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Oxyphil Cells (0):
Recent article
Oxyphil Cells
Endocrine Regulations (44)2 2010
Abstract
Among 37 patients with Hürthle cell predominance in FNAB, 29 had benign diseases and 8 had malignant diseases resulting in 21.6% prevalence of malignancy. There were no differences in age, sex, functional status of the thyroid gland, and nodule size between patients with benign versus malignant dis...
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PMID: 20429635
PDF is available here.
PDF is available here.
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Clinical Neuropathology (29)1 2010
Abstract
We report an unusual choroid plexus carcinoma with extensive oncocytic transformation. A 13-month-old girl presented with acute lethargy which quickly progressed to coma. A CT scan of the head revealed impending herniation due to hemorrhage within an intracranial tumor. An MRI scan showed a large, p...
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PMID: 20040328
PDF is available here.
PDF is available here.
Abstract
We designed, synthesized, and tested a novel molecular probe, in which the antisense oligodeoxynucleotide (ASODN) was labeled with superparamagnetic iron oxide (SPIO), and its efficiency was examined by in vitro MR imaging after SK-Br-3 mammary carcinoma cell lines (oncocytes) transfection. The SPIO...
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PMID: 19337837
PDF is available here.
PDF is available here.
Abstract
Abstract
Sialolipoma and lipoadenoma with or without oncocytosis and/or sebaceous differentiation should be considered organ-specific tumors with a distinct histological appearance and specific terminology....
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PMID: 19679967
PDF is available here.
PDF is available here.
Abstract
Abstract
A 42-year-old patient had a stage III ovarian endometrioid adenocarcinoma with areas of hepatoid carcinoma (HC) of clear cell and eosinophilic pseudoglandular type that was difficult to differentiate from endometrioid carcinoma of oxyphilic type and sex cord-stromal tumor. Immunohist...
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PMID: 18753970
PDF is available here.
PDF is available here.
Abstract
We prepared the SPIO-labeled ASODN probe successfully. It can effectively transfect SK-Br3 oncocyte and enter SK-Br3 oncocyte, and thus reduce the signal intension in MRI....
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PMID: 19024385
PDF is available here.
PDF is available here.
Abstract
Oncocytic cytology is seen in a variety of thyroid conditions that are associated with a broad differential diagnosis and care must be used for accurate diagnosis. Newer molecular-based techniques may be useful for further classification of thyroid neoplasms with oncocytic pathology....
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PMID: 18684023
PDF is available here.
PDF is available here.
Abstract
We report 2 cases of this rare entity with emphasis on the diagnostic histomorphological features. The cases are also distinctive, in that they have an epithelial lining, which is oncocytic throughout. One of our cases was detected in an 8-year-old male child, which is itself a rarity....
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PMID: 18573791
PDF is available here.
PDF is available here.
Abstract
An oncocyte is a cell containing an abundant amount of deeply eosinophilic finely granular cytoplasm, rounded nuclei, and variable presence of nucleoli in conventional hematoxylin-eosin-stained sections. In the head and neck, a small number of lesions are constructed overwhelmingly of oncocytes; a l...
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PMID: 18486901
PDF is available here.
PDF is available here.
Abstract
An association was found between calcitriol and/or cinacalcet therapy and a high prevalence of nodular hyperplasia, and between cinacalcet therapy and high oxyphil/chief cell ratio. The meaning of the observed associations remains uncertain....
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PMID: 18322048
PDF is available here.
PDF is available here.
Abstract
Abstract
Both adenoma weight and oxyphil cell content were found to significantly correlate with positive sestamibi scan results. In patients with high-weight adenomas, adenoma weight was the most significant factor in obtaining positive MIBI scan results, whereas in patients with low adenoma weights, high o...
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PMID: 18082541
PDF is available here.
PDF is available here.
Molecular Vision (14) 2008
Abstract
AFM is ideal for morphological observation and for analyzing the molecular structure of synthesized c-erbB2 oncogene antisense probes....
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PMID: 18253092
PDF is available here.
PDF is available here.
Annals of Surgical Oncology (14)12 2007
Abstract
There is a statistically significant difference in the expression of p16, p21, cyclin D1, and cyclin E between DTCs and benign thyroid lesions, and p16 expression correlates with clinicopathologic variables predicting poor outcomes for DTC. These results suggest that evaluation of cell cycle derange...
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PMID: 17882495
PDF is available here.
PDF is available here.
Abstract
We investigated the expression of RET, RAS, and ERK proteins in oxyphil cells in the vicinity of large lymphoid HT infiltrates and in malignant PTC cells. BRAF and N-RAS missense mutations were also examined in oxyphil cells of the HT. We used 47 PTC samples with no HT diagnosis, 28 PTC with HT, 39...
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PMID: 17900235
PDF is available here.
PDF is available here.
Abstract
Abstract
We sequenced the entire mtDNA in 50 oncocytic lesions (45 thyroid tumors of epithelial cell derivation and 5 mitochondrion-rich breast tumors) and 52 control cases (21 nononcocytic thyroid tumors, 15 breast carcinomas, and 16 gliomas) by using recently developed technology that allows specific and r...
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PMID: 17517629
PDF is available here.
PDF is available here.
Abstract
PA cells showed the typical immunohistochemical profile, including positivity for Ck5/6, Ck8/18, Ck14, vimentin, ASMA, S100 protein, p63, epidermal growth factor receptor and beta-catenin, whereas oncocytic cells showed a luminal phenotype, expression of anti-mitochondria antibody and reduced beta-c...
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PMID: 16467165
PDF is available here.
PDF is available here.
Abstract
We describe a patient with simultaneous bilateral involvement of the parotid glands and neck by multiple Warthin's tumours, an occurrence not previously described....
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PMID: 16207506
PDF is available here.
PDF is available here.
Cytopathology (18)2 2007
Abstract
Galectin-3 expression was found in 29% follicular adenoma (FA), 26% Hashimoto thyroiditis (HT), and in 24% nodular goitre (NG). We found a statistically significant relationship between the presence of macrophages and galectin-3 positivity in NG and HT samples (P < 0.0001 and P = 0.0087 respectively...
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PMID: 17397496
PDF is available here.
PDF is available here.
Abstract
We report a 55-year-old man with oncocytic schneiderian papilloma confined to the sphenoid sinus, which was initially detected by positron emission tomography with 18F-fluorodeoxyglucose (FDG-PET) at a very early stage. Based on CT and MRI findings, we suspected that the tumor was most likely benign...
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PMID: 17432078
PDF is available here.
PDF is available here.
Virchows Archiv (450)3 2007
Abstract
Acta Cytologica (51)4 2007
Abstract
Acta Cytologica (51)4 2007
Abstract
Acta Cytologica (51)4 2007
Abstract
BACKGROUND: Multifocal nodular oncocytic hyperplasia (MNOH) is a rare lesion of the parotid gland. Fine needle aspiration cytology (FNAC) in MNOH has not been described previously to the best of our knowledge. CASE: A 55-year-old woman presented with a lump at the left angle of her mouth for 2 month...
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PMID: 17718138
PDF is available here.
PDF is available here.
Abstract
We report a case of sclerosing polycystic adenosis in a 45-year-old white woman....
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PMID: 16054736
PDF is available here.
PDF is available here.
Endocrine Pathology (18)3 2007
Abstract
We present a case of oncocytic adrenocortical carcinoma in a 25-year-old man who presented with persistent hypertension, hypokalemia, and a large right adrenal mass. Clinical workup revealed increased serum aldosterone level, suppressed serum ACTH level and high 24-h urine cortisol. Histologically t...
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PMID: 18058268
PDF is available here.
PDF is available here.
Abstract
The presence of papillary carcinoma of the thyroid in multiple generations of one kindred is a statistical impossibility as an occurrence of chance. However, traditional and molecular genetic analyses to date have failed to support the notion of a single gene mutation or identify one, in distinct con...
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PMID: 17131396
PDF is available here.
PDF is available here.
Abstract
Present study results suggest that MIBI scintigraphy was clearly superior to US as a diagnostic tool. However, P-gp expression, oxyphilic cell content, and tumoral volume may have not a main effect on MIBI parathyroid scintigraphy results in parathyroid adenoma....
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PMID: 17257073
PDF is available here.
PDF is available here.
Journal of Neurosurgery (105)5 2006
Oncocytic meningiomas: Cases with benign histopathological features and a favorable clinical course.
Abstract
Data in the presented cases did not confirm a previously described propensity to aggressiveness in this meningioma subtype. In fact, the histological features as well as the long-term favorable clinical course may suggest benign behavior of such neoplasms, as in the common forms of meningiomas....
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PMID: 17121136
PDF is available here.
PDF is available here.
Abstract
We investigated whether pathologists consistently interpret FNA specimens from these lesions. In the present study, 22 FNA specimens that showed Hürthle cells as the predominant cell type were reviewed by 7 pathologists. Cytologic features were assessed semiquantitatively. IV was calculated, and in...
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PMID: 16938664
PDF is available here.
PDF is available here.
Abstract
The changes in these cells differ from those described previously in endocrine cells encountered in pretreated rectal cancers. Oncocytic change in this particular clinical context occurs as a reflection of cytotoxic damage or cellular hypoxia induced by chemoradiation resulting in degeneration of th...
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PMID: 16467161
PDF is available here.
PDF is available here.
Histopathology (49)3 2006
Abstract
Abstract
Oxyphil cell predominance within an adenoma augments technetium Tc 99m sestamibi scan sensitivity in a statistically significant manner. The use of technetium Tc 99m sestamibi preoperative localization may therefore be differentially greater in patients with these types of lesions....
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PMID: 16847189
PDF is available here.
PDF is available here.
Abstract
We report the clinicopathologic, immunohistochemical, ultrastructural, and interphase cytogenetic features of 12 papillary RCC composed by oncocytes. Ten patients were males and their median age was 67 years. The tumors were well demarcated and their median diameter was 7.1 cm. Solid oncocytoma-like...
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PMID: 16730306
PDF is available here.
PDF is available here.
Abstract
In the current study of 139 FNAB specimens of thyroid Hurthle cell nodules, 14 cytologic features were examined and 6 were found to be statistically significant in identifying HCN. The following four features, when found in combination, were found to be highly predictive of HCN: nonmacrofollicular a...
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PMID: 16453320
PDF is available here.
PDF is available here.
Pathologica (98)2 2006
Abstract
This review aims to describe and assist in the categorization of most of the unusual non-neoplastic conditions, encountered in the surgical pathology of the thyroid. The conditions included are: normal intrathyroidal vestigial tissues/structures (i.e. rests of the ultimobranchial body and thyrogloss...
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PMID: 16929786
PDF is available here.
PDF is available here.
Virchows Archiv (448)4 2006
Abstract
The purpose of the study is to highlight oncocytic modifications in rectal adenocarcinomas and evaluate a possible correlation with preoperative radiochemotherapy (RCT). Twenty-eight cases of advanced rectal carcinoma, treated preoperatively by 5-fluorouracil (200-225 mg/m(2)) and 44-46 Gy in 22-23...
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PMID: 16365727
PDF is available here.
PDF is available here.
Abstract
We present a case of laryngeal oncocytic cysts presenting as bilateral laryngoceles and surgical emphysema of the neck. Although there is a rare, but well-documented association of laryngoceles with laryngeal carcinoma, coexistence with another laryngeal pathology is less well reported.
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PMID: 16362263
PDF is available here.
PDF is available here.
Abstract
Abstract
Neoplastic disease accounts for two thirds of the pathology in patients with a predominance of Hürthle cells on FNAB specimen and neither clinical nor cytologic features reliably exclude Hürthle cell adenoma or carcinoma. As a result, thyroidectomy is recommended for all patients with a thyroid no...
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PMID: 16269293
PDF is available here.
PDF is available here.
Cytopathology (16)5 2005
Abstract
The CIs were present in 36 (30.0%) of HT, 26 (34.2%) of neoplastic goitres, 3 (27.3%) of HN, and 4 (4.0%) colloid goitres. As compared to colloid goitres, CIs were present in a significant higher number of cases in HN (P = 0.0202), neoplastic goitres (P < 0.0001), and HT (P < 0.0001). Among neoplasm...
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PMID: 16181309
PDF is available here.
PDF is available here.
Abstract
We preferred a close follow-up to an elective neck dissection, and reserved the neck dissection for a recurrence. The prognosis of oncocytic carcinomas is not well known because of their low incidence. Further investigation of the prognosis of patients with oncocytic carcinoma of the parotid gland i...
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PMID: 15592856
PDF is available here.
PDF is available here.
Abstract
Abstract
Virchows Archiv (446)4 2005
Abstract
We present clinical, morphological, immunohistochemical, ultrastructural and molecular genetic features of 20 cases of a peculiar form of chromophobe renal cell carcinoma (CRCC) with morphology differing from that of conventional CRCC. Microscopically, the typical features of the tumors were microcy...
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PMID: 15756595
PDF is available here.
PDF is available here.
Abstract
We report 2 previously undescribed morphological variants of pancreatic intraepithelial neoplasia (PanIN). The first variant with an intestinal phenotype was associated with mucinous carcinomas that occurred in the tail of the pancreas of 2 men (60 and 65 years old). The carcinomas lacked the charac...
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PMID: 15806512
PDF is available here.
PDF is available here.
Abstract
We have previously shown that the epitope H is present in more than one polypeptide and in various types of normal and pathological cells. In the present study, we focused on mitochondria-rich normal, metaplastic, and neoplastic cells, prompted by our recent immuno-electron microscopy findings that...
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PMID: 15991839
PDF is available here.
PDF is available here.
Abstract
A malignant melanoma was diagnosed in an axillary lymph node of a 49-year-old man. The tumor was examined by electron microscopy and was found to be composed of large oncocytic cells, filled with abundant mitochondria. No primary tumor could be identified on the skin or within internal organs. Appro...
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PMID: 16257866
PDF is available here.
PDF is available here.
Virchows Archiv (446)1 2005
Abstract
Abstract
Hürthle cell papillary thyroid carcinoma is a variant of papillary thyroid carcinoma (PTC). Its pathologic and clinical significance has not been well documented. The authors studied the relative incidence of Hürthle cell PTC and the relationship of Hürthle cell PTC to other variants of thyroid c...
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PMID: 15536332
PDF is available here.
PDF is available here.
Archives of Surgery (139)11 2004
Abstract
A strong relationship between volume of the parathyroid gland, serum parathyroid hormone levels, and MIBI uptake exists in primary hyperparathyroidism. Gamma probe-guided localization of abnormal gland(s) can be more successful if surgery is undertaken at maximum uptake ratio. High Pgp expression in...
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PMID: 15545562
PDF is available here.
PDF is available here.
Abstract
Abstract
We report a case of diffuse hyperplastic oncocytosis of the parotid gland in a 63-year-old male with a brief review of literature. To the best of our knowledge this is the first case from Indian subcontinent....
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PMID: 16295393
PDF is available here.
PDF is available here.
Abstract
Surgery is indicated for all nodular lesions with more than 50% Hürthle cells in FNAC....
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PMID: 15296995
PDF is available here.
PDF is available here.
Pathology International (54)8 2004
Abstract
We suggest that most oncocytic adrenocortical carcinomas might be low-grade malignancies with less aggressive histological features compared with conventional carcinomas. However, they should be excised completely because of the likelihood of recurrence and metastasis during the follow-up period....
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PMID: 15260851
PDF is available here.
PDF is available here.
Abstract
We studied Ron protein expression by immunohistochemistry in a larger number of renal cell neoplasms with emphasis on chromophobe renal cell carcinomas. Tissue microarrays containing 141 renal cell neoplasms, including 55 oncocytomas and 52 chromophobe renal cell carcinomas, were constructed. In add...
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PMID: 15252311
PDF is available here.
PDF is available here.