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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Myeloid Cells (4):
Recent article
Myeloid Cells
Journal of Neuroscience (31)31 2011
Abstract
We targeted myeloid cell subsets from different compartments and examined disease pathogenesis in three different mouse models of AD (APP(swe/PS1), APP(swe), and APP23 mice). We identified chemokine receptor 2 (CCR2)-expressing myeloid cells as the population that was preferentially recruited to β-...
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PMID: 21813677
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Abstract
Hematopoietic stem cells (HSCs) differentiate into mature lineage restricted blood cells under the influence of a complex network of hematopoietic cytokines, cytokine-mediated transcriptional regulators, and manifold intercellular signaling pathways. The classical model of hematopoie...
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PMID: 21426948
PDF is available here.
PDF is available here.
Abstract
We examined prostaglandin E₂ (PGE₂) metabolism and myeloid cell subsets that infiltrate tumor tissue using two xenograft models of human bladder cancer. Human bladder tumor xenografts implanted into athymic nude mice become highly infiltrated with host CD11b myeloid cells of bone marrow origin....
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PMID: 21315786
PDF is available here.
PDF is available here.
Abstract
Recent investigations of regulatory myeloid cell mobilization and amplification in response to cancer and chronic inflammation associated with infectious disease and autoimmunity have provided numerous insights into the suppressive mechanisms, pathobiology and potential pharmaceutica...
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PMID: 21315784
PDF is available here.
PDF is available here.
Abstract
We increase our understanding of the biological mechanisms involved for each phenotypic and/or functionally distinct leukocyte subset, immunotherapeutic strategies can be developed to overcome the inherent barriers to the development of improved strategies for the treatment of liver disease and tumo...
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PMID: 21241810
PDF is available here.
PDF is available here.
Abstract
We increase our understanding of the biological mechanisms involved for each phenotypic and/or functionally distinct leukocyte subset, immunotherapeutic strategies can be developed to overcome the inherent barriers to the development of improved strategies for the treatment of liver disease and tumo...
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PMID: 21241810
PDF is available here.
PDF is available here.
Abstract
We have previously demonstrated that inflammation, which frequently accompanies tumor onset and progression, increases the rate of accumulation and the suppressive potency of MDSC. To determine how inflammation enhances MDSC levels and activity we used mass spectrometry to identify proteins produced...
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PMID: 21191032
PDF is available here.
PDF is available here.
Abstract
We found that regulator of G protein signaling-2 (Rgs2) is highly increased in tumor-derived MDSCs compared to control MDSCs. We further demonstrate that hypoxia, a common feature associated with solid tumors, upregulates the gene expression. Genetic deletion of Rgs2 in mice resulted in a significan...
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PMID: 21494556
PDF is available here.
PDF is available here.
Abstract
We have assessed by real-time in vivo imaging the dynamic and temporal contribution of different immune factors in infected red blood cell (IRBC) accumulation and distribution in different organs during PbA infection. Using deficient mice or depleting antibodies, we observed that CD8(+) T cells and...
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PMID: 21494565
PDF is available here.
PDF is available here.
Abstract
We and others recently observed that lipopolysaccharide (LPS) administration, as other TLR ligands, induces MDSC. In this case, MDSC regulate immune response independently of L-arginine metabolism through heme oxygenase-1 activity. Manipulating MDSC as immunoregulators represents an attractive appro...
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PMID: 20941610
PDF is available here.
PDF is available here.
Abstract
We generated two transgenic (Tg) murine models with constitutive Tl1a expression in either lymphoid or myeloid cells. Compared to wildtype (WT) mice, constitutive expression of Tl1a in either lymphoid or myeloid cells showed mild patchy inflammation in the small intestine, which was more prominent i...
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PMID: 21264313
PDF is available here.
PDF is available here.
Cancer Cell (18)6 2010
Abstract
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production. Mutational and epigenetic profiling of a large acute myeloid leukemia (AML) patient cohort revealed that IDH1/2-mutant AMLs display global DNA hypermethy...
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PMID: 21130701
PDF is available here.
PDF is available here.
Abstract
To give an overview on the clinical spectrum and the molecular background of host defence against Candida.
For many decades the molecular causes and the pathogenesis for an increased susceptibility to Candida - and fungal infections in general - have been elusive. In...
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PMID: 20859203
PDF is available here.
PDF is available here.
Cell Host & Microbe (8)5 2010
Abstract
We generated myeloid-lineage specific CMG2-deficient mice to examine the roles of macrophages, neutrophils, and other myeloid cells in anthrax pathogenesis. Macrophages and neutrophils isolated from these mice were resistant to anthrax toxin. However, the myeloid-specific CMG2-deficient mice remaine...
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PMID: 21075356
PDF is available here.
PDF is available here.
Abstract
A microglial cell is both a glial cell of the central nervous system and a mononuclear phagocyte, which belongs to the haematopoietic system and is involved in inflammatory and immune responses. As such, microglia face a challenging task. The neurons of the central nervous system cannot divide and b...
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PMID: 21068834
PDF is available here.
PDF is available here.
Abstract
We have measured the numbers of bone marrow-derived versus resident endothelial cells in spontaneous prostate cancers during different stages of tumor progression and in age-matched normal prostates. Bone marrow-derived endothelial cells were rare in dysplasia and in well differentiated cancers repr...
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PMID: 20453162
PDF is available here.
PDF is available here.
Molecular Therapy (18)11 2010
Abstract
We used a previously reported DC-targeting approach to deliver small interfering RNA (siRNA) against SOCS-1 to human myeloid-derived DCs (MDDCs). SOCS1-silencing in MDDCs resulted in enhanced cytokine responses to lipopolysaccharide (LPS) and a strong mixed-lymphocyte reaction. Moreover, only DCs tr...
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PMID: 20648001
PDF is available here.
PDF is available here.
Abstract
Myeloid-derived suppressor cells (MDSC) accumulate in most cancer patients and experimental animals with cancer. They accumulate in response to pro-inflammatory mediators and they use a variety of mechanisms to block both innate and adaptive antitumor immunity. Because of their critical role in obst...
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PMID: 20414655
PDF is available here.
PDF is available here.
Journal of Immunology (185)2 2010
Abstract
We generated OP9 cells expressing a series of incrementally discrete and equivalent levels of Dll1 or Dll4. In keeping with previous findings, OP9 cells expressing high levels of either Dll1 or Dll4 gave rise to T lineage cells with similar efficacy, and prevented the differentiation of B and myeloi...
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PMID: 20548034
PDF is available here.
PDF is available here.
Journal of Immunology (185)2 2010
Abstract
We have investigated the cross talk between receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis and particle phagocytosis-induced activation of human monocytes. Understanding interconnected signals is of particular importance to disorders, such as periprosthetic osteolysis, in...
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PMID: 20543106
PDF is available here.
PDF is available here.
Abstract
The graft take rate was significantly impaired in the KO group (P = .009), whereas epithelialization (P = .46) or granulation (P = .41) tissue formation scores did not reveal any significant differences. CONCLUSION: Hypoxia-inducible factor 1alpha in myeloid cells may be an important molecule for re...
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PMID: 20644069
PDF is available here.
PDF is available here.
Abstract
We show that abrogation of APP production by hepatocyte-specific gp130 deletion, the signaling receptor shared by IL-6 family cytokines, strongly increased mortality despite normal bacterial clearance. Hepatic gp130 signaling through STAT3 was required to control systemic inflammation. Notably, hepa...
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PMID: 20530204
PDF is available here.
PDF is available here.
Mayo Clinic Proceedings (85)7 2010
Abstract
The association between malignancy and development of a paraneoplastic leukocytosis, the so-called leukemoid reaction, has long been appreciated. Although a leukemoid reaction has conventionally been defined as a peripheral blood leukocytosis composed of both mature and immature gran...
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PMID: 20592171
PDF is available here.
PDF is available here.
Nature Immunology (11)7 2010
Abstract
We provide a comprehensive analysis of the human hematopoietic hierarchy by clonally mapping the developmental potential of seven progenitor classes from neonatal cord blood and adult bone marrow. Human multilymphoid progenitors, identified as a distinct population of Thy-1(neg-lo)CD45RA(+) cells in...
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PMID: 20543838
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
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PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.
Haematologica (95)7 2010
Abstract
We utilized an ex vivo differentiation system in which umbilical cord blood-derived CD34(+) cells were treated with trichostatin A, sodium butyrate and valproic acid to evaluate the effect of histone deacetylase inhibitor treatment on myeloid lineage development, colony-forming potential, proliferat...
|
PMID: 20107159
PDF is available here.
PDF is available here.