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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Cytoplasmic Structures (3):
Recent article
Cytoplasmic Structures
Abstract
We present evidence that the RNA-binding proteins (RBPs) heterogeneous nuclear ribonucleoprotein (hnRNP) C and fragile X mental retardation protein (FMRP) associate with the same APP mRNA coding region element, and they influence APP translation competitively and in opposite directions. Silencing hn...
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PMID: 20473314
PDF is available here.
PDF is available here.
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Abstract
Cyanobacterial carbon fixation is a major component of the global carbon cycle. This process requires the carboxysome, an organelle-like proteinaceous microcompartment that sequesters the enzymes of carbon fixation from the cytoplasm. Here, fluorescently tagged carboxysomes were foun...
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PMID: 20203050
PDF is available here.
PDF is available here.
Abstract
GW bodies (GWB or P bodies) are cytoplasmic foci thought to result from microRNA (miRNA) regulation of messenger RNA (mRNA) targets and subsequent mRNA degradation. The purpose of this study is to examine the effects of lipopolysaccharide (LPS) stimulation of human monocytes on GWB formation, miRNA...
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PMID: 19918258
PDF is available here.
PDF is available here.
Abstract
The apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G (APOBEC3G or APOBEC3G) and its fellow cytidine deaminase family members are potent restrictive factors for human immunodeficiency virus type 1 (HIV-1) and many other retroviruses. However, the cellular function of APOBEC3G remain...
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PMID: 19841882
PDF is available here.
PDF is available here.
Acta Cytologica (54)5 Suppl 2010
Abstract
Abstract
We report a case of a lymphadenoma occurring in the parotid gland of a 15-year-old girl. The tumor was composed of variably sized cystic cavities within abundant reactive lymphoid tissue. The cystic spaces were filled with eosinophilic secretions with occasional histiocytes. Many of these features w...
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PMID: 20021220
PDF is available here.
PDF is available here.
Abstract
The present study was designed to investigate the neuropathological effect of the two carbamate pesticides: methomyl and methiocarb on the neurons of the buccal ganglia in the land snail Eobania vermiculata using topical application and baiting technique. Their in vivo effects on acetylcholinesteras...
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PMID: 18470629
PDF is available here.
PDF is available here.
Abstract
Leishmania major possesses, apparently uniquely, four families of ATG8-like genes, designated ATG8, ATG8A, ATG8B and ATG8C, and 25 genes in total. L. major ATG8 and examples from the ATG8A, ATG8B and ATG8C families are able to complement a Saccharomyces cerevisiae ATG8-deficient strain, indicating f...
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PMID: 19066473
PDF is available here.
PDF is available here.
Abstract
Better hypoxia tolerance is demonstrated by the young myocardium, and an obvious hypoxia-protective effect of EGb 761 in both age groups....
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PMID: 19225264
PDF is available here.
PDF is available here.
Abstract
The ultrastructural pathology of GATA-1, V205M and G208S macrothrombocytes was discussed in earlier investigations. This study has used the same technology to evaluate macrothrombocytes from a patient with the GATA-1, R216Q mutation. Some of the pathological features observed in macrothrombocytes fr...
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PMID: 19172521
PDF is available here.
PDF is available here.
Proteomics (9)2 2009
Abstract
We studied a set of plasma proteins accessed from the Healthy Human Individual's Integrated Plasma Proteome (HIP(2)) database, a larger set of curated human proteins, and a subset of inflammatory proteins, for overlap with sets of known protein biomarkers, drug targets, and secreted proteins. Most i...
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PMID: 19105179
PDF is available here.
PDF is available here.
Abstract
The ultrastructure of normal development and JHA-treated egg was examined with the transmission electron microscope. In newly oviposited egg, the chorion consists of exo- and endochorion. Between the chorion and plasma membrane lies vitelline (envelope) membrane, a thin non cellular membrane. The pe...
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PMID: 19209765
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1779)11 2008
Abstract
We show that short interfering RNA (siRNA) and microRNA share some similarities in their response to cellular stress. miR16 expedites the degradation of mRNAs containing AU-rich elements (ARE) in their 3' untranslated region (UTR). si20 is an siRNA designed to target a non-ARE sequence in the TNF 3'...
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PMID: 18423387
PDF is available here.
PDF is available here.
Abstract
We show that in Drosophila cells, Tral and EDC3 specifically interact with the decapping activator DCP1 and the DEAD-box helicase Me31B. Nevertheless, only Tral associates with the translational repressor CUP, whereas EDC3 associates with the decapping enzyme DCP2. Like EDC3, Tral interacts with DCP...
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PMID: 18765641
PDF is available here.
PDF is available here.
Nature Cell Biology (10)10 2008
Abstract
We identify 101 human genes required for SG assembly, 39 genes required for PB assembly, and 31 genes required for coordinate SG and PB assembly. Although 51 genes encode proteins involved in mRNA translation, splicing and transcription, most are not obviously associated with RNA metabolism. We find...
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PMID: 18794846
PDF is available here.
PDF is available here.
Abstract
We can see that As2O3 inhibited LS-174T cell growth mainly by inducing cell apoptosis, partly by the inhibition of telomerase activity....
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PMID: 18606528
PDF is available here.
PDF is available here.
Journal of Cell Biology (182)3 2008
Abstract
We find that repressed maternal mRNAs and their regulators localize to P body-like mRNP granules in the Caenorhabditis elegans germ line. Surprisingly, several distinct types of regulated granules form during oocyte and embryo development. 3' untranslated region elements direct mRNA targeting to one...
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PMID: 18695046
PDF is available here.
PDF is available here.
Journal of Cell Biology (182)3 2008
Abstract
We have investigated in Caenorhabditis elegans whether Dhh1 and Pat1 generally function together, and how they influence mRNA sequestration during oogenesis. We show that in somatic tissues, the Dhh1 orthologue (CGH-1) forms Pat1 (patr-1)-dependent P bodies that are involved in mRNA decapping. In co...
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PMID: 18695045
PDF is available here.
PDF is available here.
Abstract
We purified epitope-tagged Htt and identified Argonaute as associated proteins. Colocalization studies demonstrated Htt and Ago2 to be present in P bodies, and depletion of Htt showed compromised RNA-mediated gene silencing. Mouse striatal cells expressing mutant Htt showed fewer P bodies and reduce...
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PMID: 18669659
PDF is available here.
PDF is available here.
Biochemical Society Transactions (36)Pt 4 2008
Abstract
Selective protein synthesis in oocytes, eggs and early embryos of many organisms drives several critical aspects of early development, including meiotic maturation and entry into mitosis, establishment of embryonic axes and cell fate determination. mRNA-binding proteins which (usually) recognize 3'-...
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PMID: 18631138
PDF is available here.
PDF is available here.
Biochemical Society Transactions (36)Pt 4 2008
Abstract
We discuss the link between P-bodies and NMD in view of recent studies that suggest that P-bodies are not required for NMD in Drosophila....
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PMID: 18631143
PDF is available here.
PDF is available here.
Journal of Cell Biology (182)1 2008
Abstract
We demonstrate that deadenylation is required for mammalian P-body formation and mRNA decay. We identify Pan2, Pan3, and Caf1 deadenylases as new P-body components and show that Pan3 helps recruit Pan2, Ccr4, and Caf1 to P-bodies. Pan3 knockdown causes a reduction of P-bodies and has differential ef...
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PMID: 18625844
PDF is available here.
PDF is available here.
Abstract
We suggest reclassifying fibroblastic polyps reactive to perineurial markers as perineuriomas. To reach an accurate diagnosis, we recommend employing at least 2 markers of perineurial differentiation, and performing EMA immunostaining with high antibody concentration, prolonged incubation time, and/...
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PMID: 18520438
PDF is available here.
PDF is available here.
Molecular Microbiology (68)6 2008
Abstract
We have characterized the Blastocystis succinyl-CoA synthetase (SCS), a tricarboxylic acid cycle enzyme that conserves energy by substrate-level phosphorylation. We show that SCS localizes to the enigmatic Blastocystis organelles, indicating that these organelles might play a similar role in energy...
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PMID: 18452512
PDF is available here.
PDF is available here.
Molecular Microbiology (68)6 2008
Abstract
We show that PbSR is synthesized in macrogametocytes, gets targeted to the crystalloids of developing ookinetes and is involved in crystalloid formation. While oocyst sporulation rates of PbSR knockout parasites are highly reduced in parasite-infected mosquitoes, sporulation rates in vitro are not a...
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PMID: 18452513
PDF is available here.
PDF is available here.
Biochemical Society Transactions (36)Pt 3 2008
Abstract
We address the target specificity of TTP, summarize TTP-interacting proteins and discuss how phosphorylation regulates the activity, localization and stability of TTP....
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PMID: 18481987
PDF is available here.
PDF is available here.
Abstract
We therefore describe the application of automated methods, previously developed and validated by our laboratory on fluorescence micrographs of cultured cell lines, to analyze subcellular patterns in tissue images from the Human Protein Atlas. The Atlas currently contains images of over 3000 protein...
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PMID: 18435555
PDF is available here.
PDF is available here.
Abstract
We hypothesized that the bioactive constituents of ubiquitin-proteasome pathway were secreted in the mammalian epididymal fluid (EF) and capable of ubiquitinating extrinsic substrates. Western blotting indeed detected the presence of the ubiquitin-activating enzyme E1 and presumed E1-ubiquitin thiol...
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PMID: 18064599
PDF is available here.
PDF is available here.
EMBO Journal (27)7 2008
Abstract
We show that autophagy is controlled by recognizing conserved pathogen-associated molecular patterns (PAMPs). We screened a PAMP library for effects on autophagy in RAW 264.7 macrophages and found that several prototype Toll-like receptor (TLR) ligands induced autophagy. Single-stranded RNA and TLR7...
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PMID: 18337753
PDF is available here.
PDF is available here.
Abstract
MicroRNAs represent a large family of non-coding small RNAs that function as the major endogenous triggers for RNA interference. Hundreds of microRNAs have been identified through small RNA cloning, bioinformatic predictions, and high-throughput pyrosequencing. They are believed to suppress gene exp...
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PMID: 18329869
PDF is available here.
PDF is available here.
Cell and Tissue Research (332)1 2008
Abstract
We published a method for isolating functional murine FDCs in high purity. We reasoned that disruption of FDC reticula in vivo would alter FDC morphology. The present study was undertaken to determine the morphological features of isolated FDCs. FDC-M1 and immune complex (IC) labeling were used to i...
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PMID: 18236080
PDF is available here.
PDF is available here.
Abstract
We report the detailed characterization of the dyc-1 gene. dyc-1 encodes two isoforms, which are expressed in neurons and muscles. Isoform-specific RNAi experiments show that the absence of the muscle isoform, and not that of the neuronal isoform, is responsible for the dyc-1 mutant phenotype. In th...
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PMID: 18094057
PDF is available here.
PDF is available here.
Abstract
We demonstrate that the yeast translation initiation factor Ded1p can localize to P-bodies. Moreover, depletion of Ded1p leads to defects in P-body formation. Overexpression of Ded1p results in increased size and number of P-bodies and inhibition of growth in a manner partially suppressed by loss of...
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PMID: 18162578
PDF is available here.
PDF is available here.
Abstract
We report the three-dimensional structures of two proteins of previously unknown function, CcmL and OrfA (or CsoS4A), from the two known classes of carboxysomes, at resolutions of 2.4 and 2.15 angstroms. Both proteins assemble to form pentameric structures whose size and shape are compatible with fo...
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PMID: 18292340
PDF is available here.
PDF is available here.
Abstract
We analyze Pat1 in Saccharomyces cerevisiae function by deletion and functional analyses. Our results identify two primary functional domains in Pat1: one promoting translation repression and P-body assembly and a second domain promoting mRNA decapping after assembly of the mRNA into a P-body mRNP....
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PMID: 18086885
PDF is available here.
PDF is available here.
Nucleic Acids Research (36)2 2008
Abstract
The nuclear RNA export factor (NXF) family proteins have been implicated in various aspects of post-transcriptional gene expression. This study shows that mouse NXF7 exhibits heterologous localization, i.e. NXF7 associates with translating ribosomes, stress granules (SGs) and processing bodies (P-bo...
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PMID: 18063567
PDF is available here.
PDF is available here.
Abstract
The malaria parasite, Plasmodium falciparum, invades the red blood cells (RBCs) of its human host and initiates a series of morphological rearrangements within the host cell cytoplasm. The mature RBC has no endogenous trafficking machinery; therefore, the parasite generates novel structures to media...
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PMID: 18088325
PDF is available here.
PDF is available here.
Abstract
We demonstrate that A3F specifically interacts with cellular signal recognition particle (SRP) RNA (7SL RNA), which is selectively packaged into HIV-1 virions. Efficient packaging of 7SL RNA as well as A3F was mediated by the RNA-binding nucleocapsid domain of HIV-1 Gag. Reducing 7SL RNA packaging b...
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PMID: 18067920
PDF is available here.
PDF is available here.
Abstract
We investigated the specific functions of Src in the organization and dynamics of podosomes. We found that podosome number and the podosome-associated actin cloud were decreased in Src(-/-) OCLs. Videomicroscopy and fluorescence recovery after photobleaching analysis revealed that the life span of S...
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PMID: 17978100
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1773)12 2007
Abstract
We describe the identification of two human PAT1 genes and show that one of them, PATL1, codes for an ORF with similar features as the yeast PAT1. As expected for a protein with a fundamental role in translation control, PATL1 mRNA was ubiquitously expressed in all human tissues as were the mRNAs of...
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PMID: 17936923
PDF is available here.
PDF is available here.
FEBS Letters (581)25 2007
Abstract
We previously reported that Saccharomyces cerevisiae mutants in mRNA decapping and mutants expressing a truncated form of the KlLSM4 gene, showed premature senescence and apoptotic phenotypes. Here, we show that this truncated protein is dispersed in the cytoplasm and does not assemble to P-bodies....
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PMID: 17888427
PDF is available here.
PDF is available here.
Experimental Cell Research (313)16 2007
Abstract
We show that RhoB-null macrophages are more rounded than wild-type macrophages on fibronectin and uncoated glass, and have reduced adhesion to ICAM-1 and glass but not fibronectin. This correlated with lower cell surface expression of beta2 and beta3 integrins but not beta1 integrin. RhoB-null cells...
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PMID: 17692842
PDF is available here.
PDF is available here.
Abstract
We have identified a conserved motif (Motif 1) near the amino terminus of Cnn that is essential for its function in vivo. Cnn Motif 1 is necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to e...
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PMID: 17671162
PDF is available here.
PDF is available here.
Journal of Cell Biology (178)7 2007
Abstract
We identified NMD inhibitor 1 (NMDI 1) as a small molecule inhibitor of the NMD pathway. We characterized the mode of action of this compound and demonstrated that it acts upstream of hUPF1. NMDI 1 induced the loss of interactions between hSMG5 and hUPF1 and the stabilization of hyperphosphorylated...
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PMID: 17893241
PDF is available here.
PDF is available here.
Journal of Cell Biology (178)7 2007
Abstract
We show that Rpb7p is involved in the two mRNA decay pathways and possibly couples them. Rpb7p stimulates the deadenylation stage required for execution of both pathways. Additionally, Rpb7p is both an active component of the P bodies, where decapping and 5' to 3' degradation occur, and is capable o...
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PMID: 17875743
PDF is available here.
PDF is available here.
Abstract
We show that transfection of functional siRNA induced larger and greater numbers of GWB. This siRNA-induced increase of GWB depended on the endogenous expression of the target mRNA. Knockdown of GW182 or Ago2 demonstrated that the siRNA-induced increase of GWB required these two proteins and correla...
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PMID: 17596515
PDF is available here.
PDF is available here.
Abstract
We show here that in aged Vero cytoplasts (17 h after enucleation) microtubule system lost radial organization and became chaotic. To clear up the reasons of that, we studied centrosome activity, its position in the cytoplasts and microtubule dynamics. We found that centrosome in aged cytoplasts was...
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PMID: 17352417
PDF is available here.
PDF is available here.
Abstract
We describe the structure of the shell protein CsoS1A from the chemoautotrophic bacterium Halothiobacillus neapolitanus. The CsoS1A protein forms hexameric units that pack tightly together to form a molecular layer, which is perforated by narrow pores. Sulfate ions, soaked into crystals of CsoS1A, a...
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PMID: 17518518
PDF is available here.
PDF is available here.
Abstract
We show that processes such as mRNA decay, NMD, and RNA-mediated gene silencing are functional in cells lacking detectable microscopic P bodies. Although P bodies are not required for silencing, blocking small interfering RNA or microRNA silencing pathways at any step prevents P-body formation, indi...
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PMID: 17403906
PDF is available here.
PDF is available here.
Abstract
We show that the telomere association of HeT-A(vir) Gag is indistinguishable from that of HeT-A(mel) Gag. Deletion derivatives show that organization of localization signals within the two proteins is strikingly similar. Gag proteins of TART(mel) and TART(vir) are only 13% identical. In contrast to...
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PMID: 17483480
PDF is available here.
PDF is available here.
Abstract
We report the identification and cloning of a Trypanosoma cruzi Dhh1 homolog gene. TcDhh1 expression is not regulated through the parasite life cycle or under stress conditions. We show that TcDhh1 is present in polysome-independent complexes and is localized to discrete cytoplasmic foci, resembling...
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PMID: 17399688
PDF is available here.
PDF is available here.
Plant Cell Online (19)5 2007
Abstract
We analyzed two phenotypically similar mutants, varicose (vcs) and trident (tdt). We had previously identified VCS, and recently, human VCS was shown to function in mRNA decapping. Here, we report that TDT encodes the mRNA-decapping enzyme. VCS and TDT function together in small cytoplasmic foci tha...
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PMID: 17513503
PDF is available here.
PDF is available here.
Journal of Cell Science (120)Pt 8 2007
Abstract
We propose a working model for GW body assembly in terms of its relationship to RNA interference. In this process, one or more heteromeric protein complexes accumulate in successive steps into larger ribonucleoprotein structures....
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PMID: 17401112
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1773)4 2007
Abstract
Mutations of the Fibroblast Growth Factor Receptor 3 (FGFR3) gene have been implicated in a series of skeletal dysplasias including hypochondroplasia, achondroplasia and thanatophoric dysplasia. The severity of these diseases ranges from mild dwarfism to severe dwarfism and to perinatal lethality, r...
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PMID: 17320202
PDF is available here.
PDF is available here.
EMBO Journal (26)7 2007
Abstract
We show that endogenous gephyrin undergoes proline-directed phosphorylation, which is followed by the recruitment of the peptidyl-prolyl isomerase Pin1. The interaction between gephyrin and Pin1 is strictly dependent on gephyrin phosphorylation and requires serine-proline consensus sites encompassin...
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PMID: 17347650
PDF is available here.
PDF is available here.
Molecular Cell (25)5 2007
Abstract
Recent results indicate that many untranslating mRNAs in somatic eukaryotic cells assemble into related mRNPs that accumulate in specific cytoplasmic foci referred to as P bodies. Transcripts associated with P body components can either be degraded or return to translation. Moreover, P bodies are al...
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PMID: 17349952
PDF is available here.
PDF is available here.
Journal of Experimental Biology (210)Pt 6 2007
Abstract
We used sequence analysis and molecular modeling to show that MVP and the toxic anion resistance protein, TelA of Rhodobacter sphaeroides strain 2.4.1, share a novel fold that consists of a three-stranded antiparallel beta-sheet. Because of this strong structural correspondence, we examined whether...
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PMID: 17337707
PDF is available here.
PDF is available here.
Trends in Cell Biology (17)3 2007
Abstract
MicroRNAs are approximately 21-nucleotide-long regulators of gene expression that gain access to their target mRNAs by complementary base pairing. Recent studies have revealed that animal microRNAs might take diverse routes to repress gene expression, affecting both target mRNA levels and translatio...
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PMID: 17197185
PDF is available here.
PDF is available here.
Abstract
We have created new PALS1 stable knockdown cell lines with more profound reduction of PALS1 expression, and a more severe defect in tight junction formation was observed. Unexpectedly, we also observed a severe adherens junction defect, and both defects were corrected when PALS1 wild type and certai...
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PMID: 17182851
PDF is available here.
PDF is available here.
Abstract
This work examined the colocalization, trafficking, and interactions of key proteins involved in lipolysis during brief cAMP-dependent protein kinase A (PKA) activation. Double label immunofluorescence analysis of 3T3-L1 adipocytes indicated that PKA activation increases the translocation of hormone...
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PMID: 17189257
PDF is available here.
PDF is available here.