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Myoblasts (3):
Recent article
Myoblasts
Abstract
Engineering three-dimensional (3D) cell-dense tissues with a well-organized structure remains a challenge in tissue engineering. In this study, highly oriented fibrous bundles, consisted of composite fibers of poly(L-lactide-co-glycolide)/superparamagnetic iron oxide nanoparticles, w...
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PMID: 21375393
PDF is available here.
PDF is available here.
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Minerva chirurgica (66)2 2011
Abstract
Abdominal wall defects and tissue loss that result from traumatic injury, surgical resection, failure of abdominal closures (i.e., incisional hernias) or ventral hernias are a common clinical problem. Currently, the repair of these tissue defects represents a reconstructive challenge to surgeons. The...
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PMID: 21593715
PDF is available here.
PDF is available here.
Abstract
We also investigated the multi-differentiation potentials of the dedifferentiated cells. TGF-β(1) pre-treated C2C12 myoblasts were implanted into mice to repair dystrophic skeletal muscle or injured bone. In addition to the C2C12 myoblasts, similar effects of TGF-β(1) were also observed in the pri...
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PMID: 20184662
PDF is available here.
PDF is available here.
Abstract
Epidemiological studies have correlated arsenic exposure with cancer, skin diseases, and adverse developmental outcomes such as spontaneous abortions, neonatal mortality, low birth weight, and delays in the use of musculature. The current study used C2C12 mouse myoblast cells to examine whether low...
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PMID: 20965206
PDF is available here.
PDF is available here.
Abstract
Recent evidence suggests that hydrogen sulfide is capable of mitigating the degree of cellular damage associated with ischemia-reperfusion injury. The purpose of this study was to determine whether it is protective in skeletal muscle.
This study used both in vitro (cultured myotubes subjected to seq...
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PMID: 21124129
PDF is available here.
PDF is available here.
Macromolecular Bioscience (10)11 2010
Abstract
We combined micromolding and microablation technologies to create muscle tissue engineering scaffolds from the biodegradable elastomer poly(glycerol sebacate). These scaffolds exhibited well defined surface patterns and pores and robust elastomeric tensile mechanical properties. Cultured C2C12 muscl...
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PMID: 20718054
PDF is available here.
PDF is available here.
Cell Biology International (34)11 2010
Abstract
We identified that, compared with SLD fibroblasts, normal fibroblasts promoted myogenesis of primary SLD myoblasts by improving their differentiation potential in a paracrine fashion, and this effect was involved in both primary and secondary fusions. This process was also coupled with up-regulation...
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PMID: 20569202
PDF is available here.
PDF is available here.
Acta Biomaterialia (6)11 2010
Abstract
We evaluate the adhesive behaviour of skeletal muscle cells (C2C12 myoblasts) during the initial steps of spreading on layer-by-layer films of controlled stiffness made of poly(L-lysine) and hyaluronan as model biomaterial surfaces for muscle tissue engineering. We show that integrin clustering, int...
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PMID: 20601233
PDF is available here.
PDF is available here.
Abstract
We have examined the role of the IGF-IR signaling in differentiation and repair of muscle fibers after damage-induced muscle regeneration. This process is impaired in MKR muscle, with incomplete regeneration, persistence of infiltrating cells and sustained expression of differentiation markers. Anal...
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PMID: 20458740
PDF is available here.
PDF is available here.
Chemico-Biological Interactions (187)1-3 2010
Abstract
We tested this hypothesis by following the effect of siRNA AChE silencing on apoptotic markers and by determination of AChE level after staurosporine-induced apoptosis in cultured human myoblasts. Decreased apoptosis in siRNA AChE silenced myoblasts and increased AChE expression in staurosporine-tre...
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PMID: 20338155
PDF is available here.
PDF is available here.
Abstract
We investigate the ability of MSC, exposed to short-term hypoxic conditions, to participate in vascular and tissue regeneration in an in vivo model of hindlimb ischemia. Transplantation of hypoxic preconditioned murine MSC (HypMSC) enhanced skeletal muscle regeneration at day 7, improved blood flow...
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PMID: 20551912
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We used the same molecular tools to explore whether the Ca(2+) mechanism of excitation-contraction coupling also relies on STIM1 and STIM2. Live cell imaging of early differentiating myoblasts revealed a characteristic clustering of activated STIM1 and STIM2 during the first few hours of differentia...
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PMID: 20436167
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)29 2010
Abstract
We and others previously demonstrated that lung fibroblast expression of Thy-1 prevents lung fibrosis. The mechanisms underlying the anti-fibrotic effect of Thy-1 are not well understood. In this study, we showed that Thy-1 interacts with integrin alpha(v)beta(5), both in a cell-free system and on t...
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PMID: 20463011
PDF is available here.
PDF is available here.
Abstract
Only a minority of PC cells are sensitive to the antiproliferative effects of alpha-TOS, any sensitivity appearing to be correlated with SMAD4/DPC4 homozygous deletion and Bax/Bak expression....
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PMID: 20562578
PDF is available here.
PDF is available here.
FASEB Journal (24)7 2010
Abstract
We have identified glucose-6-phosphate dehydrogenase (G6PDH) as an important source of NADPH in mitochondria. Activity analysis, submitochondrial fractionation, fluorescence microscopy, and protease sensitivity assays revealed that G6PDH is localized to the mitochondrial matrix. 6-ANAM, a specific G...
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PMID: 20228249
PDF is available here.
PDF is available here.
Journal of Cell Biology (189)7 2010
Abstract
We report that expression of the muscle-specific micro-RNA (miRNA) miR-1 is regulated by mTOR both in differentiating myoblasts and in mouse regenerating skeletal muscle. We have found that mTOR controls MyoD-dependent transcription of miR-1 through its upstream enhancer, most likely by regulating M...
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PMID: 20566686
PDF is available here.
PDF is available here.
Journal of Cell Biology (189)7 2010
Abstract
We report that expression of the muscle-specific micro-RNA (miRNA) miR-1 is regulated by mTOR both in differentiating myoblasts and in mouse regenerating skeletal muscle. We have found that mTOR controls MyoD-dependent transcription of miR-1 through its upstream enhancer, most likely by regulating M...
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PMID: 20566686
PDF is available here.
PDF is available here.
Abstract
We demonstrate that hepatic stellate cells (HSC) isolated from Lewis rats have in vitro antigen-presentation cell (APC) functionality and are able to process and present exogenous antigens. We show activation of a major histocompatibility complex II (RT1BI)-restricted T-cell hybridoma specific for g...
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PMID: 20403338
PDF is available here.
PDF is available here.
Abstract
I for 24 h and applied with or without a biaxial deformation at 1 Hz using the Flexcell FX-4000 system. MMP-9 activity was increased in fibroblasts when the cells were in contact with fibronectin and laminin, while in myoblasts, enhanced activity of the secreted enzyme was only observed when collage...
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PMID: 20218972
PDF is available here.
PDF is available here.
Abstract
We tested the hypothesis that modulation of the microenvironment (using antioxidants) will increase stem cell survival in hypoxia and after transplantation to the myocardium.
Rat cardiomyoblasts were stably transfected with a reporter gene (firefly luciferase) for bioluminescence ima...
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PMID: 20013064
PDF is available here.
PDF is available here.
Ginekologia polska (81)5 2010
Abstract
We review publications of experimental investigations and clinical trials of the muscle-derived cells and the application in the treatment of stress urinary incontinence among women. Mesenchymal stem cells (MSCs) can be obtained from bone marrow but it is associated with a painful biopsy procedure....
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PMID: 20568520
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (319)1-2 2010
Abstract
We demonstrate that PGD(2) strongly inhibits C2C12 myogenesis as measured by cell fusion, creatine kinase activity and MyoD, myogenin and alpha-actin expression. Inhibition of myogenesis required micromolar PGD(2) concentrations and was independent of the known PGD(2) receptors DP1 and DP2. Unlike i...
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PMID: 20109525
PDF is available here.
PDF is available here.
Matrix Biology (29)4 2010
Abstract
We have shown that OTR4120 or heparin induced transient increases of intracellular calcium concentration ([Ca(2+)]i) in pre-fusing myoblasts from both mouse SolD7 cell line and rat skeletal muscle satellite cells grown in primary culture by mobilising sarcoplasmic reticulum store. This [Ca(2+)]i was...
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PMID: 20193761
PDF is available here.
PDF is available here.
Neuromuscular Disorders (20)5 2010
Abstract
We demonstrate that reverse protein arrays are a novel and excellent material-saving method for the measurement and quantification of changes in protein expression between healthy and diseased muscle tissue as well as cultured primary myotubes. We evaluated a set of antibodies and found reproducible...
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PMID: 20304647
PDF is available here.
PDF is available here.
Abstract
Magnetic fields may delay the rate of cell cycle progression, and there are reports that magnetic fields induce neurite outgrowth in cultured neuronal cells. To demonstrate whether magnetic field also effects on myoblast cells in cell growth, C2C12 cell lines were cultured and 2000G static magnetic...
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PMID: 20361274
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)16 2010
Abstract
We have investigated the impact of muscle targets on transmitter specification in Xenopus spinal neurons using a neuron-muscle coculture system. We find that neuron-muscle contact reduces the number of neurons expressing the noncholinergic transmitters GABA, glycine, and glutamate, while having no e...
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PMID: 20410131
PDF is available here.
PDF is available here.
Abstract
We had examined the efficacy of stem cell therapy using tissue engineered sheet technique compared to needle injection. This technique has advantages such as the ability for treatment to large area, and less invasive for host heart such as lethal arrhythmia. In vivo, implantation of autologous myobl...
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PMID: 20387567
PDF is available here.
PDF is available here.
Abstract
We sought to determine if estrogen influences Fhl1 gene expression levels in rat L6GNR4 myoblastocytes that express the estrogen receptor beta (ERbeta), while luciferase assay, electrophoretic mobility shift assay (EMSA), and chromatin immunoprecipitation (ChIP) assay were employed to confirm the in...
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PMID: 20149813
PDF is available here.
PDF is available here.
Abstract
Both LAs, especially bupivacaine, prevented cell growth and caused cell death in a dose-dependent manner. The half maximal inhibitory concentrations (IC(50)) for bupivacaine and lidocaine were 0.49+/-0.04 and 3.37+/-0.53 mmol/L, respectively. When applied at the same dilutions of commercially availa...
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PMID: 20228829
PDF is available here.
PDF is available here.
Abstract
We have developed a drug-screening system using C2C12 myoblasts expressing a reporter green fluorescent phosphate (GFP), with its reading frame disrupted by the insertion of a targeted dystrophin exon. A library of 2,000 compounds (Spectrum collection; Microsource Discovery System) was screened to i...
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PMID: 20087314
PDF is available here.
PDF is available here.
Abstract
We examined whether this modality could reach a sufficient sensitivity to allow evaluation of the regeneration process of enhanced green fluorescent protein (eGFP)-labeled muscle precursors (myoblasts). Using a basic FLI station, we were able to detect clear fluorescence signals generated by 40,000...
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PMID: 20125125
PDF is available here.
PDF is available here.
Abstract
ADSCs have the ability of differentiating into multiple lineages, including myoblasts. This ability to induce myoblasts can be used to treat stress incontinence, with the advantages of minimal invasion and faster recovery.
2010 Elsevier Inc. All rights reserved....
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PMID: 19969332
PDF is available here.
PDF is available here.
Abstract
Although inducing mild hypothermia (32 degrees C) in animal models of cardiac arrest with highly attenuated cardiac and neurological injury, the protective effects of hypothermia molecular mechanisms were not fully elucidated, and thus, were examined here on the H9c2 rat ventricular myoblasts that u...
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PMID: 20220335
PDF is available here.
PDF is available here.
Physical Biology (7)1 2010
Abstract
I offer a simple model in which one or more CPPs and the phosphatidylserines of the inner leaflet form a kind of capacitor with a voltage in excess of about 200 mV, high enough to create a molecular electropore. The model is consistent with an empirical upper limit on the cargo peptide of 40-60 amin...
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PMID: 20009189
PDF is available here.
PDF is available here.
Acta Biomaterialia (6)3 2010
Abstract
Collagen is an abundant protein found in the extracellular matrix of many tissues. Due to its biocompatibility, it is a potentially ideal biomaterial for many tissue engineering applications. However, harvested collagen often requires restructuring into a three-dimensional matrix to...
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PMID: 19733702
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (315)1-2 2010
Abstract
Pathways involved in mitochondrial biogenesis associated with myogenic differentiation are poorly defined. Therefore, C(2)C(12) myoblasts were differentiated into multi-nucleated myotubes and parameters/regulators of mitochondrial biogenesis were investigated. Mitochondrial respiration, citrate synt...
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PMID: 19804813
PDF is available here.
PDF is available here.
Abstract
We show that VCP is essential for autophagosome maturation. We generated cells stably expressing dual-tagged LC3 (mCherry-EGFP-LC3) which permit monitoring of autophagosome maturation. We determined that VCP deficiency by RNAi-mediated knockdown or overexpression of dominant-negative VCP results in...
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PMID: 20104022
PDF is available here.
PDF is available here.
Abstract
We generated a monoclonal antibody specific for Myf5 utilizing a rat medial iliac lymph node method. Immunoblot analysis using our monoclonal antibody enabled us to identify Myf5 protein from rat myoblast L6E9 cell extract. Moreover, cell immunostaining revealed the nuclear localization of Myf5 in t...
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PMID: 20199153
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
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PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
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PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Biotechnology Letters (32)2 2010
Abstract
We report that a spontaneously immortalized bovine embryonic fibroblast cell line (BEFS) undergoes differentiation into adipogenic or myogenic lineages when ectopically transduced with PPARgamma2 (an adipogenic lineage determinant) or MyoD (a myogenic lineage determinant) and grown in adipogenic and...
|
PMID: 19834648
PDF is available here.
PDF is available here.
Canadian Journal of Physiology and Pharmacology/Revue Canadienne de Physiologie et Pharmacologie (88)2 2010
Abstract
We discuss evidence showing that a series of stretched contractions of mdx muscle fibres causes a prolonged increase in resting intracellular calcium concentration ([Ca2+]i). The rise in [Ca2+]i is caused by Ca2+ entry through a class of stretch-activated channels (SACNSC) for which one candidate ge...
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PMID: 20237582
PDF is available here.
PDF is available here.
Cell Proliferation (43)1 2010
Abstract
The aim of this study was to evaluate whether hypoxia and/or erythropoietin would be able to modulate proliferation/differentiation processes of rat and human myoblasts.
Rat L6 and primary human myoblasts were grown in 21% or 1% O(2) in the presence or absence of reco...
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PMID: 20070732
PDF is available here.
PDF is available here.
Cell Proliferation (43)1 2010
Abstract
The aim of this study was to evaluate whether hypoxia and/or erythropoietin would be able to modulate proliferation/differentiation processes of rat and human myoblasts.
Rat L6 and primary human myoblasts were grown in 21% or 1% O(2) in the presence or absence of reco...
|
PMID: 20070732
PDF is available here.
PDF is available here.
Cell Proliferation (43)1 2010
Abstract
The aim of this study was to evaluate whether hypoxia and/or erythropoietin would be able to modulate proliferation/differentiation processes of rat and human myoblasts.
Rat L6 and primary human myoblasts were grown in 21% or 1% O(2) in the presence or absence of reco...
|
PMID: 20070732
PDF is available here.
PDF is available here.