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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Sarcolemma (0):
Recent article
Sarcolemma
Abstract
We show that the extracellular matrix protein biglycan regulates utrophin expression in immature muscle and that recombinant human biglycan (rhBGN) increases utrophin expression in cultured myotubes. Systemically delivered rhBGN up-regulates utrophin at the sarcolemma and reduces muscle pathology in...
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PMID: 21187385
PDF is available here.
PDF is available here.
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Abstract
These results indicate that, for a proper MgATP up-regulation of NCX1, the enzyme responsible for PtdIns-4,5P2 synthesis must be (i) functionally competent and (ii) set in the NCX1 microenvironment closely associated to the exchanger. This kind of supramolecular structure is needed to optimize bindi...
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PMID: 20933499
PDF is available here.
PDF is available here.
Circulation Journal (74)11 2010
Abstract
These results suggest that the inhibition of contractile activity during IPost prevents cardiomyocyte oncosis and enhances cardioprotection through PI3K-dependent restoration of sarcolemmal dystrophin....
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PMID: 20877127
PDF is available here.
PDF is available here.
Circulation Journal (74)11 2010
Abstract
Proteomics (10)17 2010
Abstract
We separated the two mitochondrial subpopulations from skeletal muscle using a refined method that provides an excellent division of these unique mitochondrial subpopulations. Using proteomics of mitochondria and its subfractions (intermembrane space, matrix and inner membrane), a total of 325 disti...
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PMID: 20665633
PDF is available here.
PDF is available here.
FASEB Journal (24)7 2010
Abstract
We then examined whether insulin-stimulated translocation of the facilitative glucose transporter GLUT4 from its storage sites to the skeletal muscle sarcolemma depends on Rac1. We show that ectopic expression of constitutively activated Rac1, as well as intravenous administration of insulin, caused...
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PMID: 20203090
PDF is available here.
PDF is available here.
Abstract
The mechanisms responsible for anti-arrhythmic protection during ischemia-reperfusion (IR) in exercised hearts are not fully understood. The purpose of this investigation was to examine whether the ATP-sensitive potassium channels in the mitochondria (mito K(ATP)) and sarcolemma (sarc K(ATP)) provid...
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PMID: 20435852
PDF is available here.
PDF is available here.
Annals of Neurology (67)6 2010
Abstract
We studied CFTR expression in human skeletal muscle by Western blot with anti-CFTR antibody (Ab) L12B4 and demonstrated a single band with expected molecular weight of 168kDa. We isolated the cDNA by reverse transcription polymerase chain reaction and directly sequenced a 975bp segment (c. 3,600-4,5...
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PMID: 20517942
PDF is available here.
PDF is available here.
Abstract
The primary aim of the present study was to investigate in which cellular compartments fatty acid trans-locase CD36 (FAT/CD36) is localized. Intact and fully functional skeletal muscle mitochondria were isolated from lean and obese female Zucker rats and from 10 healthy male individuals. FAT/CD36 cou...
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PMID: 20023206
PDF is available here.
PDF is available here.
Experimental Physiology (95)5 2010
Abstract
I present a two-stage hypothesis for muscle damage in the dystrophinopathies, as follows: stage 1, the absence of dystrophin disrupts ion channel function, causing an activation of necrotizing Ca(2+)-activated proteases, which results in regenerated branched fibres; and stage 2, branched fibres are...
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PMID: 20139167
PDF is available here.
PDF is available here.
Abstract
Abstract
We combined nanoscale live-cell scanning ion conductance and fluorescence resonance energy transfer microscopy techniques and found that, in cardiomyocytes from healthy adult rats and mice, spatially confined beta2AR-induced cAMP signals are localized exclusively to the deep transverse tubules, wher...
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PMID: 20185685
PDF is available here.
PDF is available here.
Abstract
This study describes increased sarcolemmal permeability and myofilamentar damage that occur together with lipid peroxidation and protein nitration in the myocardium in severe sepsis induced by cecal ligation and puncture. Male C57BL/6 mice were submitted to moderate and severe septic injury and sham...
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PMID: 20160610
PDF is available here.
PDF is available here.
Abstract
Our study was the first to demonstrate that UT-II activates the cardiac sarcolemmal NHE1 and that the phenomenon may involve, at least in part, the phospholipase C-protein kinase C-ERK pathway....
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PMID: 20040885
PDF is available here.
PDF is available here.
Abstract
This study aimed to analyse the sarcolemma of Col6a1-/- fibers in comparison with wild type and mdx fibers, taken as positive control in view of the known structural and functional alterations of their membranes. Structural and mechanical properties were studied in single muscle fibers prepared from...
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PMID: 20396399
PDF is available here.
PDF is available here.
Abstract
In the last few years endomyocardial biopsy becomes a useful diagnostic tool for the investigation of idiopathic dilated cardiomyopathy. The aim of our current study was to try to identify ultrastructural and immunohistochemical specificity of truncated cardiac proteins in affected heart. The focal...
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PMID: 20383812
PDF is available here.
PDF is available here.
Ukrainskij biokhimicheskij zhurnal/Ukrayins'kij biokhimichnij zhurnal/Ukrainian biochemical journal (82)1 2010
Abstract
Prospects of the use of flow cytometry analysis for investigation of forming K(+)- equilibrium membrane potential on the experimental model of myometrium plasma membrane vesicles in the presence of valinomycine using potential-sensitive probe of DiOC6(3). Transmembrane potential magnitude correspond...
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PMID: 20684228
PDF is available here.
PDF is available here.
Abstract
We demonstrated that a cell polarity-regulating kinase, PAR-1b, interacts with the utrophin-DG complex, and positively regulates the interaction between utrophin and DG. In this study, we demonstrate that the 8th and 9th spectrin-like repeats (R8 and R9) of utrophin cooperatively form a PAR-1b-inter...
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PMID: 19945424
PDF is available here.
PDF is available here.
FEBS Letters (583)22 2009
Abstract
Duchenne myopathy is a lethal disease due to the absence of dystrophin, a cytoskeletal protein. Muscles from dystrophin-deficient mice (mdx) typically present an exaggerated susceptibility to eccentric work characterized by an important force drop and an increased membrane permeability consecutive t...
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PMID: 19840792
PDF is available here.
PDF is available here.
Rinsho Shinkeigaku (49)11 2009
Abstract
We recently reported that systemic delivery of Morpholino antisense oligonucleotides targeting exon 6 and 8 of the canine DMD gene, efficiently recovered functional dystrophin proteins at the sarcolamma of dystrophic dogs, and improved performance of affected dogs without serious side effects (Yokot...
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PMID: 20030230
PDF is available here.
PDF is available here.
Bioscience Reports (29)4 2009
Abstract
Cationic L-amino acids enter cardiac-muscle cells through carrier-mediated transport. To study this process in detail, L-[(14)C]lysine uptake experiments were conducted within a 10(3)-fold range of L-lysine concentrations in giant sarcolemmal vesicles prepared from rat cardiac ventricles. Vesicles h...
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PMID: 19032145
PDF is available here.
PDF is available here.
Abstract
We demonstrate that this would result in a slowing of inotropic responses due to changes of SR calcium content. We conclude that the large sarcolemmal calcium fluxes facilitate rapid changes of contractility....
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PMID: 19525376
PDF is available here.
PDF is available here.
Abstract
We compared the proteome of subsarcolemmal and intermyofibrillar mitochondria isolated from the myocardium of sedentary (control) and exercise-trained Sprague-Dawley rats. To achieve this goal, we utilized isobaric tags for relative and absolute quantitation, which allows simultaneous identification...
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PMID: 19429812
PDF is available here.
PDF is available here.
Molecular and Cellular Biochemistry (326)1-2 2009
Abstract
Electrical stimulation of rat hindlimb muscle resulted in an increase in FABPpm protein content in the GSV of 61% (P < 0.05) and in FAT/CD36 protein content in the GSV of 33% (P < 0.05). AICAR stimulation increased FAT/CD36 protein content in GSV by 22% (P < 0.05), whereas FABPpm protein content in...
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PMID: 19142713
PDF is available here.
PDF is available here.
Matrix Biology (28)4 2009
Abstract
We also try to envisage a sort of worry list featuring and dwelling on some of the most compelling "mysteries" that should be solved to finally understand DG's functional diversity....
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PMID: 19303439
PDF is available here.
PDF is available here.
Der Pathologe (30)3 2009
Abstract
We were able to examine eight patients suspected of LGMD2B clinically, histochemically. The genotype was determined in every case. We found sarcolemmal and interstitial amyloid deposits in four muscle sections. All of the mutations associated with amyloid were located in the N-terminal region of dys...
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PMID: 19326120
PDF is available here.
PDF is available here.
Abstract
We studied isolated ventricular myocytes from patients with ischemic heart disease, idiopathic dilated cardiomyopathy, and hypertrophic obstructive cardiomyopathy and determined T-tubule structure with either the fluorescent membrane dye di-8-ANNEPs or the scanning ion conductance microscope (SICM)....
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PMID: 19342485
PDF is available here.
PDF is available here.
Abstract
We investigated cytosolic and sarcolemmal nNOS expression in muscle biopsies from 32 patients with 7 forms of limb-girdle muscular dystrophy. Primary calpainopathy, dysferlinopathy, and caveolinopathy biopsies showed normal levels of cytosolic nNOS and preserved sarcolemmal nNOS immunoreactivity. By...
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PMID: 19287313
PDF is available here.
PDF is available here.
Biophysical Journal (96)6 2009
Uniform action potential repolarization within the sarcolemma of in situ ventricular cardiomyocytes.
Abstract
We used confocal line-scan imaging in conjunction with the fast response voltage-sensitive dyes ANNINE-6 and ANNINE-6plus to resolve action potential-related changes in fractional dye fluorescence (DeltaF/F) at the t-tubule and surface membranes of in situ mouse ventricular cardiomyocytes. Peak Delt...
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PMID: 19289075
PDF is available here.
PDF is available here.
Abstract
We wished to determine whether dystrophin functions in subcellular localization of nNOS and which regions may be necessary. Using in vivo transfection of dystrophin deletion constructs, we show that sarcolemmal targeting of nNOS was dependent on the spectrin-like repeats 16 and 17 (R16/17) within th...
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PMID: 19229108
PDF is available here.
PDF is available here.
Abstract
These results suggest that KR-31761 exerts potent cardioprotective effects through the opening of both mitoK+(ATP) and sarcK+(ATP) channels in rat hearts with a minimal vasorelaxant effect....
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PMID: 19234365
PDF is available here.
PDF is available here.
Abstract
Although blocking the SAC function completely eliminated the expected adaptive response in biomechanical parameters during the exercise regimen, there remained evidence of an acquired RBE, albeit with an attenuated response when compared with the muscles with intact SAC function. CONCLUSION: Blockin...
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PMID: 19127190
PDF is available here.
PDF is available here.
Abstract
We propose the two disorders of diabetes and hypertension have a similar etiology of cardiomyopathy resulting, in part, from an increase in the number of incomplete CRU's, due to a morphological change in the architecture and orientation of the t-tubules. These architectural changes could potentiall...
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PMID: 19924547
PDF is available here.
PDF is available here.
Abstract
In addition to the highly specialized contractile apparatus, it is becoming increasingly clear that there is an extensive actin cytoskeleton which underpins a wide range of functions in striated muscle. Isoforms of cytoskeletal actin and actin-associated proteins (non-muscle myosins,...
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PMID: 19997772
PDF is available here.
PDF is available here.
Ukrainskij biokhimicheskij zhurnal/Ukrayins'kij biokhimichnij zhurnal/Ukrainian biochemical journal (81)4 2009
Abstract
The action of hydrogen peroxide on acetylcholinesterase enzymatic activity in myometrium sarcolemma fraction is investigated. Hydrogen peroxide (0.1-26 microM), depending on the concentration, suppressed the activity. Acetylcholinesterase proved to be highly sensitive to the action of H2O2, making K...
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PMID: 20387632
PDF is available here.
PDF is available here.
Medicinski pregled (62)11-12 2009
Abstract
The term cardiodynamics refers to dynamic events associated with cardiac contraction and relaxation. The occurring wave of excitement spreads very quickly along the entire atrial musculature and after a brief AV retention it affects all muscle cells of the ventricles. Excitation, that is, the increa...
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PMID: 20491382
PDF is available here.
PDF is available here.
Abstract
We present evidence for an ankyrin-based mechanism for sarcolemmal localization of dystrophin and beta-DG. Dystrophin binds ankyrin-B and ankyrin-G, while beta-DG binds ankyrin-G. Dystrophin and beta-DG require ankyrin-G for retention at costameres but not delivery to the sarcolemma. Dystrophin and...
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PMID: 19109891
PDF is available here.
PDF is available here.
Abstract
Satellite cells are considered to be adult skeletal muscle stem cells. Their ability to regenerate large muscle defects is highly dependent on their specific niche. When these cells are cultured in vitro, the loss of this niche leads to a loss of proliferative capacity and defective...
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PMID: 18817477
PDF is available here.
PDF is available here.
Abstract
Satellite cells are considered to be adult skeletal muscle stem cells. Their ability to regenerate large muscle defects is highly dependent on their specific niche. When these cells are cultured in vitro, the loss of this niche leads to a loss of proliferative capacity and defective regeneration whe...
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PMID: 18817477
PDF is available here.
PDF is available here.
Abstract
We have previously reported a group of patients with congenital onset weakness associated with a deficiency of members of the syntrophin-alpha-dystrobrevin subcomplex and have demonstrated that loss of syntrophin and dystrobrevin from the sarcolemma of skeletal muscle can also be associated with den...
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PMID: 19026398
PDF is available here.
PDF is available here.
Abstract
Circulation Research (103)12 2008
Abstract
Abstract
We have determined whether the 8 month old mdx mouse, an animal model of muscular dystrophy, also has abnormal cardiac function and energetics. In vivo cardiac MRI revealed 33% and 104% larger right ventricular end-diastolic and end-systolic volumes, respectively, and 17% lower right ventricular eje...
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PMID: 18929569
PDF is available here.
PDF is available here.
Abstract
We show, using mouse models, that this exaggerated fatigue response is distinct from a loss in specific force production by muscle, and that sarcolemma-localized signalling by neuronal nitric oxide synthase (nNOS) in skeletal muscle is required to maintain activity after mild exercise. We show that...
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PMID: 18953332
PDF is available here.
PDF is available here.
Circulation (118)19 2008
Abstract
Expression of caveolin-3 is both necessary and sufficient for cardiac protection, a conclusion that unites long-standing ultrastructural and molecular observations in the ischemic heart. The present results indicate that increased expression of caveolins, apparently via actions that depend on phosph...
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PMID: 18936328
PDF is available here.
PDF is available here.
Circulation Research (103)10 2008
Abstract
T-type Ca(2+) channels (TTCCs) are expressed in the developing heart, are not present in the adult ventricle, and are reexpressed in cardiac diseases involving cardiac dysfunction and premature, arrhythmogenic death. The goal of this study was to determine the functional role of increased Ca(2+) inf...
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PMID: 18832749
PDF is available here.
PDF is available here.
Journal of Cell Biology (183)3 2008
Abstract
We show that sarcospan (SSPN), a unique tetraspanin-like component of the DGC, ameliorates muscular dystrophy in dystrophin-deficient mdx mice. SSPN stabilizes the sarcolemma by increasing levels of the utrophin-glycoprotein complex (UGC) at the extrasynaptic membrane to compensate for the loss of d...
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PMID: 18981229
PDF is available here.
PDF is available here.
Abstract
We summarize the current and limited understanding of the cellular mechanisms underlying this cardiac anoxia tolerance. What emerges is that cold temperature substantially modifies cardiac electrophysiology to precondition the heart for winter anoxia. Intrinsic heart rate is slowed and density of sa...
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PMID: 18589002
PDF is available here.
PDF is available here.
Neuroreport (19)16 2008
Abstract
We assessed contractile function, sarcolemmal integrity, and myogenesis before and after injury from large-strain lengthening contractions in dysferlin-null and control mice. We report that dysferlin-null muscles produce higher contractile torque, and are equally susceptible to initial injury but re...
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PMID: 18815587
PDF is available here.
PDF is available here.
Neurobiology of Disease (32)2 2008
Abstract
We observed an increase in dystrophin expression level in all the fibers, although lower than that observed in normal fibers, and found a concomitant recovery of aquaporin-4 at sarcolemma. A significant reduction in centronucleated fibers, in the area of necrosis and in the percentage of nuclear fac...
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PMID: 18694830
PDF is available here.
PDF is available here.
Circulation Research (103)9 2008
Abstract
Sarcolemmal ATP-sensitive potassium channels (K(ATP)) act as metabolic sensors that facilitate adaptation of the left ventricle to changes in energy requirements. This study examined the mechanism by which K(ATP) dysfunction impairs the left ventricular response to stress using transgenic mouse stra...
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PMID: 18802029
PDF is available here.
PDF is available here.
Circulation Research (103)8 2008
Abstract
Circulation Research (103)8 2008
Abstract
Our objectives were to determine whether NHE1 is phosphorylated by protein kinase B (PKB), identify any pertinent phosphorylation site(s), and delineate the functional consequences of such phosphorylation. Active PKBalpha phosphorylated in vitro a glutathione S-transferase (GST)-NHE1 fusion protein...
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PMID: 18757828
PDF is available here.
PDF is available here.
Pharmacology & Therapeutics (120)1 2008
Abstract
The activation of cardiac cell membrane ATP-sensitive potassium channels during myocardial ischemia promotes potassium efflux, reductions in action potential duration, and heterogeneities in repolarization, thereby creating a substrate for re-entrant arrhythmias. Drugs that block this channel should...
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PMID: 18708091
PDF is available here.
PDF is available here.
Cell Calcium (44)4 2008
Abstract
We tested the hypothesis that chronic downregulation of SL Ca2+ entry regulates SL extrusion. We studied mRNA and Ca2+ handling responses to chronic down-regulation of Ca2+ channel current induced by over-expression of the small GTPase Rem. Rem lowered net SL diastolic Ca2+ entry, and reduced the tw...
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PMID: 19230140
PDF is available here.
PDF is available here.
Abstract
We used the yeast two-hybrid system to search for potential novel ligands of the Z-line portion of nebulin. We found that the C-terminal region of nebulin (residues 6457-6528) interacted with the C-terminus of archvillin (residues 1419-1687). Archvillin is a membrane skeletal protein that localizes...
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PMID: 18639526
PDF is available here.
PDF is available here.
Abstract
Both fractionation methods revealed a 200-350% increase in PLM in the sarcolemma after 30 min of treadmill running, while the phosphorylation of Ser-68 of PLM appeared to be unchanged. Exercise did not change V(max) or K(m) for Na(+) of the Na(+)/K(+)-ATPase in muscle homogenate, but induced a 67% i...
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PMID: 18373741
PDF is available here.
PDF is available here.
Abstract
Cardiovascular Research (79)4 2008
Abstract
Journal of Biological Chemistry (283)36 2008
Abstract
We performed gene expression profiling of laminin alpha2 chain-deficient mouse limb muscle. One of the down-regulated genes encodes a protein called Cib2 (calcium- and integrin-binding protein 2) whose expression and function is unknown. However, the closely related Cib1 has been reported to bind in...
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PMID: 18611855
PDF is available here.
PDF is available here.