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All › Respiratory System › Lung › Pulmonary Alveoli › Blood-Air Barrier

Blood-Air Barrier (0)

      Articles on Blood-Air Barrier

      1. Tetrastarch sustains pulmonary microvascular perfusion and gas exchange during systemic inflammation.
        Kai K Heckel, Bjoern B Winkelmann, ... Alwin E AE Goetz

        Crit Care Med 40(2):518-31 (2012) PMID 21926574

        According to Fick's law of diffusion, gas exchange depends on the size and thickness of the blood perfused alveolocapillary membrane. Impairment of either one is tenuous. No data are available concerning the impact of hydroxyethyl starches and saline on pulmonary microperfusion and g...
      2. Neuregulin-1-human epidermal receptor-2 signaling is a central regulator of pulmonary epithelial permeability and acute lung injury.
        James H Finigan, Jihane A Faress, ... Jeffrey A Kern

        J Biol Chem 286(12):10660-70 (2011) PMID 21247898 PMCID PMC3060517

        We hypothesized that the tyrosine kinase receptor human epidermal growth factor receptor-2 (HER2) would be activated in an inflammatory setting and participate in ALI. Interleukin-1β (IL-1β) exposure resulted in HER2 activation in human epithelial cells and markedly increased conductance across a...
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      3. Keratinocyte growth factor enhances barrier function without altering claudin expression in primary alveolar epithelial cells.
        Michael J LaFemina, Deepti Rokkam, ... James A Frank

        Am J Physiol Lung Cell Mol Physiol 299(6):L724-34 (2010) PMID 20833776 PMCID PMC3006268

        We then examined the effect of KGF on the protein levels of the claudins with the highest mRNA levels: -3, -4, -5, -7, -12, -15, and -18. KGF did not alter the levels of any of the claudins tested, nor of zona occludens-1 (ZO-1) or occludin. Moreover, localization of claudins-3, -4, -18, and ZO-1 wa...
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      4. Systematic influence induced by 3 nm titanium dioxide following intratracheal instillation of mice.
        Yufeng Y Li, Jungang J Li, ... Qingnuan Q Li

        J Nanosci Nanotechnol 10(12):8544-9 (2010) PMID 21121364

      5. Leptin integrates vertebrate evolution: From oxygen to the blood-gas barrier
        JS Torday, FL Powell, ... AJ Hall

        Respir Physiol Neurobiol (2010) PMID 20096383

        The following are the proceedings of a symposium held at the Second International Congress for Respiratory Science in Bad Honnef, Germany. The goals of the symposium were to delineate the blood-gas barrier phenotype across vertebrate species; to delineate the interrelationship betwee...
      6. Reconstituting organ-level lung functions on a chip.
        Dongeun Huh, Benjamin D Matthews, ... Donald E Ingber

        Science 328(5986):1662-8 (2010) PMID 20576885

        We describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. This bioinspired microdevice reproduces complex integrated organ-level responses to bacteria and inflammatory cytokines introduced into the alveolar space. In nanotoxicolog...
      7. Side-specific effects by cadmium exposure: Apical and basolateral treatment in a coculture model of the blood-air barrier
        Mirko Papritz, Christine Pohl, ... Kai Kehe

        Toxicol Appl Pharmacol 245(3):9 (2010) PMID 20399800

        We could demonstrate that a high concentration of Ca(2+) could prevent the barrier-disrupting effect of Cd(2+). In conclusion, the exposure of Cd(2+) to cocultures of lung cells caused a decrease in TER, major morphological changes, a reduction of cell viability and an increase of cytokine release,...
      8. Has the time come to rethink the pathogenesis of asthma?
        Stephen T Holgate

        Curr Opin Allergy Clin Immunol 10(1):48-53 (2010) PMID 19915457

      9. Pulmonary tissue engineering using dual-compartment polymer scaffolds with integrated vascular tree.
        Clemens S CS Fritsche, Oliver O Simsch, ... Joseph P JP Vacanti

        Int J Artif Organs 32(10):701-10 (2009) PMID 19943231

        The microcarriers evenly distributed MLE-12 cells on the parenchymal compartment surface. Confluent cell layers were confirmed by fluorescent and electron microscopy. Adequate proliferation of MLE-12 cells within the construct was monitored via the DNA content. Viability of the cells was maintained...
      10. In vivo measurement of O(2) and CO(2) gas exchange across the human tympanic membrane.
        Sancak S Yuksel, J Douglas JD Swarts, ... William J WJ Doyle

        Acta Otolaryngol 129(7):716-25 (2009) PMID 18728916

        Consistent with expectations for transTM gas exchange, ECP + EC O(2) decreased and CO(2) increased during the experiments. CO(2) increase was faster after application of epinephrine to the TM. The ratio of O(2)/CO(2) conductances was not consistent with the gas exchange through a primarily water or...
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