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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Cell Membrane Structures (10):
Recent article
Cell Membrane Structures
Biology of the Cell (102)9 2010
Abstract
We show that Cdc42 (cell-division cycle 42), Rac1 and RhoA activities are stimulated in NaF-treated cells. However, podosome assembly is dependent on Cdc42 and Rac1, but not RhoA. Although the sole activation of Cdc42 is sufficient to induce individual podosomes, a balance between RhoGTPase activiti...
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PMID: 20504277
PDF is available here.
PDF is available here.
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Abstract
We identified that sibling HeLa cell pairs, in contrast to random cell pairs, underwent apoptosis synchronously. This allowed us to use high-speed cellular imaging to investigate mitochondrial outer membrane permeabilization (MOMP), a highly coordinated, rapid process during apoptosis, at a temporal...
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PMID: 19136937
PDF is available here.
PDF is available here.
Abstract
We asked whether normal human airway epithelial cells can form podosomes, a cellular structure discovered from cancer and mesenchymal cells that controls migration and invasion. Herein, we report that phorbol-12, 13-dibutyrate (PDBu), a protein kinase C activator, induced reorganization of cytoskele...
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PMID: 18932175
PDF is available here.
PDF is available here.
Abstract
We for the first time demonstrated that LPLI could induce the production of circular ruffle structures in COS-7 cells. These structures were proved to be actin-based and originated from membrane microdomains enriched in cholesterol. Ras was shown to be activated by LPLI and expression of YFP-H-Ras (...
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PMID: 19142854
PDF is available here.
PDF is available here.
New Phytologist (181)1 2009
Abstract
The nitrogen-fixing symbiosis between cyanobacteria and the water fern Azolla microphylla is, in contrast to other cyanobacteria-plant symbioses, the only one of a perpetual nature. The cyanobacterium is vertically transmitted between the plant generations, via vegetative fragmentation of the host o...
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PMID: 19076717
PDF is available here.
PDF is available here.
Abstract
Piecemeal microautophagy of the nucleus (PMN) selectively removes and degrades small fragments of the Saccharomyces cerevisiae nucleus. Inter-organelle contact sites called nucleus-vacuole (NV) junctions determine the selectivity of PMN by establishing a platform for the biogenesis of PMN blebs and...
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PMID: 18989095
PDF is available here.
PDF is available here.
Abstract
The Z-disc, appearing as a fine dense line forming sarcomere boundaries in striated muscles, when studied in detail reveals crosslinked filament arrays that transmit tension and house myriads of proteins with diverse functions. At the Z-disc the barbed ends of the antiparallel actin...
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PMID: 19830582
PDF is available here.
PDF is available here.
Abstract
We show a type of peptide-induced pore that is not framed by a peptide structure. Peptide-induced pores in multiple bilayers were long-range correlated into a periodically ordered lattice and analyzed by X-ray diffraction. We found the pores induced by Bax-derived helical peptides were at least part...
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PMID: 18987313
PDF is available here.
PDF is available here.
Abstract
We report that dynamic membrane ruffles in activated macrophages promote binding of C3bi-opsonized particles. We identify these ruffles as components of the macropinocytosis machinery in both PMA- and LPS-stimulated macrophages. C3bi-particle capture is facilitated by enrichment of high-affinity Mac...
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PMID: 18768756
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)41 2008
Abstract
We have generated genetically modified parasites that express IMC1b tagged with green fluorescent protein, and we show that it is targeted exclusively to the pellicle of ookinetes. We also show that IMC1b-deficient ookinetes display abnormal cell shape, reduced gliding motility, decreased mechanical...
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PMID: 18650444
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)41 2008
Abstract
We report that FHOD1 physically associates via the N-terminal part of its FH2 domain with the central domain of ROCK1. Although FHOD1 does not affect the kinase activity of ROCK1, the DRF is an efficient substrate for phosphorylation by ROCK1. Co-expression of FHOD1 and ROCK1 results in the generati...
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PMID: 18694941
PDF is available here.
PDF is available here.
Abstract
Innate Immunity (14)4 2008
Abstract
We now know that sialic acid (N-acetylneuraminic acid or Neu5Ac) and certain oligosaccharide extensions are important in the pathogenesis of NTHi; however, the biological implications for many of the various features are still unknown. Electrospray ionization mass spectrometry in combination with se...
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PMID: 18669606
PDF is available here.
PDF is available here.
Journal of Cell Biology (182)2 2008
Abstract
We find that in nuf mutant embryos, an initial loss of F-actin at the furrow is followed by loss of the associated furrow membrane. Wild-type embryos treated with Latrunculin A or Rho inhibitor display similar defects. Drug- or Rho-GTP-induced increase of actin polymerization or genetically mediated...
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PMID: 18644888
PDF is available here.
PDF is available here.
Journal of Bacteriology (190)16 2008
Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native state.
Abstract
We have used cryo-electron microscopy of vitreous sections (CEMOVIS) to perform a detailed ultrastructural analysis of three species belonging to the Corynebacterineae suborder, namely, Mycobacterium bovis BCG, Mycobacterium smegmatis, and Corynebacterium glutamicum, in their native state. We provid...
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PMID: 18567661
PDF is available here.
PDF is available here.
Genes & Development (28)13 2008
Abstract
We show here that the Rictor protein is also present in cultured adipocytes in complexes containing Myo1c, a molecular motor that promotes cortical actin remodeling. Interestingly, the Rictor-Myo1c complex is biochemically distinct from the previously reported mTORC2 and can be immunoprecipitated in...
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PMID: 18426911
PDF is available here.
PDF is available here.
Journal of Cell Biology (181)7 2008
Abstract
We sought to determine whether MAPK signaling regulates podosome formation. Unlike extracellular signal-regulated kinase 1/2 (ERK1/2), ERK5 is constitutively activated in Src-transformed fibroblasts. ERK5-deficient cells expressing v-Src exhibited increased RhoA activation and signaling, which lead...
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PMID: 18573916
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)27 2008
Abstract
We now show that IpaD specifically binds fluorescein-labeled deoxycholate and, based on energy transfer measurements and docking simulations, this interaction appears to occur where the N-terminal domain of IpaD meets its central coiled-coil, a region that may also be involved in needle-tip interact...
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PMID: 18450744
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)22 2008
Abstract
We report that ER stress-induced autophagy requires the activation of protein kinase C (PKC), a member of the novel-type PKC family. Induction of ER stress by treatment with either thapsigargin or tunicamycin activated autophagy in immortalized hepatocytes as monitored by the conversion LC3-I to LC3...
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PMID: 18356160
PDF is available here.
PDF is available here.
Journal of Cell Science (121)Pt 11 2008
Abstract
We ask how cortical compartments arise along the plasma membrane furrows that cellularize the early Drosophila embryo, and investigate the influence that this compartmentalization has on furrow ingression. We find that the zygotic gene product Nullo aids the establishment of discrete cortical compar...
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PMID: 18460582
PDF is available here.
PDF is available here.
Abstract
An increased risk of death or severe injury due to late-morning thrombotic events is well established. Tissue factor (TF) is the initiator of the coagulation cascade, and endothelial stresses, coupled with production of pro-coagulant microparticles (MP) are also important factors in loss of haemosta...
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PMID: 18449421
PDF is available here.
PDF is available here.
Abstract
We examined the effects of the overexpression of ET(A) in conjunction with T-tubule loss in cultured adult rat ventricular myocytes. In adult myocytes cultured for 3 to 4 days, the normally robust positive inotropic effect (PIE) of ET-1 was lost in parallel with T-tubule degeneration and a decline i...
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PMID: 18326801
PDF is available here.
PDF is available here.
Journal of Cell Science (121)Pt 9 2008
Abstract
We show here that most tissues express all three paralogs, and immunoprecipitation and immunofluorescence experiments demonstrated that the SNX9-family proteins act as individual entities in cells. Their SH3 domains displayed a high selectivity for dynamin 2, and the PX-BAR units had the capacity to...
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PMID: 18411244
PDF is available here.
PDF is available here.
Molecular Immunology (45)7 2008
Abstract
We demonstrate that Lsc exists physiologically in primary B lymphocytes as a large molecular weight complex resembling a homo-tetramer. Interfering with the assembly of this large molecular weight Lsc oligomer results in the activation of both Lsc functional activities and leads to cell rounding and...
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PMID: 18157933
PDF is available here.
PDF is available here.
Abstract
To characterize the cytoplasmic structure reorganization during plant meiosis, the male meiocytes of Althaea rosea (L.) Cavan were examined under the combination of light and electron microscopy. Light microscopic observation of the toluidine blue-stained thick resin sections of young anthers reveal...
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PMID: 18262810
PDF is available here.
PDF is available here.
Abstract
We examined the evolution of these and other characters in light of previously published phylogenies of oxymonads based on molecular data. The presence of concavities in Saccinobaculus and families Pyrsonymphidae and Oxymonadidae strengthens support for a clade comprising these three families. A gly...
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PMID: 18024180
PDF is available here.
PDF is available here.
Journal of Cell Biology (180)5 2008
Abstract
We show that Ca2+-dependent resealing after permeabilization with the bacterial toxin streptolysin O (SLO) requires endocytosis via a novel pathway that removes SLO-containing pores from the plasma membrane. We also find that endocytosis is similarly required to repair lesions formed in mechanically...
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PMID: 18316410
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1780)3 2008
Abstract
We become witnesses to another miracle of nature that has endowed the simplest lysophospholipids with functions seemingly ubiquitous to every mammalian cell. A decade after the discovery of the EDG family lysophospholipid receptors, the field has gained unimaginable impetus explaining the biological...
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PMID: 17931789
PDF is available here.
PDF is available here.
Abstract
We provide evidence that higher-order AQP4 complexes correspond to square arrays, with the AQP4 isoform M23 playing a dominant role. Our data are consistent with the idea that square arrays consist of aggregates of AQP4 tetramers complexed with multiples of dimers. By comparison, Aquaporin-1 and Aqu...
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PMID: 18247481
PDF is available here.
PDF is available here.
Abstract
We are currently using an impedance-based flow cytometer to accurately size and enumerate TF-bearing microparticles to explore the association between cancer thrombosis and elevations in circulating TF-bearing microparticles....
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PMID: 18645925
PDF is available here.
PDF is available here.
Abstract
We discuss the roles of tissue factor and microparticles with regard to chemotherapy-induced hypercoagulability....
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PMID: 18645926
PDF is available here.
PDF is available here.
Abstract
Described 40 years ago as cell dust, microparticles (MPs) are now considered a key component in the haemostatic response. Owing to their plasma membrane reactivity, platelets are believed to constitute the main source of circulating procoagulant microparticles and behave as true sensors for the haem...
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PMID: 18231934
PDF is available here.
PDF is available here.
Thrombosis Research (122 Suppl 1) 2008
Abstract
Cellular microparticles (MP) are small membrane vesicles that are released from cells upon activation or apoptosis. They constitute a heterogeneous population of submicron elements differing in cellular origin, number, size, antigenic composition and functional properties. Circulating MP provide an...
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PMID: 18691501
PDF is available here.
PDF is available here.
Thrombosis Research (122 Suppl 1) 2008
Abstract
Upon stimulation or apoptosis, eukaryotic cells shed membrane vesicles of submicron size. These so-called microparticles (MPs) are detected and characterized based on the exposure of antigens characteristic of their respective parental cells and on the increased distribution of negatively charged ph...
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PMID: 18691500
PDF is available here.
PDF is available here.
Neuroscience Research (60)1 2008
Abstract
We examined the immuno-localization of the markers for the axon initial segments (AISs), betaIV-spectrin and sodium channels, to determine whether or not heterogeneous parvalbumin-positive neurons have axons. We confirmed their localization on the AISs of the large short-axon cells and periglomerula...
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PMID: 17976845
PDF is available here.
PDF is available here.
Abstract
ChemPhysChem (8)17 2007
Abstract
We have amperometrically measured dopamine release from rat pheochromocytoma cells (PC12 cells) in high osmolarity conditions with and without L-3,4-dihydroxyphenylalanine (L-DOPA) treatment. We observe an increase in the number of release events displaying a prespike feature or "foot" when the cell...
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PMID: 17966970
PDF is available here.
PDF is available here.
Abstract
We have examined the structural requirements for ASAP1-dependent formation of invadopodia and related structures in NIH 3T3 fibroblasts called podosomes. We found that both predominant splice variants of ASAP1 (ASAP1a and ASAP1b) associated with invadopodia and podosomes. Podosomes were highly dynam...
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PMID: 17893324
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)47 2007
Abstract
We have shown that the WASP C-terminal activity is critical for the phagocytic cup formation in macrophages. We demonstrated that WASP is phosphorylated on tyrosine 291 in macrophages, and the WASP phosphorylation is important for the phagocytic cup formation. In addition, we showed that WASP and WA...
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PMID: 17890224
PDF is available here.
PDF is available here.
Plant Cell Online (19)11 2007
Abstract
We found that only one guanine nucleotide exchange factor (GEF), named VPS9a, can activate all Rab5 members to GTP-bound forms in vitro in spite of their diverged structures. In the vps9a-1 mutant, whose GEF activity is completely lost, embryogenesis was arrested at the torpedo stage. Green fluoresc...
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PMID: 18055610
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (282)42 2007
Abstract
We have previously shown that actin ligands inhibit the fusion of yeast vacuoles in vitro, which suggests that actin remodeling is a subreaction of membrane fusion. Here, we demonstrate the presence of vacuole-associated actin polymerization activity, and its dependence on Cdc42p and Vrp1p. Using a...
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PMID: 17726018
PDF is available here.
PDF is available here.
Development (134)19 2007
Abstract
We have identified two redundant GTPase activating proteins (GAPs) - RGA-3 and RGA-4 - that regulate Rho GTPase function at the plasma membrane in early Caenorhabditis elegans embryos. Knockdown of both RhoGAPs resulted in extensive membrane ruffling, furrowing and pronounced pseudo-cleavages. In ad...
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PMID: 17728351
PDF is available here.
PDF is available here.
Abstract
We synthesize evidence for the origin, adaptive significance and diversification of the euglenid cytoskeleton, especially pellicle ultrastructure, pellicle surface patterns, pellicle strip number and the feeding apparatus. We also highlight holes in our knowledge that must be filled before we are ab...
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PMID: 17876783
PDF is available here.
PDF is available here.
Fertility and Sterility (88)4 Suppl 2007
Abstract
OBJECTIVE: To assess pinopode formation in Lif null and Hoxa10 null mice with infertility secondary to failed implantation. DESIGN: Controlled animal experiment. SETTING: Animal research and laboratory facility. ANIMAL(S): Lif null, Hoxa10 null, and ICR mice and Sprague-Dawley rats. INTERVENTION(S):...
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PMID: 17313947
PDF is available here.
PDF is available here.
Proteomics (7)17 2007
Abstract
We identified 141 protein components of Escherichia coli-derived native OMVs with high confidence; two separate analyses yielded identifications of 104 and 117 proteins, respectively, with 80 proteins overlapping between the two trials. In the group of identified proteins, the outer membrane protein...
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PMID: 17787032
PDF is available here.
PDF is available here.
Endocrinology (148)8 2007
Abstract
We present here an investigation of the cell membrane dynamics during exocytosis in anterior pituitary cells, especially gonadotropes, which secrete LH, a hormone central to ovulation. Gonadotrope enrichment was achieved using immunolabeled magnetic nanobeads. Three complementary imaging techniques...
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PMID: 17494998
PDF is available here.
PDF is available here.
Experimental Cell Research (313)10 2007
Abstract
Vimentin is the major intermediate filament (IF) protein of mesenchymal cells. It shows dynamically altered expression patterns during different developmental stages and high sequence homology throughout all vertebrates, suggesting that the protein is physiologically important. Still, until recently...
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PMID: 17512929
PDF is available here.
PDF is available here.
Journal of Infectious Diseases (195)11 2007
Abstract
We document that outer membrane vesicles (OMVs) carrying ubiquitous surface protein (Usp) A1 and UspA2 (hereafter, UspA1/A2) were secreted. Further analyses revealed that OMVs isolated in vitro also contained UspA1/A2, which mediate interactions with, among other proteins, the third component of the...
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PMID: 17471436
PDF is available here.
PDF is available here.
Abstract
We solved the crystal structures of the EFC domains of human FBP17 and CIP4. The structures revealed a gently curved helical-bundle dimer of approximately 220 A in length, which forms filaments through end-to-end interactions in the crystals. The curved EFC dimer fits a tubular membrane with an appr...
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PMID: 17512409
PDF is available here.
PDF is available here.
Fertility and Sterility (87)5 2007
Abstract
OBJECTIVE: To assess pinopode formation in human endometrium during the luteal phase of the menstrual cycle and in the first trimester of pregnancy. DESIGN: Prospective clinical study. SETTING: Outpatient infertility clinics and outpatient family planning clinic. PATIENT(S): Thirty-two regularly cyc...
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PMID: 17224147
PDF is available here.
PDF is available here.
Biology of the Cell (99)5 2007
Abstract
The results of the present study suggest that the expression of the Longin domain of TI-VAMP regulates lysosomal secretion of epithelial cells and provide molecular evidence for a role of the late endocytic system in cell migration....
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PMID: 17288539
PDF is available here.
PDF is available here.
Abstract
The freezing-thawing process significantly influenced the viability and integrity of the spermatozoa ([74.43 +/- 13.78]% vs. [46.25 +/- 2.69]%; [64.26 +/- 7.03]% vs. [6.27 +/- 2.90]%, P < 0.01). The results showed differences in acrosome integrity rate between the fresh and frozen samples ([80.77 +/...
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PMID: 17569253
PDF is available here.
PDF is available here.
Abstract
The sarcolemmal membrane of mammalian ventricular cardiomyocytes are characterised by the presence of invaginations called transverse tubules (T-tubules) which constitute a network, the transverse tubule system. T-tubules occur at the Z line as transverse elements with also longitudinal extensions....
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PMID: 17536428
PDF is available here.
PDF is available here.
Virus Research (124)1-2 2007
Abstract
In rat liver epithelial (WB) cells, the protein kinase C inhibitor H7 blocked gap junctional intercellular communication (GJIC) and reduced virus infectivity. Octanol, 18-beta-glycyrrhetinic acid, and staurosporine, agents that reduce GJIC, had no effect upon virus infectivity. Previous studies demo...
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PMID: 17157406
PDF is available here.
PDF is available here.
Journal of Cell Science (120)Pt 3 2007
Abstract
We show that overexpression of LBR causes membrane overproduction, inducing NE invagination and membrane stack formation, and that these processes require the transmembrane domain of LBR. Biochemical analysis shows that the N-terminal domain of LBR directly interacts with importin beta in a Ran sens...
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PMID: 17251381
PDF is available here.
PDF is available here.
Abstract
We evaluated their presence in Crotalus durissus terrificus venom glands and also in freshly collected venom. Microvesicles were found in the venom glands mainly in regions of exocytosis. They ranged from 40 to 80 nm in diameter. Freeze-fracture replicas of the glands revealed particles on the cytop...
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PMID: 17084429
PDF is available here.
PDF is available here.
Abstract
Within the last decade, a great number of reports have discussed cellular redox signalization depending on the levels of oxygen and reactive oxygen species (ROS). Experiments have proven that ROS can not only be damaging, but are also able to induce the synthesis of cell defense systems. The initiat...
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PMID: 17396559
PDF is available here.
PDF is available here.
Current Medicinal Chemistry (14)29 2007
Abstract
Increasing evidence supports the hypothesis that nutrition habits play a critical role in the incidence and growth of colorectal cancer. Among dietary factors, fish-derived n-3 polyunsaturated fatty acids (PUFAs) have gained particular interest, since epidemiological studies have shown a reduced inc...
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PMID: 18220742
PDF is available here.
PDF is available here.
Abstract
With one or two exceptions, biological materials are "soft", meaning that they combine viscous and elastic elements. This mechanical behavior results from self-assembled supramolecular structures that are stabilized by noncovalent interactions. It is an ongoing and profound challenge to understand t...
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PMID: 17516592
PDF is available here.
PDF is available here.
Journal of Immunology (177)12 2006
Abstract
We report that two classes of membrane nanotubes between human monocyte-derived macrophages can be distinguished by their cytoskeletal structure and their functional properties. Thin membrane nanotubes contained only F-actin, whereas thicker nanotubes, i.e., those > approximately 0.7 microm in diame...
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PMID: 17142745
PDF is available here.
PDF is available here.