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LLC-PK1 Cells (0):
Recent article
LLC-PK1 Cells
Biochimica et Biophysica Acta (1808)7 2011
Abstract
The influence of P-glycoprotein (ABCB1) in drug resistance as well as drug absorption and disposition is an important factor to be considered during the development of new drugs. Thus, the early identification and exclusion of compounds showing a high affinity towards P-glycoprotein can help to selec...
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PMID: 21439263
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
To explore whether bioartificial kidney (BAK) ameliorates cytokine response and biochemical indices, and prolongs the survival time in acute uremic pigs with multiple organ dysfunction syndrome (MODS).
Hybridized pigs suffering from MODS and acute renal failure (ARF) were treated with BAK (Group A,...
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PMID: 20872347
PDF is available here.
PDF is available here.
Abstract
We investigated the signals that determine apical expression of NaPi-IIc with a focus on the role of the N- and the C-terminal tails of mouse NaPi-IIc in renal epithelial cells [opossum kidney (OK) and Madin-Darby canine kidney cells]. Wild-type NaPi-IIc, the cotransporter NaPi-IIa, as well as sever...
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PMID: 20410212
PDF is available here.
PDF is available here.
Molecular Pharmacology (77)6 2010
Abstract
We have screened a chemical library and identified several novel structures of Na/K-ATPase inhibitors. One group of these inhibitors belongs to polyphenolic xanthone derivatives. Functional characterization reveals the following properties of this group of inhibitors. First, like ouabain, they are p...
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PMID: 20335388
PDF is available here.
PDF is available here.
Abstract
TNF-alpha has recently been implicated in diabetic nephropathy, which is usually accompanied by higher sodium retention. The kidneys play a major role in sodium homeostasis by regulating tubular sodium reabsorption, a process geared by the sodium gradient established by the Na(+)/K(+) ATPase. The ai...
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PMID: 20222869
PDF is available here.
PDF is available here.
Canadian Journal of Physiology and Pharmacology/Revue Canadienne de Physiologie et Pharmacologie (88)4 2010
Abstract
We examined 2 nephrotoxic agents, ifosfamide (IFO) and acyclovir, that exhibit different clinical nephrotoxic patterns. HK-2 cells metabolized IFO to its nephrotoxic metabolite, chloroacetaldehyde (CAA). Acyclovir induced a concentration-dependent decrease in HK-2 cell viability, suggesting that acy...
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PMID: 20555413
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
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PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Cancer Science (101)3 2010
Abstract
We speculated that altered gap junctions might contribute to the antitumor activities of proteasome inhibition. Incubation of Hepa-1c1c7 cells with the proteasome inhibitor MG132 elevated the levels of gap junction protein connexin 43 (Cx43) and promoted gap junctional intercellular communication. T...
|
PMID: 19961488
PDF is available here.
PDF is available here.
Abstract
Lithium, a prophylactic drug for the treatment of bipolar disorder, is prescribed with caution due to its side effects, including renal damage. In this study porcine LLC-PK1 renal tubular cells were used to establish the direct toxicity of lithium on proximal cells and gain insights into the molecul...
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PMID: 19947924
PDF is available here.
PDF is available here.
Abstract
Lithium, a prophylactic drug for the treatment of bipolar disorder, is prescribed with caution due to its side effects, including renal damage. In this study porcine LLC-PK1 renal tubular cells were used to establish the direct toxicity of lithium on proximal cells and gain insights...
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PMID: 19947924
PDF is available here.
PDF is available here.
Abstract
Lithium, a prophylactic drug for the treatment of bipolar disorder, is prescribed with caution due to its side effects, including renal damage. In this study porcine LLC-PK1 renal tubular cells were used to establish the direct toxicity of lithium on proximal cells and gain insights...
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PMID: 19947924
PDF is available here.
PDF is available here.
Abstract
Lithium, a prophylactic drug for the treatment of bipolar disorder, is prescribed with caution due to its side effects, including renal damage. In this study porcine LLC-PK1 renal tubular cells were used to establish the direct toxicity of lithium on proximal cells and gain insights...
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PMID: 19947924
PDF is available here.
PDF is available here.
Abstract
We investigated its potential role in the regulation of MRTF nuclear shuttling and in the regulation of the SMA promoter.
Transfection of a constitutive active (CA) Cdc42 construct alone induced the activation of the SMA promoter. The dominant negative (DN) Cdc42 construct prevented...
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PMID: 20016221
PDF is available here.
PDF is available here.
Abstract
These results suggest that KML is a promising antioxidant by scavenging free radicals. Furthermore, under the LLC-PK(1) cellular model, the cells showed declines in viability and increases in lipid peroxidation through oxidative stress induced by sodium nitroprusside (SNP) and pyrogallol, generators...
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PMID: 20606306
PDF is available here.
PDF is available here.
Abstract
Darunavir (DRV) is a nonpeptidic protease inhibitor (PI) approved for the treatment of human immunodeficiency virus (HIV) infection. DRV displays potent activity against HIV strains resistant to other available PIs. Coadministration with ritonavir (RTV) improves the oral bioavailability of DRV. Inhi...
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PMID: 19721237
PDF is available here.
PDF is available here.
Abstract
We conclude that preconditioning could be a useful tool to prevent the nephrotoxicity induced by gentamicin....
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PMID: 19466282
PDF is available here.
PDF is available here.
Abstract
We conclude that preconditioning could be a useful tool to prevent the nephrotoxicity induced by gentamicin....
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PMID: 19466282
PDF is available here.
PDF is available here.
Abstract
We conclude that preconditioning could be a useful tool to prevent the nephrotoxicity induced by gentamicin....
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PMID: 19466282
PDF is available here.
PDF is available here.
Abstract
The occurrence and magnitude of the MDR1 G1199A effect is drug specific. Overall, the MDR1 G1199A polymorphism may impact anticancer efficacy through modulation of drug distribution and delivery to target tumor cells....
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PMID: 19123050
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that: (1) TauT is down-regulated by the p53 tumor suppressor gene in renal proximal tubule LLC-PK1 cells; (2) cisplatin down-regulates the expression of TauT in renal proximal tubule cells through, at least in part, a p53-dependent pathway; and (3) forced overexpression of TauT...
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PMID: 19239141
PDF is available here.
PDF is available here.
Toxicological Sciences (106)1 2008
Abstract
Quantum dots (QDs) are being investigated as novel in vivo imaging agents. The leaching of toxic metals from these QDs in biological systems is of great concern. This study compared the cytotoxic mechanisms of two QD species made of different core materials (cadmium selenide [CdSe] vs. indium galliu...
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PMID: 18632727
PDF is available here.
PDF is available here.
Abstract
We hypothesize that superoxide (O(2)(*-)) accumulation is not a crucial causative factor in inducing nitroglycerin (NTG) tolerance. In LLC-PK1 cells, pre-exposure to NTG resulted in increased O(2)(*-) accumulation and reduced cGMP response to NTG versus vehicle control. O(2)(*-) stimulated by NTG wa...
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PMID: 18653825
PDF is available here.
PDF is available here.
Pharmaceutical Research (25)10 2008
Abstract
Data suggest different modes of substrate and inhibitor binding to Bcrp. In order to not overlook potential drug-drug interactions when testing drug candidates for inhibitory potential towards Bcrp, distinct Bcrp probe substrates should be used....
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PMID: 18523872
PDF is available here.
PDF is available here.
Abstract
We believe that the aggregation of the COM crystals does not occur in the bulk urine due to short travel time through the nephron. If so, the kidney stone formation is determined by COM-seeding on the tubules walls. The further growth of the stone on the seed can take practically unlimited time beca...
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PMID: 18619606
PDF is available here.
PDF is available here.
Abstract
We studied the role of GSK3beta in advanced glycation end-product (AGE)-induced effects in the proximal tubule-like LLC-PK1 cells. We found that AGE (100 microg/ml) time-dependently (8-48 h) increased phospho-GSK3beta-Tyr216 (active GSK3beta) and time-dependently (4-24 h) decreased phospho-GSK3beta-...
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PMID: 18474214
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the phosphorylation-deficient (pd) PTH1R confers dramatically enhanced coupling to G(q/11) proteins upon PTH stimulation predominantly caused by elimination of Ser(491/492/493), Ser(501), or Ser(504). Reportedly, impaired internalization of the pd PTH1R, however, is not dependent...
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PMID: 18577695
PDF is available here.
PDF is available here.
Abstract
We investigated the capacity of hydroxytyrosol (HT), 3,4-dihydroxyphenylethanol, and homovanillic alcohol (HVA), 4-hydroxy-3-methoxy-phenylethanol, to inhibit H(2)O(2) induced oxidative damage in LLC-PK1, a porcine kidney epithelial cell line, studying the effect of H(2)O(2) on specific cell membran...
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PMID: 18588937
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)32 2008
Abstract
We used this 17 aa region as bait in a yeast two-hybrid screen, and identified, for the first time, an intracellular protein interacting with the 5-HT(1A)R. This protein is homologous to the yeast Yif1p, previously implicated in vesicular trafficking between the endoplasmic reticulum (ER) and the Go...
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PMID: 18685031
PDF is available here.
PDF is available here.
Abstract
Our data suggest that caution should be exercised when piperine is to be co-administered with drugs that are P-gp substrates, particularly for patients whose diet relies heavily on pepper....
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PMID: 18417181
PDF is available here.
PDF is available here.
Abstract
Ochratoxin A (OTA), a mycotoxin mostly produced by Aspergillus ochraceus and Penicillium verrucosum, is a worldwide contaminant of food and feedstuff. OTA is nephrotoxic and a renal carcinogen in rodents. The underlying molecular and cellular mechanisms by which OTA exhibits its toxicity have yet no...
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PMID: 18547704
PDF is available here.
PDF is available here.
Abstract
Zonampanel monohydrate ([2,3-dioxo-7-(1H-imidazol-1-yl)-6-nitro-1,2,3,4-tetrahydro-1-quinoxalinyl] acetic acid monohydrate, YM872) is a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist. In humans, almost all administered zonampanel is excreted in the urine unchanged...
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PMID: 18443035
PDF is available here.
PDF is available here.
Abstract
para-aminophenol (PAP) causes nephrotoxicity by biochemical mechanisms that have not been fully elucidated. PAP can undergo enzymatic or non-enzymatic oxidation to form reactive intermediates. Using modulators of reactive oxygen species (ROS), the role of ROS in PAP toxicity in LLC-PK(1) cells was i...
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PMID: 18396305
PDF is available here.
PDF is available here.
European Journal of Pharmacology (588)2-3 2008
Abstract
The goal of this research was to investigate the renoprotective effect of erythropoietin against aristolochic acid-induced apoptosis in cultured LLC-PK1 cells as well as underlying mechanism. LLC-PK1 cells impaired by aristolochic acid were used in this study as the cell model of aristolochic acid n...
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PMID: 18501345
PDF is available here.
PDF is available here.