Abstract
JXG is a benign histiocytic disorder that usually appears early in childhood but is also encountered in 13%-18% of cases in the second decade. The histiocytes usually stain positively for CD68 and negatively for S-100 and CD1a. Correctly distinguishing JXG from the more aggressive spectrum of Langer...
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PMID: 20458239
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Abstract
Neurocysticercosis causes significant morbidity due to neurologic manifestations including seizures. Sudden unexpected death in epilepsy (SUDEP) is responsible for mortality associated with seizure disorders. This case highlights death from neurocysticercosis and possible SUDEP in a nonendemic count...
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PMID: 20139756
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Abstract
We report the biopsy findings in 4 cases of acute pulmonary histoplasmosis, which seem to be unique to this form of Histoplasma infection. There were 3 men and 1 woman who ranged in age from 40 to 68 years. All presented acutely with fever and other flu-like symptoms. Radiographically, a solitary no...
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PMID: 20351490
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Abstract
We studied skin biopsies from 10 patients with H syndrome. The characteristic morphology included widespread fibrosis (moderate in dermis and severe in subcutis); striking mononuclear infiltrates consisting mainly of monocyte-derived cells (small CD68 histiocytes and CD34 and FXIIIa dendrocytes) and...
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PMID: 20010285
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Abstract
Indeterminate fibrohistiocytic lesions of the skin share histological and immunohistochemical features of both benign fibrous histiocytoma/dermatofibroma and dermatofibrosarcoma protuberans (DFSP). Unlike dermatofibroma, DFSP harbors recurrent genetic aberrations resulting in the fusion of COL1A1 on...
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PMID: 19940748
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Abstract
We present the case of a 72-year-old woman with a history of mucinous carcinoma of the breast who now presents with a painful subareolar nodule of the same breast. Biopsy and histological examination confirmed nodular mucinosis of the breast....
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PMID: 20010404
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Abstract
We report the case of a 43-year-old Senegalese woman who presented with a polypoid, intranasal mass caused by Rosai-Dorfman disease. A diagnosis of a granulomatous process, including rhinoscleroma, was initially discussed. The correct diagnosis was made histologically by demonstrating aggregates of...
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PMID: 19646302
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Abstract
The gene expression profile of T-cell/histiocyte-rich large B-cell lymphoma, in comparison with that of nodular lymphocyte-predominant Hodgkin's lymphoma, shows features suggestive of a distinct tolerogenic host immune response that may play a key role in the aggressive behavior of this lymphoma, an...
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PMID: 19797726
PDF is available here.
Eumenia C C Castro,
Cristina Blazquez,
Jaime Boyd,
Hernán Correa,
J-P de Chadarevian,
Raymond E Felgar,
Nicole Graf,
Norman Levy,
Eric J Lowe,
John T Manning,
Maria A Proytcheva,
Christof Senger,
Katayoon Shayan,
Jaroslav Sterba,
Alice Werner,
Urvashi Surti and
Ronald Jaffe
Abstract
We describe the clinicopathologic features of 15 patients who had histiocytic lesions that followed acute lymphoblastic leukemia (ALL). Twenty-one separate histiocytic lesions were evaluated that covered a wide spectrum, some conforming to the usual categories of juvenile xanthogranulomas (5), Lange...
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PMID: 19642834
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Abstract
Histiocytic proliferations involving the lung span a broad spectrum. Some proliferations are primary; others represent a histiocytic response secondary to conditions in which there may be isolated lung involvement or the lung may be involved as part of a systemic process. Primary histiocytic lung di...
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PMID: 20032634
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Abstract
We report a case of giant cell tumor of soft tissue (GCTST) in a 40-year-old woman who presented with a painful fibrous nodule on the thigh. The histological examination revealed multinucleated histiocytes admixed with eosinophils, lymphocytes, and scattered spindle-shaped cells. The clinical presen...
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PMID: 20233559
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Abstract
We report here the first published case of a male patient with progressive mucinous histiocytosis. The multiple red papules on the scalp and forearms were asymptomatic and had slowly increased over approximately the past 20 years. The patient's mother had similar lesions. Histological examination re...
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PMID: 20107728
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Abstract
We report a rare variant of PENs called a lipid-rich variant and elaborate on its cytologic features with reference to fine needle aspiration (FNA).
The patient was a 74-year-old man with a 2.1-cm mass in the body of the pancreas. The FNA showed numerous cells with vacuolated, foamy cytoplasm, mostl...
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PMID: 21053550
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Abstract
We present the case of a 27-year-old woman with local cervical lymphadenopathy without other symptoms. Due to a gradual progression of lesions, a biopsy was performed, and a specimen excised from an enlarged lymph node was subjected to histological examination. Kikuchi-Fujimoto disease (KFD), that i...
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PMID: 20010470
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Abstract
We report a case of pulmonary crystal-storing histiocytoma in a 64-year-old man, presenting as a chronic pulmonary consolidation in the lung exposed to asbestos. Video-assisted thoracoscopic surgical biopsy displayed sheets of large, epithelioid histiocytes filled with a large number of needle-like...
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PMID: 19773640
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Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome in which an exaggerated but ineffective immune response leads to severe hyperinflammation. Key players in HLH are activated lymphocytes and histiocytes which infiltrate all organs and secrete large amounts of cytokines. Cardinal...
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PMID: 19707989
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Jinyung Ju,
Yong Soo Kwon,
Kae Jung Jo,
Dong Ryeol Chae,
Jung Hwan Lim,
Hee Jung Ban,
Su Young Chi,
In Jae Oh,
Ku Sik Kim,
Yu Il Kim,
Young Chul Kim and
Sung Chul Lim
Abstract
Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder characterized by a nonneoplastic proliferation of distinctive histiocyte cells within lymph node sinuses and lymphatics in extranodal sites. SHML occurs worldwide and is primarily a disease of childhood and early adulthood. A...
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PMID: 19654967
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Abstract
The aims of this study were to evaluate ultrastructural lesions in lymph nodes from postweaning multisystemic wasting syndrome (PMWS)-affected pigs and to correlate these alterations with detection of viral-like particles (VLPs). Samples of lymph nodes were taken from 4 PMWS-affected pigs and 2 heal...
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PMID: 19276043
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Abstract
In a 2-month-old female savannah kitten that died unexpectedly, the pathologic findings of significance were restricted to the heart and included abnormal Purkinje fibers and biventricular myocardial trabeculation or noncompaction. The Purkinje fibers were large, angular, and tightly packed. They co...
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PMID: 19276060
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Abstract
We describe our experience with 16 cases of intralymphatic histiocytosis. Clinically, the lesions were located predominantly on the upper and lower limbs, and they consisted of asymptomatic and poorly demarcated erythematous plaques and livedo reticularis-like lesions. They were characterized histop...
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PMID: 19318799
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Abstract
Meconium passage in MMCs can occur early in fetal life. Fetal MMC repair may reduce the duration of meconium exposure, thereby potentially limiting the toxic injury to the vulnerable neural elements....
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PMID: 19278315
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Abstract
We report for the first time the use of isotretinoin in the treatment of GEH. An otherwise healthy 53-year-old female with a 3-month history of GEH had resolution of lesions without further development of new lesions over 8 months of treatment with isotretinoin, although, eventually, lesions began t...
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PMID: 19426623
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Abstract
We describe cardiac disease in a 42-year-old African American female with a history of MRH for 29 years and dilated cardiomyopathy for 5 years. During a congestive heart failure flare, the patient was slow to respond to standard treatment. A left/right heart catheterization and endomyocardial biopsy...
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PMID: 18679136
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Abstract
We describe a 60 year-old woman presenting with visual loss of her left eye. No lymphadenopathies, fever, or weight loss were detected. Neuroimaging studies revealed an extra-axial mass along the posterior aspect of the left optic nerve. The mass was resected and showed xanthomatous histiocytes that...
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PMID: 19076782
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Abstract
Hydatidiform moles are associated with numeric alterations of immune cell infiltrate. The numeric dominance of immune cells in the hydatidiform moles may reflect either non-specific or specific immunological processes. The possible pathogenetic and prognostic ramifications of our findings are open f...
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PMID: 19160109
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Abstract
A total of 49 cases of inflammatory breast aspirates were identified, of which 15 cases were GM. The microbiologic cultures of all 15 cases were available. Six of 15 cases had positive culture for Brucella melitenses, and 2 cases were positive for TB, which was further confirmed by TB/PCR. The funga...
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PMID: 20014556
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Abstract
Hodgkin and Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (HL) and lymphocytic and histiocytic (L&H) cells in nodular lymphocyte-predominant HL (NLPHL) are derived from germinal-center B cells. HRS cells have, however, largely lost their B cell phenotype and aberrantly express markers and...
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PMID: 19400691
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Abstract
6.0% CMC acted as a modifier of the oculomotor system of rabbits, facilitating or impairing movements. It was not possible to conclude whether the increase in force occurred as a consequence of the inflammatory process alone or of the sum of inflammation and a possible viscous attrition provoked by...
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PMID: 20098902
PDF is available here.
Abstract
According to biologic features, there is a substantial "gray zone" between nodular lymphocyte predominant Hodgkin lymphomas (NLPHLs) (Poppema lymphomas) and T-cell/histiocyte-rich B-cell lymphomas (T/HRBCLs). Transformation from an NLPHL to a T/HRBCL can occur and is associated with a worsening of t...
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PMID: 19131792
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Abstract
A 20-year-old man presented with a rare case of germinoma with a large component of epithelioid cell granuloma manifesting as oscillopsia. Magnetic resonance imaging demonstrated a mass in the pineal region with homogeneous enhancement with gadolinium. Craniotomy was performed, ending in biopsy. The...
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PMID: 19106497
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Abstract
We present the case of a woman with diabetes insipidus with subsequent genital and multiorgan Langerhans cell histiocytosis (LCH). A monolateral and slightly infiltrated erythematous plaque of the vulva was observed. Hematoxylin and eosin and immunophenotypic studies were performed. The primary anti...
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PMID: 19076626
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Abstract
We should consider this entity before we carry out radical procedures. In this short report, we will present a case of an aggressive IPT involving the mandible and a review of literatures....
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PMID: 19098549
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Abstract
We report a patient with Morbihan disease showing persistent lymphoedema on the upper half of the face accompanied by unique histological findings of striking dermal dilated lymphatics and damage of the lymphatics at the site of the adjacent epithelioid cell granulomas, with histiocytes bulging into...
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PMID: 18627384
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Abstract
We describe a case of lipoma in the posterior mediastinum that contained solid areas on computed tomography. Histology showed that these areas were fat necrosis....
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PMID: 19007571
PDF is available here.
Abstract
We report 3 cases of a previously uncharacterized form of histiocytosis presenting in early infancy and showing ALK immunoreactivity. The patients presented with pallor, massive hepatosplenomegaly, anemia, and thrombocytopenia. Liver biopsy showed infiltration of the sinusoids by large histiocytes w...
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PMID: 18660380
PDF is available here.
Abstract
A child with acute pre-B cell lymphoblastic leukemia underwent haploidentical bone marrow transplantation (BMT) after first relapse. Approximately 8 months after the BMT, he developed a soft tissue mass overlying a defect in the left frontal bone. He was found to have several additional osteolytic l...
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PMID: 18493991
PDF is available here.
Abstract
We propose a diagnosis of primary cutaneous indeterminate cell sarcoma for this unusual histiocytic neoplasm. Current classification of histiocytic neoplasms and differential diagnosis are reviewed....
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PMID: 18422973
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Abstract
Our case presents minor variations on the recorded features. Possible reasons for the scarcity of reports and for the confirmation of this lymphoma as a variant of T-cell-rich large B-cell lymphoma are discussed....
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PMID: 18620998
PDF is available here.
Abstract
A 6-year-old boy with Alagille syndrome, characterised by marked hyperbilirubinaemia, presented with malunion of a pathological fracture of the femur with local bone atrophy and insufficient callus formation. During corrective osteotomy, it was noted that the femur was stained dark green, suggestive...
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PMID: 18725687
PDF is available here.
Abstract
We investigated the effect of a single in vivo exposure of macrophages to physiologically relevant levels of ethanol (1.2 and 2.9 g/kg) followed by ex vivo stimulation with lipopolysaccharide (LPS) or bacteria. Our study confirms the work of others showing that a single administration of ethanol sup...
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PMID: 18597620
PDF is available here.
Abstract
Malakoplakia is a form of chronic granulomatous inflammation that in humans most commonly affects the urinary bladder of middle-aged women. Naturally occurring malakoplakia is rare in animals, having been described twice in the pig only. An 8-week-old kitten was diagnosed with malakoplakia of the ur...
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PMID: 18440547
PDF is available here.
Abstract
We present two cases of this rare disorder illustrating its clinical spectrum; a 22 years old woman with involvement of submandibular lymph nodes, nasal septum and sub-glottic region and a 45 years old male with prominent skin involvement....
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PMID: 18988397
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Abstract
Keratoacanthoma (KA) is a common keratinizing squamous cell neoplasm of unknown origin characterized by rapid growth and spontaneous involution. Trauma-induced forms have been observed with various types of skin injury. To our knowledge, reports of KA arising at tattoo sites are scarce in the litera...
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PMID: 17976209
PDF is available here.
Abstract
We performed an immunohistochemical study with double staining, in a case of ICH of a 74-year-old male, who presented multiple yellowish papules in chest, back and both arms. Their sizes varied between 1 and 3 mm. One of the biopsies from one lesion of the back showed a dermal histiocytic infiltrate...
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PMID: 18819325
PDF is available here.
Abstract
We report on a 5-year-old boy with cranial bone involvement, proptosis and xanthomatous cutaneous lesions, treated successfully with systemic corticosteroids....
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PMID: 18391701
PDF is available here.
Abstract
A case of multiple myeloma is reported in which the bone marrow contained sheets of histiocytes with light microscopic features mimicking Gaucher cells. The patient had no clinical evidence of inherited Gaucher's disease. These pseudo-Gaucher cells obscured neoplastic plasma cells causing diagnostic...
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PMID: 18417675
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Abstract
Although extranodal manifestations are common in RDD and the lack of lymph node involvement is rare, our study supports that whenever there is an epibulbar tumor as a manifestation of RDD, the absence of lymphadenopathy is characteristic. Only 2 of the 9 reported cases presented with lymphadenopathy...
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PMID: 18362675
PDF is available here.