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Erythroid Cells (1):
Recent article
Erythroid Cells
Abstract
We used ChIP sequencing and loss-of-function strategies to define the GATA-2-instigated genetic network in human endothelial cells. In contrast to erythroid cells, GATA-2 occupied a unique target gene ensemble consisting of genes encoding key determinants of endothelial cell identity and inflammatio...
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PMID: 21808000
PDF is available here.
PDF is available here.
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Abstract
Our data indicate that the terminal maturation and enucleation of human primitive RBCs occurs in first trimester placental villi. Extravascular ζ-globin(+) primitive erythroid cells were found in placental villi between 5-7 weeks of development, at which time the frequency of enucleated RBCs was hi...
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PMID: 20628147
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
We examined the effects of three γ-secretase inhibitors (GSI-IX, GSI-XII and GSI-XXI) that inhibit Notch signaling on the in vitro growth and differentiation of HEL and AA erythroid leukemia cell lines.
GSI treatment induced morphologic erythroid differentiation and promoted hemoglobin production....
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PMID: 21036721
PDF is available here.
PDF is available here.
Abstract
We searched nuclear JAK2 in total bone marrow (BM) cells and in 4 sorted BM cell populations (CD34(+), CD15(+), CD41(+), and CD71(+)) of 10 myeloproliferative neoplasia (MPN) patients with JAK2V617F mutation and 5 patients with wild-type JAK2 MPN. Confocal immunofluorescent images and Western blot a...
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PMID: 20861460
PDF is available here.
PDF is available here.
Abstract
We show that expression of the locus encoding miR-144 and miR-451 is strictly dependent on Argonaute 2 and is required for erythroid homeostasis. Mice deficient for the miR-144/451 cluster display a cell autonomous impairment of late erythroblast maturation, resulting in erythroid hyperplasia, splen...
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PMID: 20513743
PDF is available here.
PDF is available here.
Rinsho Ketsueki (51)6 2010
Abstract
We recognized marked anemia (Hb 6.0 g/dl) and reticulocytopenia (2.0 per thousand), but this was not accompanied by any other significant changes in laboratory findings. Bone marrow examination demonstrated a low percentage of erythroid precursors without an increase of blast cells. Rheumatoid arthr...
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PMID: 20622490
PDF is available here.
PDF is available here.
Abstract
The TNF-alpha (tumour necrosis factor) affects a wide range of biological activities, such as cell proliferation and apoptosis. Cell life or death responses to this cytokine might depend on cell conditions. This study focused on the modulation of factors that would affect the sensitivity of erythroi...
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PMID: 20218968
PDF is available here.
PDF is available here.
Genes & Development (24)8 2010
Abstract
We determine chromatin occupancy of BCL11A at the human beta-globin locus and other genomic regions in vivo by high-resolution chromatin immunoprecipitation (ChIP)-chip analysis. BCL11A binds the upstream locus control region (LCR), epsilon-globin, and the intergenic regions between gamma-globin and...
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PMID: 20395365
PDF is available here.
PDF is available here.
Abstract
We used human epsilon-globin gene regulatory elements to drive lineage-specific expression of a histone-H2B::EGFP fusion protein, allowing us to label the chromatin of EryP during their development and to track and quantify EryP nuclei following their expulsion from the cell. Using this transgenic f...
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PMID: 20181503
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of p...
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PMID: 19855965
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of p...
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PMID: 19855965
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of p...
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PMID: 19855965
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of p...
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PMID: 19855965
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of p...
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PMID: 19855965
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of p...
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PMID: 19855965
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of p...
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PMID: 19855965
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of p...
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PMID: 19855965
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of p...
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PMID: 19855965
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of p...
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PMID: 19855965
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of p...
|
PMID: 19855965
PDF is available here.
PDF is available here.
Annals of Hematology (89)4 2010
Abstract
We performed a long-term follow-up analysis of 42 patients with low or intermediate risk myelodysplastic syndromes and 5q deletion treated with lenalidomide. At a median follow-up of 40 months, 58% of the patients achieved an erythroid response and 48% a cytogenetic response. Thirty-six percent of p...
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PMID: 19855965
PDF is available here.
PDF is available here.
Leukemia & Lymphoma (51)4 2010
Abstract
We previously identified aberrant expression of miR-451 and miR-150 in polycythemia vera (PV) erythroid differentiating cells. To address the functional relevance of these miRNAs in erythroid differentiation, we employed synthetic mimics and inhibitors of miR-451 and miR-150 in erythroid differentia...
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PMID: 20218812
PDF is available here.
PDF is available here.
EMBO Journal (29)2 2010
Abstract
We generated mice with a mutation that specifically disrupts FOG-1/NuRD interaction (FOG-1(R3K5A)). Homozygous FOG-1(R3K5A) mice were found to have splenomegaly, extramedullary erythropoiesis, granulocytosis and thrombocytopaenia secondary to a block in megakaryocyte maturation. FOG-1(R3K5A/R3K5A) m...
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PMID: 20010697
PDF is available here.
PDF is available here.
Acta Haematologica (123)1 2010
Abstract
In vitro treatment with deferiprone, deferasirox and deferoxamine reduced the cytosolic LIP in RBCs and reticulocytes, and both the cytosolic and mitochondrial LIP in cultured erythroid precursors. This was associated with reduced oxidative stress (ROS and external phosphatidylserine). While the eff...
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PMID: 19923794
PDF is available here.
PDF is available here.
Abstract
Ukrainskij biokhimicheskij zhurnal/Ukrayins'kij biokhimichnij zhurnal/Ukrainian biochemical journal (82)2 2010
Abstract
The apoptotic index, cell cycle progression and caspase-3 activation in K-562 cells induced to differentiate by DMSO or quercetin have been studied. Quercetin treatment of K-562 cells was accompanied by cell cycle arrest in G2/M and apoptosis with caspase-3 activation. In contrast, DMSO-induced diff...
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PMID: 20684251
PDF is available here.
PDF is available here.
Seminars in Hematology (46)4 2009
Abstract
Important advances in our understanding of iron metabolism have been made during the past 10 years, highlighting the mechanisms by which dysregulated iron homeostasis leads to hematologic, metabolic, and neurodegenerative diseases. In particular, the discovery of hepcidin and its fundamental role as...
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PMID: 19786201
PDF is available here.
PDF is available here.
Seminars in Hematology (46)4 2009
Abstract
Inherited sideroblastic anemia comprises several rare anemias due to heterogeneous genetic lesions, all characterized by the presence of ringed sideroblasts in the bone marrow. This morphological aspect reflects abnormal mitochondrial iron utilization by the erythroid precursors. The most common X-l...
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PMID: 19786205
PDF is available here.
PDF is available here.
Experimental Hematology (37)10 2009
Abstract
Hydroxyurea (30-100 microM) induced NOS-dependent production of NO in human macrophages (up to 1.2 microM). Coculture studies of human macrophages with erythroid progenitor cells also resulted in induction of gamma-globin mRNA expression (up to threefold) in the presence of hydroxyurea. NOS-dependen...
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PMID: 19576950
PDF is available here.
PDF is available here.
Stem Cells (27)9 2009
Abstract
We show that Gfi-1 transcription is positively regulated early after induction of erythroid differentiation and remains highly active to late erythroblasts. Using chromatin immunoprecipitation assays in CD34+ cells from human cord blood, we found that Gfi-1 and GATA-2 in immature progenitors and the...
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PMID: 19522008
PDF is available here.
PDF is available here.
B M B Reports (42)8 2009
Abstract
We have first analyzed by microarray the miR-profile in erythroid precursor cells from one normal and two thalassemic patients expressing different levels of fetal hemoglobin (one of them displaying HPFH phenotype). The microarray data were confirmed by RT-PCR analysis, and allowed us to identify mi...
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PMID: 19712585
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)31 2009
Abstract
We show that loss of EKLF leads to aberrant entry into S-phase of the cell cycle during both primitive and definitive erythropoiesis. This cell cycle defect was associated with a significant reduction in the expression levels of E2f2 and E2f4, key factors necessary for the induction of S-phase gene...
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PMID: 19457859
PDF is available here.
PDF is available here.
Experimental Hematology (37)8 2009
Abstract
We observed interaction between STAT3 and GATA-1 in K562 and mouse erythroleukemia cells in vivo at the gamma-globin 5'UTR by chromatin immunoprecipitation assay. Electrophoretic mobility shift assay performed with a 41-base pair gamma-globin DNA probe (gamma41) demonstrated the presence of STAT3 an...
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PMID: 19447160
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (284)30 2009
Abstract
We show here that the protein levels of upstream stimulatory factor (USF) increase during differentiation of murine erythroleukemia (MEL) cells. USF was subject to degradation by the Ca(2+)-dependent protease m-calpain in undifferentiated but not in differentiated MEL cells. Treatment of MEL cells w...
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PMID: 19491096
PDF is available here.
PDF is available here.
Abstract
We previously developed transplantation assays to test the repopulation potentials of candidate hematopoietic progenitor cells. We have been impaired, however, in determining cellular differentiation potentials by a lack of short-term functional assays. To enable more precise analyses of hematopoiet...
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PMID: 19433857
PDF is available here.
PDF is available here.
Abstract
We compared the effects of butyrate and hemin on the expression of the different globin genes in progenitors-derived erythroid cells from patients with beta-Thal intermedia and SCD. Exposure to butyrate resulted in an augmentation of gamma-globin mRNA levels in both SCD and beta-Thal. Interestingly,...
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PMID: 19346141
PDF is available here.
PDF is available here.
Abstract
We performed an in vitro erythroid expansion from peripheral blood mononuclear cells of controls and PV patients and evaluated the cells for proliferation, apoptosis, erythroid differentiation, and morphology at the defined time points. PV erythroid progenitors exhibited increased proliferation at d...
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PMID: 19264517
PDF is available here.
PDF is available here.
Abstract
Knowledge about the processes that control RBC production has been applied to the establishment of culture conditions allowing ex-vivo generation of RBCs in numbers close to those (2.5 x 10 cells/ml) present in a transfusion, from cord blood, donated blood units or embryonic stem cells. In addition,...
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PMID: 19444099
PDF is available here.
PDF is available here.
Abstract
We demonstrate a specific in vitro interaction between the transactivation domain of p53 (p53TAD) and a segment of the GATA-1 DNA-binding domain that includes the carboxyl-terminal zinc-finger domain. We also show by immunoprecipitation that the native GATA-1 and p53 interact in erythroid cells and...
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PMID: 19411634
PDF is available here.
PDF is available here.
Abstract
During erythroid differentiation and maturation, it is critical that the components of hemoglobin are made in stoichiometric amounts. It is, therefore, conceivable that factors that modify this process intrinsically or extrinsically will also affect erythropoiesis. Several proteins have the potentia...
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PMID: 19318943
PDF is available here.
PDF is available here.
Abstract
We examined the expression profile of mRNAs in YN-1 human erythroleukemia cells under hypoxia. DNA array analysis revealed that the expression of transforming growth factor (TGF)-beta1 and mitoferrin, which is a mitochondrial iron transporter, was induced after 6 h under hypoxia in YN-1 cells, where...
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PMID: 19187226
PDF is available here.
PDF is available here.
Abstract
We show here the inhibitory effect of tumor necrosis factor alpha (TNFalpha), a proinflammatory cytokine, on hemoglobinization and erythroid transcription factor GATA-1 expression in erythroleukemia (HEL) as well as in chronic myelogenous leukemia (K562) cells, which were induced to differentiate to...
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PMID: 19212691
PDF is available here.
PDF is available here.
Experimental Hematology (37)2 2009
Abstract
BIM expression increases in primary murine erythroid cells and HCD57 cells deprived of EPO. Whereas Bim mRNA increased less than twofold, BIM protein increased more than 10-fold after EPO withdrawal, suggesting posttranscriptional regulation of BIM. EPO treatment resulted in rapid phosphorylation of...
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PMID: 19100675
PDF is available here.
PDF is available here.
Stem Cells (27)1 2009
Abstract
We analyzed expression status, histone modifications, and subnuclear positioning relative to repressive compartments, of hematopoietic loci in multipotent and lineage-committed primary human hematopoietic progenitors. We report here that positioning of lineage-affiliated loci relative to pericentrom...
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PMID: 18974210
PDF is available here.
PDF is available here.
Abstract
Human genetic studies have led to the identification of a transcriptional regulator that could serve as a therapeutic target for adult hemoglobin disorders. National Heart, Lung and Blood Institute, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA. E-mail: michelsonam{at}mail....
PDF is available here.
PDF is available here.
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.
Abstract
We examine BCL11A as a potential regulator of HbF expression. The high-HbF BCL11A genotype is associated with reduced BCL11A expression. Moreover, abundant expression of full-length forms of BCL11A is developmentally restricted to adult erythroid cells. Down-regulation of BCL11A expression in primar...
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PMID: 19056937
PDF is available here.
PDF is available here.
Abstract
Abstract
We show that it is feasible to differentiate and mature human embryonic stem cells (hESCs) into functional oxygen-carrying erythrocytes on a large scale (10(10)-10(11) cells/6-well plate hESCs). We also show for the first time that the oxygen equilibrium curves of the hESC-derived cells are comparab...
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PMID: 18713948
PDF is available here.
PDF is available here.
Abstract
We investigated the physiological roles of c-Jun in cell proliferation, apoptosis and erythroid differentiation of K562 cells. Firstly, we generated K562 cell lines stably overexpressing c-Jun. These clones have the same proliferation rate as the parental cell line in general culture medium. Endogen...
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PMID: 19006173
PDF is available here.
PDF is available here.
Cellular Signalling (20)11 2008
Abstract
We identified tyrosine 913 (Y(913)) as a novel and functional phosphorylation site, which negatively regulates Jak2. Phosphorylation at Y(913) rapidly occurred and was sustained for at least 120 min after Epo stimulation, in contrast to the transient phosphorylation of Y(1007/1008) in the activation...
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PMID: 18682290
PDF is available here.
PDF is available here.
Abstract
Erythropoiesis strictly depends on signal transduction through the erythropoietin receptor (EpoR)-Janus kinase 2 (Jak2)-signal transducer and activator of transcription 5 (Stat5) axis, regulating proliferation, differentiation, and survival. The exact role of the transcription factor Stat5 in erythr...
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PMID: 18694996
PDF is available here.
PDF is available here.
Human Pathology (39)10 2008
Abstract
The goal of the current study is to evaluate the role of beta-catenin in chronic myeloproliferative disorders. Expression of beta-catenin was analyzed by immunohistochemistry in formalin-fixed decalcified bone marrow biopsy specimens from 52 chronic myeloproliferative disorder cases and 6 nonchronic...
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PMID: 18619646
PDF is available here.
PDF is available here.
Cellular Signalling (20)10 2008
Abstract
We analyse the role of different erythropoietin receptor substructures for the activation of Egr-1 and the functional consequences of Egr-1 overexpression in the erythroleukemic cell line ELM-I-1. The investigation of receptor variants revealed that the activity of JAK2 and the phosphorylation of re...
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PMID: 18627790
PDF is available here.
PDF is available here.
Abstract
We have investigated how the acetylation of EKLF plays a role in its ability to alter the beta-like globin locus chromatin structure and activate transcription of the adult beta-globin gene. By establishing an EKLF-null erythroid line whose closed beta-locus chromatin structure and silent beta-globi...
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PMID: 18710946
PDF is available here.
PDF is available here.
Abstract
We compared SCF-dependent gene expression between total and polysome-bound mRNA. This identified 111 genes primarily subject to translational regulation. For 8 of 9 genes studied in more detail, the SCF-induced polysome recruitment of transcripts exceeded 5-fold regulation and was PI3K-dependent and...
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PMID: 18625885
PDF is available here.
PDF is available here.
Abstract
Experimental Hematology (36)9 2008
Abstract
We directly genotyped 23 patients who underwent hematopoietic stem cell transplantation and their human leukocyte antigen-matched donors and found a median of three informative SNPs (i.e., discordant between donor and recipient) per pair. By using the informative RBC SNPs to quantify donor-derived R...
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PMID: 18550258
PDF is available here.
PDF is available here.
Abstract
We demonstrated that Id2 is an intrinsic negative regulator of B-cell development. Hematopoietic progenitor cells overexpressing Id2 did not reconstitute B-cell development in vivo, which resembled the phenotype of E2A null mice. The B-cell population in bone marrow was significantly expanded in Id2...
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PMID: 18523151
PDF is available here.
PDF is available here.
Abstract
We present how a new flow technology, the ImageStream (Amnis Corporation, Seattle, WA), blends morphology and flow cytometry and can be used to analyze cell populations in ways not possible by standard histology or flow cytometry alone. The ImageStream captures brightfield, darkfield and multiple fl...
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PMID: 18539294
PDF is available here.
PDF is available here.
Abstract
We demonstrated that N1IC interacted with the c-Myc-regulating proteins alpha-enolase and c-myc promoter binding protein 1 (MBP-1). Both alpha-enolase and MBP-1 suppressed the N1IC-enhanced activity of the c-myc promoter in a CBF1-independent manner. The YY1 response element in front of the P2 c-myc...
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PMID: 18490439
PDF is available here.
PDF is available here.