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Cellular Structures (8):
Recent article
Cellular Structures
Abstract
We investigated the utility of a visual discrimination model (VDM) and other distortion metrics for predicting JPEG 2000 bit rates corresponding to visually lossless compression of virtual slides for breast biopsy specimens. Threshold bit rates were determined experimentally with human observers for...
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PMID: 20875970
PDF is available here.
PDF is available here.
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Abstract
We propose a model to be used for statistical unsupervised CLSM image segmentation. The model is derived from the CLSM image formation mechanics and its performance is compared to the existing alternatives. Results show that it provides a much better description of the data on classes characterized...
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PMID: 20363677
PDF is available here.
PDF is available here.
Abstract
We showed that pam-1 mutants fail to polarize the A-P axis. Here we show that PAM-1 can be found in mature sperm and in cytoplasm throughout early embryogenesis where it concentrates around mitotic centrosomes and chromosomes. We provide further evidence that PAM-1 acts early in the polarization pro...
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PMID: 20599902
PDF is available here.
PDF is available here.
Abstract
The plasma membrane of a eukaryotic cell is impermeable to most hydrophilic substances, yet the insertion of these materials into cells is an extremely important and universal requirement for the cell biologist. To address this need, many transfection techniques have been developed i...
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PMID: 20064901
PDF is available here.
PDF is available here.
Abstract
We established a novel method of specifically tagging the surface of MMP2- and MT1-MMP-positive cells, and applied it to the development of an optical imaging probe. We constructed a protein-based probe composed of a glutathione-S-transferase (GST)-tag (Inhibitory [I]-domain), a polypeptide as a spe...
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PMID: 20096316
PDF is available here.
PDF is available here.
Abstract
This study formulates governing equations for active transport across semi-permeable membranes within the framework of the theory of mixtures. In mixture theory, which models the interactions of any number of fluid and solid constituents, a supply term appears in the conservation of linear momentum...
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PMID: 20213212
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (128)3 2010
Abstract
The CS-treated animals showed significant increases in epididymal sperm count and absolute testes weights compared to the control group. CS also increased the expression of GDNF at both the mRNA and protein levels. These results suggest that CS may improve male fertility by enhancing spermatogenesis...
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PMID: 20219665
PDF is available here.
PDF is available here.
Biology of Reproduction (82)4 2010
Abstract
We tested this premise directly on septin 4 knockout mice, whose sperm are viable but lack an annulus, by following the diffusing membrane protein basigin. Basigin is normally confined to the principal piece domain on testicular and caput sperm, but undergoes relocation into the midpiece during sper...
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PMID: 20042538
PDF is available here.
PDF is available here.
Abstract
We favour the hypothesis that post-apoptotic debris accumulates in germinal centres, activates complement, and serves as a survival signal for B-cells that had stochastically become autoreactive in the process of somatic hypermutation (etiology). In the presence of autoantibodies against apoptotic c...
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PMID: 20107814
PDF is available here.
PDF is available here.
Zhen ci yan jiu = Acupuncture research / [Zhongguo yi xue ke xue yuan Yi xue qing bao yan jiu suo bian ji] (35)1 2010
Abstract
Optical microscopic observation showed that in normal control group, the cellular nucleus was distinct, and the granular cell layer well-arranged and tight. In model group, the intracellular space was widened, and the granular cell layer was out of order in the arrangement. In EA group, the celluldr...
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PMID: 20458905
PDF is available here.
PDF is available here.
Abstract
Hb-vesicles (HbV) are artificial O(2) carriers encapsulating concentrated Hb solution (35 g/dL) with a phospholipid bilayer membrane (liposome). The concentration of the HbV suspension is extremely high ([Hb] = 10 g/dL) and it has an O(2) carrying capacity that is comparable to that of blood. HbV is...
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PMID: 20204826
PDF is available here.
PDF is available here.
Abstract
It remains controversial whether blastomeres of 2-cell stage mouse embryos show bias in their contribution to the blastocyst and whether there is any effect of superovulation. Two-cell stage embryos from CF1 mice were derived by either natural breeding (N) or superovulation (S) and cultured in vitro...
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PMID: 20209440
PDF is available here.
PDF is available here.
Zhongguo Xiufu Chongjian Waike Zazhi/Chinese Journal of Reparative and Reconstructive Surgery (24)1 2010
Abstract
HE staining and SEM observation showed that there were residual cells in groups A and B, and there were no residual cells in groups C, D, and E. Nest-PCR test revealed the occurrence of DAP12 in each group. The contents of DAP12 in groups A, B, C, D, E, and F were (18.01 +/- 9.53), (11.87 +/- 2.35),...
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PMID: 20135981
PDF is available here.
PDF is available here.
Biochemistry (Washington) (48)35 2009
Abstract
We describe E2-Crimson, a far-red derivative of the tetrameric FP DsRed-Express2. Unlike other far-red FPs, E2-Crimson is noncytotoxic in bacterial and mammalian cells. E2-Crimson is brighter than other far-red FPs and matures substantially faster than other red and far-red FPs. Approximately 40% of...
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PMID: 19658435
PDF is available here.
PDF is available here.
Biomedical Engineering (11)1 2009
Abstract
We discuss emerging bioengineered tools enabled by microscale technologies for studying the roles of mechanical forces in cell biology. In addition to traditional mechanobiology experimental techniques, we review recent advances of microelectromechanical systems (MEMS)-based approaches for cell mech...
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PMID: 19400708
PDF is available here.
PDF is available here.
Abstract
[An experimental study of using chitinous membrane as the culture scaffold for epidermal stem cells]
Abstract
Chitinous membrane may be used as ESCs culture vehicle, and biological compatibility is good....
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PMID: 19842556
PDF is available here.
PDF is available here.
Abstract
We present a molecular and genetic analysis of ALP-Enigma function in C. elegans. We show that ALP-1 and alpha-actinin colocalize at dense bodies where actin filaments are anchored and that the proper localization of ALP-1 at dense bodies is dependent on alpha-actinin. Our analysis of alp-1 mutants...
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PMID: 19261811
PDF is available here.
PDF is available here.
Zhongguo Xiufu Chongjian Waike Zazhi/Chinese Journal of Reparative and Reconstructive Surgery (23)4 2009
Abstract
Many researchers improved the properties of cartilage ACM scaffold through co-application of solution diosmosis method, freeze-drying method and physical and chemical cross-linking method etc., and the experimental results of applying cartilage ACM scaffold for the construction of tissue engineered...
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PMID: 19431995
PDF is available here.
PDF is available here.
Abstract
Subsets of proteins present and the interactions between them are fundamental determinants of the properties of complex biological systems. Monoclonal antibodies (mAbs) are highly versatile tools for characterisation of such systems, being employed to analyse the structures, functions, locations and...
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PMID: 19212659
PDF is available here.
PDF is available here.
Abstract
Cells display on the outer surface of the plasma membrane a large number of protein thiols that can be reversibly labelled with suitably designed Gd(III)-based contrast agents for cell tracking by MRI.
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PMID: 19214307
PDF is available here.
PDF is available here.
Abstract
We discuss recent vibrational spectroscopic advances in microbial identification of yeast and bacterial cells for bulk environment and single-cell analysis. IR absorption spectroscopy enables a bulk analysis whereas micro-Raman-spectroscopy with excitation in the near infrared or visible range has t...
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PMID: 19156822
PDF is available here.
PDF is available here.
Experimental Cell Research (315)1 2009
Abstract
We describe SD-BMSC (serumdeprivation-induced BMSC) which are induced as a distinct subpopulation after complete serumdeprivation. SD-BMSC are generated from small-sized nestin-positive BMSC (S-BMSC) organized as round-shaped cells in the top layer of BMSC-cultures. The generation of SD-BMSC is caus...
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PMID: 18992240
PDF is available here.
PDF is available here.
Methods in Enzymology (467) 2009
Abstract
We describe an HCAM workflow that can be set up in a medium size interdisciplinary laboratory, and its application to produce high-throughput QCT data for cancer cell motility and proliferation. This type of data is ideally suited to populate cell-scale computational and mathematical models of cance...
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PMID: 19897088
PDF is available here.
PDF is available here.
Abstract
We found that cell adhesion was reduced on the swollen PEM films and further decreased by deposition of PEI-g-PEG as the topmost layer. The ability in cell resistance was enhanced with increasing PEG contents of PEGylated PEM films. PEGylated PEM films were stable for long-term incubation in phospha...
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PMID: 19619401
PDF is available here.
PDF is available here.
Abstract
We have adapted sequential detergent extraction for use with the high-throughput non-electrophoretic proteomics method of liquid chromatography and electrospray ionisation tandem mass spectrometry. This method of extraction yields comprehensive proteomes that include up to twice as many membrane pro...
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PMID: 19153687
PDF is available here.
PDF is available here.
Abstract
Recent investigations have highlighted new roles for neutrophils in the biology of infection and inflammation. Neutrophils are one of the main players in the innate immune system and actively contribute to host defense by killing pathogens. Added to their ability to eliminate microor...
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PMID: 20375575
PDF is available here.
PDF is available here.
International Conference of the IEEE Engineering in Medicine and Biology Society. Proceedings (2009) 2009
Abstract
We present a new technique, called "divergence filter," for detecting subcellular structure motion modalities. The plausibility of the efficient technique was applied to caveolar membrane trafficking sequences obtained using confocal microscopy....
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PMID: 19963932
PDF is available here.
PDF is available here.
Abstract
Cell mechanics provides an integrated view of many biological phenomena which are intimately related to cell structure and function. Because breathing constitutes a sustained motion synonymous with life, pulmonary cells are normally designed to support permanent cyclic stretch without breaking, whil...
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PMID: 18565804
PDF is available here.
PDF is available here.
Cancer Research (68)22 2008
Abstract
We show that cathepsin B participates in podosomes-mediated focal matrix degradation and invasion in v-Src-transformed fibroblasts. We observed that lysosomal marker LAMP-1 localized at the center of podosome rosettes protruding into extracellular matrix using confocal microscopy. Time-lapse live-ce...
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PMID: 19010886
PDF is available here.
PDF is available here.
Biochemistry (Washington) (47)43 2008
Abstract
MotA and MotB are membrane proteins that form the stator of the bacterial flagellar motor. Each motor contains several MotA 4MotB 2 complexes, which function independently to conduct protons across the membrane and couple proton flow to rotation. The mechanism of rotation is not understood in detail...
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PMID: 18834143
PDF is available here.
PDF is available here.
Journal of Cell Science (121)Pt 21 2008
Abstract
We explored the enlargement of micron-scale pores in syncytium formation, which was initiated by a well-characterized fusogen baculovirus gp64. Radial expansion of a single or, more often, of multiple fusion pores proceeds without loss of membrane material in the tight contact zone. Pore growth requ...
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PMID: 18946025
PDF is available here.
PDF is available here.
Abstract
We solved the crystal structure of EABR bound to an ALIX peptide at a resolution of 2.0 angstroms. The structure shows that EABR forms an aberrant dimeric parallel coiled coil. Bulky and charged residues at the interface of the two central heptad repeats create asymmetry and a single binding site fo...
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PMID: 18948538
PDF is available here.
PDF is available here.
Abstract
The recent discovery of three closely related cell surface receptors that bind to progesterone and mediate its actions on various cytoplasmic signalling cascades has been heralded as a major break-through. The reason for this is all too obvious. Progesterone is an essential regulator of all major re...
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PMID: 18221973
PDF is available here.
PDF is available here.
Molecular Pharmacology (74)4 2008
Abstract
We conclude that positively charged amino acids in transmembrane helices 6 and 12 contribute to the MRP4 substrate-binding pocket....
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PMID: 18612080
PDF is available here.
PDF is available here.
Abstract
We consider two models, derived from the clusteron (Mel, Adv Neural Inf Process Syst 4:35-42, 1992), to study this method of learning. The models show a direct relationship between the speed of memory acquisition and the probability of forming appropriate synaptic connections. Moreover, the strength...
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PMID: 18273697
PDF is available here.
PDF is available here.
Abstract
For decades, authors have described unusual cell structures, referred to as cell-in-cell structures, in which whole cells are found in the cytoplasm of other cells. One well-characterized process that results in the transient appearance of such structures is the engulfment of apoptotic cells by phag...
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PMID: 18784728
PDF is available here.
PDF is available here.
Physical Review E (78)4 Pt 1 2008
Abstract
We investigate here the mechanical excitation of such waves when the membrane is perturbed by an external oscillatory force. The external perturbation may trigger the propagation of such waves away from the force application. This scheme is then suggested as a method to probe the properties of the e...
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PMID: 18999459
PDF is available here.
PDF is available here.
Abstract
We describe a simple technical solution for 3D nanoscopy of fixed samples: biological specimens are fluorescently labeled, embedded in a polymer resin, cut into thin sections, and then imaged via STED microscopy with nanoscale resolution. This approach allows a 3D image reconstruction with a resolut...
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PMID: 18512740
PDF is available here.
PDF is available here.
Abstract
We generated shRNA mediated 4E-BP1 knock-down in Rh30 rhabdomyosarcoma cells. 4E-BP1 knock-down relieved hypoxia-mediated inhibition of cycle progression in vitro and was correlated with increased expression of cyclin D1 and c-Myc. Xenograft tumors derived from these cells also displayed enhanced ex...
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PMID: 18708753
PDF is available here.
PDF is available here.
Abstract
Our findings therefore suggest that reduced glucose use and altered mitochondrial metabolism mediated by SIRT1 is one of several alterations that contribute to cellular resistance to cisplatin....
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PMID: 18723829
PDF is available here.
PDF is available here.
Heart Rhythm (5)9 2008
Abstract
Heart Rhythm (5)9 2008
Abstract
Angiotensin II and its downstream mitogen-activated protein kinase signaling pathways are involved in the pathogenesis of AF. Pro-inflammatory JAK/STAT is another downstream signaling pathway of Angiotensin II, and its status in AF remains unknown.
The aim of this stu...
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PMID: 18774104
PDF is available here.
PDF is available here.
Abstract
Cytokinesis is the final step of mitosis whereby two daughter cells physically separate. It is initiated by the assembly of an actomyosin contractile ring at the mitotic cell equator, which constricts the cytoplasm between the two reforming nuclei resulting in the formation of a narrow intercellular...
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PMID: 18472411
PDF is available here.
PDF is available here.
Biology of the Cell (100)8 2008
Abstract
Hsp20 was shown to be associated with a specialized membranous structure of the parasite, the IMC. This discontinuous striped-arrangement is unique in T. gondii, indicating that the topology of the outer leaflet of the IMC is not homogeneous....
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PMID: 18315523
PDF is available here.
PDF is available here.
Journal of Cell Science (121)Pt 15 2008
Abstract
These results suggest that the MT-mediated BAF accumulation at the core facilitates NE assembly at the end of mitosis....
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PMID: 18628300
PDF is available here.
PDF is available here.
Abstract
We can identify a handful of simple design principles that seem to underlie cellular architecture and assembly....
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PMID: 18648373
PDF is available here.
PDF is available here.
Cancer Research (68)14 2008
Abstract
We discuss the possible relevance of cell competition to cancer....
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PMID: 18632598
PDF is available here.
PDF is available here.
Abstract
We speculate that the flattening of the vesicles is a consequence of lipid phase separation and the formation of condensed complexes and areas of different bending elasticities. This phenomenon eventually leads to agglomeration of deformed liposomal structures, becoming more pronounced with the incr...
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PMID: 18359207
PDF is available here.
PDF is available here.
Journal of Cell Science (121)Pt 14 2008
Abstract
We sought to identify a PE-induced phosphorylation site in AFAP-110 and determine whether phosphorylation is linked to the formation of podosomes. Mutational analysis revealed Ser277 of AFAP-110 to be phosphorylated in PE-treated cells. The use of a newly generated, phospho-specific antibody directe...
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PMID: 18577577
PDF is available here.
PDF is available here.
Journal of Nuclear Medicine (49 Suppl 2) 2008
Abstract
We summarize recent data on the molecular mechanisms underlying the increased metabolic activity of cancer cells and discuss imaging techniques for studies of tumor glucose, lipid, and amino acid metabolism....
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PMID: 18523065
PDF is available here.
PDF is available here.
Trends in Cell Biology (18)5 2008
Abstract
We discuss new evidence suggesting that exosomes participate in the transport of morphogens and RNA, and thus influence cell polarity and developmental patterning of tissues....
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PMID: 18396047
PDF is available here.
PDF is available here.
Abstract
The results of the development and introduction of universal production standards for cell products of mesenchymal origin are presented: technology for obtaining and culturing of primary cell cultures from human postnatal organs and tissues, cell product quality and safety control procedures, method...
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PMID: 19110609
PDF is available here.
PDF is available here.
Abstract
Single walled carbon nanotubes (SWCNT) find their way in various industrial applications. Due to the expected increased production of various carbon nanotubes and nanoparticle containing products, exposure to engineered nanoparticles will also increase dramatically in parallel. In this study the eff...
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PMID: 17990080
PDF is available here.
PDF is available here.
Abstract
We present the case of a 23-year-old woman with a parotid gland tumor, the fine-needle aspiration biopsy smears of which showed epithelial cells with wide cytoplasm, isolated or arranged in micropapillary groups together with psammoma bodies. The surgical specimen contained a 5-cm tumor with the his...
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PMID: 18417682
PDF is available here.
PDF is available here.
Abstract
We proposed that electron tomography data should be shared in a manner analogous to structural data at the protein and sequence scales. At that time, we outlined our progress in creating a database to bring together cell level imaging data across scales, The Cell Centered Database (CCDB). The CCDB w...
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PMID: 18054501
PDF is available here.
PDF is available here.
Abstract
The tripeptide glutathione is a major antioxidant and redox buffer with multiple roles in plant metabolism. Glutathione biosynthesis is restricted to the cytosol and the plastids and the product is distributed to the various organelles by unknown mechanisms. In the present study immunogold cytochemi...
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PMID: 18977750
PDF is available here.
PDF is available here.
Abstract
We developed an illumination system in which light from a mercury arc lamp is scrambled to make homogeneous light by passing it through a multi-mode optical fiber. This illumination system provides incoherent light with continuous wavelengths, enabling the observation of a wide range of fluorophores...
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PMID: 18685226
PDF is available here.
PDF is available here.
Abstract
Tsitologiia (50)2 2008
Abstract
In the present review the description of history of the centrosome investigation is given and the current state of knowledge of this cellular structure in morphological, biochemical, and functional aspects is presented. Besides of the classical functions of the centrosome as a MT nucleating, MT anco...
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PMID: 18540189
PDF is available here.
PDF is available here.