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Macrophages, Peritoneal (0):
Recent article
Macrophages, Peritoneal
Abstract
We reported that vitamin K₃ (menadione, 2-methyl-1,4-naphthoquinone) (compound 2) inhibits the activity of human mitochondrial DNA polymerase γ (pol γ). In this study, we investigated the inhibitory effects (IEs) of vitamin K3 and its derivatives, such as 1,4-naphthoquinone (compound 1) and 1,2-...
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PMID: 21837358
PDF is available here.
PDF is available here.
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Abstract
We have used conditional gene targeting in mice to address the role of the deubiquitinating activity of CYLD in the myelomonocytic lineage. Truncation of the deubiquitinating domain of CYLD specifically in myelomonocytic cells impaired the development of lethal LPS-induced endotoxic shock and the ac...
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PMID: 21283724
PDF is available here.
PDF is available here.
Abstract
We used a variety of methods, including FACS analysis, cytotoxicity assays, cell depletion, imaging of tumor growth, cytokine blockade, and survival experiments, to study how SV therapy affects Natural Killer (NK) cell function in SCID mice bearing human ovarian carcinoma tumors. Surprisingly, we fo...
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PMID: 21674047
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of astaxanthin on IL-6 in activated microglial cells because excessive interleukin-6 (IL-6) production by activated brain microglia has been linked to many neurological disorders and proper regulation of IL-6 is critical for maintaining brain homeostasis. Astaxanthin inhib...
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PMID: 20932499
PDF is available here.
PDF is available here.
Abstract
Interactions between different types of immune cells and organically-modified silica nanoparticles were studied. The silica particles functionalized with amine groups were prepared by sol-gel technique. Sheep immunoglobulin labeled with fluoresceine isothiocyanate was immobilized by adsorption onto...
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PMID: 20648538
PDF is available here.
PDF is available here.
Abstract
We hypothesized that mechanical strain initiates or aggravates proinflammatory responses in intestinal smooth muscle cells (iSMC) or macrophages. First, an appropriate isolation and culture method for neonatal rat iSMC was established. Purified iSMC and primary peritoneal macrophages (pMacs) were su...
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PMID: 20829523
PDF is available here.
PDF is available here.
Abstract
Longan (Dimocarpus longan Lour.) is used as a traditional edible and medicinal material in China. In this paper, the effects of polysaccharides from longan pulp with ultrasonic extraction (UELP) on the radicals scavenging, immunity-modulatory and antitumor activities in S180 tumor mice models were i...
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PMID: 20685359
PDF is available here.
PDF is available here.
Abstract
We examined the effects of diosgenin on the production of inflammatory mediators in lipopolysaccharide (LPS)/interferon gamma (IFN-gamma)-activated murine macrophage. Macrophages pre-exposed to diosgenin (0.1-10 microM) were stimulated with LPS/IFN-gamma. Pretreatment with diosgenin resulted in the...
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PMID: 20601188
PDF is available here.
PDF is available here.
Abstract
We isolated sulfuretin from R. verniciflua and demonstrated that sulfuretin inhibited inducible nitric oxide synthase (iNOS) protein and mRNA expression, reduced iNOS-derived NO, suppressed COX-2 protein and mRNA expression, and reduced COX-derived PGE(2) production in lipopolysaccharide (LPS)-stimu...
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PMID: 20450988
PDF is available here.
PDF is available here.
Abstract
These results indicated that the downregulation of TNF-alpha by S. tenuifolia water extract may have involved the inhibition of both IkappaBalpha degradation and activation of c-Jun and ATF-2 involving suppression of JNK/SAPK....
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PMID: 20663042
PDF is available here.
PDF is available here.
Abstract
The current formulation of paclitaxel causes significant side effects, so there is a need to develop a safer delivery system. In this study, novel semi-solid lipid nanoparticles (PEG-PE-SSLN) were prepared, and evaluated as delivery vehicles for paclitaxel. The PEG-PE-SSLN are approximately 213 nm i...
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PMID: 20662317
PDF is available here.
PDF is available here.
Infection and Immunity (78)7 2010
Abstract
We employ bacterial and mammalian genetic approaches to demonstrate that loss of motility, not the loss of the flagellum per se, is the critical factor in the development of resistance to phagocytosis by P. aeruginosa. We demonstrate that isogenic P. aeruginosa mutants deficient in flagellar functio...
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PMID: 20457788
PDF is available here.
PDF is available here.
Abstract
We created an apoE-mimetic peptide, COG112 (acetyl-RQIKIWFQNRRMKWKKCLRVRLASHLRKLRKRLL-amide), and found that postinjury treatment with COG112 significantly improved recovery of motor and sensory function following sciatic nerve crush in C57BL/6 mice. Morphometric analysis of injured sciatic nerves r...
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PMID: 20406857
PDF is available here.
PDF is available here.
Abstract
To compare the different expression of protein in RAW264.7 macrophage cells induced by two types of MWNTs (multi-walled carbon nanotubes) with different surface modifications (acid-treated MWNTs and tau-MWNTs modified by taurine).
Treating cells with both types of MWN...
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PMID: 20559414
PDF is available here.
PDF is available here.
Abstract
Korean mistletoe lectin (KML-C) is an adjuvant that activates systemic and mucosal immune cells to release cytokines including TNF-alpha, which induces immunity against viruses and cancer cells. Although the immunomodulatory activity of KML-C has been well established, the underlying mechanism of ac...
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PMID: 20450885
PDF is available here.
PDF is available here.
Abstract
We investigated the antileishmanial activity of eupomatenoid-5, a neolignan isolated from leaves of Piper regnellii var. pallescens. We showed that eupomatenoid-5 had a dose-dependent activity during 72h of treatment, exhibiting IC(50) of 9.0microg/mL and 13.0microg/mL for promastigote and axenic am...
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PMID: 20064628
PDF is available here.
PDF is available here.
Abstract
Himatanthus sucuuba (HsL) latex exhibited a potent leishmanicidal activity against intracellular amastigotes of Leishmania amazonensis, a causative agent of cutaneous leishmaniasis. HsL inhibited intracellular amastigote growth in a dose-dependent manner (IC(50)=15.7microg/mL). Moreover, HsL increas...
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PMID: 20096374
PDF is available here.
PDF is available here.
Abstract
We attempted to assess the levels of non-enzymatic and enzymatic mediators in the presence or absence of PC in 4-phorbol-12-beta-myristate-13-acetate (PMA)-stimulated neutrophils isolated from humans and rats, E. coli endotoxin-stimulated macrophages and macrophages isolated from E. coli endotoxin-i...
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PMID: 20653284
PDF is available here.
PDF is available here.
Immunobiology (215)6 2010
Abstract
We aimed to investigate the kinetic aspect of inflammatory leukocyte apoptosis and verify whether apart from neutrophils also other inflammatory leukocytes numerously undergo apoptosis. We observed that in physiological conditions, less than 7% of either resident peritoneal macrophages or lymphocyte...
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PMID: 19656586
PDF is available here.
PDF is available here.
Journal of Immunotherapy (33)5 2010
Abstract
Earlier studies have shown that the adoptive transfer of Th2-polarized CD4 T cells can clear established tumors from mice in an antigen-specific manner. Although eosinophils were implicated in this process, the exact mechanism of tumor clearance and which immune effector cells were i...
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PMID: 20463604
PDF is available here.
PDF is available here.
Journal of Parasitology (96)3 2010
Abstract
Our data strongly suggest the application of recently isolated parasites as sources of antigen for diagnosis procedures. Moreover, L. naiffi species possesses several characteristics relevant for its use as a source of novel antigens to be explored in the design of diagnostic tools and vaccines....
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PMID: 20557195
PDF is available here.
PDF is available here.
Abstract
This study examined the effects of ginseng polysaccharide (GPS) on mouse peritoneal macrophage (PM)-mediated cytotoxicity towards K562, HL-60, or KG1alpha cells. GPS had no direct effect on killing of tumor cells. However, when mouse PMs were treated with GPS, cytotoxic activity against K562, HL-60,...
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PMID: 20156477
PDF is available here.
PDF is available here.
Abstract
We examined the ability of the peptides to inhibit the growth of Salmonella in mammalian cells. J774A.1 macrophage-like cells and murine peritoneal macrophages were infected with Salmonella enterica serovar Typhimurium and grown in the presence or absence of peptide. We found that peptide wrwycr red...
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PMID: 20176906
PDF is available here.
PDF is available here.
Abstract
From a series of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol screened in vitro against Trypanosoma cruzi, eight (S1 to S8) were selected for in vivo screening by single-dose oral administration (200 mg/kg of body weight) to infected mice at 5 days postinfection (dpi). Based on significa...
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PMID: 20231395
PDF is available here.
PDF is available here.
Abstract
Fas-FasL interaction in the cornea balances the host innate immune response to improve disease outcome by promoting earlier apoptosis and regulating proinflammatory cytokines/chemokines and nitric oxide (nitrite) production. Dysregulation of this interaction contributes to bystander tissue damage, e...
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PMID: 20019368
PDF is available here.
PDF is available here.
Molecular Immunology (47)9 2010
Abstract
The 34 kDa major outer membrane protein (MOMP) of Shigella flexneri 2a induces combinatorial expression of TLR2 and TLR6 on peritoneal macrophages of BALB/c mice. Between the two best-characterized TLRs, to date, TLR2 and TLR4, which are chiefly responsible for recognizing majority of bacterial prod...
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PMID: 20347487
PDF is available here.
PDF is available here.
Abstract
Our results demonstrate that LITAF deficiency in vivo affects cytokines other than TNF-alpha and influences the balance between the pro- and anti-inflammatory cytokines, which protects the animals from the deleterious effects of an LPS-induced inflammatory response, resulting in a beneficial host re...
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PMID: 20219876
PDF is available here.
PDF is available here.
Abstract
Our previous studies have shown that the crude extract of S. lyratum Thunberg (SLE) induced apoptosis in colo 205 human colon adenocarcinoma cells; however, there is no report to show SLE affect immune responses in vivo. In this study, the in vivo effects of SLE on leukemia WEHI-3 cells and immune r...
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PMID: 20197453
PDF is available here.
PDF is available here.
Abstract
Our previous studies have shown that the crude extract of S. lyratum Thunberg (SLE) induced apoptosis in colo 205 human colon adenocarcinoma cells; however, there is no report to show SLE affect immune responses in vivo. In this study, the in vivo effects of SLE on leukemia WEHI-3 cells and immune r...
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PMID: 20197453
PDF is available here.
PDF is available here.
Abstract
We investigated whether and how Tregs affect macrophages foam-cell formation. Tregs were isolated by magnetic cell sorting-column and analyzed by flow cytometry. Macrophages were cultured with or without Tregs in the presence of oxidized LDL (oxLDL) for 48 h to transform foam cells. After co-culture...
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PMID: 20007839
PDF is available here.
PDF is available here.
Abstract
We investigated whether concurrent exposure of macrophages to phagocytic and fusogenic stimuli would limit fusion. Induction of phagocytosis by addition of 3.0 mum-diameter polystyrene microspheres to cells under fusogenic conditions, at ratios of 1:10, 1:1, and 10:1 did not prevent fusion. To deter...
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PMID: 19536825
PDF is available here.
PDF is available here.
Abstract
A series of novel chalconoids containing a 6-chloro-2H-chromen-3-yl group were prepared through a convenient and efficient synthetic method by using 5-chloro-2-hydroxybenzaldehyde as starting material. The target compounds were evaluated against the promastigote form of Leishmania major using MTT as...
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PMID: 20074836
PDF is available here.
PDF is available here.
Parasitology Research (106)5 2010
Abstract
We have reported the development of a rapid, inexpensive and reliable monophasic culture medium. The novel medium, designated PBHIL, promoted an excellent parasite growth, generating high quantities of promastigotes with long-term viability, and was able to induce cellular differentiation of L. amaz...
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PMID: 20177905
PDF is available here.
PDF is available here.
Abstract
We demonstrate that peritoneal macrophages (PMs) are abundant in ascitic fluid of patients with liver cirrhosis and are susceptible to HIV-1 infection. PMs expressed CD68, a differentiation marker, exhibited phagocytic activity, and survived in culture for 2 months without additional growth factors....
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PMID: 20065862
PDF is available here.
PDF is available here.
Abstract
We characterised the essential oil from Piper auritum, evaluated its cytotoxicity and determined its antileishmanial activity. The chromatogram obtained by gas chromatography revealed 60 peaks and we found that safrole was the most abundant compound, composing 87% of the oil. The oil was active agai...
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PMID: 20428676
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
Histoplasma capsulatum var. capsulatum is a thermally dimorphic fungus that causes histoplasmosis. Fungal hemagglutination activity and cases of reactive hemophagocytic syndrome (RHS) have been reported in the disseminated form of disease. In the present study, soluble components of...
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PMID: 19908162
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
Histoplasma capsulatum var. capsulatum is a thermally dimorphic fungus that causes histoplasmosis. Fungal hemagglutination activity and cases of reactive hemophagocytic syndrome (RHS) have been reported in the disseminated form of disease. In the present study, soluble components of...
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PMID: 19908162
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
Histoplasma capsulatum var. capsulatum is a thermally dimorphic fungus that causes histoplasmosis. Fungal hemagglutination activity and cases of reactive hemophagocytic syndrome (RHS) have been reported in the disseminated form of disease. In the present study, soluble components of...
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PMID: 19908162
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
Histoplasma capsulatum var. capsulatum is a thermally dimorphic fungus that causes histoplasmosis. Fungal hemagglutination activity and cases of reactive hemophagocytic syndrome (RHS) have been reported in the disseminated form of disease. In the present study, soluble components of...
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PMID: 19908162
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
Histoplasma capsulatum var. capsulatum is a thermally dimorphic fungus that causes histoplasmosis. Fungal hemagglutination activity and cases of reactive hemophagocytic syndrome (RHS) have been reported in the disseminated form of disease. In the present study, soluble components of...
|
PMID: 19908162
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
Histoplasma capsulatum var. capsulatum is a thermally dimorphic fungus that causes histoplasmosis. Fungal hemagglutination activity and cases of reactive hemophagocytic syndrome (RHS) have been reported in the disseminated form of disease. In the present study, soluble components of...
|
PMID: 19908162
PDF is available here.
PDF is available here.
Mycopathologia (169)3 2010
Abstract
Histoplasma capsulatum var. capsulatum is a thermally dimorphic fungus that causes histoplasmosis. Fungal hemagglutination activity and cases of reactive hemophagocytic syndrome (RHS) have been reported in the disseminated form of disease. In the present study, soluble components of...
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PMID: 19908162
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of fluvastatin, simvastatin, lovastatin, and pravastatin on the viability of macrophages and SMCs. All statins, except pravastatin, induced cell death of J774A.1 macrophages after 24 hours, albeit with different sensitivity. The viability of rabbit aortic SMCs was hardly...
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PMID: 20051876
PDF is available here.
PDF is available here.
IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis.
Abstract
These data provide evidence that IL-33 promotes a Th2-type immune response and reduces inflammation by polarizing the Mvarphi production of anti-inflammatory mediators in the cornea....
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PMID: 19892870
PDF is available here.
PDF is available here.
Archives of Toxicology (84)3 2010
Abstract
Leishmaniasis is caused by species of the protozoan parasite Leishmania. It is the third most important vector-borne disease and is widely distributed throughout the world. The World Health Organization recommends pentavalent antimonials as drugs of first choice in its treatment. Alt...
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PMID: 19911167
PDF is available here.
PDF is available here.
Archives of Toxicology (84)3 2010
Abstract
Leishmaniasis is caused by species of the protozoan parasite Leishmania. It is the third most important vector-borne disease and is widely distributed throughout the world. The World Health Organization recommends pentavalent antimonials as drugs of first choice in its treatment. Alt...
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PMID: 19911167
PDF is available here.
PDF is available here.
Archives of Toxicology (84)3 2010
Abstract
Leishmaniasis is caused by species of the protozoan parasite Leishmania. It is the third most important vector-borne disease and is widely distributed throughout the world. The World Health Organization recommends pentavalent antimonials as drugs of first choice in its treatment. Alt...
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PMID: 19911167
PDF is available here.
PDF is available here.
Archives of Toxicology (84)3 2010
Abstract
Leishmaniasis is caused by species of the protozoan parasite Leishmania. It is the third most important vector-borne disease and is widely distributed throughout the world. The World Health Organization recommends pentavalent antimonials as drugs of first choice in its treatment. Alt...
|
PMID: 19911167
PDF is available here.
PDF is available here.
Archives of Toxicology (84)3 2010
Abstract
Leishmaniasis is caused by species of the protozoan parasite Leishmania. It is the third most important vector-borne disease and is widely distributed throughout the world. The World Health Organization recommends pentavalent antimonials as drugs of first choice in its treatment. Alt...
|
PMID: 19911167
PDF is available here.
PDF is available here.
Archives of Toxicology (84)3 2010
Abstract
Leishmaniasis is caused by species of the protozoan parasite Leishmania. It is the third most important vector-borne disease and is widely distributed throughout the world. The World Health Organization recommends pentavalent antimonials as drugs of first choice in its treatment. Alt...
|
PMID: 19911167
PDF is available here.
PDF is available here.
Archives of Toxicology (84)3 2010
Abstract
Leishmaniasis is caused by species of the protozoan parasite Leishmania. It is the third most important vector-borne disease and is widely distributed throughout the world. The World Health Organization recommends pentavalent antimonials as drugs of first choice in its treatment. Alt...
|
PMID: 19911167
PDF is available here.
PDF is available here.
Archives of Toxicology (84)3 2010
Abstract
Leishmaniasis is caused by species of the protozoan parasite Leishmania. It is the third most important vector-borne disease and is widely distributed throughout the world. The World Health Organization recommends pentavalent antimonials as drugs of first choice in its treatment. Alt...
|
PMID: 19911167
PDF is available here.
PDF is available here.
Archives of Toxicology (84)3 2010
Abstract
Leishmaniasis is caused by species of the protozoan parasite Leishmania. It is the third most important vector-borne disease and is widely distributed throughout the world. The World Health Organization recommends pentavalent antimonials as drugs of first choice in its treatment. Alt...
|
PMID: 19911167
PDF is available here.
PDF is available here.
Abstract
We showed that a fraction without NDGA was capableof activating macrophages, principally through the production of mitochondrial anion superoxide and H(2)O(2). This could be important in the defense of infections. Moreover, this fraction decreased NO level suggesting an anti-inflammatory action. CON...
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PMID: 19831499
PDF is available here.
PDF is available here.
Experimental Parasitology (124)3 2010
Abstract
Trypanosoma cruzi is the ethiological agent for Chagas disease in Latin America. This study aimed to test the trypanocidal effect of licarin A and burchellin isolated from plants in northeastern Brazil. These neolignans were tested on T. cruzi and on peritoneal macrophages, to evaluate drug toxicity...
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PMID: 19944690
PDF is available here.
PDF is available here.
Abstract
I and II molecules and costimulatory molecule CD80 on peripheral blood mononuclear cells obtained from the FVE-treated mice were upregulated as compared with those of the PBS-treated mice. Furthermore, immunohistochemical staining showed a strong inhibition of tumor growth and angiogenesis in hepato...
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PMID: 19909827
PDF is available here.
PDF is available here.
Abstract
We investigated concentrations of cytokines, and in the spleen we determined subsets of CD3(+), CD4(+), CD8(+), and CD19(+) lymphocytes....
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PMID: 20136448
PDF is available here.
PDF is available here.
Abstract
A lectin specific for glucuronic acid and galacturonic acid has been isolated from seeds of the French bean Phaseolus vulgaris using a procedure that involved affinity chromatography on Affi-gel blue gel, fast protein liquid chromatography (FPLC)-ion exchange chromatography on Mono S, and FPLC-gel f...
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PMID: 20214646
PDF is available here.
PDF is available here.
Abstract
We show that CD200R expression was specifically induced on human in vitro polarized macrophages of the alternatively activated M2a subtype, generated by incubation with IL-4 or IL-13. In mice, peritoneal M2 macrophages, elicited during infection with the parasites Taenia crassiceps or Trypanosoma br...
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PMID: 20375636
PDF is available here.
PDF is available here.
Tsitologiia (52)2 2010
Abstract
We studied in detail changes in cell population size and in the level of reactive oxygen species in the tumor growth zone and in the blood plasma of tumor carrier. It was found that reduction-oxidation conditions in the blood plasma and in the tumor growth zone were different. Thus, because of hyper...
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PMID: 20352695
PDF is available here.
PDF is available here.