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Epithelial Cells (33):
  • Somatotrophs
  • Luteal Cells
  • Labyrinth Supporting Cells
  • Melanocytes
  • Lactotrophs
  • Thyrotrophs
  • Neuroepithelial Cells
  • CHO Cells
  • Leydig Cells
  • Keratinocytes
  • Ameloblasts
  • Merkel Cells
  • Hela Cells
  • Enterocytes
  • Endothelial Cells
  • Dendritic Cells
  • Chromatophores
  • Parietal Cells, Gastric
  • Melanotrophs
  • Granulosa Cells
  • Goblet Cells
  • Enteroendocrine Cells
  • Caco-2 Cells
  • Paneth Cells
  • HT29 Cells
  • Chief Cells, Gastric
  • Podocytes
  • Hepatocytes
  • Gonadotrophs
  • Corticotrophs
  • LLC-PK1 Cells
  • Vero Cells
  • Sertoli Cells
Home > Cells > Epithelial Cells

Recent article

Epithelial Cells

Transplantation (92)9 2011
Epithelial phenotypic changes detect cyclosporine in vivo nephrotoxicity at a reversible stage.
Pierre Galichon, Nathalie Vittoz, Yi-Chun Xu-Dubois, Emilie Cornaire, Sophie Vandermeersch, Laurent Mesnard, Alexandre Hertig and Eric Rondeau
Abstract
We hypothesized that CsA is able to trigger these EPCs in tubular cells in vivo. We studied the kinetics of the EMT markers β-catenin, snail, vimentin, collagen III, and HSP47 at the messenger RNA and protein levels in the kidneys from rats injected with 15 mg/kg/day of CsA or its v... | PMID: 21909056

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Transplantation (92)9 2011
Epithelial phenotypic changes detect cyclosporine in vivo nephrotoxicity at a reversible stage.
Pierre Galichon, Nathalie Vittoz, Yi-Chun Xu-Dubois, Emilie Cornaire, Sophie Vandermeersch, Laurent Mesnard, Alexandre Hertig and Eric Rondeau
Abstract
We hypothesized that CsA is able to trigger these EPCs in tubular cells in vivo. We studied the kinetics of the EMT markers β-catenin, snail, vimentin, collagen III, and HSP47 at the messenger RNA and protein levels in the kidneys from rats injected with 15 mg/kg/day of CsA or its v... | PMID: 21909056

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Transplantation (92)9 2011
Epithelial phenotypic changes detect cyclosporine in vivo nephrotoxicity at a reversible stage.
Pierre Galichon, Nathalie Vittoz, Yi-Chun Xu-Dubois, Emilie Cornaire, Sophie Vandermeersch, Laurent Mesnard, Alexandre Hertig and Eric Rondeau
Abstract
We hypothesized that CsA is able to trigger these EPCs in tubular cells in vivo. We studied the kinetics of the EMT markers β-catenin, snail, vimentin, collagen III, and HSP47 at the messenger RNA and protein levels in the kidneys from rats injected with 15 mg/kg/day of CsA or its v... | PMID: 21909056

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Cellular and Molecular Life Sciences (68)22 2011
Establishment of intestinal homeostasis during the neonatal period.
Silvia Stockinger, Mathias W Hornef and Cécilia Chassin
Abstract
We summarize the current knowledge on the mechanisms underlying the transition of the intestinal mucosa during the neonatal period leading to the establishment of a stable, life-long host-microbial homeostasis. The environmental exposure and microbial colonization during the neonatal period, and als... | PMID: 21952827

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Human Molecular Genetics (20)21 2011
Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs.
Binghua Li, Alysha A Rauhauser, Julie Dai, Ramanavelan Sakthivel, Peter Igarashi, Anton M Jetten and Massimo Attanasio
Abstract
We previously found that loss-of-function mutations in the transcription factor GLIS2, a putative vertebrate ortholog of Drosophila Ci, cause nephronophthisis type 7 in humans and mice. Kidney tubular cells in Glis2-knockout mice acquire mesenchymal phenotype, but the cellular mechanisms of this tra... | PMID: 21816948

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Stem Cells and Development (20)10 2011
Adipose-derived stem cells and their potential to differentiate into the epithelial lineage.
Patrick C Baer
Abstract
Adipose-derived stem cells (ASCs) possess a multilineage differentiation potential, can be used from an autologous origin, and are, therefore, attractive candidates for clinical applications to repair or regenerate damaged tissues and organs. Adipose tissue as a stem cell source is u... | PMID: 21495915

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Stem Cells and Development (20)10 2011
Adipose-derived stem cells and their potential to differentiate into the epithelial lineage.
Patrick C Baer
Abstract
Adipose-derived stem cells (ASCs) possess a multilineage differentiation potential, can be used from an autologous origin, and are, therefore, attractive candidates for clinical applications to repair or regenerate damaged tissues and organs. Adipose tissue as a stem cell source is u... | PMID: 21495915

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Stem Cells and Development (20)10 2011
Adipose-derived stem cells and their potential to differentiate into the epithelial lineage.
Patrick C Baer
Abstract
Adipose-derived stem cells (ASCs) possess a multilineage differentiation potential, can be used from an autologous origin, and are, therefore, attractive candidates for clinical applications to repair or regenerate damaged tissues and organs. Adipose tissue as a stem cell source is u... | PMID: 21495915

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The American Journal of Surgical Pathology (35)9 2011
Diffuse expression of PAX2 and PAX8 in the cystic epithelium of mixed epithelial stromal tumor, angiomyolipoma with epithelial cysts, and primary renal synovial sarcoma: evidence supporting renal tubular differentiation.
Matthew Karafin, Anil V Parwani, Georges J Netto, Peter B Illei, Jonathan I Epstein, Marc Ladanyi and Pedram Argani
Abstract
We performed PAX2 and PAX8 immunohistochemistry on representative sections of cases of AMLEC (8 cases), MEST (8 cases), and renal SS (3 cases). The relative percentage and intensity (none, weak, moderate, and strong) of nuclear labeling were evaluated in both the benign adjacent renal tubules and th... | PMID: 21836481

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Anaesthesia and Intensive Care (39)5 2011
Cerebrospinal fluid cytology in patients undergoing combined spinal epidural versus spinal anaesthesia without an introducer.
B B Sharma, S S Gupta, N N Jain, A A Handoo and J J Sood
Abstract
I to III undergoing infra-umbilical surgery were enrolled. Seven patients were excluded from the study and the rest divided into two groups to receive either combined spinal epidural anaesthesia (group A) or isolated subarachnoid anaesthesia, unaided by an introducer (group B). The two groups were c... | PMID: 21970139

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Journal of Infectious Diseases (204)6 2011
Altered pathogenicity for seasonal influenza virus by single reassortment of the RNP genes derived from the 2009 pandemic influenza virus.
Erh-Fang Hsieh, Sue-Jane Lin, Chee-Keng Mok, Guang-Wu Chen, Chih-Heng Huang, Yeau-Ching Wang, Tzu-Chun Chen, Chi-Jene Chen, David M Ojcius and Shin-Ru Shih
Abstract
We consistently observed that the PA gene of H1N1(pdm) results in increased polymerase activity, better replication in mice, and lower LD₅₀. Our findings suggest that monitoring of gene reassortment for the 2009 pandemic influenza and seasonal human viruses is also important, which would help to... | PMID: 21849283

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Journal of Urology (186)3 2011
Oxalate impairs aminophospholipid translocase activity in renal epithelial cells via oxidative stress: implications for calcium oxalate urolithiasis.
Shi-Liang Yu, Xiu-Guo Gan, Jin-Ming Huang, Yan Cao, Yong-Quan Wang, Shang-Ha Pan, Li-Yan Ma, Yue-Qiu Teng and Rui-Hua An
Abstract
We evaluated the possible involvement of phospholipid transporters and reactive oxygen species in the oxalate induced redistribution of renal epithelial cell phosphatidylserine. Madin-Darby canine kidney cells were labeled with the fluorescent phospholipid NBD-PS in the inner or oute... | PMID: 21784463

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Journal of Urology (186)3 2011
Oxalate impairs aminophospholipid translocase activity in renal epithelial cells via oxidative stress: implications for calcium oxalate urolithiasis.
Shi-Liang Yu, Xiu-Guo Gan, Jin-Ming Huang, Yan Cao, Yong-Quan Wang, Shang-Ha Pan, Li-Yan Ma, Yue-Qiu Teng and Rui-Hua An
Abstract
We evaluated the possible involvement of phospholipid transporters and reactive oxygen species in the oxalate induced redistribution of renal epithelial cell phosphatidylserine. Madin-Darby canine kidney cells were labeled with the fluorescent phospholipid NBD-PS in the inner or oute... | PMID: 21784463

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Journal of Urology (186)3 2011
Oxalate impairs aminophospholipid translocase activity in renal epithelial cells via oxidative stress: implications for calcium oxalate urolithiasis.
Shi-Liang Yu, Xiu-Guo Gan, Jin-Ming Huang, Yan Cao, Yong-Quan Wang, Shang-Ha Pan, Li-Yan Ma, Yue-Qiu Teng and Rui-Hua An
Abstract
We evaluated the possible involvement of phospholipid transporters and reactive oxygen species in the oxalate induced redistribution of renal epithelial cell phosphatidylserine. Madin-Darby canine kidney cells were labeled with the fluorescent phospholipid NBD-PS in the inner or oute... | PMID: 21784463

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Stem Cells and Development (20)9 2011
Human amniotic fluid promotes retinal pigmented epithelial cells' trans-differentiation into rod photoreceptors and retinal ganglion cells.
Shima Ghaderi, Zahra-Soheila Soheili, Hamid Ahmadieh, Maliheh Davari, Fatemeh Sanie Jahromi, Shahram Samie, Mozhgan Rezaie-Kanavi, Jalil Pakravesh and Abdolkhalegh Deezagi
Abstract
To evaluate the effect of human amniotic fluid (HAF) on retinal pigmented epithelial cells growth and trans-differentiation into retinal neurons, retinal pigmented epithelium (RPE) cells were isolated from neonatal human cadaver eye globes and cultured in Dulbecco's modified Eagle's... | PMID: 21142973

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Tissue Engineering, Part A: Tissue Engineering (17)13-14 2011
A multicellular approach forms a significant amount of tissue-engineered small intestine in the mouse.
Frédéric G Sala, Jamil A Matthews, Allison L Speer, Yasuhiro Torashima, Erik R Barthel and Tracy C Grikscheit
Abstract
We transitioned the technique to a mouse model, allowing investigation of the processes involved during TESI formation through the transgenic tools available in this species. This is a necessary step toward applying the technique to human therapy. Multicellular organoid units were derived from small... | PMID: 21395443

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Nature (474)7349 2011
Immunology: In command of commensals.
Menno van Lookeren Campagne and Vishva M Dixit
Abstract
PMID: 21637249

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Journal of Immunotoxicology (8)2 2011
Sulforaphane inhibits de novo synthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract.
Warren Starrett and David J Blake
Abstract
We hypothesized that activating NRF2-dependent cytoprotective gene expression with sulforaphane (SFN) affords protection against CS-induced lung damage by inhibiting chemokine production. Results indicate that in the human BEAS-2B epithelial cell line, 5 μM SFN activated NRF2-dependent gene express... | PMID: 21401388

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Proteomics (11)12 2011
Proteome profiling reveals potential toxicity and detoxification pathways following exposure of BEAS-2B cells to engineered nanoparticle titanium dioxide.
Yue Ge, Maribel Bruno, Kathleen Wallace, Witold Winnik and Raju Y Prasad
Abstract
We identified 46 proteins that were altered at protein expression levels. The protein changes detected by 2-DE/MS were verified by functional protein assays. These identified proteins include some key proteins involved in cellular stress response, metabolism, adhesion, cytoskeletal dynamics, cell gr... | PMID: 21595037

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RNA (54)11 2011
Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus.
Amanda L AL Garner, Christian C Gloeckner, Nancy N Tricoche, Joseph S JS Zakhari, Moses M Samje, Fidelis F Cho-Ngwa, Sara S Lustigman and Kim D KD Janda
Abstract
We have disclosed evidence that the larval-stage-specific chitinase, OvCHT1, may be a potential biological target for affecting nematode development. On the basis of screening efforts, closantel, a known anthelmintic drug, was discovered as a potent and highly specific OvCHT1 inhibitor. Originally,... | PMID: 21534605

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Kidney International (79)9 2011
Bardet-Biedl syndrome highlights the major role of the primary cilium in efficient water reabsorption.
Vincent Marion, Dominique Schlicht, Anaïs Mockel, Sophie Caillard, Olivier Imhoff, Corinne Stoetzel, Paul van Dijk, Christian Brandt, Bruno Moulin and Hélène Dollfus
Abstract
We studied a cohort of patients with BBS where we found that these patients had a urinary concentration defect even when kidney function was near normal and in the absence of major cyst formation. Subsequent in vitro analysis showed that renal cells in which a BBS gene was knocked down were unciliat... | PMID: 21270763

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Kidney International (79)9 2011
Bardet-Biedl syndrome highlights the major role of the primary cilium in efficient water reabsorption.
Vincent Marion, Dominique Schlicht, Anaïs Mockel, Sophie Caillard, Olivier Imhoff, Corinne Stoetzel, Paul van Dijk, Christian Brandt, Bruno Moulin and Hélène Dollfus
Abstract
We studied a cohort of patients with BBS where we found that these patients had a urinary concentration defect even when kidney function was near normal and in the absence of major cyst formation. Subsequent in vitro analysis showed that renal cells in which a BBS gene was knocked down were unciliat... | PMID: 21270763

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Kidney International (79)9 2011
Bardet-Biedl syndrome highlights the major role of the primary cilium in efficient water reabsorption.
Vincent Marion, Dominique Schlicht, Anaïs Mockel, Sophie Caillard, Olivier Imhoff, Corinne Stoetzel, Paul van Dijk, Christian Brandt, Bruno Moulin and Hélène Dollfus
Abstract
We studied a cohort of patients with BBS where we found that these patients had a urinary concentration defect even when kidney function was near normal and in the absence of major cyst formation. Subsequent in vitro analysis showed that renal cells in which a BBS gene was knocked down were unciliat... | PMID: 21270763

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European Journal of Pharmaceutics and Biopharmaceutics (77)3 2011
Nanoparticles attenuate P-glycoprotein/MDR1 function in A549 human alveolar epithelial cells.
Johanna J Salomon and Carsten Ehrhardt
Abstract
We aimed to investigate how far nanoparticulates impair the function of the P-gp transport system and which particle properties govern these interactions. Expression and function of P-gp was confirmed in A549 cell monolayers. Rhodamine 123 (Rh123) release studies were carried out in the presence of... | PMID: 21093586

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Nature Immunology (12)4 2011
Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β.
Joanne E Konkel, Takashi Maruyama, Andrea C Carpenter, Yumei Xiong, Brian F Zamarron, Bradford E Hall, Ashok B Kulkarni, Pin Zhang, Remy Bosselut and WanJun Chen
Abstract
We show that transforming growth factor-β (TGF-β) controls the development of TCRαβ+CD8αα+ IELs. Mice with either a null mutation in the gene encoding TGF-β1 or T cell-specific deletion of TGF-β receptor I lacked TCRαβ+CD8αα+ IELs, whereas mice with transgenic overexpression of TGF-β1 h... | PMID: 21297643

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Journal Of Tissue Engineering And Regenerative Medicine (5)4 2011
Preparation of keratinocyte culture medium for the clinical applications of regenerative medicine.
Ryo Takagi, Masayuki Yamato, Daisuke Murakami, Makoto Kondo, Joseph Yang, Takeshi Ohki, Kohji Nishida, Chinatsu Kohno and Teruo Okano
Abstract
Keratinocyte culture medium (KCM) has been used for the in vitro culture of keratinocytes and other types of epithelial cells, and the medium includes various ingredients. In this study, two modified KCMs were prepared. In the first, insulin, hydrocortisone and antibiotics that are n... | PMID: 20740688

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Kidney International (79)5 2011
Origin of new cells in the adult kidney: results from genetic labeling techniques.
Jeremy S Duffield and Benjamin D Humphreys
Abstract
For nearly 100 years, developmental biologists have utilized fate mapping to understand the contributions of progenitor populations to organogenesis. More recently, Cre-Lox technology has allowed genetic fate mapping in adult mice, clarifying cell hierarchies in adult kidney disease... | PMID: 20861816

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Kidney International (79)5 2011
Origin of new cells in the adult kidney: results from genetic labeling techniques.
Jeremy S Duffield and Benjamin D Humphreys
Abstract
For nearly 100 years, developmental biologists have utilized fate mapping to understand the contributions of progenitor populations to organogenesis. More recently, Cre-Lox technology has allowed genetic fate mapping in adult mice, clarifying cell hierarchies in adult kidney disease... | PMID: 20861816

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Autoimmunity Reviews (10)5 2011
Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy.
Jun Wei, Swati Bhattacharyya, Warren G Tourtellotte and John Varga
Abstract
I interferon, type 2 immune responses and mechanical stress as extracellular cues that modulate fibroblast function and differentiation, and as potential targets for therapy. Moreover, fibrillin-1 has a major role in storing and regulating the bioavailability of TGF-ß and other cytokines, and fibri... | PMID: 20863909

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Infection, Genetics and Evolution (11)2 2011
Identification of Corynebacterium diphtheriae gene involved in adherence to epithelial cells.
Valentina Kolodkina, Tatyana Denisevich and Leonid Titov
Abstract
We describe a novel gene involved in adherence to epithelial cells. Transformation of C. diphtheriae 225, biotype gravis, ribotype St-Petersburg by EZ:TN(KAN-2)Tnp Transposome was undertaken. A C. diphtheriae 225 Tn5 insertion library of 2800 mutants was created. Five hundred and eighty five transfo... | PMID: 21111065

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Mucosal Immunology (4)2 2011
Reactive oxygen species mediate inflammatory cytokine release and EGFR-dependent mucin secretion in airway epithelial cells exposed to Pseudomonas pyocyanin.
B Rada, P Gardina, T G Myers and T L Leto
Abstract
We find that exposure of bronchiolar epithelial cells to pyocyanin results in MUC2/MUC5AC induction and mucin secretion through release of inflammatory cytokines and growth factors (interleukin (IL)-1β, IL-6, heparin-bound epidermal growth factor, tissue growth factor-α, tumor necrosis factor-α)... | PMID: 20962773

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Disease Models & Mechanisms (4)2 2011
MMP9 is protective against lethal inflammatory mass lesions in the mouse colon.
Andreas Hald, Birgitte Rønø, Maria C Melander, Ming Ding, Susanne Holck and Leif R Lund
Abstract
We here present genetic data showing that concomitant ablation of MMP9 (gelatinase B) and the serine protease plasmin results in lethal inflammatory mass lesions in the colon. These lesions possessed several histological attributes that are characteristic of mucosal prolapse seen in humans, and they... | PMID: 21123624

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RNA (13)6 2011
HIV-1 does not significantly influence Chlamydia trachomatis serovar L2 replication in vitro.
Andrew A Broadbent, Patrick P Horner, Gillian G Wills, Alexandra A Ling, Raffaella R Carzaniga and Myra M McClure
Abstract
We tested this by characterising for the first time in vitro C. trachomatis L2 replication in the presence of HIV-1. The human epithelial cell-line, MAGI P4R5 was infected with C. trachomatis L2 and HIV-1 (MN strain). Co-infected cultures contained fewer and larger chlamydial inclusions, but the inc... | PMID: 21315827

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Journal Of Tissue Engineering And Regenerative Medicine (5)2 2011
Carrier-free epithelial cell sheets prepared by enzymatic degradation of collagen gel.
Qicheng Ke, Xiaoran Wang, Qianying Gao, Zheng Wu, Pengxia Wan, Weijiao Zhan, Jian Ge and Zhichong Wang
Abstract
We developed a novel method for preparing carrier-free epithelial cell sheets, which have potential for use in repairing defects of the ocular surface. Stratified corneal epithelial cell sheets were prepared in culture dishes coated with biodegradable type I collagen. Haematoxylin and eosin staining... | PMID: 20603893

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Current Opinion in Allergy and Clinical Immunology (11)1 2011
The crucial role of dendritic cells in rhinitis.
Alex KleinJan
Abstract
Dendritic cells generally play an important role as sentinels in the immune system. They are also very important in protecting the airways from invading pathogens and harmful particles and antigens. This review discusses current knowledge about dendritic cell function and the interac... | PMID: 21150432

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Audio, Transactions of the IRE Professional Group on (6)3 2011
Depletion of murine intestinal microbiota: effects on gut mucosa and epithelial gene expression.
Dag Henrik DH Reikvam, Alexander A Erofeev, Anders A Sandvik, Vedrana V Grcic, Frode Lars FL Jahnsen, Peter P Gaustad, Kathy D KD McCoy, Andrew J AJ Macpherson, Leonardo A LA Meza-Zepeda and Finn-Eirik FE Johansen
Abstract
We aimed at refining a protocol that in a robust manner would deplete the cultivable intestinal microbiota of conventionally raised mice and that would prove to have significant biologic validity. Previously published protocols for depleting mice of their intestinal microbiota by adm... | PMID: 21445311

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Audio, Transactions of the IRE Professional Group on (6)4 2011
Regulated expression of ADAMTS-12 in human trophoblastic cells: a role for ADAMTS-12 in epithelial cell invasion?
Alexander G AG Beristain, Hua H Zhu and Peter C K PC Leung
Abstract
We have examined the function and regulation of members of this gene family in epithelial cell invasion using cultures of highly invasive extravillous cytotrophoblasts and the poorly invasive JEG-3 cytotrophoblast cell line as model systems. Of the multiple ADAMTS subtypes identified in first trimes... | PMID: 21494557

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Voprosy Virusologii (56)1 2011
[Effect of Zanamivir substance on infection induced by highly pathogenic avian influenza A/H5N1 in cell cultures].
P G PG Deriabin, G A GA Galegov, A G AG Botikov, E I EI Burtseva, D V DV Mishin and M Iu MIu Shchelkanov
Abstract
In vitro experiments revealed that Zanamivir substance had high antiviral activity against infection induced by genotypes 2.2 and 2.3.2 of highly virulent influenza A/H5N1 virus in the porcine embryonic renal epithelial (PERE) cell cultures. Zanamivir at used concentrations (1.0 microg/ml or lower) h... | PMID: 21427950

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Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie (52)1 2011
Myofibroblast involvement in tubular basement membrane remodeling in type II diabetic nephropathy.
E Mandache, Mihaela Gherghiceanu, C Serafinceanu, M Penescu and G Mircescu
Abstract
Diabetic nephropathy is always accompanied by tubulointerstitial damage. The mechanisms and the cells involved are not entirely clarified. The damaged tubules may regenerate or undergo necrosis or apoptosis. The purpose of this work was to investigate the structural transformations o... | PMID: 21424035

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Contributions to Nephrology (169) 2011
Pathogenesis of tubular interstitial nephritis.
Tetsuhiro Tanaka and Masaomi Nangaku
Abstract
Injury to the interstitium of the kidney is regarded as a common pathway leading to end-stage renal insufficiency, regardless of etiology. Tubular interstitial nephritis is characterized histologically by inflammatory changes in the tubulointerstitial compartment, such as interstitia... | PMID: 21252528

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Contributions to Nephrology (169) 2011
Pathogenesis of tubular interstitial nephritis.
Tetsuhiro Tanaka and Masaomi Nangaku
Abstract
Injury to the interstitium of the kidney is regarded as a common pathway leading to end-stage renal insufficiency, regardless of etiology. Tubular interstitial nephritis is characterized histologically by inflammatory changes in the tubulointerstitial compartment, such as interstitia... | PMID: 21252528

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Contributions to Nephrology (169) 2011
Pathogenesis of tubular interstitial nephritis.
Tetsuhiro Tanaka and Masaomi Nangaku
Abstract
Injury to the interstitium of the kidney is regarded as a common pathway leading to end-stage renal insufficiency, regardless of etiology. Tubular interstitial nephritis is characterized histologically by inflammatory changes in the tubulointerstitial compartment, such as interstitia... | PMID: 21252528

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Contributions to Nephrology (169) 2011
Parietal epithelial cells: their role in health and disease.
Paola Romagnani
Abstract
Parietal epithelial cells of Bowman's capsules were first described by Sir William Bowman in 1842 in his paper On the Structure and Use of the Malpighian Bodies of the Kidney [London, Taylor, 1842], but since then their functions have remained poorly understood. A large body of evide... | PMID: 21252509

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Contributions to Nephrology (169) 2011
Parietal epithelial cells: their role in health and disease.
Paola Romagnani
Abstract
Parietal epithelial cells of Bowman's capsules were first described by Sir William Bowman in 1842 in his paper On the Structure and Use of the Malpighian Bodies of the Kidney [London, Taylor, 1842], but since then their functions have remained poorly understood. A large body of evide... | PMID: 21252509

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Contributions to Nephrology (169) 2011
Parietal epithelial cells: their role in health and disease.
Paola Romagnani
Abstract
Parietal epithelial cells of Bowman's capsules were first described by Sir William Bowman in 1842 in his paper On the Structure and Use of the Malpighian Bodies of the Kidney [London, Taylor, 1842], but since then their functions have remained poorly understood. A large body of evide... | PMID: 21252509

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PLoS ONE (6)3 2011
Oligosaccharide binding proteins from Bifidobacterium longum subsp. infantis reveal a preference for host glycans.
Daniel Garrido, Jae Han Kim, J Bruce German, Helen E Raybould and David A Mills
Abstract
We have used the Mammalian Glycan Array to determine the specific affinities of these proteins. This was correlated with binding protein expression induced by different prebiotics including HMO. Half of the F1SBPs in B. infantis were determined to bind mammalian oligosaccharides. Their affinities in... | PMID: 21423604

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Virulence (2)2 2011
Differential recognition of viral RNA by RIG-I.
Alina Baum and Adolfo García-Sastre
Abstract
We were able to identify viral RNA molecules which specifically associated with RIG-I during infection. We showed that in Sendai virus infected cells, RIG-I specifically and preferentially associated with the copy-back defective interfering (DI) particle RNA and not with the full-length Sendai virus... | PMID: 21422808

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PLoS ONE (6)6 2011
Role and mechanism of arsenic in regulating angiogenesis.
Ling-Zhi Liu, Yue Jiang, Richard L Carpenter, Yi Jing, Stephen C Peiper and Bing-Hua Jiang
Abstract
We show that short time exposure of arsenic induces angiogenesis in both human immortalized lung epithelial cells BEAS-2B and adenocarcinoma cells A549. To study the molecular mechanism of arsenic-inducing angiogenesis, we find that arsenic induces reactive oxygen species (ROS) generation, which act... | PMID: 21687637

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Innate Immunity (17)3 2011
Three-dimensional spheroid cultures of A549 and HepG2 cells exhibit different lipopolysaccharide (LPS) receptor expression and LPS-induced cytokine response compared with monolayer cultures.
Jian Liu, Wondwossen Abate, Jinsheng Xu, David Corry, Baksho Kaul and Simon K Jackson
Abstract
We have developed three-dimensional (3-D) cell cultures (spheroids) that are more representative of in vivo conditions than traditional monolayer cultures and may provide novel in vitro models to study the inflammatory response. In this work, we have compared F-actin organization, LPS-induced pro-in... | PMID: 20418262

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Tissue Engineering, Part A: Tissue Engineering (17)1-2 2011
Guiding epithelial cell phenotypes with engineered integrin-specific recombinant fibronectin fragments.
Ashley C Brown, Jessica A Rowe and Thomas H Barker
Abstract
We hypothesized that the Fn synergy site is critical to the regulation of epithelial cell phenotype by directing integrin specificity. Epithelial cells were cultured on Fn fragments displaying stabilized synergy and RGD (FnIII9'10), or RGD alone (FnIII10) and cell phenotype analyzed by cytoskeleton... | PMID: 20695776

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Tissue Engineering, Part A: Tissue Engineering (17)1-2 2011
Isolation and characterization of multi-potent stem cells from human orbital fat tissues.
Jennifer Hui-Chun Ho, Wei-Hsien Ma, Tzu-Ching Tseng, Yu-Fan Chen, Ming-Hsiang Chen and Oscar Kuang-Sheng Lee
Abstract
We further found that direct contact with corneal epithelial cells was essential for OFSCs to commit to corneal epithelial cells. Taken together, orbital fat tissues are a novel source for multi-potent stem cells that possess the potential to differentiate into corneal epithelial lineage. OFSCs are... | PMID: 20726817

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Cell Adhesion & Migration (5)2 2011
Formation of microvilli and phosphorylation of ERM family proteins by CD43, a potent inhibitor for cell adhesion: cell detachment is a potential cue for ERM phosphorylation and organization of cell morphology.
Junko Yamane, Hiroe Ohnishi, Hiroyuki Sasaki, Hisashi Narimatsu, Hajime Ohgushi and Kouichi Tachibana
Abstract
We found expression of CD43 induced cell rounding, inhibition of cell re-attachment, augmentation of microvilli, and phosphorylation of ERM in HEK293T cells. Mutant studies revealed the ectodomain of CD43, but not the intracellular domain, essential and sufficient for all these phenomena. We also fo... | PMID: 21045567

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PLoS ONE (6)6 2011
A fast and accessible methodology for micro-patterning cells on standard culture substrates using Parafilm™ inserts.
Sahar Javaherian, Kylie A O'Donnell and Alison P McGuigan
Abstract
We present a simple, cheap, and fast method to micropattern mammalian cells into stripes and circular patterns using Parafilm™, a common material found in most biology and bioengineering laboratories. Our method does not require any specialized equipment and does not require significant method opt... | PMID: 21687691

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Clinical and Vaccine Immunology (18)1 2011
Synthetic double-stranded RNA stimulates the expression of interferon-inducible protein 10 in human mesothelial cells.
Monika Merkle, Matthias Sauter, Andrea Ribeiro, Thomas Mussack, Roland Ladurner, Thomas Sitter and Markus Wörnle
Abstract
Interferon-inducible protein 10 (IP-10) is a chemokine playing an important role in the restriction of viral spread. A time- and dose-dependent increase in IP-10 is found upon activation of viral receptors expressed on mesothelial cells, which provides novel evidence for a link betwe... | PMID: 21106778

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Nephron Experimental Nephrology (117)4 2011
Proinflammatory/profibrotic effects of interleukin-17A on human proximal tubule epithelium.
Paul L Dudas, Sarah L Sague, M Merle Elloso and Francis X Farrell
Abstract
Interleukin-17A (IL-17A) is a T cell-derived inflammatory cytokine that is upregulated during renal allograft rejection. The present study sought to further describe the IL-17A-mediated proinflammatory/profibrotic activity of proximal tubule epithelium that may contribute to allograf... | PMID: 20924205

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Nephron Experimental Nephrology (117)4 2011
Proinflammatory/profibrotic effects of interleukin-17A on human proximal tubule epithelium.
Paul L Dudas, Sarah L Sague, M Merle Elloso and Francis X Farrell
Abstract
Interleukin-17A (IL-17A) is a T cell-derived inflammatory cytokine that is upregulated during renal allograft rejection. The present study sought to further describe the IL-17A-mediated proinflammatory/profibrotic activity of proximal tubule epithelium that may contribute to allograf... | PMID: 20924205

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Nephron Experimental Nephrology (117)4 2011
Proinflammatory/profibrotic effects of interleukin-17A on human proximal tubule epithelium.
Paul L Dudas, Sarah L Sague, M Merle Elloso and Francis X Farrell
Abstract
Interleukin-17A (IL-17A) is a T cell-derived inflammatory cytokine that is upregulated during renal allograft rejection. The present study sought to further describe the IL-17A-mediated proinflammatory/profibrotic activity of proximal tubule epithelium that may contribute to allograf... | PMID: 20924205

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Molecular BioSystems (7)1 2011
Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system.
James Keith Ellis, Toby James Athersuch, Rachel Cavill, Robert Radford, Craig Slattery, Paul Jennings, Tara McMorrow, Michael P Ryan, Timothy Mark David Ebbels and Hector Charles Keun
Abstract
We have used an NMR-based metabolic profiling approach to characterise for the first time the metabolome of the RPTEC/TERT1 cell line, an immortalised non-tumour human renal epithelial cell line that recapitulates phenotypic characteristics that are absent in other in vitro renal cell models. RPTEC/... | PMID: 21103459

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Molecular BioSystems (7)1 2011
Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system.
James Keith Ellis, Toby James Athersuch, Rachel Cavill, Robert Radford, Craig Slattery, Paul Jennings, Tara McMorrow, Michael P Ryan, Timothy Mark David Ebbels and Hector Charles Keun
Abstract
We have used an NMR-based metabolic profiling approach to characterise for the first time the metabolome of the RPTEC/TERT1 cell line, an immortalised non-tumour human renal epithelial cell line that recapitulates phenotypic characteristics that are absent in other in vitro renal cell models. RPTEC/... | PMID: 21103459

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Molecular BioSystems (7)1 2011
Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system.
James Keith Ellis, Toby James Athersuch, Rachel Cavill, Robert Radford, Craig Slattery, Paul Jennings, Tara McMorrow, Michael P Ryan, Timothy Mark David Ebbels and Hector Charles Keun
Abstract
We have used an NMR-based metabolic profiling approach to characterise for the first time the metabolome of the RPTEC/TERT1 cell line, an immortalised non-tumour human renal epithelial cell line that recapitulates phenotypic characteristics that are absent in other in vitro renal cell models. RPTEC/... | PMID: 21103459

Large_pdficon_selected PDF is available here.