Increased permeability of the BAB (albumin...
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PMID: 15073575
PDF is available here.
PDF is available here.
Current Eye Research (27)6 2003
Abstract
Mouse EVP was successfully measured based on the detection of erythrocyte reflux from an episcleral vein into Schlemm's canal. Both EVP and IOP increased with the degree of the head-down body position....
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PMID: 14704919
PDF is available here.
PDF is available here.
Abstract
The mouse eye has similar aqueous production and aqueous humor turnover rate as the human eye. The presence of both conventional and uveoscleral outflow suggests that the mouse is a useful model system for further investigations of the biology of aqueous dynamics....
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PMID: 14638713
PDF is available here.
PDF is available here.
Abstract
Acute BAB disturbance within the first 48 hours after small-incision cataract surgery showed high interpatient variability. However, many differences were not detectable 1 day after surgery....
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PMID: 14670423
PDF is available here.
PDF is available here.
Current Eye Research (27)4 2003
Abstract
Both the rate constant of the BAB and the BRB permeability were significantly increased in CSME indicating that eye-specific factors are common for both barriers in diabetic patients with CSME....
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PMID: 14562176
PDF is available here.
PDF is available here.
Abstract
A 78-year-old woman developed a severe fibrinous anterior chamber reaction 1 day after uneventful clear corneal incision cataract extraction with intraocular lens implantation. There was no history of uveitis or diabetes, and the fibrin responded immediately to topical steroids. The patient was foll...
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PMID: 12954320
PDF is available here.
PDF is available here.
Abstract
Irritation of ocular tissues by an IOL was the main cause of chronic postoperative noninfectious inflammation in pseudophakic eyes. Therefore, detecting the IOL position and its relationships to ocular tissues is very important in planning the treatment. Ultrasound biomicroscopy is a practical metho...
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PMID: 12842688
PDF is available here.
PDF is available here.
Abstract
Current Eye Research (26)5 2003
Abstract
Corneal autofluorescence was unaffected by permeability of the blood aqueous barrier suggesting that formation of advanced glycation products is limited by other factors than the concentration of glucose in the aqueous humour, or that other factors unrelated to nonenzymatic glycation of stromal prot...
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PMID: 12854060
PDF is available here.
PDF is available here.
Abstract
Highly statistically significant differences (P < 0.05) were found between preoperative aqueous humor protein concentration and those measured on days 1, 7, 14, 21 and 30 after surgery. Under transmission electron microscopy, a part of the endothelial cells and BAB damaged as shown by the leakage of...
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PMID: 12852080
PDF is available here.
PDF is available here.
Ophthalmic Research (35)6 2003
Abstract
We evaluated the effects of anti-inflammatory potency of corticosteroids and nonsteroidal anti-inflammatory drugs on prostaglandin E2 (PGE2)-induced aqueous flare elevation in pigmented rabbits. Transcorneal diffusion of PGE2, 25 microg/ml (7.09 x 10(-2) mmol/l), with the use of a glass cylinder was...
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PMID: 14688425
PDF is available here.
PDF is available here.