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Cell Physiological Phenomena (11)
Articles on Cell Physiological Phenomena
Abstracts of the 2012 World Congress on In Vitro Biology. June 3-7, 2012. Bellevue, Washington, USA.
Crosstalk in cellular signaling: background noise or the real thing?
Measurement of phase synchrony of coupled segmentation clocks.
We found the increase of amplitudes of oscillating dynamical variables of the cells as the activation rate of delta-notch signaling is increased, however, the frequencies of oscillations are decreased correspondingly. Our results show the phase transition from desynchronized to synchronized behavior...
Targeted protein-omic methods are bridging the gap between proteomic and hypothesis-driven protein analysis approaches.
We will review recent advances in methodologies and philosophies behind several microarray-based, intermediate-level, 'protein-omic' methods, including a focus on reverse-phase lysate arrays and micro-western arrays, which have been helpful for bridging gaps between large- and small-scale protein an...
Genetic approaches to alcohol addiction: gene expression studies and recent candidates from Drosophila.
Ethanol intake causes gene expression changes resulting in cellular and molecular adaptations that could be associated with a predisposition to alcohol dependence. Recently, several research groups have used high-throughput gene expression profiling to search for alcohol-responsive g...
The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology.
We summarize our current understanding of the biochemical characteristics and physiological functions of the ER-resident bZIP transcription factors....
Tissue organization by cadherin adhesion molecules: dynamic molecular and cellular mechanisms of morphogenetic regulation.
We focus on four key mechanistic elements: the molecular basis for adhesion through cadherin ectodomains, the regulation of cadherin expression at the cell surface, cooperation between cadherins and the actin cytoskeleton, and regulation by cell signaling. We discuss current progress and outline iss...
Paneth cell function--implications in pediatric Crohn disease.
We have demonstrated that children with ileal Crohn's disease show a reduced expression of small intestinal HD-5 at the age of onset suggesting that a compromised mucosal barrier function might be a key factor in the early disease pathogenesis. We also identified a disturbance of the Wnt signaling t...
When, where, which describes the order of spatiotemporal cell biology.
Statistical modeling of single target cell encapsulation.
We have modeled and experimentally verified a microdroplet-based cell encapsulation process for various combinations of cell loading and target cell concentrations. Here, we explain theoretically and validate experimentally a model to isolate and pattern single target cells from heterogeneous mixtur...