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Muscle Cells (3):
Recent article
Muscle Cells
Abstract
We describe the generation of fibrin-based EHT from a transgenic rat strain with ubiquitous expression of firefly luciferase (ROSA/luciferase-LEW Tg; ). Implantation is performed into the greater omentum of different rat strains to assess immune responses of the recipient organism following EHT impl...
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PMID: 21673633
PDF is available here.
PDF is available here.
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Abstract
I (SR-BI) in glucose uptake of HDL. Corresponding signaling molecules were detected by immunoblotting. HDL stimulated glucose uptake in a time- and concentration-dependent manner in 3T3-L1 adipocytes. GLUT4 translocation was significantly increased by HDL. Glycogen deposition got enhanced in L6 musc...
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PMID: 21886796
PDF is available here.
PDF is available here.
Abstract
Management of adverse events related to cancer therapies are seen as tertiary prevention. Concerning prostate cancer, dealing with secondary effects of treatments is crucial. Indeed, if recent advances in cancer therapy have lead to an acceptable overall prognosis, these results face increasing case...
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PMID: 21220229
PDF is available here.
PDF is available here.
Acta Biomaterialia (6)11 2010
Abstract
We evaluate the adhesive behaviour of skeletal muscle cells (C2C12 myoblasts) during the initial steps of spreading on layer-by-layer films of controlled stiffness made of poly(L-lysine) and hyaluronan as model biomaterial surfaces for muscle tissue engineering. We show that integrin clustering, int...
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PMID: 20601233
PDF is available here.
PDF is available here.
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences (368)1925 2010
Abstract
Intracellular Ca(2+) dynamics provides excitation-contraction coupling in cardiac myocytes. Under pathological conditions, spontaneous Ca(2+) release events can lead to intracellular Ca(2+) travelling waves, which can break, giving transitory or persistent intracellular re-entrant Ca(2+) scroll wave...
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PMID: 20643687
PDF is available here.
PDF is available here.
Abstract
The synthesis and biological evaluation of potent and selective PKD inhibitors are described herein. The compounds described in the present study selectively inhibit PKD among other putative HDAC kinases. The PKD inhibitors of the present study blunt phosphorylation and subsequent nuclear export of...
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PMID: 20684592
PDF is available here.
PDF is available here.
Abstract
A novel 2,6-naphthyridine was identified by high throughput screen (HTS) as a dual protein kinase C/D (PKC/PKD) inhibitor. PKD inhibition in the heart was proposed as a potential antihypertrophic mechanism with application as a heart failure therapy. As PKC was previously identified as the immediate...
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PMID: 20684591
PDF is available here.
PDF is available here.
Abstract
We constitutively overexpressed the short isoform of the human insulin receptor (hIR-A, exon 11-negative) in L6 rat skeletal myoblasts. Because the mitogenic effect of growth factors such as insulin is expected to act in G0/G1, promoting S-phase entry, we developed a combined topoinhibition + serum...
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PMID: 19898946
PDF is available here.
PDF is available here.
Journal of Nutrition (140)8 2010
Abstract
A high-lipid diet (HLD) may lead to adverse left ventricular (LV) remodeling and endothelial dysfunction in conditions of hemodynamic stress. Although congenital absence of nitric oxide synthase 3 (NOS3) leads to adverse LV remodeling after transverse aortic constriction (TAC), the effects of a HLD...
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PMID: 20554900
PDF is available here.
PDF is available here.
Endocrinology (151)7 2010
Abstract
We show that selective overexpression of androgen receptor in muscle cells (myocytes) of transgenic male rats both increases lean mass percentage and reduces fat mass. Similar changes in body composition are observed in human skeletal actin promoter driving expression of androgen receptor (HSA-AR) t...
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PMID: 20427479
PDF is available here.
PDF is available here.
Abstract
We describe 3 such cases in which we employed fluorescence in-situ hybridization analysis to detect translocation involving the EWS gene and reverse transcription polymerase chain reaction followed by sequencing to detect the fusion transcript EWS-FLI1....
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PMID: 20495444
PDF is available here.
PDF is available here.
FASEB Journal (24)7 2010
Abstract
We demonstrated that murine iPS cells have the potential to develop in vitro into skeletal muscle stem/progenitor cells, which are almost equivalent to murine embryonic stem cells. Cells with strong in vitro myogenic potential effectively were enriched by fluorescence-activated cell sorting using th...
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PMID: 20181939
PDF is available here.
PDF is available here.
Abstract
We conducted a yeast two-hybrid screen to identify its interacting partners. A yeast two-hybrid system was used to screen a mouse embryo cDNA library for proteins able to bind mouse AMPK alpha 1. We also demonstrated an endogenous interaction between AMPK alpha 1 and its interacting partner by co-im...
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PMID: 20460104
PDF is available here.
PDF is available here.
Abstract
We established LA-PCs that differentiates into cardiac/skeletal myocytes or adipocytes with almost 100% purity. In this study, we compared gene expression profiles of undifferentiated LA-PCs with those of differentiated cells [adipocytes (Adi) or cardiac/skeletal myocytes (Myo)] to identify the sign...
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PMID: 20420809
PDF is available here.
PDF is available here.
Abstract
We found that for PC-12, HeLa and HT-29 cell lines as well as primary cultures of cardiac myocytes and neurons in vitro in differing media, approximately 5 nmol/L free zinc (pZn = 8.3, where pZn is defined as--log(10) [free Zn(2+)]) produced apparently healthy cells, but 20-fold higher or (in one ca...
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PMID: 20511678
PDF is available here.
PDF is available here.
Biomaterials (31)18 2010
Abstract
We have adapted a widely used immobilized metal affinity protein purification strategy to non-covalently attach proteins to the surface of microparticles. Polyketal microparticles were surface modified with nitrilotriacetic acid-nickel complexes which have a high affinity for sequential histidine ta...
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PMID: 20346498
PDF is available here.
PDF is available here.
Abstract
The present study was designed to examine the postnatal developmental changes of atypically shaped cardiomyocytes (ACMs) prepared from the heart of newborn [postnatal day 1 (day-1)] through aged (12-month-old) mice. ACMs were identified as a novel type of self-beating cardiomyocyte with a peculiar m...
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PMID: 20197490
PDF is available here.
PDF is available here.
Circulation Research (106)10 2010
Abstract
IP(3) stimulates direct coupling between IP(3)R1 and membrane-resident TRPC3 channels in arterial myocytes, leading to I(Cat) activation and vasoconstriction. Close spatial proximity between IP(3)R1 and TRPC3 establishes this isoform-selective functional interaction....
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PMID: 20378853
PDF is available here.
PDF is available here.
Circulation Research (106)10 2010
Abstract
Acta Biomaterialia (6)6 2010
Abstract
An advanced manufacturing technique, selective laser sintering (SLS), was utilized to fabricate a porous polycaprolactone (PCL) scaffold designed with an automated algorithm in a parametric library system named the "computer-aided system for tissue scaffolds" (CASTS). Tensile stiffne...
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PMID: 20026436
PDF is available here.
PDF is available here.
Abstract
The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to describe the hypothetical factor responsible for myocyte hyperpolarisations not associated with nitric oxide (EDRF) or prostacyclin. Two broad categories of EDHF response exist. The classical EDHF pathway is blocked...
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PMID: 20383718
PDF is available here.
PDF is available here.
médecine/sciences (26)5 2010
Abstract
Abstract
Emerging evidences have assigned a critical role to oxidative stress in muscle homeostasis and in the physiopathology of skeletal muscle, suggesting that reactive oxygen species are not merely damaging agent inflicting random destruction to the cell structure and function, but useful signaling molec...
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PMID: 20098320
PDF is available here.
PDF is available here.
Hypertension (55)5 2010
Abstract
We tested involvement of biochemical and biophysical parameters and potential transcription factors Forkhead box (FOX) and hypoxia-inducible factor (HIF-1alpha). Right atrial tissues were obtained during surgery from 28 children with heart disease. Expression of K(+)-inward-rectifier subunits Kir6.1...
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PMID: 20212266
PDF is available here.
PDF is available here.
Genes & Development (24)8 2010
Abstract
We examined whether genes assume specific subnuclear positions during Caenorhabditis elegans development. Monitoring the radial position of developmentally controlled promoters in embryos and larval tissues, we found that small integrated arrays bearing three different tissue-specific promoters have...
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PMID: 20395364
PDF is available here.
PDF is available here.
Connecticut medicine (74)4 2010
Abstract
British Journal of Nutrition (103)7 2010
Abstract
We therefore compared the effects of hypercaloric diets enriched with fructose (HFrD) or glucose (HGlcD) in healthy men. Eleven subjects were studied in a randomised order after 7 d of the following diets: (1) weight maintenance, control diet; (2) HFrD (3.5 g fructose/kg fat-free mass (ffm) per d, +...
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PMID: 19930762
PDF is available here.
PDF is available here.
European Journal of Pharmacology (629)1-3 2010
Abstract
We performed voltage-clamp experiments to directly investigate the effects of 4OH-tamoxifen on the repolarizing K(+) currents in adult mouse ventricular myocytes in order to determine whether the effects of tamoxifen on repolarization could be ascribed to 4OH-tamoxifen. K(+) currents were recorded b...
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PMID: 20006599
PDF is available here.
PDF is available here.
Abstract
We established the inflammatory index in order to classify the severity of myocarditis, by counting the mean number of inflammatory foci per section of myocardium. Based on the inflammatory index, myocardial inflammation was classified into four grades. Based on this classification, 47% of the cases...
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PMID: 20091145
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (Chapter 15) 2010
Abstract
We describe cell population-based assays to measure the steady-state levels of GLUT4 at the cell surface, as well as to separately measure the rates of GLUT4 endocytosis and endocytosis....
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PMID: 20235101
PDF is available here.
PDF is available here.
A novel small-animal model for accelerated investigation of tissue-engineered aortic valve conduits.
Abstract
Our new model leads to accelerated and reproducible results, suited to investigation of biological patterns of tissue engineering. The observed adventitial fibrosis emphasized the importance of careful selection of optimal cell types for repopulation in tissue-engineered constructs....
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PMID: 19351241
PDF is available here.
PDF is available here.
Biological Cybernetics (102)2 2010
Abstract
We suggested that adaptive gap junctions (GJs) might be a basis of cardiac memory, a phenomenon which refers to persistent electrophysiological response of the heart to external pacing. Later, it was also shown that the proposed mechanism of adaptation of GJs is consistent with known electrophysiolo...
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PMID: 20012545
PDF is available here.
PDF is available here.
Abstract
We investigate the properties of several widely used visualization techniques and show that a commonly used algorithm based on rendering Gaussians may lead to a 1.44-fold loss of resolution. Existing methods typically do not explicitly take sampling considerations into account and thus may produce s...
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PMID: 20082730
PDF is available here.
PDF is available here.
Abstract
Myoepithelial cells have an important role in salivary gland tumor development, contributing to a low grade of aggressiveness of these tumors. Normal myoepithelial cells are known by their suppressor function presenting increased expression of extracellular matrix genes and protease inhibitors. The...
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PMID: 20379686
PDF is available here.
PDF is available here.
Cell Transplantation (19)5 2010
Abstract
We investigated the effects of myoblasts injected with cardiotoxin on the contractile properties and resistance to eccentric contractions of transplanted and nontransplanted muscles. We used the extensor digitorum longus (EDL) as a model for our study. We conclude that the sole presence of dystrophi...
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PMID: 20650035
PDF is available here.
PDF is available here.
Abstract
We observed that after nuclear import of Foxo3a by PI3K/Akt pathway inhibition, activation of stress-activated protein kinase (SAPK) pathways induced nuclear export of Foxo3a through CRM1. This mechanism involved the c-Jun NH(2)-terminal kinase (JNK) signaling pathway and was independent of Akt. Lik...
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PMID: 19917721
PDF is available here.
PDF is available here.
Abstract
Diabetic cardiomyopathy (DCM), although a distinct clinical entity, is also a part of the diabetic atherosclerosis process. It may be independent of the coexistence of ischemic heart disease, hypertension, or other macrovascular complications. Its pathological substrate is characterized by the prese...
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PMID: 21057575
PDF is available here.
PDF is available here.
Abstract
Our previous studies have shown that daurisoline (DS) exerted antiarrhythmic effects on various experimental arrhythmias. In this study, the effects of DS on early afterdepolarizations (EADs) and its possible mechanisms have been investigated. Cardiac hypertrophy was induced in rabbits by coarctatin...
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PMID: 20128043
PDF is available here.
PDF is available here.
Abstract
The muscle regulatory factor MRF4 is expressed in both embryonic and adult vertebrate skeletal muscle cells. In mammals the MRF4 gene has a complex cis-regulatory structure, with many kilobases (kb) of upstream sequence required for embryonic expression in transgenic mice. Here, initial functional c...
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PMID: 20209434
PDF is available here.
PDF is available here.
Abstract
We consider the mechanisms of endogenous cardiomyocyte regeneration and exogenous cell differentiation (with respect to myoblasts, stem cells, and induced pluripotent cells being researched for cell therapies). We begin by reviewing some of the cues that are being harnessed in strategies of gene/cel...
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PMID: 20528736
PDF is available here.
PDF is available here.
Disease Models & Mechanisms (3)5-6 2010
Abstract
Our results suggest a possible link between genetic defects in synapse formation or function, and sensitivity to environmental factors in the development of autism spectrum disorders....
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PMID: 20083577
PDF is available here.
PDF is available here.
Journal of Physiology (587)Pt 18 2009
Abstract
We investigate the effects of S100A1 on voltage sensor activation in skeletal muscle utilizing whole-cell patch clamp electrophysiology to record intra-membrane charge movement currents in isolated flexor digitorum brevis (FDB) muscle fibres from wild-type and S100A1 knock-out (KO) mice. In contrast...
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PMID: 19651767
PDF is available here.
PDF is available here.
Abstract
During the past few years, studies involving the implantation of stem cells, chemical factors, and scaffolds have demonstrated the ability to augment the mammalian heart's native regenerative capacity. Scaffolds comprised of extracellular matrix (ECM) have been used to repair myocardial defects. The...
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PMID: 19231971
PDF is available here.
PDF is available here.
Clinical Immunology (132)2 2009
Abstract
The study reported below describes increased expression of IL-4 receptor in cultured rat myocytes following exposure to an antibody reactive with the acetylcholine receptor (AChR). In addition, upon up-regulation of IL-4R, myocytes demonstrated an increased responsiveness to IL-4 by producing increa...
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PMID: 19395316
PDF is available here.
PDF is available here.
Abstract
We have reported that transgenic mice with cardiac-specific overexpression of heat shock protein 27 (Hsp27 Tg) exhibited the protection against doxorubicin-induced cardiac dysfunction. We hypothesized that overexpression of Hsp27 will attenuate cardiac dysfunction during endotoxemia. Hsp27 Tg and ag...
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PMID: 19106822
PDF is available here.
PDF is available here.
Abstract
Chagas disease is caused by the parasite Trypanosoma cruzi. It is a common cause of heart disease in endemic areas of Latin America. The year 2009 marks the 100th anniversary of the discovery of T cruzi infection and Chagas disease by the Brazilian physician Carlos Chagas. Chagasic cardiomyopathy de...
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PMID: 19410685
PDF is available here.
PDF is available here.
Abstract
In this work, a bioartificial system consisting of VEGF-loaded porous silica gel and myoblasts cultured on acellular diaphragmatic matrix (ADM) has been implanted to repair a surgically created diaphragmatic defect in Lewis rats. ADMs exerted a strong angiogenic response on chorio-allantoic membrane...
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PMID: 18431788
PDF is available here.
PDF is available here.
Abstract
We present a novel approach for mathematical modeling of electrical conduction in cardiac tissue composed of myocytes, fibroblasts, and the extracellular space. The model is an extension of established cardiac bidomain models, which include a description of intra-myocyte and extracellular conductivi...
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PMID: 19283480
PDF is available here.
PDF is available here.
Abstract
The length and sequences of inserted DNA were right. Compared with the RNA interferencing group, significant atrophy and upregulated expression of Atrogin-1 of myotubes treated by TNF-alpha was found in the control group. CONCLUSION: Atrogin-1 gene silencing could be used to inhibit malnutrition of...
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PMID: 19615244
PDF is available here.
PDF is available here.
Biomaterials (30)12 2009
Abstract
We hypothesized that ECM extracted from skeletal muscle would provide muscle progenitor cells and myoblasts with an ideal substrate for growth and differentiation ex vivo. To test this hypothesis, we developed a method to extract ECM from the large thigh muscles of adult rats and present it to cells...
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PMID: 19168212
PDF is available here.
PDF is available here.
Abstract
This study evaluated the histological changes in muscle tissue after limb lengthening in skeletally mature and immature rabbits and assessed the most vulnerable level of striated muscle. Twenty-three male domestic white rabbits, divided into six groups, were operated on and different lengthening pro...
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PMID: 18259704
PDF is available here.
PDF is available here.
Orvosi Hetilap (150)13 2009
Abstract
We present an overview about of myofibroblasts and their roles in inflammation and neoplastic processes....
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PMID: 19293061
PDF is available here.
PDF is available here.
Abstract
We have previously shown that GCIP-27, can prevent the hypertrophyc responses in cultured rat cardiomyocytes induced by noradrenaline and angiotensin II. Male Sprague-Dawley rats were given a single dose (50 mg/kg) of MCT subcutaneouly to induce pulmonary hypertension (PH) and RV hypertrophy. GCIP-2...
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PMID: 19252281
PDF is available here.
PDF is available here.
Bioscience Reports (29)1 2009
Abstract
We review: (i) evidence supporting the co-existence of clathrin-dependent and independent GLUT4 internalization in adipocytes and muscle cells; (ii) the contrasting regulation of GLUT4 internalization by insulin in these cells; and (iii) evidence suggesting regulation of GLUT4 endocytosis in muscle...
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PMID: 19143591
PDF is available here.
PDF is available here.
Abstract
Abstract
We have developed a stroboscopic near-field optical microscope for observation of biological specimens and observed glycerinated muscles before and after muscle contraction with the developed system. In the system, the optical field distribution localized near the specimen is recorded as the surface...
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PMID: 19220693
PDF is available here.
PDF is available here.
Abstract
This study evaluated the effects of supplemental oral glutamine (GLN) on acute cardiotoxicity of cyclophosphamide (CPA) in experimental rats. The dose-related cardiotoxicity of CPA is associated with a rapid decrease in cardiac glutathione (GSH) and oxidative cardiac injury. GLN is a...
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PMID: 19251394
PDF is available here.
PDF is available here.
BioFactors (35)3 2009
Abstract
We investigated if a green tea polyphenol blend (GTP) and its major polyphenol (-)-epigallocatechin gallate (EGCg), could protect muscle cell primary cultures from oxidative damage induced by hydrogen peroxide (H(2)O(2)) in the widely used mdx mouse model. On-line fluorimetric measurements using an...
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PMID: 19322813
PDF is available here.
PDF is available here.
Abstract
The results indicate that action potential configuration fails to influence the amplitude of I (Kr) and I (K1) during the ventricular action potential in dogs and humans, suggesting that rate-dependent changes in action potential duration are not likely related to rate-dependent alterations in I (Kr...
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PMID: 18604626
PDF is available here.
PDF is available here.
Autoimmunity (42)3 2009
Abstract
I muscle fibers. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and precise molecular weight derived from mass spectrometer identified P25 as carbonic anhydrase III (CA III). Some members of CA family are related to autoimmune diseases and CA III is recently reported to...
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PMID: 19301202
PDF is available here.
PDF is available here.