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Osteoclasts (0):
Recent article
Osteoclasts
Abstract
We evaluated the effects of decreasing interleukin-6 (IL-6) production by tumor cells and TAMs in a mouse model of bone metastasis. Human PC-3MM2 cells that produce IL-6 were transfected with lentivirus containing IL-6 small hairpin RNA (shRNA) or nonspecific RNA and injected into the tibias of nude...
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PMID: 21251905
PDF is available here.
PDF is available here.
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Abstract
We evaluated the effects of decreasing interleukin-6 (IL-6) production by tumor cells and TAMs in a mouse model of bone metastasis. Human PC-3MM2 cells that produce IL-6 were transfected with lentivirus containing IL-6 small hairpin RNA (shRNA) or nonspecific RNA and injected into the tibias of nude...
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PMID: 21251905
PDF is available here.
PDF is available here.
MMW Fortschritte der Medizin (153)19 2011
Abstract
Abstract
We observed that in vitro osteoclastogenesis varies among healthy individuals and hypothesized that increased osteoclastogenesis could be a marker for the presence of RA. Our objective in the present study was to determine if in vitro osteoclastogenesis from peripheral blood mononuclear cells (PBMCs...
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PMID: 20959150
PDF is available here.
PDF is available here.
Abstract
These results suggest that a surface treatment with a nanotubular TiO2 surface enhances the early osteoblast responses, such as cell spreading and cytokine release, which are important for subsequent cell functions and bone healing in vivo....
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PMID: 21456297
PDF is available here.
PDF is available here.
Abstract
We have developed two methods to induce osteoclasts, the bone matrix remodeling cells, from murine ESCs. Surprisingly, one of these induction methods produces osteoclasts, osteoblasts, and also endothelial cells in the same culture dish. Hence, it is likely that ESCs in culture mimic the in vivo dev...
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PMID: 21042997
PDF is available here.
PDF is available here.
Abstract
We describe here methods for the identification of osteoclasts formed in vitro....
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PMID: 21042999
PDF is available here.
PDF is available here.
Abstract
Bisphosphonates, especially nitrogen-containing bisphosphonates (N-BPs), are widely used to preserve and improve bone health in patients with cancer because they inhibit osteoclast-mediated bone resorption. In addition to their effects on bone, preclinical evidence strongly suggests...
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PMID: 20655399
PDF is available here.
PDF is available here.
Abstract
We report here that although ATP6v0d2-deficient (ATP6v0d2 KO) mice exhibit an osteopetrotic phenotype due to inefficient osteoclast maturation, this deficiency fails to protect mice from ovariectomy (OVX)-induced bone loss, a model for post-menopause-associated osteoporosis. Moreover, we show that a...
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PMID: 21040703
PDF is available here.
PDF is available here.
Abstract
We identified a novel interaction in human osteoclast-like cells between SQSTM1 and Autophagy-Linked FYVE domain-containing protein (ALFY/WDFY3). Endogenous ALFY and SQSTM1 both localised within the nuclei of osteoclasts and their mononuclear precursors. When osteoclasts were starved to induce autop...
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PMID: 20971078
PDF is available here.
PDF is available here.
Abstract
We will briefly discuss the biological features of Tregs and summarize recent advances on the role of Tregs in the pathogenesis and treatment of bone loss in metabolic bone diseases.
Crown Copyright © 2010. Published by Elsevier Inc. All rights reserved....
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PMID: 20920469
PDF is available here.
PDF is available here.
Abstract
Osteoclasts are multinucleated cells that have a unique role in bone degradation. Modulation of osteoclast formation and/or its activity is an important approach for the treatment of bone-destructive diseases such as osteoporosis and rheumatoid arthritis. In this study, Gymnasterkore...
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PMID: 20831919
PDF is available here.
PDF is available here.
Abstract
We have recently developed biodegradable, biocompatible nanoparticles (NP) made of a conjugate between poly (D,L-lactide-co-glycolic) acid and alendronate, suitable for systemic administration, and directly targeting the site of tumor-induced osteolysis. Here, we loaded NP with doxorubicin (DXR), an...
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PMID: 20578992
PDF is available here.
PDF is available here.
Abstract
Evidence presented over the past 20 years has shown that long-chain polyunsaturated fatty acids (LCPUFAs), especially the n-3 fatty acids such as eicospentaenoic acid (EPA) and docosahexaenoic acid (DHA) are beneficial for bone health. Some studies in humans indicate that LCPUFAs can increase bone f...
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PMID: 20600307
PDF is available here.
PDF is available here.
Oral Diseases (16)7 2010
Abstract
Tooth extraction has been identified as an important risk factor for bisphosphonate-induced osteonecrosis of the jaw. Therefore, the main goal of this study was to determine the effects of alendronate on healing of the extraction socket and on interdental alveolar bone after tooth extraction in rats...
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PMID: 20846154
PDF is available here.
PDF is available here.
Abstract
We will briefly discuss the biological features of osteoporosis and summarize recent advances on the role of V-ATPase in the pathogenesis and treatment of osteoporosis....
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PMID: 20182803
PDF is available here.
PDF is available here.
Laboratory Investigation (90)10 2010
Abstract
We found that IP3R1 binds an endosomal isoform of the IP3R-associated cGMP-dependent kinase substrate (IRAG). IRAG is a substrate of cGMP-dependent kinase-1 (PKG1) and binds the PKG1 isoform PKG1β, which was the predominant form of PKG1 in human osteoclasts. Western blots of IRAG were consistent wi...
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PMID: 20567233
PDF is available here.
PDF is available here.
Clinical calcium (20)10 2010
Abstract
Bone resorption is regulated by various cytokines. In postmenopausal osteoporosis, bone loss due to estrogen deficiency is closely related to the production of bone-resorbing cytokine. Especially, the increased production of IL-1, IL-6 and TNF-α could induce the expression of RANKL in bone tissues...
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PMID: 20890027
PDF is available here.
PDF is available here.
Clinical calcium (20)10 2010
Abstract
Multiple myeloma develops and expands almost exclusively in the bone marrow, and generates devastating bone destruction. MM cells produce a variety of cytokines to stimulate bone resorption by enhancing osteoclast formation and suppress bone formation by inhibiting osteoblast differentiation, leadin...
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PMID: 20890028
PDF is available here.
PDF is available here.
Clinical calcium (20)10 2010
Abstract
Clinical calcium (20)10 2010
Abstract
We would like to show a brief review on a genetic disorder familial expansile osteolysis (FEO) , in which RANK gene mutation was identified, and other genetic disorders of the RANKL-RANK-OPG system....
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PMID: 20890036
PDF is available here.
PDF is available here.
Abstract
RANKL was expressed in all cases with a cytoplasmic staining pattern, whereas OPG expression was detected in 21 of the 22 cases examined. Active multinucleated giant cells exhibited intense immunoreactivity for both proteins.Conclusion: RANKL and OPG are expressed in peripheral giant cell granulomas...
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PMID: 20701665
PDF is available here.
PDF is available here.
Abstract
I describe the clinicopathologic findings for a 13-year-old adolescent boy with T7 spinal osteoblastoma and review salient clinical, radiographic, and pathologic features of osteoblastoma, as well as the differential diagnoses....
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PMID: 20923301
PDF is available here.
PDF is available here.
Abstract
We discuss how NFκB activation affects osteoblast function and bone formation. In particular, we describe how reduced NFκB activity in osteoblasts results in an increase in bone formation via enhanced c-Jun N-terminal kinase (JNK) activity, which regulates FOSL1 (also known as Fra1) expression. Fu...
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PMID: 20703218
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (325)1-2 2010
Abstract
Our findings point towards direct and indirect inhibitory effects of medicarpin on osteoclastogenesis in vitro that contribute to its bone sparing effect in OVx mice.
Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved....
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PMID: 20570709
PDF is available here.
PDF is available here.
Abstract
Developmental Biology (344)2 2010
Abstract
Bone development is dependent on the functionality of three essential cell types: chondrocytes, osteoclasts and osteoblasts. If any of these cell types is dysfunctional, a developmental bone phenotype can result. The bone disease osteopetrosis is caused by osteoclast dysfunction or impaired osteocla...
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PMID: 20599900
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)33 2010
Abstract
Physiological bone remodeling is a highly coordinated process responsible for bone resorption and formation and is necessary to repair damaged bone and to maintain mineral homeostasis. In addition to the traditional bone cells (osteoclasts, osteoblasts, and osteocytes) that are necessary for bone re...
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PMID: 20501658
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)33 2010
Abstract
We have shown that osteoblasts produce LPA, raising the possibility that it mediates intercellular signaling among osteoblasts and osteoclasts. Here we investigated the expression, signaling and function of LPA receptors in osteoclasts. Focal application of LPA elicited transient increases in cytoso...
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PMID: 20551326
PDF is available here.
PDF is available here.
Dental Materials Journal (29)4 2010
Abstract
These results suggest that CS-E structure on the surface of osteoblasts or bone matrix binds to cell adhesion molecule such as integrin on the pre-osteoclastic cells and inhibits the differentiation into osteoclasts. CS-E may have a potential in treating bone defect if combined with CaP materials....
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PMID: 20610874
PDF is available here.
PDF is available here.
Abstract
Tooth movement was found to be greater in Group 1 than in Group 2 for all time periods (on days 3, 7, and 14), although a significant difference was observed only on days 7 and 14 (p < 0.05). The number of osteoclasts was smaller in Group 1 than in Group 2, whereas the number of Howship's lacunae wa...
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PMID: 20618717
PDF is available here.
PDF is available here.
Abstract
An exquisite interplay of developmental cues, transcription factors, and coregulatory and signaling proteins support formation of skeletal elements of the jaw during embryogenesis and dynamic remodeling of alveolar bone in postnatal life. These molecules promote initial condensation of the mesenchym...
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PMID: 20713262
PDF is available here.
PDF is available here.
Abstract
This article reviews the principles of bone healing and bone grafting. There are many different ways to reach the same goal when bone grafting procedures are performed. With all of the available methods and materials, a clear understanding of these basic principles will assist in the selection of a...
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PMID: 20713263
PDF is available here.
PDF is available here.
Abstract
Expression of CB2 mRNA and protein was detected in hPDL cells. HU-308 enhanced the mRNA levels of the above osteogenic genes. Expression of the OPG gene was up-regulated, whereas RANKL gene expression was down-regulated, contributing to the elevated OPG/RANKL ratio. Accelerated mineralization was ob...
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PMID: 20412420
PDF is available here.
PDF is available here.
Abstract
Histologically, alveolar bone was gradually destroyed from day 3 to 11 and then stabilized. Collagen fibers were slightly dissociated on day 3 and extensively broken on day 7. They were reconstructed from day 11 to 21. EMMPRIN was localized predominantly in infiltrating cells and adjacent fibroblast...
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PMID: 20412416
PDF is available here.
PDF is available here.
Cellular Signalling (22)9 2010
Abstract
We used microarray analyses to examine gene expression profiles in the context of bone marrow-derived macrophages overexpressing a constitutively active form of NFATc1. Herein, we demonstrate that MHC class II transactivator (CIITA) is up-regulated downstream of NFATc1. Overexpression of CIITA in os...
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PMID: 20466061
PDF is available here.
PDF is available here.
Abstract
The aim of this study was to assess the effect of type 1 diabetes mellitus (DM) on the structure of mandibular bone and on the changes of alveolar/jaw bone formation. Experimental DM was induced in 3-wk-old male Wistar rats by a single dose of 60 mg/kg body weight of streptozotocin. All rats were in...
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PMID: 20662909
PDF is available here.
PDF is available here.
MyD88 expression in the rat dental follicle: implications for osteoclastogenesis and tooth eruption.
Abstract
Myeloid differentiation factor 88 (MyD88) is a key adaptor molecule in the interleukin (IL)-1 and IL-18 toll-like receptor signaling pathways. Because MyD88 is present in dental follicle (DF) cells in vitro, the purpose of this study was to determine its chronological expression in vivo, as well as...
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PMID: 20662905
PDF is available here.
PDF is available here.
Abstract
There is mounting evidence that innate and adaptive immunity are critical for periodontal disease-mediated bone resorption. These studies examined the role of B and CD4 T cells in adaptive immunity of rats infected with Aggregatibacter actinomycetemcomitans (Aa). Sprague-Dawley male...
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PMID: 20618701
PDF is available here.
PDF is available here.
Abstract
We studied 25 consecutive patients treated with bisphosphonates for osteoporosis or tumoral pathologies. We provide good evidence of hyperactive osteoclastic bone resorption and suggest a direct cytotoxic effect of bisphosphonates on bone tissue through induction of osteocyte cell death. We also dem...
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PMID: 20594040
PDF is available here.
PDF is available here.
Abstract
We targeted expression of ATF4 to the OCL lineage using the Trap promoter or through deletion of Atf4 in mice. OCL differentiation was drastically decreased in Atf4-/- bone marrow monocyte (BMM) cultures and bones. Coculture of Atf4-/- BMMs with WT OBLs or a high concentration of RANKL failed to res...
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PMID: 20628199
PDF is available here.
PDF is available here.
Journal of Immunology (185)2 2010
Abstract
We have investigated the cross talk between receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis and particle phagocytosis-induced activation of human monocytes. Understanding interconnected signals is of particular importance to disorders, such as periprosthetic osteolysis, in...
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PMID: 20543106
PDF is available here.
PDF is available here.
Abstract
Abstract
We found that EXD at a concentration of 50-200 microg/mL significantly enhanced osteoblastic UMR-106 cell proliferation, alkaline phosphatase (ALP) activity and formation of bone nodules, and decreased tartrate-resistant acid phosphatase (TRAP) activity and the bone resorption action of osteoclasts...
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PMID: 20657386
PDF is available here.
PDF is available here.
Abstract
We conclude that correcting vitamin D deficiency in older women suppresses the age-induced increase in bone turnover and reduces bone resorption which would normally be exacerbated in conditions of low serum 25(OH)D.
Copyright (c) 2010 Elsevier Ltd. All rights reserved....
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PMID: 20304051
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of vitamin D metabolism on osteoclastogenesis using both the murine RAW 264.7 cell line and the human peripheral blood mononuclear cell (PBMC) models. PBMC-derived osteoclasts expressed cytoplasmic cyp27b1 and nuclear vdr proteins. PBMC expressed CYP27B1 mRNA, levels of w...
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PMID: 20304055
PDF is available here.
PDF is available here.
Abstract
IL-6 is not a crucial regulator in an animal model of TNF-mediated bilateral, erosive sacroiliitis. This finding questions the potential of IL-6 blockade as a new treatment in patients with AS....
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PMID: 20498200
PDF is available here.
PDF is available here.
FASEB Journal (24)7 2010
Abstract
We determined whether A(1)R occupancy similarly promotes osteoclast function and formation. Bone marrow cells (BMCs) were harvested from C57Bl/6 female mice or A(1)R-knockout mice and their wild-type (WT) littermates and differentiated into osteoclasts in the presence of colony stimulating factor-1...
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PMID: 20181934
PDF is available here.
PDF is available here.
Abstract
We generated mice with an osteoclast-specific Ilk gene ablation by mating mice with a floxed Ilk allele with TRAP-Cre transgenic mice. The TRAP-Cre mice specifically excised floxed alleles in osteoclasts, as revealed by crossing them with the ROSA26R reporter strain. Osteoclast-specific Ilk mutant m...
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PMID: 20564195
PDF is available here.
PDF is available here.
British Journal of Cancer (103)1 2010
Abstract
Statistical analysis of the OS transcriptomes found differential expression of several metallothionein family members, as well as deregulation of genes involved in antigen presentation. Tumours also exhibited significantly increased expression of ID1 and profound down-regulation of S100A8, highlight...
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PMID: 20551950
PDF is available here.
PDF is available here.
Cancer Research (70)12 2010
Abstract
We evaluated the ability of GM-CSF to promote bone metastases of breast cancer or prostate cancer in a mouse model of chemotherapy-induced leukopenia. In this model, GM-CSF reversed cyclophosphamide-induced leukopenia but also promoted breast cancer and prostate cancer growth in the bone but not in...
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PMID: 20501834
PDF is available here.
PDF is available here.
Abstract
We review our current understanding of the mechanisms by which bisphosphonates inhibit osteoclast function, the current roles for these medications in clinical practice, and areas of concern that have emerged with widespread bisphosphonate use....
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PMID: 20539033
PDF is available here.
PDF is available here.
Abstract
We established an orthotropic implantation model using the murine OSCC cell line, SCCVII, showing direct invasion of the mandible by OSCC. Using this model, we examined the molecular mechanisms of bone invasion and the role of parathyroid-related protein (PTHrP). We established PTHrP, stable, knock-...
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PMID: 20428761
PDF is available here.
PDF is available here.
Medical Oncology (27)2 2010
Abstract
I collagen and increased RANKL/OPG (osteoprotegerin) ratio were detected in SCLC patients. Increased serum levels of OPG were observed in all lung cancer patients. OPG may be actively involved in the development of lung cancer metastasis. Furthermore, OC, OPN, and RANKL in NSCLC and CTX and RANKL in...
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PMID: 19373566
PDF is available here.
PDF is available here.
Abstract
We should look for a biological more than for a mechanical cause. Probably a vascular non-traumatic process, with a minor infarction pattern in the proximal subchondral area, is nearest to the truth. Bone remodelling results from bone resorption by osteoclasts and the formation of new bone by osteob...
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PMID: 20552544
PDF is available here.
PDF is available here.
Abstract
To date, over 2 million patients worldwide have been treated with anti-tumor necrosis factor (TNF) therapies, dramatically improving the treatment outcomes of immune-mediated inflammatory diseases (IMID). Observations from clinicians have identified some curious disconnects between c...
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PMID: 20436165
PDF is available here.
PDF is available here.
Abstract
Distraction osteogenesis is a fundamental pillar for craniomaxillofacial reconstruction processes. Nonetheless, although the clinical, biomechanical, and histologic changes associated with distraction osteogenesis have been widely described, this is not the case with the molecular mechanisms that re...
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PMID: 20163972
PDF is available here.
PDF is available here.
Anticancer Research (30)5 2010
Abstract
The GC of all lesions were immunoreactive for CD68 and CD51. Factors indicating the differentiation and activation of osteoclasts were detected in all lesions (RANK, M-CSF, cathepsin K, MMP9). The expression profile of M-CSF in GC and stroma cells was of a medium grade in cases with no apparent dest...
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PMID: 20592356
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of saturated fatty acids (SFA) on osteoclastogenesis. The level of free fatty acids and adiposity in bone marrow was significantly elevated in obese mice. SFA increased osteoclast (OC) survival by preventing apoptosis. SFA caused the production of MIP-1alpha and led to act...
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PMID: 20388920
PDF is available here.
PDF is available here.
Matrix Biology (29)4 2010
Abstract
We show here that NBCn1, encoded by the SLC4A7 gene, is directly involved in bone resorption. NBCn1 protein was specifically found at the bone-facing ruffled border areas, and metabolic acidosis increased NBCn1 expression in rats in vivo. In human hematopoietic stem cell cultures, NBCn1 mRNA express...
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PMID: 20079835
PDF is available here.
PDF is available here.