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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neurons (15):
Recent article
Neurons
Journal of Neurochemistry (119)5 2011
Abstract
We have used neuroblastoma cells expressing NDM29 at its basal level (Mock cells) or at 5.4-fold higher levels (S1 cells) to investigate whether a functional differentiation correlates with morphological and biochemical development induced by NDM29 expression. First, analyzing the expression of spec...
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PMID: 21933186
PDF is available here.
PDF is available here.
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Abstract
We demonstrate that zebrafish Neuregulin 1 (Nrg1) type III, which signals through ErbB receptors, controls Schwann cell migration in addition to its previously known roles in proliferation and myelination. Chimera analyses indicate that ErbB receptors are required in all migrating Schwann cells, and...
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PMID: 21965611
PDF is available here.
PDF is available here.
Abstract
We concluded that GES pulse width increases had the largest effect on VMH neuronal activity, and these effects were paralleled by pulse width-dependent reductions in food intake and body weight. Lengthening pulse width beyond the range used in prior clinical studies may be critical to making GES a v...
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PMID: 21852365
PDF is available here.
PDF is available here.
Abstract
We report that early gamma oscillations (EGOs) enable precise spatiotemporal thalamocortical synchronization in the neonatal rat whisker sensory system. Driven by a thalamic gamma oscillator and initially independent of cortical inhibition, EGOs synchronize neurons in a single thalamic barreloid and...
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PMID: 21998388
PDF is available here.
PDF is available here.
Developmental Cell (21)4 2011
Abstract
We use a combination of in vivo quantitative proteomics and analyses of cyclin E knockout mice to demonstrate that in terminally differentiated neurons cyclin E forms complexes with Cdk5 and controls synapse function by restraining Cdk5 activity. Ablation of cyclin E led to a decreased number of s...
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PMID: 21944720
PDF is available here.
PDF is available here.
Abstract
We find that the infant human subventricular zone and RMS contain an extensive corridor of migrating immature neurons before 18 months of age but, contrary to previous reports, this germinal activity subsides in older children and is nearly extinct by adulthood. Surprisingly, during this limited win...
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PMID: 21964341
PDF is available here.
PDF is available here.
Abstract
We combine cell-type-specific electrophysiological, pharmacological, and optogenetic techniques to dissect neural circuits and molecular pathways controlling synaptic plasticity onto AGRP neurons, a population that regulates feeding. We find that food deprivation elevates excitatory synaptic input,...
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PMID: 21925320
PDF is available here.
PDF is available here.
Brain research (1410) 2011
Abstract
These results suggest that erythropoietin decreases the excitatory neurotransmitter release probability and may in this way protect the synapses from toxic levels of glutamate. Erythropoietin perfusion increased the expression of long-term potentiation in the hippocampus which is considered as basic...
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PMID: 21803333
PDF is available here.
PDF is available here.
Brain research (1410) 2011
Abstract
We attempted to characterize protein expression profiles in P301S tau-Tg mouse by using two-dimensional differential in-gel electrophoresis (2D-DIGE) coupled by peptide mass fingerprinting (PMF). As a result, we identified four upregulated proteins; heat shock protein 27 (Hsp27), peroxiredoxin 6 (Pr...
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PMID: 21803337
PDF is available here.
PDF is available here.
Abstract
Dysfunction of inhibitory synaptic transmission can destroy the balance between excitatory and inhibitory synaptic inputs in neurons, thereby inducing epileptic activity. The aim of the paper is to investigate the effects of successive excitatory inputs on the epileptic activity indu...
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PMID: 21887845
PDF is available here.
PDF is available here.
Abstract
We have performed genome-wide association scans on four iris characteristics (crypt frequency, furrow contractions, presence of peripupillary pigmented ring, and number of nevi) in three Australian samples of European descent. Both the discovery (n = 2121) and replication (n = 499 and 73) samples sh...
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PMID: 21835309
PDF is available here.
PDF is available here.
Brain research (1407) 2011
Abstract
Serine proteases, serine protease inhibitors, and protease-activated receptors have been intensively investigated in the periphery and their roles in a wide range of processes-coagulation, inflammation, and digestion, for example-have been well characterized (see Coughlin, 2000; Macf...
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PMID: 21782155
PDF is available here.
PDF is available here.
Molecular Cell (43)3 2011
Abstract
We show that CUL4B, but not its paralog, CUL4A, targets WDR5, a core subunit of histone H3 lysine 4 (H3K4) methyltransferase complexes, for ubiquitylation and degradation in the nucleus. Knocking down CUL4B increases WDR5 and trimethylated H3K4 (H3K4me3) on the neuronal gene promoters and induces th...
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PMID: 21816345
PDF is available here.
PDF is available here.
Abstract
We describe the efficient generation of human-induced neuronal (hiN) cells from adult skin fibroblasts of unaffected individuals and Alzheimer's patients, using virally transduced transcription regulators and extrinsic support factors. hiN cells from unaffected individuals display morphological, el...
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PMID: 21816272
PDF is available here.
PDF is available here.
Abstract
Journal of Cell Biology (194)3 2011
Abstract
We find here that in a key dendritic RNA transport pathway (exemplified by BC1 RNA, a dendritic regulatory RNA, and protein kinase M ζ [PKMζ] mRNA, a dendritic mRNA), noncanonical purine•purine nucleotide interactions are functional determinants of RNA targeting motifs. These motifs are specific...
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PMID: 21807882
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)32 2011
Abstract
We show that PS impairs the morphological and functional maturation of hippocampal granule cells in adult offspring via the downregulated expression of mineralocorticoid receptors. PS reduced the dendritic complexity and spine density of neonatal-generated granule cells, which persists into adulthoo...
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PMID: 21832180
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)32 2011
Abstract
We now show using electrophysiology and anatomic tracing that (1) the monkey has an inhibitory structure similar to the rat RMTg; (2) RMTg neurons receive excitatory input from the LHb, exhibit negative reward-prediction errors, and send axonal projections near DA soma; and (3) stimulating this stru...
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PMID: 21832176
PDF is available here.
PDF is available here.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology (27)8 2011
Abstract
To investigate the effects of adipose-derived stem cell (ADSC) transplanting on the outgrowth of neuronal axons and the expressions of GFAP, Neuritin, NF-200 in the brain post focal cerebral ischemia in rats.
54 male adult Sprague-Dawley rats were randomly divided int...
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PMID: 21806883
PDF is available here.
PDF is available here.
Acta Biomaterialia (7)8 2011
Abstract
The objective of the present in vitro research was to investigate cardiac tissue cell functions (specifically cardiomyocytes and neurons) on poly(lactic-co-glycolic acid) (PLGA) (50:50 wt.%)-carbon nanofiber (CNF) composites to ascertain their potential for myocardial tissue engineer...
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PMID: 21571106
PDF is available here.
PDF is available here.
Abstract
We discuss the role of AD-linked calcium signaling alterations in neurons and how this may be linked to synaptic dysfunctions at both early and late stages of the disease....
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PMID: 21786198
PDF is available here.
PDF is available here.
Abstract
Experimental data indicate that moderate uncoupling oxidative phosphorylation induces reduction in production of reactive oxygen species (ROS) and promotes an increase in survival of neurons and cardiomyocytes under hypoxia and re-oxygenation conditions. Uncoupling proteins (UCP) are...
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PMID: 21961301
PDF is available here.
PDF is available here.
Journal of Neuroscience (31)31 2011
Abstract
We examine the effect of endotoxin-induced inflammation on Ox neuron biology and LMA in rats. Our results demonstrate a vital role for diminished Ox signaling in mediating inflammation-induced lethargy. This work defines a specific population of inflammation-sensitive, arousal-associated Ox neurons...
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PMID: 21813697
PDF is available here.
PDF is available here.
Abstract
We combined fluorescent retrograde tracing of CeA projections to nuclei that modulate fear-related freezing or cardiovascular responses with in vitro electrophysiological recordings and with in vivo monitoring of related behavioral and physiological parameters. CeA projections emerged from separate...
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PMID: 21719680
PDF is available here.
PDF is available here.
Nature Genetics (43)7 2011
Abstract
Abstract
We discuss how Ca2+ signaling via VDCCs and TRP channels mediates various neuronal processes....
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PMID: 21747135
PDF is available here.
PDF is available here.
Abstract
In Wistar rats, specific inhibitor UPS lactacystin induced degeneration of 24% of the dopaminergic neurons in the black substance. The work shows that a moderate weakening of the UPS function is characterized by an enhanced activity of the shaperon system. This process seems to resto...
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PMID: 21961290
PDF is available here.
PDF is available here.
Abstract
We have demonstrated the relationship between the stimulation of ³H-AA release by persistent chemicals, such as polychlorinated biphenyls and polybrominated diphenyl ethers, and the associated cytotoxicity following in vitro exposure. Understanding the role of the AA signaling pathway in chemically...
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PMID: 21815076
PDF is available here.
PDF is available here.
Journal of Proteomics (74)7 2011
Abstract
We used the fluorescent phosphospecific Pro-Q Diamond dye to identify proteins that showed alterations in their overall phosphorylation in the hippocampus of AD vs. control (CTR) subjects. Significant changes were found for 17 proteins involved in crucial neuronal process such as energy metabolism o...
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PMID: 21515431
PDF is available here.
PDF is available here.
Abstract
We review the cellular signaling networks that regulate the activity of transcription factors during brain development and discuss the functional roles of specific activity-regulated transcription factors in specific stages of synapse formation, refinement, and maturation. Interestingly, a number of...
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PMID: 21555405
PDF is available here.
PDF is available here.
Abstract
We review the cellular signaling networks that regulate the activity of transcription factors during brain development and discuss the functional roles of specific activity-regulated transcription factors in specific stages of synapse formation, refinement, and maturation. Interestingly, a number of...
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PMID: 21555405
PDF is available here.
PDF is available here.
Abstract
We present a model of plasticity induction for reinforcement learning in a population of leaky integrate and fire neurons which is based on a cascade of synaptic memory traces. Each synaptic cascade correlates presynaptic input first with postsynaptic events, next with the behavioral decisions and f...
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PMID: 21738460
PDF is available here.
PDF is available here.
Abstract
The past two decades have witnessed tremendous advances in noninvasive and postmortem neuroscientific techniques, advances that have made it possible, for the first time, to compare in detail the organization of the human brain to that of other primates. Studies comparing humans to c...
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PMID: 21599696
PDF is available here.
PDF is available here.
Abstract
We describe implementation of a method for digitizing at microscopic resolution brain tissue sections containing normal and experimental data and for making the content readily accessible online. Web-accessible brain atlases and virtual microscopes for online examination can be developed using exist...
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PMID: 21599693
PDF is available here.
PDF is available here.
Abstract
The University of Geneva brain collection was founded at the beginning of the 20th century. Today, it consists of 10,154 formaldehyde- or buffered formaldehyde-fixed brains obtained from the autopsies of the Department of Psychiatry and, since 1971, from the Department of Geriatrics....
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PMID: 21599692
PDF is available here.
PDF is available here.
Abstract
The Zagreb Collection of developing and adult human brains was founded in 1974 by Ivica Kostović and consists of 1,278 developing and adult human brains, including 610 fetal, 317 children, and 359 adult brains. It is one of the largest collections of developing human brains. The col...
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PMID: 21599691
PDF is available here.
PDF is available here.
Abstract
We performed a comprehensive, loss- of-function analysis of Rem2 function in cultured hippocampal neurons using RNAi to substantially decrease Rem2 protein levels. We found that knockdown of Rem2 decreases the density and maturity of dendritic spines, the primary site of excitatory synapses onto pyr...
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PMID: 21485012
PDF is available here.
PDF is available here.
PLoS Genetics (7)5 2011
Abstract
Abstract
We found two distinct homozygous mutations of NDE1, c.83+1G>T (p.Ala29GlnfsX114) in a Turkish family and c.684_685del (p.Pro229TrpfsX85) in two families of Pakistani origin. Using patient cells, we found that c.83+1G>T led to the use of a novel splice site and to a frameshift after NDE1 exon 2. Tran...
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PMID: 21529752
PDF is available here.
PDF is available here.
Abstract
We show here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b. Both Sema-2a and Sema-2b utilize the same neuronal receptor, plexin B (Ple...
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PMID: 21521614
PDF is available here.
PDF is available here.
Abstract
We have found that multidendritic nociceptors in the head respond to harsh touch throughout their receptive field but respond to gentle touch only at the tip of the nose. Whereas the harsh touch response depends solely on cell-autonomous mechanosensory channels, gentle nose touch responses require f...
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PMID: 21521615
PDF is available here.
PDF is available here.
Abstract
We provide evidence for an end-product inhibition of dopamine neuron regeneration that is mediated by dopamine. Ablation of midbrain dopamine neurons leads to complete regeneration in salamanders. Regeneration involves extensive neurogenesis and requires activation of quiescent ependymoglia cells, w...
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PMID: 21474106
PDF is available here.
PDF is available here.
Physiological Reviews (91)2 2011
Abstract
Microglial cells are the resident macrophages in the central nervous system. These cells of mesodermal/mesenchymal origin migrate into all regions of the central nervous system, disseminate through the brain parenchyma, and acquire a specific ramified morphological phenotype termed "...
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PMID: 21527731
PDF is available here.
PDF is available here.
Endocrinology (152)4 2011
Abstract
We used the slice preparation from female guinea pigs to study the endogenous conductances and the effects of leptin on kisspeptin neurons. We targeted the arcuate kisspeptin neurons using visualized-patch whole-cell recording and identified kisspeptin neurons using immuocytochemical staining for ki...
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PMID: 21285322
PDF is available here.
PDF is available here.
Orvosi Hetilap (152)15 2011
Abstract
Amniotic fluid has been used in prenatal diagnosis for more than decades. It yields a simple and reliable screening and diagnostic tool for a variety of congenital malformations and genetic diseases such as chromosomal aberrations, neural tube defects or storage diseases. Nowadays the widening knowle...
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PMID: 21436022
PDF is available here.
PDF is available here.
Abstract
We report that, in the rat hippocampus, learning leads to a significant increase in extracellular lactate levels that derive from glycogen, an energy reserve selectively localized in astrocytes. Astrocytic glycogen breakdown and lactate release are essential for long-term but not short-term memory f...
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PMID: 21376239
PDF is available here.
PDF is available here.
Abstract
We identify a new parkin interacting substrate, PARIS (ZNF746), whose levels are regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parkin. PARIS is a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in human P...
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PMID: 21376232
PDF is available here.
PDF is available here.
Abstract
In virtually all organisms, life expectancy is profoundly affected by caloric intake. For example, dietary restriction (DR; a feeding regimen of fewer calories compared to the ad libitum level without causing malnutrition) has been shown to lengthen, whereas hypercaloric (HC) diet fe...
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PMID: 21464518
PDF is available here.
PDF is available here.
Abstract
We have used a combined approach in which we first used an in vitro system to select compounds able to inhibit recombinant GSK3β. Subsequently, we subjected the candidate compounds to three consecutive cell-based complementary screening assays. First, cell viability was assessed using a neuroblasto...
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PMID: 21222634
PDF is available here.
PDF is available here.
Long-term self-renewable feeder-free human induced pluripotent stem cell-derived neural progenitors.
Abstract
We have established a homogenous, expandable, and self-renewable population of multipotent NPs from hiPSCs, using an adherent system and defined medium supplemented with a combination of factors. The established hiPSC-NPs highly expressed Nestin and Sox1. These NPs were continuously propagated for ~...
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PMID: 20632795
PDF is available here.
PDF is available here.
Journal of Neurotrauma (28)3 2011
Abstract
We examined the effect of vascular endothelial growth factor (VEGF), and the correlation between VEGF and the Raf/MEK/ERK cascade in neurogenesis after traumatic brain injury (TBI). The expression of VEGF and the phosphorylation level of Raf/MEK/ERK were analyzed by Western blot, and TBI-induced neu...
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PMID: 21091268
PDF is available here.
PDF is available here.
Stable kinesin and dynein assemblies drive the axonal transport of mammalian prion protein vesicles.
Abstract
We characterize the intracellular transport and steady-state motor subunit composition of mammalian prion protein (PrP(C)) vesicles. We identify Kinesin-1 and cytoplasmic dynein as major PrP(C) vesicle motor complexes and show that their activities are tightly coupled. Regulation of normal retrograd...
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PMID: 21335237
PDF is available here.
PDF is available here.
Abstract
We show that mammalian Dpy-30, a core subunit of the SET1/MLL histone methyltransferase complexes, modulates H3K4 methylation in vitro, and directly regulates chromosomal H3K4 trimethylation (H3K4me3) throughout the mammalian genome. Depletion of Dpy-30 does not affect ESC self-renewal, but signific...
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PMID: 21335234
PDF is available here.
PDF is available here.
Abstract
We report mutants of a novel Drosophila gene twenty-four (tyf) that show weak behavioural rhythms. Weak rhythms are accompanied by marked reductions in the levels of the clock protein Period (PER) as well as more modest effects on Timeless (TIM). Nonetheless, PER induction in pacemaker neurons can r...
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PMID: 21331043
PDF is available here.
PDF is available here.
Nano Letters (11)2 2011
Abstract
We employ simple geometrical rules to design a set of nanotopographies able to interfere with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint lithography techniques on cyclic-olefin-copolymer films, we demonstrate that by varying a single topographical parameter...
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PMID: 21241061
PDF is available here.
PDF is available here.
Abstract
We recorded the activity of 1019 neurons while twelve subjects performed self-initiated finger movement. We report progressive neuronal recruitment over ∼1500 ms before subjects report making the decision to move. We observed progressive increase or decrease in neuronal firing rate, particularly i...
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PMID: 21315264
PDF is available here.
PDF is available here.
Abstract
We investigate the neural mechanisms of tactile motion integration by presenting tactile gratings and plaids to the fingertips of monkeys, using the tactile analogue of a visual monitor and recording the responses evoked in somatosensory cortical neurons. The perceived directions of the gratings and...
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PMID: 21315263
PDF is available here.
PDF is available here.
Abstract
We show that Dab1, an essential component of the reelin pathway, is required in radially migrating neurons for glia-independent somal translocation, but not for glia-guided locomotion. During migration, Dab1 acts in translocating neurons to stabilize their leading processes in a Rap1-dependent manne...
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PMID: 21315259
PDF is available here.
PDF is available here.
Abstract
We identify five distinct classes of fru neuron that trigger or compose the song. Our data suggest that P1 and pIP10 neurons in the brain mediate the decision to sing, and to act upon this decision, while the thoracic neurons dPR1, vPR6, and vMS11 are components of a central pattern generator that t...
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PMID: 21315261
PDF is available here.
PDF is available here.
Abstract
We show that Notch1 and its ligand Jagged1 are present at the synapse, and that Notch signaling in neurons occurs in response to synaptic activity. In addition, neuronal Notch signaling is positively regulated by Arc/Arg3.1, an activity-induced gene required for synaptic plasticity. In Arc/Arg3.1 mu...
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PMID: 21315255
PDF is available here.
PDF is available here.