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Synaptic Membranes (0):
Recent article
Synaptic Membranes
Proteomics (11)7 2011
Abstract
We describe the first proteomic characterization of the radial nerve cord (RNC) of an echinoderm, the sea star Marthasterias glacialis. The combination of 2-DE with MS (MALDI-TOF/TOF) resulted in the identification of 286 proteins in the RNC. Additionally, 158 proteins were identified in the synapto...
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PMID: 21365759
PDF is available here.
PDF is available here.
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Abstract
A new lycopodane-type Lycopodium alkaloid, 6α-hydroxy-5,15-oxide-lycopodane (1), and seven known alkaloids were isolated from the whole plants of Huperzia serrata. Their structures were elucidated by means of spectroscopic methods. 12-Deoxyhuperzine O (2) was reported as a naturally occurring alkal...
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PMID: 21061224
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)4 2010
Abstract
We used a reversible inhibitor of dynamin, dynasore, to dissect the vesicle pool dynamics underlying the three forms of neurotransmitter release in hippocampal GABAergic inhibitory synapses. In dynasore, evoked synchronous release and asynchronous neurotransmission detected after activity showed mar...
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PMID: 20107062
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)4 2010
Abstract
We made recordings from synaptically coupled pairs of pyramidal neurons in rat visual cortex. The mean peak amplitude of EPSPs recorded from pairs of L2/3 neurons ranged between 40 microV and 2.9 mV. EPSP rise times were consistent with the majority of the synapses being located on basal dendrites;...
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PMID: 20107071
PDF is available here.
PDF is available here.
Abstract
We demonstrated that its dynamics could be of both Type 1 and Type 2, depending on ion channel density. In the present study we analyse the effect of varying channel density on threshold firing frequency on two well-studied axon membranes, namely the frog myelinated axon and the squid giant axon. Mo...
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PMID: 20421932
PDF is available here.
PDF is available here.
Abstract
We summarize literature data that provide growing evidence that several Syts are involved in the pathophysiological mechanisms of temporal lobe epilepsy and Parkinson's disease, as well as few reports related to brain ischemia and Alzheimer's disease (AD). We also report new data from our laboratori...
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PMID: 19943339
PDF is available here.
PDF is available here.
Psychoneuroendocrinology (34 Suppl 1) 2009
Abstract
We have been considering implications of the observations that steroids are quite lipophilic and that recently identified putative steroid binding sites are in transmembrane domains of the receptor. Accordingly, we expect that both the effective plasma membrane steroid concentration and steroid phar...
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PMID: 19541427
PDF is available here.
PDF is available here.
Abstract
We imaged Rohon-Beard cells in zebrafish embryos expressing GFP-tagged wild-type N-cadherin (NCAD-GFP) or a GFP-tagged N-cadherin mutant expressing an uncleavable prodomain (PRON-GFP) rendering it nonadhesive. NCAD-GFP accumulated at synaptic microdomains in a developmentally regulated manner, and i...
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PMID: 19365814
PDF is available here.
PDF is available here.
Neuromuscular Disorders (19)5 2009
Abstract
We show that the formation and maintenance of neuromuscular junctions in Large(myd) mice are greatly compromised. Neuromuscular junctions are not confined to the muscle endplate zone but are widely spread and are frequently accompanied by exuberant nerve sprouting. Nerve terminals are highly fragmen...
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PMID: 19346129
PDF is available here.
PDF is available here.
Muscle & Nerve (39)3 2009
Abstract
We show here that alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionate (AMPA) receptor subunits, together with glutamate, are present at the mammalian NMJ. Both AMPA and NMDA (N-methyl-D-aspartate) glutamate receptor subunits display overlapping postsynaptic localization patterns with Dlg at all NM...
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PMID: 19208409
PDF is available here.
PDF is available here.
Developmental Neurobiology (69)2-3 2009
Abstract
We have investigated synaptic endosomal compartments in the presynaptic terminals of C. elegans GABAergic motor neurons. Using RAB reporters, we find that several subsynaptic compartments reside in, or near, presynaptic regions. Loss of function in the C. elegans JIP3 protein, UNC-16, causes a RAB-5...
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PMID: 19105215
PDF is available here.
PDF is available here.
Journal of Neurochemistry (108)4 2009
Abstract
We analyzed the distribution of five septins, Sept6, Sept7, Sept8, Sept9 and Sept11, in various rat tissues by western blot analyses and found all septins to be expressed in brain. We also examined the developmental changes of expression of these septins in the rat brain and found that the level of...
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PMID: 19196426
PDF is available here.
PDF is available here.
Journal of Neurochemistry (108)4 2009
Abstract
We hypothesized that daily MPH administration would reverse striatal neurotransmission deficits observed in the controlled cortical impact (CCI) model of TBI. CCI or naïve rats received daily injections of MPH (5 mg/kg) or saline for 14 days and were assessed on day 15 using fast scan cyclic volt...
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PMID: 19077052
PDF is available here.
PDF is available here.
Neuroscience (158)1 2009
Abstract
We focus on the role of GluR2 subunit in synaptic function and plasticity....
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PMID: 18977416
PDF is available here.
PDF is available here.
Abstract
The present investigation was undertaken to study the nature of neuro-melanophore junction in the white-spotted rabbit fish Siganus canaliculatus. In vitro experiments using split fin preparation indicated that melanophores of S. canaliculatus are highly responsive to potassium ions and adrenergic a...
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PMID: 19579911
PDF is available here.
PDF is available here.
NeuroSignals (17)3 2009
Abstract
We investigated the effects of dopamine (DOP) agonists that are involved in modulatory actions on synaptic transmission in the isolated labyrinth preparations of frogs. The external application of DOP (0.1-1 mM), the D(1) agonist chloro-APB hydrobromide (CAPB, 50-100 microM) and the D2 agonist quine...
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PMID: 19546593
PDF is available here.
PDF is available here.
Abstract
Autonomic Neuroscience (144)1-2 2008
Abstract
Our data also indicate that acetylcholine and nicotinic receptors may be involved in mediating these processes....
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PMID: 18955021
PDF is available here.
PDF is available here.
Autonomic Neuroscience (144)1-2 2008
Abstract
Our data also indicate that acetylcholine and nicotinic receptors may be involved in mediating these processes....
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PMID: 18955021
PDF is available here.
PDF is available here.
Abstract
We and others have demonstrated the presence of CB2-Rs in neuronal and glial cells in the brain. In this study, we show the subcellular distribution of CB2-Rs in neuronal, glial, and endothelial cells in the rat hippocampus using immunohistochemical electron microscopy. Brain sections from the hippo...
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PMID: 18798269
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)49 2008
Abstract
We show that the vesicular GABA transporter (VGAT) possesses an uneven number of transmembrane domains, with the N terminus facing the cytoplasm and the C terminus residing in the synaptic vesicle lumen. Antibodies recognizing the C terminus of VGAT (anti-VGAT-C) selectively label GABAergic nerve te...
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PMID: 19052203
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)49 2008
Abstract
We expressed modified delta-subunits, with one (delta1YFP) or two yellow fluorescent protein (delta2YFP) molecules fused at the intracellular loop, under the control of an alpha-actin promoter. AChRs containing these fusion proteins are fluorescent, assemble on the plasma membrane, make clusters und...
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PMID: 19052214
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)49 2008
Abstract
The role of cGMP-dependent pathways in synaptic vesicle recycling in motor nerve endings during prolonged high-frequency stimulation was studied at frog neuromuscular junctions using electrophysiological and fluorescent methods. An increase of intracellular cGMP concentration (8-Br-cGMP or 8-pCPT-cG...
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PMID: 19052213
PDF is available here.
PDF is available here.
Abstract
We examined the initial changes that develop in presynaptic and postsynaptic elements in sympathetic ganglia of aged and diabetic mice and found numerous synaptic changes involving both presynaptic and postsynaptic elements. Early alterations in presynaptic axon terminal size, vesicle content, and m...
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PMID: 19018240
PDF is available here.
PDF is available here.
Abstract
We exploit the unique input-specificity of the calyx of Held to characterize NO modulation at this glutamatergic synapse in the auditory pathway. NO is generated in an activity-dependent manner by MNTB principal neurons receiving a calyceal synaptic input. It acts in the target neuron and adjacent i...
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PMID: 19038221
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)48 2008
Abstract
We show that neurexins are trafficked throughout neurons via transport vesicles and the plasma membrane insertion of neurexins occurs preferentially in the axonal/synaptic compartment. We also observed that exit of neurexins from the ER/Golgi and correct targeting require their PDZ-binding motif at...
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PMID: 19036990
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)48 2008
Abstract
We investigated the effects of HIV-1 transactivator of transcription (Tat), a protein released by virus-infected cells, on synapses between hippocampal neurons using an imaging-based assay that quantified clusters of the scaffolding protein postsynaptic density 95 fused to green fluorescent protein...
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PMID: 19036954
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)48 2008
Abstract
We examined the biochemical changes produced following chemically induced long term depression in acute hippocampal CA1 minislices. Using three independent methods, we found that this treatment did not lead to an internalization of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) re...
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PMID: 18819923
PDF is available here.
PDF is available here.
Brain Research (1241) 2008
Abstract
We previously reported 5 C-terminal isoforms of synGAP (alpha1, alpha2, beta1/2, beta 3/4 and gamma) [Li et al., 2001, J. Biol. Chem. 276: 21417-21424]. In this study, we investigated the expression profiles of the two major isoforms, synGAP alpha1 and synGAP beta, in the adult rat brain and culture...
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PMID: 18824155
PDF is available here.
PDF is available here.
FASEB Journal (22)11 2008
Abstract
This study examined the effects on cognitive behaviors of giving normal adult gerbils three compounds, normally in the circulation, which interact to increase brain phosphatides, synaptic proteins, dendritic spines, and neurotransmitter release. Animals received supplemental uridine (as its monophos...
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PMID: 18606862
PDF is available here.
PDF is available here.
Abstract
We report that LRP4, a low-density lipoprotein receptor (LDLR)-related protein, is expressed specifically in myotubes and binds to neuronal agrin. Its expression enables agrin binding and MuSK signaling in cells that otherwise do not respond to agrin. Suppression of LRP4 expression in muscle cells a...
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PMID: 18957220
PDF is available here.
PDF is available here.
Journal of Neurophysiology (100)4 2008
Abstract
We conducted voltage-clamp experiments in patches from CA1 pyramidal neurons expressing short-interfering RNA (siRNA) targeting the DPPL variant known to be expressed in hippocampal pyramidal neurons, DPPX (siDPPX). In accordance with heterologous studies, we found that DPPX downregulation in neuron...
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PMID: 18667548
PDF is available here.
PDF is available here.
Journal of Neurochemistry (107)1 2008
Abstract
We show, using biochemical analyses, that p140Cap is expressed in rat brain in a developmental stage-dependent manner, and is relatively abundant in the synaptic plasma membrane fraction in adults. Immunohistochemistry showed localization of p140Cap in the neuropil in rat brain and immunofluorescent...
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PMID: 18662323
PDF is available here.
PDF is available here.
Journal of Cell Biology (182)5 2008
Abstract
We test clathrin function during synaptic endocytosis using clathrin heavy chain (chc) mutants combined with chc photoinactivation to circumvent early embryonic lethality associated with chc mutations in multicellular organisms. Acute inactivation of chc at stimulated synapses leads to substantial m...
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PMID: 18762582
PDF is available here.
PDF is available here.
Abstract
We examined the effect of 1-amino-3,5-dimethyladamantane (memantine) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) on the inhibition of [(3)H]MK-801 binding to crude synaptic membranes of rat forebrains in the absence or presence of Ca(2+). Ca(2+) decreased the potenc...
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PMID: 18758084
PDF is available here.
PDF is available here.
Neuroscience Research (62)1 2008
Abstract
We have examined the LTD induced by LFS (1Hz, 900 pulses) paired with a certain pattern at the Schaffer collateral-CAl synapse in adult hippocampal slices. We found that, in the 90-day-old rat hippocampus, LTD could be induced reliably by LFS paired with stronger stimulus intensity than that used du...
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PMID: 18602428
PDF is available here.
PDF is available here.
Neuroreport (19)13 2008
Abstract
We examined the effect of riboflavin, vitamin B2, on the release of endogenous glutamate from nerve terminals purified from rat cerebral cortex. The release of glutamate evoked by 4-aminopyridine was inhibited by riboflavin. Further experiments indicated that riboflavin-mediated inhibition of glutam...
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PMID: 18695519
PDF is available here.
PDF is available here.
Abstract
In the Rs1-KO mouse, retinal layer formation and synaptic protein expression in the OPL is normal up to P14, implying normal development of synaptic connections. Aberrant localization of synaptic proteins by P21 indicates that displacement of developing and/or mature synapses contributes to the b-wa...
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PMID: 18660429
PDF is available here.
PDF is available here.
Abstract
We asked if functional nAChRs are present in serotonergic (5-HT) and nonserotonergic (non-5-HT) neurons of the dorsal raphe nucleus (DRN). In rat midbrain slices, field stimulation at the tegmental pedunculopontine (PPT) nucleus evoked postsynaptic currents (eEPSCs) with different components in DRN...
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PMID: 18512214
PDF is available here.
PDF is available here.
Cell and Tissue Research (333)2 2008
Abstract
We report that pinealocyte SRs are associated with CAZ proteins such as Bassoon, Piccolo, CtBP1, Munc13-1, and the motorprotein KIF3A and, therefore, consist of a protein complex that resembles the ribbon complex of retinal and other sensory ribbon synapses. The pinealocyte ribbon complex is biochem...
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PMID: 18523806
PDF is available here.
PDF is available here.
Psychiatry Research (163)2 2008
Abstract
We found no regional differences in D(1) receptor density between controls and PD, and no overall differences in frontostriatal performance. Although D(1) receptor density did not relate to frontostriatal cognition, K(i) decreases in the putamen predicted performance on the Wisconsin Card Sorting Te...
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PMID: 18504119
PDF is available here.
PDF is available here.
Abstract
This effect of GABAA receptors in hypothalamus suggests a regulatory role during active regeneration of pancreas that will have significance in insulin secretion....
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PMID: 18580435
PDF is available here.
PDF is available here.
Abstract
Fluorescent probe techniques were used to evaluate the effect of propoxycaine.HCl on the physical properties (transbilayer asymmetric lateral and rotational mobilities, annular lipid fluidity and protein distribution) of synaptosomal plasma membrane vesicles (SPMVs) isolated from bovine cerebral cor...
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PMID: 18407836
PDF is available here.
PDF is available here.
Molecules and Cells (25)4 2008
Abstract
We carried out combined fluorescence in situ hybridization (FISH) and immunocytochemistry (IC) and showed that more than half of the eukaryotic elongation factor 1A (eEF1A) mRNA clusters overlapped with or were immediately adjacent to clusters of PSD-95, a postsynaptic marker, in the dendrites of cu...
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PMID: 18443410
PDF is available here.
PDF is available here.
Abstract
Studies were performed on mechanically isolated spinal cord multipolar cells (presumptive motoneurons) from the frog Rana temporaria using patch-clamp methods in the whole-cell configuration. These experiments showed that the amplitudes of transmembrane currents arising in response to simultaneous a...
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PMID: 18607736
PDF is available here.
PDF is available here.
Experimental Neurology (212)1 2008
Abstract
Journal of Neuroscience (28)27 2008
Abstract
We demonstrate that the C2A domain of DOC2B interacts directly with the PM in a calcium-dependent manner. Using a combination of electrophysiological, morphological, and total internal reflection fluorescent measurements, we found that DOC2B acts as a priming factor and increases the number of fusio...
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PMID: 18596155
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)26 2008
Abstract
We performed a characterization of bulk endocytic retrieval using action potential trains of increasing intensity. Bulk endocytosis was monitored by the loading of the fluorescent dyes FM2-10 and FM1-43, uptake of tetramethylrhodamine-dextran (40 kDa), or morphological analysis of uptake of the flui...
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PMID: 18579735
PDF is available here.
PDF is available here.
Brain Research (1215) 2008
Abstract
We studied the postnatal development of VGLUT3 from day 0 through adult in the rat retina, and compared this with the expression patterns of VGLUT1 and VGLUT2. VGLUT3 expression was restricted to a population of amacrine cells. Expression of VGLUT3 was first observed at postnatal day 10 (P10) in the...
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PMID: 18482716
PDF is available here.
PDF is available here.
Abstract
We have tracked synaptogenesis in the OB during this period by electron microscopy (EM) and immunolabelling of the transmembrane synaptic vesicle glycoprotein SV-2. No SV-2 labelling or synapses were detected at E13, although electrodense junctions lacking synaptic vesicles could be observed by EM....
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PMID: 18588529
PDF is available here.
PDF is available here.
Abstract
In experimental mice injected with anti-MuSK-positive patient IgG, postsynaptic AChR staining was reduced to as little as 22% of that seen in control mice. Experimental mice showed reduced apposition of the nerve terminal (labeled with antibodies against synaptophysin and neurofilament) and the post...
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PMID: 18384168
PDF is available here.
PDF is available here.
Abstract
We have analyzed the molecular mechanism for AMPAR-trafficking and function by focusing on PSD-95, a major postsynaptic scaffolding protein. Here, we review the novel regulatory mechanisms of AMPARs by 1) the PSD-95 palmitoylating enzyme, which determines the position of PSD-95 at postsynapses, and...
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PMID: 18646599
PDF is available here.
PDF is available here.
Brain Research (1210) 2008
Abstract
Interactions between the opioidergic and dopaminergic systems in the nucleus accumbens (NAcb) play a critical role in mediating cocaine withdrawal-induced effects on cell signaling and behavior. In support of this, increased activation of striatal dopamine-D1 receptors (D1R) results in desensitizati...
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PMID: 18417105
PDF is available here.
PDF is available here.
Abstract
Abstract
We performed a morphofunctional study of inhibitory synapses in the developing hypoglossal nucleus of C57BL/6J SPA mice. In this mutant, the inhibitory synaptic activity was mainly GABAergic. Accordingly, we observed a developmental loss of glycinergic presynaptic terminals and an increase in the de...
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PMID: 18445051
PDF is available here.
PDF is available here.
Abstract
We now show that a presynaptic ERK1/2 signalling pathway mediates the nongenomic effect, as it was blocked by the MEK inhibitors U0126 (10 microm) and PD098059 (40 microm) and occluded in H-Ras(G12V)-mutant mice with constitutive activation of the ERK1/2 presynaptic pathway. Notably, the increase in...
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PMID: 18547242
PDF is available here.
PDF is available here.
Abstract
We learn from this study, although increasing complexity of protein knowledge, that the estrous cycle and not only the sex per se has to be taken into account for design of future studies and interpretation of previous work at the protein level....
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PMID: 18036704
PDF is available here.
PDF is available here.
Abstract
The effect of alpha-tocopherol, the major vitamin E component, on the release of endogenous glutamate has been investigated using rat cerebrocortical nerve terminals. Results showed that alpha-tocopherol facilitated the Ca2+-dependent but not the Ca2+-independent glutamate release evoked by 4-aminop...
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PMID: 18037536
PDF is available here.
PDF is available here.
Journal of Neurochemistry (105)3 2008
Abstract
We have cloned an Aplysia Dlg-MAGUK protein, which we identify as Aplysia synapse associated protein (ApSAP). As revealed by western blot, RT-PCR, and immunocytochemical analyses, ApSAP is predominantly expressed in the CNS and is located in both sensory neuron and motor neurons. The overall amino a...
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PMID: 18182049
PDF is available here.
PDF is available here.
Journal of Neurochemistry (105)3 2008
Abstract
The RIC-3 protein acts as a regulator of acetylcholine nicotinic receptor (nAChR) expression. In Xenopus laevis oocytes the human RIC-3 (hRIC-3) protein enhances expression of alpha7 receptors and abolishes expression of alpha4beta2 receptors. In vitro translation of hRIC-3 evidenced its membrane in...
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PMID: 18179477
PDF is available here.
PDF is available here.