Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
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PMID: 22120178
PDF is available here.
Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
Sergiu P Paşca,
Thomas Portmann,
Irina Voineagu,
Masayuki Yazawa,
Aleksandr Shcheglovitov,
Anca M Paşca,
Branden Cord,
Theo D Palmer,
Sachiko Chikahisa,
Seiji Nishino,
Jonathan A Bernstein,
Joachim Hallmayer,
Daniel H Geschwind and
Ricardo E Dolmetsch
Abstract
We generated cortical neuronal precursor cells and neurons from induced pluripotent stem cells derived from individuals with Timothy syndrome. Cells from these individuals have defects in calcium (Ca(2+)) signaling and activity-dependent gene expression. They also show abnormalities in differentiati...
|
PMID: 22120178
PDF is available here.
Abstract
We report here that testicular nuclear receptor 4 (TR4), a member of the nuclear receptor family, modulates DNA repair specifically through the transcription-coupled (TC) NER pathway but not the global genomic NER pathway. The level of Cockayne syndrome B protein (CSB), a member of the TC-NER pathwa...
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PMID: 21918225
PDF is available here.
Angela L AL Rasmussen,
Deborah L DL Diamond,
Jason E JE McDermott,
Xiaoli X Gao,
Thomas O TO Metz,
Melissa M MM Matzke,
Victoria S VS Carter,
Sarah E SE Belisle,
Marcus J MJ Korth,
Katrina M KM Waters,
Richard D RD Smith and
Michael G MG Katze
Abstract
We present the results of studies confirming the importance of DCI to HCV pathogenesis. Computational models incorporating proteomic data from HCV patient liver biopsy specimens recapitulated our original predictions regarding DCI and link HCV-associated alterations in cellular metabolism and liver...
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PMID: 21917952
PDF is available here.
Abstract
We demonstrate that the RNA-binding activity of NP is necessary for stabilization of cRNA, whereas, surprisingly, homo-oligomerization of NP is not essential. However, both RNA binding and homo-oligomerization activities are essential for genome replication....
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PMID: 21917965
PDF is available here.
Abstract
We report that BST-2 antibody treatment facilitates virus release from BST-2(+) cells by interfering with the tethering activity of BST-2. BST-2 antibodies were unable to release already tethered virions and were most effective when added early during virus production. BST-2 antibody treatment did n...
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PMID: 21917971
PDF is available here.
Abstract
We used C57BL/6 wild type mice to determine the durations of antagonist action of novel κ-opioid receptor ligands and examined their efficacies for JNK1 activation compared with conventional competitive antagonists. Of the 12 compounds tested, 5 had long durations of action that positively correlat...
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PMID: 21832171
PDF is available here.
Abstract
We show that the negatively charged phospholipid phosphatidylserine (PS) is exposed in the outer leaflet of their plasma membrane not only in tumor cell lines, but also in metastases and primary cultures thereof, which contrasts with a lack of PS exposure by differentiated non-tumorigenic counterpar...
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PMID: 21810406
PDF is available here.
Abstract
We previously showed that UCP3 turns over rapidly in C2C12 myoblasts, with a half-life of 0.5-4h, and that turnover can be reconstituted in vitro. We show here that rapid degradation of UCP3 in vitro in isolated brown adipose tissue mitochondria required the 26S proteasome, ubiquitin, ATP, succinate...
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PMID: 21820402
PDF is available here.
Abstract
Persistent infections with human papillomavirus type 16 (HPV16), HPV18, or HPV31 are necessary for the development of cervical cancer, implying that HPVs have evolved immunoevasive mechanisms. Recent global transcriptome analyses indicated that these HPV types downregulate the consti...
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PMID: 21849431
PDF is available here.
Abstract
We have shown recently that epimorphin (EPM), a protein exclusively expressed on the surface of hepatic stellate cells and myofibroblasts of the liver, induces bile duct formation of hepatic stem-like cells (WB-F344 cells) in a putative biophysical way. Therefore, the aim of this study was to presen...
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PMID: 21935930
PDF is available here.
Abstract
A broad range of technologies have been developed to enable three dimensional (3D) cell culture. Few if any however are adaptable for routine everyday use in a straightforward and cost effective manner. Alvetex(®) is a rigid highly porous polystyrene scaffold designed specifically to enable routine...
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PMID: 21042981
PDF is available here.