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Blood-Air Barrier (0)
Articles on Blood-Air Barrier
Tetrastarch sustains pulmonary microvascular perfusion and gas exchange during systemic inflammation.
According to Fick's law of diffusion, gas exchange depends on the size and thickness of the blood perfused alveolocapillary membrane. Impairment of either one is tenuous. No data are available concerning the impact of hydroxyethyl starches and saline on pulmonary microperfusion and g...
Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury.
We hypothesized that the tyrosine kinase receptor human epidermal growth factor receptor-2 (HER2) would be activated in an inflammatory setting and participate in ALI. Interleukin-1β (IL-1β) exposure resulted in HER2 activation in human epithelial cells and markedly increased conductance across a...
Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells.
We then examined the effect of KGF on the protein levels of the claudins with the highest mRNA levels: -3, -4, -5, -7, -12, -15, and -18. KGF did not alter the levels of any of the claudins tested, nor of zona occludens-1 (ZO-1) or occludin. Moreover, localization of claudins-3, -4, -18, and ZO-1 wa...
Systematic influence induced by 3 nm titanium dioxide following intratracheal instillation of mice.
Leptin integrates vertebrate evolution: From oxygen to the blood-gas barrier
The following are the proceedings of a symposium held at the Second International Congress for Respiratory Science in Bad Honnef, Germany. The goals of the symposium were to delineate the blood-gas barrier phenotype across vertebrate species; to delineate the interrelationship betwee...
Reconstituting organ-level lung functions on a chip.
We describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. This bioinspired microdevice reproduces complex integrated organ-level responses to bacteria and inflammatory cytokines introduced into the alveolar space. In nanotoxicolog...
Side-specific effects by cadmium exposure: Apical and basolateral treatment in a coculture model of the blood-air barrier
We could demonstrate that a high concentration of Ca(2+) could prevent the barrier-disrupting effect of Cd(2+). In conclusion, the exposure of Cd(2+) to cocultures of lung cells caused a decrease in TER, major morphological changes, a reduction of cell viability and an increase of cytokine release,...
Has the time come to rethink the pathogenesis of asthma?
Pulmonary tissue engineering using dual-compartment polymer scaffolds with integrated vascular tree.
The microcarriers evenly distributed MLE-12 cells on the parenchymal compartment surface. Confluent cell layers were confirmed by fluorescent and electron microscopy. Adequate proliferation of MLE-12 cells within the construct was monitored via the DNA content. Viability of the cells was maintained...
In vivo measurement of O(2) and CO(2) gas exchange across the human tympanic membrane.
Consistent with expectations for transTM gas exchange, ECP + EC O(2) decreased and CO(2) increased during the experiments. CO(2) increase was faster after application of epinephrine to the TM. The ratio of O(2)/CO(2) conductances was not consistent with the gas exchange through a primarily water or...