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Neoplastic Cells, Circulating (0):
Recent article
Neoplastic Cells, Circulating
Abstract
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Abstract
The most frequent cause of treatment failure following surgery for gastric cancer is peritoneal metastasis. The ability to predict the likelihood of peritoneal recurrence should improve the therapeutic approach to gastric cancer. Cytological analysis of peritoneal washings is thought to be useful for...
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PMID: 21372769
PDF is available here.
PDF is available here.
Abstract
There are two hypotheses that explain tumor progression. The first one, the stochastic hypothesis, assumes that any cell within a tumor has the capacity to form and maintain the tumor mass. The second, the so-called hierarchical hypothesis, suggests the existence of a group of cells with a stem pheno...
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PMID: 21714437
PDF is available here.
PDF is available here.
Abstract
Localized prostate tumors have various clinical, biological and histopathologic characteristics that lead to different progression profiles. High-risk, clinically localised disease has been classically defined by clinical examination, PSA levels and histopathologic data. High-risk localized prostate...
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PMID: 21220228
PDF is available here.
PDF is available here.
Abstract
We isolate for the first time viable tumorigenic melanoma CTC and demonstrate that this cell population is capable of metastasis formation in human-to-mouse xenotransplantation experiments. The presence of CTC among peripheral blood mononuclear cells (PBMC) of murine recipients of subcutaneous (s.c....
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PMID: 20977885
PDF is available here.
PDF is available here.
Abstract
Circulating tumor cells (CTCs) photoacoustic detection systems can aid clinical decision-making in the treatment of cancer. Interaction of melanin within melanoma cells with nanosecond laser pulses generates photoacoustic waves that make its detection possible. This study aims at: (1) determining me...
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PMID: 20589533
PDF is available here.
PDF is available here.
Abstract
To critically review the latest findings concerning the role of circulating tumor cells (CTCs) and other blood biomarkers in breast cancer.
CTCs are epithelial tumor cells detected in the peripheral blood of patients with solid tumors using mainly cytometric/antibody-based and molecular approaches....
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PMID: 20706122
PDF is available here.
PDF is available here.
Abstract
We previously demonstrated the effectiveness of a microfluidic device, the CTC-Chip, in capturing these epithelial cell adhesion molecule (EpCAM)-expressing cells using antibody-coated microposts. Here, we describe a high-throughput microfluidic mixing device, the herringbone-chip, or "HB-Chip," whi...
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PMID: 20930119
PDF is available here.
PDF is available here.
Abstract
We first divided the lt-RV occluded by the tumor thrombus using a Linear Cutter® and then divided the lt-RA before the dissection of the tumor to avoid excessive bleeding. Even transarterial embolization of lt-RA were to be performed,the tumor was too large to dissect without division of lt-RV and...
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PMID: 21063161
PDF is available here.
PDF is available here.
Clinical Breast Cancer (10)5 2010
Abstract
We collected 23 mL of blood from each of the 76 consecutive patients before and during chemotherapy to determine CTC numbers and HER2 overexpression. CTCs were isolated with the CellSearch System® (Veridex, LLC; Raritan, NJ) and fluorescently stained with the Epithelial Cell Kit®. Tumor Phenotypin...
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PMID: 20920984
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
E-Cadherin functions as a tumor suppressor in some invasive breast carcinomas and metastasis is promoted when its expression is lost. It has been observed, however, that in one of the most aggressive human breast cancers, inflammatory breast cancer (IBC), E-cadherin is overexpressed and this account...
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PMID: 21036701
PDF is available here.
PDF is available here.
Oncology Reports (24)3 2010
Abstract
Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer deaths. The serum prostate specific antigen (PSA) is the only biomarker routinely used in screening. The aim of this study was to develop a system to test the presence of circulating prostate cells in...
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PMID: 20664974
PDF is available here.
PDF is available here.
Abstract
We diagnosed pulmonary tumor embolism, not pulmonary tumor thrombotic microangiopathy (PTTM), because the pathological findings did not reveal either thrombus formation or recanalization, and the patient did not show hemodynamic effects such as hemolytic anemia, severe pulmonary hypertension, or dis...
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PMID: 20803977
PDF is available here.
PDF is available here.
Abstract
To analyze the clinicopathologic features and prognostic factors of hepatocellular carcinoma.
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PMID: 21122415
PDF is available here.
PDF is available here.
Abstract
We did not adopt a standard therapeutic strategy, we performed surgical resection, chemotherapy, immunotherapy, and radiotherapy either alone or in combination; all procedures resulted in poor outcomes. A 67-year-old woman presented with a swallowing disorder. An esophagogastroduodenoscopy was perfo...
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PMID: 20716882
PDF is available here.
PDF is available here.
Abstract
We diagnosed right renal cancer (stage III), and he underwent radical nephrectomy and resection of tumor thrombus with extracorporeal circulation. Operative time was 9 hours. Time for extracorporeal circulation was 119 minutes, and it took 60 minutes for intraoperative balloon occlusion of descendin...
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PMID: 20715501
PDF is available here.
PDF is available here.
Abstract
We present an unusual case of embolic occlusion of the right renal artery from a left ventricular myxoma. Excision of the tumor required cardiac autotransplantation and mitral valve replacement. Subsequent right nephrectomy revealed renal artery occlusion with pathologically viable myxoma tissue.
Co...
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PMID: 20609801
PDF is available here.
PDF is available here.
Breast Cancer (17)3 2010
Abstract
Because the change in the number of CTCs was highly correlated with results from imaging before and after therapy, CTCs can be considered a biomarker that may predict the effect of treatment earlier than imaging modalities....
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PMID: 19649686
PDF is available here.
PDF is available here.
Der Chirurg (81)7 2010
Abstract
Current treatment guidelines for follicular thyroid carcinoma (FTC) recommend total thyroidectomy, lymphadenectomy and radioiodine ablation. Considering the low malignant potential of minimally invasive follicular thyroid carcinoma (MIFTC), a limited radical therapeutic procedure may be adequate. MI...
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PMID: 20544166
PDF is available here.
PDF is available here.
Abstract
Most deaths from breast cancer are from metastatic disease. Tests that predict an individual's risk of developing metastatic disease could be useful. There is growing evidence that circulating tumor cells (CTC) could help predict recurrence and effectiveness of therapy. However, there are unresolved...
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PMID: 20497919
PDF is available here.
PDF is available here.
Abstract
Although it is a complex and high-risk procedure, aggressive surgery performed by an experienced team with liver transplant and cardiothoracic skills may enable resection of apparently advanced caval tumors. The case is discussed in the light of the current literature....
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PMID: 20525562
PDF is available here.
PDF is available here.
Abstract
This rare complication, though theoretically possible, is unreported because of the short overall survival of advanced gallbladder cancer patients. This highlights that with the availability of better chemotherapeutic/biotherapeutic agents for increasing in the lifespan of cancer patients, we may co...
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PMID: 20525563
PDF is available here.
PDF is available here.
Anticancer Research (30)6 2010
Abstract
Expression of hMAM was found only in peripheral blood of patients with invasive BC (9.5%) and multivariate logistic regression analysis indicated its association with lymph node involvement (pN1-pN3 vs. pN0, OR=5.6, 95% CL=1.4-22.6; p=0.009), tumour size (pT2-pT4 vs. pT1, OR=2.3, 95% CL=0.6-9.0; p=0...
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PMID: 20651396
PDF is available here.
PDF is available here.
Abstract
A 31-year-old man presented with edema in left lower leg and dyspnea. Computed tomographic scanning detected a right testicular tumor, multiple lung nodules, and inferior vena cava (IVC) thrombus. After insertion of an IVC filter, high inguinal orchiectomy was performed after the first combination c...
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PMID: 20519928
PDF is available here.
PDF is available here.
Abstract
Oral panobinostat with and without docetaxel is feasible, and docetaxel had no apparent effect on the pharmacokinetics of panobinostat. Since preclinical studies suggest a dose-dependent effect of panobinostat on PSA expression, and other phase I data demonstrate that intravenous panobinostat produc...
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PMID: 20217089
PDF is available here.
PDF is available here.
Abstract
We exposed both nontumorigenic and tumor-derived epithelial cell lines to two antitumor compounds, jasplakinolide and paclitaxel (Taxol), in a series of attached and detached states. We report here that jasplakinolide promoted the extension of microtubule-based projections and microtentacle protrusi...
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PMID: 19593636
PDF is available here.
PDF is available here.
Annales de Dermatologie et de Vénéréologie (137 Suppl 1) 2010
Abstract
Hyaluronic acid (HA), one of the main components of extra-cellular matrix and most notably of the fundamental substance of conjunctive tissues, is not an inert structure. Conversely, it displays important biological properties and plays a significant role in crucial physiological processes especiall...
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PMID: 20435252
PDF is available here.
PDF is available here.
Abstract
Rinsho Shinkeigaku (50)4 2010
Abstract
We therefore suspected tumor metastasis. The patient was given heparin as well as pulse therapy with methylprednisolone, but she died 7 weeks after symptom onset. At postmortem examination, the dura was thickened. Histopathologically, numerous tumor cell emboli in the dura were confined to the lumen...
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PMID: 20411805
PDF is available here.
PDF is available here.
Abstract
A 65-year-old man was admitted with history of claudication symptoms and painful skin lesions of the lower legs. Physical examination showed palpable purpura of the lower legs and livedo reticularis, most marked at the forefoot and toes. INVESTIGATIONS: Computed tomography (CT) showed an aortic mass...
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PMID: 20391310
PDF is available here.
PDF is available here.
Abstract
Since the association of circulating DNA level changes with tumor growth was discovered many attempts have been made to develop the sensitive and robust blood-based tests for early tumor diagnostics. Both genomic as well as mitochondrial DNA quantification in the circulation have been extensively ev...
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PMID: 20196731
PDF is available here.
PDF is available here.
Abstract
Abstract
We wanted to demonstrate the value of multiparameter flow cytometry in detecting human tumor cells of breast cancer (BC) (SKBR-3) in normal peripheral blood. In addition, we investigated a cluster of patients to compare the overall survival (OS) between advanced BC patients [circulating tumor cells...
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PMID: 20169594
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
We explored the possibility of the cysteinyl leukotriene receptor antagonists, pranlukast and montelukast, preventing tumor cell migration through both cerebral and peripheral capillaries. To study tumor cell migration through brain capillaries, male Fisher rats were cannulated via the cisterna magn...
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PMID: 20375653
PDF is available here.
PDF is available here.
Pharmacogenomics (11)3 2010
Abstract
SVV was detectable in 48 out of 62 patients (77%). Stepwise multivariate Cox linear regression models demonstrated a significant and independent association of measured SVV with overall survival (6.6 exp[b]; 95% CI: 1.97-22.12; p = 0.002). Increased SVV levels after the operation were linked to shor...
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PMID: 20235790
PDF is available here.
PDF is available here.
Neurological Surgery (38)3 2010
Abstract
We report a case of intramedullary cervical metastasis from cerebellar anaplastic oligodendroglioma without any MR appearance for CSF dissemination or recurrence in the primary tumor site. The case was a 73-year-old female who underwent tumor resection for cerebellar anaplastic oligodendroglioma fol...
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PMID: 20229774
PDF is available here.
PDF is available here.
Cirugía Española (87)3 2010
Abstract
Acta Cardiologica (65)1 2010
Abstract
Primary cardiac tumours are uncommon, with an estimated incidence between 0.0017% and 0.19%. Cardiac myxoma is a rare cause of cerebrovascular disease, especially in children. This case report emphasizes the importance of cardiac evaluation, especially echocardiographic examination in cases with str...
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PMID: 20306900
PDF is available here.
PDF is available here.
Abstract
Changes in CTC numbers during follow-up might predict tumour relapse. Further evaluation of CTC prognostic and predictive value in patients with early CRC is warranted....
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PMID: 20156783
PDF is available here.
PDF is available here.
Abstract
We review current and emerging technologies for CTC isolation, with a focus on capture efficiency, purity, and viability of CTCs, and their potential clinical applications.
Copyright 2009 Elsevier Ltd. All rights reserved....
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PMID: 20071161
PDF is available here.
PDF is available here.
Future Oncology (6)2 2010
Abstract
In spite of the heterogeneity of breast cancer at the molecular level, circulating tumor cells (CTCs) may provide a novel prognostic marker. Approximately 20-40% of early breast cancer patients have detectable CTCs using reverse transcription PCR for CK19. The detection of CTCs before adjuvant chemo...
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PMID: 20146580
PDF is available here.
PDF is available here.
Abstract
Testing for circulating tumor cells has emerged as a new and promising tool for stratifying and monitoring patients with metastatic disease. Appropriate risk and biologic stratification in breast cancer is important for the development of more effectively tailored targeted therapies. To optimize pat...
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PMID: 20131993
PDF is available here.
PDF is available here.
Abstract
These findings also highlight the need to prompt further prospective studies on more cases of CRC to further establish the clinical relevance of activating KRAS mutation detection from peripheral blood in anti- EGFR-based chemotherapy that uses activating KRAS detection chips and the WCHMA analysis...
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PMID: 19937133
PDF is available here.
PDF is available here.
Oncology Reports (23)2 2010
Quantitative determination of HER2 expression by confocal microscopy assay in CTCs of breast cancer.
Abstract
We performed quantitative analysis by confocal microscopy assay for evaluation of HER2 expression in individual tumor cells. HER2 testing by confocal microscopy assay exhibited high concordance with results of real-time PCR, Western blot analysis and FISH analysis. We found that there was a signific...
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PMID: 20043103
PDF is available here.
PDF is available here.
Connecticut medicine (74)2 2010
Abstract
We report an unusual case of hepatocellular carcinoma with three histologically and immunohistochemically distinct components, arising in a noncirrhotic liver, with a pulmonary tumor embolus from one of the three components. The histological patterns of the three components were fibrolamellar, well-...
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PMID: 20218042
PDF is available here.
PDF is available here.
Toxicologic Pathology (38)2 2010
Abstract
I reproduction toxicity study died at the age of fifteen weeks. At necropsy, the thymus was abnormally enlarged and virtually obliterated the thoracic cavity. Histopathological examination of thymus revealed abundant cell population consisting of mature lymphocytes and few lymphoblasts arranged in c...
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PMID: 20100842
PDF is available here.
PDF is available here.
Toxicologic Pathology (38)2 2010
Abstract
I reproduction toxicity study died at the age of fifteen weeks. At necropsy, the thymus was abnormally enlarged and virtually obliterated the thoracic cavity. Histopathological examination of thymus revealed abundant cell population consisting of mature lymphocytes and few lymphoblasts arranged in c...
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PMID: 20100842
PDF is available here.
PDF is available here.
Toxicologic Pathology (38)2 2010
Abstract
I reproduction toxicity study died at the age of fifteen weeks. At necropsy, the thymus was abnormally enlarged and virtually obliterated the thoracic cavity. Histopathological examination of thymus revealed abundant cell population consisting of mature lymphocytes and few lymphoblasts arranged in c...
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PMID: 20100842
PDF is available here.
PDF is available here.
Toxicologic Pathology (38)2 2010
Abstract
I reproduction toxicity study died at the age of fifteen weeks. At necropsy, the thymus was abnormally enlarged and virtually obliterated the thoracic cavity. Histopathological examination of thymus revealed abundant cell population consisting of mature lymphocytes and few lymphoblasts arranged in c...
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PMID: 20100842
PDF is available here.
PDF is available here.
Toxicologic Pathology (38)2 2010
Abstract
I reproduction toxicity study died at the age of fifteen weeks. At necropsy, the thymus was abnormally enlarged and virtually obliterated the thoracic cavity. Histopathological examination of thymus revealed abundant cell population consisting of mature lymphocytes and few lymphoblasts arranged in c...
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PMID: 20100842
PDF is available here.
PDF is available here.
Toxicologic Pathology (38)2 2010
Abstract
I reproduction toxicity study died at the age of fifteen weeks. At necropsy, the thymus was abnormally enlarged and virtually obliterated the thoracic cavity. Histopathological examination of thymus revealed abundant cell population consisting of mature lymphocytes and few lymphoblasts arranged in c...
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PMID: 20100842
PDF is available here.
PDF is available here.
Toxicologic Pathology (38)2 2010
Abstract
I reproduction toxicity study died at the age of fifteen weeks. At necropsy, the thymus was abnormally enlarged and virtually obliterated the thoracic cavity. Histopathological examination of thymus revealed abundant cell population consisting of mature lymphocytes and few lymphoblasts arranged in c...
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PMID: 20100842
PDF is available here.
PDF is available here.
Toxicologic Pathology (38)2 2010
Abstract
I reproduction toxicity study died at the age of fifteen weeks. At necropsy, the thymus was abnormally enlarged and virtually obliterated the thoracic cavity. Histopathological examination of thymus revealed abundant cell population consisting of mature lymphocytes and few lymphoblasts arranged in c...
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PMID: 20100842
PDF is available here.
PDF is available here.
Toxicologic Pathology (38)2 2010
Abstract
I reproduction toxicity study died at the age of fifteen weeks. At necropsy, the thymus was abnormally enlarged and virtually obliterated the thoracic cavity. Histopathological examination of thymus revealed abundant cell population consisting of mature lymphocytes and few lymphoblasts arranged in c...
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PMID: 20100842
PDF is available here.
PDF is available here.
Abstract
We describe here an indolent leukaemic patient with cutaneous T-cell lymphoma, who initially had a nodulo-tumourous eruption with a crop of solid papules, but finally presented with papuloerythroderma. Histologically, the skin lesions showed non-epidermotropic dermal infiltration of atypical lymphoc...
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PMID: 20107729
PDF is available here.
PDF is available here.
Abstract
We attempt to provide a logical approach of the surgical strategies in a stepwise fashion.
Over 6-years 9 patients with renal cell carcinoma invading the IVC, underwent surgery. There were 6 males. The extension was at level IV in 4 and III in 5 cases. CPB used in 8 and hypothermia and circulatory a...
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PMID: 21054828
PDF is available here.
PDF is available here.
Abstract
Cell migration and invasion are crucial steps in many physiological events. However, they are also implicated in the physiopathology of many diseases, such as cancer. To spread through the tissues, tumor cells use mechanisms that involve several molecular actors: adhesion receptor families, receptor...
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PMID: 20348621
PDF is available here.
PDF is available here.
Respiration (79)1 2010
Abstract
We present a patient with anti-Hu antibody-associated paraneoplastic sensory polyneuropathy and tumor embolism diagnosed by endovascular biopsy to be due to small cell cancer, the primary site of which was not evident. To our knowledge, this patient represents only the second individual to be descri...
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PMID: 19546521
PDF is available here.
PDF is available here.