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Embryonal Carcinoma Stem Cells (0)
Articles on Embryonal Carcinoma Stem Cells
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Epigenetic regulation by RARα maintains ligand-independent transcriptional activity.
Nucleic Acids Res 40(1):102-15 (2012) PMID 21911359 PMCID PMC3245912
We identified transcripts differentially expressed between F9 wild-type (Wt) and RARα knockout cells cultured in the absence or presence of the RAR-specific ligand all trans retinoic acid (RA). We validated the decreased Mest, Tex13, Gab1, Bcl11a, Tcfap2a and HMGcs1 transcript levels, and increased... -
Histological evidence for the existence of germ cell tumor cells showing embryonal carcinoma morphology but lacking OCT4 expression and cisp...
Histochem Cell Biol 134(2):197-204 (2010) PMID 20532795
We recently characterized EC cells that lack OCT4 expression and show cisplatin resistance. In the present, immunohistochemical study we analyzed the composition of NSGCT with the focus on such OCT4-negative EC cells using a NSGCT xenograft model as well as patient-derived NSGCT samples. In the xeno... -
Targeted Vezf1-null mutation impairs vascular structure formation during embryonic stem cell differentiation.
Arterioscler Thromb Vasc Biol 30(7):1378-88 (2010) PMID 20431070 PMCID PMC2903440
Together, these results suggest that Vezf1 is involved in early differentiation processes of the vasculature by regulating cell differentiation, proliferation, and ECM distribution and deposition.... -
Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress.
Nucleic Acids Res 38(11):3595-604 (2010) PMID 20110257
We report that excess Prep1 increases the sensitivity of cells to genotoxic stress and the extent of the apoptosis directly correlates with the level of Prep1. The apoptotic response of Prep1-overexpressing cells is mediated by the pro-apoptotic p53 protein that we show is a direct target of Prep1,... -
Epigenetic analysis of human embryonic carcinoma cells during retinoic acid-induced neural differentiation.
Biochem Cell Biol 88(3):527-38 (2010) PMID 20555394
We induced neural differentiation of a human embryonal carcinoma stem cell line, NTERA2/NT2, by retinoic acid (RA) treatment, primarily according to two different methods of adherent cell culture (rosette formation) and suspension cell culture (EB formation) conditions, and histone modifications and... -
Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation
Mol Cell Neurosci 44(2):12 (2010) PMID 20346398 PMCID PMC2866295
We demonstrate that NeuroD2 suppresses REST during differentiation in culture. In the hippocampus of NeuroD2 knockout mice, higher level of REST is detected. Functional significance of NeuroD2-REST interplay is uncovered by showing that forced expression of REST interferes with neuronal differentiat... -
Chemical induction of cardiac differentiation in p19 embryonal carcinoma stem cells.
Stem Cells Dev 19(3):403-12 (2010) PMID 20163207 PMCID PMC3032260
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Threshold in stage-specific embryonic glycotypes uncovered by a full portrait of dynamic N-glycan expression during cell differentiation.
Audio, Transactions of the IRE Professiona... 9(3):523-37 (2010) PMID 20008832
We describe a novel concept for the characterization of dynamic glycoform alteration during cell differentiation by means of "glycoblotting-based cellular glycomics," the only method allowing for rapid and quantitative glycan analysis. We demonstrated that processes of dynamic cellular differentiati... -
Nuclear magnetic resonance detects phosphoinositide 3-kinase/Akt-independent traits common to pluripotent murine embryonic stem cells and th...
Neoplasia 11(12):1301-8 (2009) PMID 20019838
We used mES (ES-D3) and murine embryonal carcinoma cells (EC-F9) and compared the metabolic profiles of 1) pluripotent mES (ESD0), 2) differentiated mES (ESD14), and 3) pluripotent F9 cells. Involvement of the PI3K/Akt pathway was assessed using LY294002, a selective PI3K inhibitor. Metabolic profil... -
Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells
Cell 138(3):12 (2009) PMID 19665978
We found 37 microRNAs that were differentially expressed between human BCSCs and nontumorigenic cancer cells. Three clusters, miR-200c-141, miR-200b-200a-429, and miR-183-96-182 were downregulated in human BCSCs, normal human and murine mammary stem/progenitor cells, and embryonal carcinoma cells. E...
