In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on galectin-3 expression in neonates, however, are limited, and expression of this lectin in cord blood has not yet been reported. The aim of this study was to determine ga...

Pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells could be good sources for obtaining massive hematopoietic stem cells (HSC) and mature blood cells. Coculture with feeder cells and embryoid body formation are two major strategies to induce hematop...

The electric discharge of living cells and Z-potential of cell membrane are among the most important indicators to determine at cell level the homeostasis of any living organism, including organs and tissues. The cell electrophoresis is considered as the most handy, accurate and reli...

The standardized technique to detect the blood cells cytokine production ex vivo was developed. The complex of mitogens of phytohemagglutinin P, phytohemagglutinin M, lipopolysaccharide, concanavalin A is applied to provide the mitogen activation. This approach permits to activate th...

We assessed iron metabolic markers, including levels of zinc-protoporphyrin (Zn-pp), transferrin receptor, and red blood cell numbers and morphology in IPAH, associated PAH and sleep apnea-induced pulmonary hypertension patients in comparison to healthy controls and asthmatics. Despite similarly nor...

We assessed the impact of viral inoculum size on both viral and immune events within two groups of Rhesus macaques that were non-traumatically, orally inoculated with either multiple low (1000 to 4000 TCID(50)) or high (100,000 TCID(50)) doses of SIV. In agreement with previous studies, more diverse...

We demonstrated a novel function of human γδ T cells as regulatory cells by detecting their suppressive effect on the proliferation of autologous naive CD4(+) T cells. These regulatory γδ T cells (γδ Tregs) could be generated in vitro by stimulating with anti-TCRγδ in the presence of TGF-β...

In addition to the dysregulation of arachidonic acid metabolism in aspirin-intolerant asthma (AIA), aspirin acetylsalicylic acid (ASA) exerts effects on inflammation and immunity; however, many of these effects are unknown. The aim of the study was to evaluate the met...

Chronic obstructive pulmonary disease (COPD) is characterised by an inflammatory and systemic response that increases during exacerbations of the disease (ECOPD), although the mechanisms of this inflammatory process are not well known. OBJECTIVES: To explore the inflammatory changes and possible mec...