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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Pericytes (0):
Recent article
Pericytes
Abstract
We show that implanted vascular networks anastomose with host vessels through a previously unidentified process of "wrapping and tapping" between the engrafted endothelial cells (ECs) and the host vasculature. At the host-implant interface, implanted ECs first wrap around nearby host vessels and the...
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PMID: 21835951
PDF is available here.
PDF is available here.
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Abstract
Our preliminary findings also suggested the pericyte phenotype underlying such cell lineage, which supported a novel interpretation about the common origin of mesenchymal stem cells and tissue-specific stem cells within blood vessel walls. Current research on DFAT cells indicated that this alternati...
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PMID: 21789960
PDF is available here.
PDF is available here.
Journal of Immunotherapy (34)3 2011
Abstract
We investigated the molecular mechanism of the effects of this combination therapy on melanoma tumor growth. In B16 tumor-bearing mice, the addition of IFN-α to DTIC treatment significantly reduced tumor volume, compared with control or DTIC alone. Consistently, Digital Radiography data showed less...
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PMID: 21389866
PDF is available here.
PDF is available here.
Autoimmunity Reviews (10)5 2011
Abstract
I interferon, type 2 immune responses and mechanical stress as extracellular cues that modulate fibroblast function and differentiation, and as potential targets for therapy. Moreover, fibrillin-1 has a major role in storing and regulating the bioavailability of TGF-ß and other cytokines, and fibri...
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PMID: 20863909
PDF is available here.
PDF is available here.
Abstract
I in Dulbecco's modified Eagle's medium containing 5.5 mM glucose. For cocultures, pericytes and endothelial cells were seeded together on rat tail collagen type I-coated cell culture plates. After 24 h of initial culture, the medium was replaced with serum-free medium containing 0-100 mM g...
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PMID: 21091050
PDF is available here.
PDF is available here.
Abstract
Cell turnover in the healthy adult kidney is very slow but the kidney has a strong capacity for regeneration after acute injury. Although many molecular aspects of this process have been clarified, the source of the newly-formed renal epithelial cells is still being debated. Several...
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PMID: 20714827
PDF is available here.
PDF is available here.
Abstract
Mesenchymal stem cells are multipotent adult stem cell populations that have broad differentiation plasticity and immunosuppressive potential that render them of great importance in cell-based therapies. They are identified by in vitro characteristics based on their differentiation potential for cli...
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PMID: 20836622
PDF is available here.
PDF is available here.
Abstract
Analyses of microvascular networks with traditional tracer filling techniques suggest that the blood and lymphatic systems are distinct without direct communications, yet involvement of common growth factors during angiogenesis and lymphangiogenesis suggest that interactions at the c...
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PMID: 20648570
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Maturation of tumor vasculature by interferon-beta disrupts the vascular niche of glioma stem cells.
Abstract
Although IFN-β was not directly toxic to glioma stem cells in vitro, IFN-β decreased tumor size and the number of stem cells recovered in both heterotopic and orthotopic models. Treatment with IFN-β increased perivascular cells investing the tumor vasculature (6-fold) distancing stem cells from e...
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PMID: 20944101
PDF is available here.
PDF is available here.
Developmental Biology (344)2 2010
Abstract
Tightly regulated crosstalk between endothelial cells and pericytes is required for formation and maintenance of functional blood vessels. When the NG2 proteoglycan is absent from pericyte surfaces, vascularization of syngeneic tumors growing in the C57Bl/6 mouse brain is aberrant in several respect...
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PMID: 20599895
PDF is available here.
PDF is available here.
Abstract
The anti-tumor efficacy of paclitaxel was significantly improved 7 days after the treatment of rh-endostatin. Tumor microvascular density was decreased by rh-endostatin, although it became even higher 7 days after termination of rh-endostatin. Non-necrotic hypoxic fraction was significantly reduced...
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PMID: 20130910
PDF is available here.
PDF is available here.
Abstract
Despite promising results in preclinical and clinical studies, the therapeutic efficacy of antiangiogenic therapies has been restricted by a narrow focus on inhibiting the growth of endothelial cells. Other cell types in the tumor stroma are also critical to the progression of cancer, including mura...
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PMID: 20540157
PDF is available here.
PDF is available here.
Abstract
Abstract
Angiogenesis has been recognised as a precursor of fibrosis in several pathologic conditions. Its participation has been demonstrated in schistosomiasis, both during periovular granuloma formation and in the genesis of schistosomal periportal fibrosis. Paradoxically, proliferation of new blood vesse...
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PMID: 20721486
PDF is available here.
PDF is available here.
Abstract
We used (4-hydroxy-3-nitrophenyl)acetyl chicken gamma-globulin immunisation and mice lacking CD248 to study whether CD248 modulates popliteal LN (pLN) expansion and subsequent immune responses. We have found that CD248 is required for complete pLN expansion but not for co-ordination of B and T cell...
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PMID: 20432232
PDF is available here.
PDF is available here.
Abstract
PURPOSE. To examine whether diabetes-induced connexin 43 downregulation promotes retinal vascular lesions characteristic of diabetic retinopathy (DR). METHODS. Two animal models, streptozotocin-induced diabetic mice and Cx43 heterozygous knockout (Cx43(+/-)) mice, were studied to directly assess whe...
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PMID: 20130277
PDF is available here.
PDF is available here.
Abstract
The outer zone of the renal inner medulla (IM) is spatially partitioned into two distinct interstitial compartments in the transverse dimension. In one compartment (the intercluster region), collecting ducts (CDs) are absent and vascular bundles are present. Ascending vasa recta (AVR) that lie withi...
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PMID: 20392799
PDF is available here.
PDF is available here.
Cancer Research (70)12 2010
Abstract
We have reinvestigated the putative benefits of doubly targeting endothelial cells and pericytes in the treatment of experimental tumors. For this purpose, we used two highly specific tools, the pericyte-deficient pdgfb(ret/ret) mouse and the recently developed specific anti-VEGF-A antibody G6-31, w...
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PMID: 20501841
PDF is available here.
PDF is available here.
Acta Diabetologica (47)2 2010
Abstract
We reported on reduced pericyte adhesion to high glucose-conditioned ECM and correction by thiamine. We aimed at verifying the effects of thiamine and benfotiamine on MMP-2, MMP-9 and TIMP expression and activity in human vascular cells with high glucose. In HRP, MMP-2 activity, though not expressio...
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PMID: 19404565
PDF is available here.
PDF is available here.
Endocrine Reviews (31)3 2010
Abstract
We review the role of the vasculature in insulin secretion, islet function, and peripheral insulin delivery, and highlight a potential role for the vascular pericyte in these processes....
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PMID: 20164242
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (9)11 2010
Abstract
We demonstrate that TEM-1 mediates proliferation of primary human pericytes through a PDGF receptor signaling pathway. Normal pericytes expressing high levels of TEM-1 were able to proliferate, respond to PDGF-BB stimulation by phosphorylating both the PDGF receptor and the MAP kinase ERK-1/2, and i...
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PMID: 20484976
PDF is available here.
PDF is available here.
Abstract
Purpose. p38 mitogen-activated protein kinase (MAPK) is known to play a regulatory role in inflammatory processes in disease. Inflammation has been linked also to the development of diabetic retinopathy in rodents. This study was conducted to evaluate the effect of a p38 MAPK inhibitor on the develo...
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PMID: 20071676
PDF is available here.
PDF is available here.
Abstract
Our aim was to gain deeper histological and physiological insight into these relations. An intricate network of subendothelial cells, characterized by histological features specific for true pericytes, was detected even in healthy vessels and forms, coupled to the luminal endothelium, a second leafl...
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PMID: 20023125
PDF is available here.
PDF is available here.
Brain research (1315) 2010
Abstract
We found a dependence of the Abeta-mediated toxicity and apolipoprotein E (apoE) production by cultured pericytes on apoE genotype. Given their close association with the cerebrovascular wall both astrocytes and pericytes may be involved in CAA development, a process that includes Abeta deposition a...
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PMID: 20034483
PDF is available here.
PDF is available here.
Neurosurgery (66)2 2010
Abstract
Abstract
Abstract
We show that systemic delivery of VEGF and placental growth factor (PlGF) by protein implantation, tumors, and adenoviral vectors ablates pericytes from the mature retinal vasculature through the VEGF receptor 1 (VEGFR1)-mediated signaling pathway, leading to increased vascular leakage. In contrast,...
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PMID: 20080765
PDF is available here.
PDF is available here.
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer (180) 2010
Abstract
Pericytes are smooth muscle-like cells found in close contact with the endothelium in capillaries, where they regulate the morphology and function of the vessels. During vessel formation, platelet-derived growth factor-BB (PDGF-BB) is required for the recruitment and differentiation of pericytes. Tu...
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PMID: 20033380
PDF is available here.
PDF is available here.
Kardiologiia (50)2 2010
Abstract
We used the model of co-cultivation of ASCs with cells isolated from postnatal hearts (fraction of cardiomyocutes - CMC). CMC fraction contained mature cardiomyocytes, endothelial and progenitor cells. On the 2-nd day spontaneously beating colonies of CMC with growing from them CD31-positive capilla...
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PMID: 20146680
PDF is available here.
PDF is available here.
Molecular Vision (16) 2010
Abstract
The results demonstrate pathways through which two different mediators, TNF-alpha and an advanced glycation endproduct, can induce pericyte apoptosis through activation of the transcription factor FOXO1....
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PMID: 20300563
PDF is available here.
PDF is available here.
Cell Cycle (8)24 2009
Abstract
We have chosen primary culture of human vascular smooth muscle cells (SMC), a non-epithelial mesenchymal cells in order to test them as a control cell type regarding their morphology and expression of NSC and neuronal markers. Utilization of estradiol (E2), progesterone (PG) or testosterone (TS) alo...
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PMID: 19946214
PDF is available here.
PDF is available here.
Abstract
The in situ data clearly support the hypothesis of fibroblasts to contribute to vascular maturation phenomena in colon cancers. The in vivo design of only 500 tumour cells co-injected with normal fibroblast is feasible, results in 100% engraftment and is the basis for further developments....
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PMID: 19895278
PDF is available here.
PDF is available here.
Rinsho Shinkeigaku (49)11 2009
Abstract
We successfully established human immortalized cell lines originating from BNB using temperature-sensitive SV40 large T antigen and the cellular properties of human cell lines are presented in this paper. Human PnMEC cell line showed high transendothelial electrical resistance and expressed tight ju...
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PMID: 20030260
PDF is available here.
PDF is available here.
Abstract
We demonstrate that, in organotypic cocultures, dermal pericytes substantially enhanced the intrinsically low tissue-regenerative capacity of human epidermal cells that have committed to differentiate and that this enhancement was independent of angiogenesis. We used microarray analysis to identify...
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PMID: 19652362
PDF is available here.
PDF is available here.
Hearing Research (254)1-2 2009
Abstract
We developed a method to visualize cochlear pericytes using diaminofluorescein-2 diacetate (DAF-2DA) and intravital fluorescence microscopy. This method can permit the study of the effect of vasoactive agents on pericytes under the in vivo and normal physiological condition. The specificity of the l...
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PMID: 19422897
PDF is available here.
PDF is available here.
Abstract
This study systematically analyzes platelet-derived growth factor (PDGF) receptor expression in six types of common tumors as well as examines associations between PDGF beta-receptor status and clinicopathological characteristics in breast cancer. PDGF receptor expression was determined by immunohis...
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PMID: 19498003
PDF is available here.
PDF is available here.
Abstract
We report on a novel mechanism that explains how this process is accomplished. Our current investigation demonstrates that soluble platelet derived growth factor- (PDGF)-BB activates a cohort of PDGF-beta receptors primarily confined to the lipid raft component of the cell membrane, specifically cav...
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PMID: 19497991
PDF is available here.
PDF is available here.
Abstract
We sought to identify the target cells of NO in the rat skeletal musculature, using subtypes of sGCalpha1 and sGCbeta1 antibodies. Immunohistochemistry revealed that both antibodies stained the same cells with round or oval shapes, having several long processes. The sGC-immunopositive cells co-expre...
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PMID: 20009348
PDF is available here.
PDF is available here.
Abstract
We review the morphofunctional characteristics of pericytes and report our observations. After a brief historical background, we consider the following aspects of pericytes: A) Origin in embryonic vasculogenesis (mesenchymal stem cells, neurocrest and other possible sources) and in embryonic and pos...
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PMID: 19475537
PDF is available here.
PDF is available here.
Abstract
We compared transcription levels in entire rat retina of genes related to these pathways between control conditions and after 6 and 12 weeks of streptozotocin-induced diabetes, as well as in bovine retinal endothelial cells (BRECs) exposed to VEGF and bovine retinal pericytes (BRPCs), using real-tim...
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PMID: 19284967
PDF is available here.
PDF is available here.
Radiation Research (171)5 2009
Abstract
A variety of antiangiogenic strategies have proven effective in preclinical tumor models, either as single agents or in combination with radiation. Clinical gains have been relatively modest, however, and questions remain regarding optimal scheduling. The objectives of the current work were to evalu...
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PMID: 19580496
PDF is available here.
PDF is available here.
Abstract
Molecular genetic studies have identified various signaling proteins that regulate the formation and function of CNS neurovascular units. These include members of the integrin family of ECM adhesion receptors, ECM proteins such as Wnts and latent transforming growth factor betas, and various transcr...
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PMID: 19318941
PDF is available here.
PDF is available here.
Brain Research (1260) 2009
Abstract
We investigated if Abeta may influence production and expression of two major Abeta-associated HSPG species, agrin and glypican-1. When human brain pericytes (HBP) were cultured in the presence of Abeta, protein and mRNA expression of both agrin and glypican-1 were increased and more radioactive sul...
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PMID: 19166823
PDF is available here.
PDF is available here.
Journal of Pathology (217)4 2009
Abstract
We therefore assessed the vascular morphology of two mouse mammary carcinoma xenotransplants (M6378 and M6363) which differ in their natural angiopoietin expression. M6378 displayed Ang-1 in tumour cells but no Ang-2 in tumour endothelial cells in vivo. In contrast, M6363 tumours expressed Ang-2 in...
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PMID: 19116989
PDF is available here.
PDF is available here.
Abstract
We aimed at establishing an immortalized human retinal pericyte (HRP) line, as a species-specific model to investigate the pericyte-related aspects of diabetic retinopathy. Primary human retinal pericytes (WT-HRP) were immortalized through electroporation with a plasmid vector containing the Bmi-1 o...
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PMID: 19212656
PDF is available here.
PDF is available here.
Abstract
We provide that the recruitment of pericytes and astrocytes to vascular tube of endothelial cells is closely associated with the formation of tight junction in developing retinal vessels. At P4, endothelial cells of retinal vessels behind the invading front directly contact to pericytes, but not to...
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PMID: 18816791
PDF is available here.
PDF is available here.
Journal of the American College of Cardiology (53)5 Suppl 2009
Abstract
Hyperglycemia can promote vascular complications by multiple mechanisms, with formation of advanced glycation end products and increased oxidative stress proposed to contribute to both macrovascular and microvascular complications. Many of the earliest pathologic responses to hyperglycemia are manif...
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PMID: 19179216
PDF is available here.
PDF is available here.
Pathologica (101)1 2009
Abstract
Seven cases of cerebellar haemangioblastoma, not associated with von Hippel-Lindau disease (sporadic haemangioblastomas), were studied by light and electron transmission microscopy. Morphological features that might provide information about the histogenesis of the tumour were examined. The ultrastr...
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PMID: 19771763
PDF is available here.
PDF is available here.
Cell and Tissue Research (335)1 2009
Abstract
We present and discuss the role of endothelial and astroglial cells in managing the blood-brain barrier (BBB) and aspects of pathological alterations in the BBB. The impact of astrocytes, pericytes, and perivascular cells on the induction and maintenance of the gliovascular unit is largely unidentif...
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PMID: 18633647
PDF is available here.
PDF is available here.
Abstract
Our data suggest that apoptosis induced by HOG-LDL in HRCP is independent of the activation of MAPK signaling pathways....
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PMID: 19158958
PDF is available here.
PDF is available here.
Abstract
Anticancer Research (29)1 2009
Abstract
The incidence of peg-socket junctions was approximately 8% in 5 out of 9 cases. The remaining 4 cases showed a very low rate, including two cases in whom interactions were totally absent. Peg-socket junctions consisted of cytoplasmic projection from the pericyte protruding into the endothelial inden...
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PMID: 19331185
PDF is available here.
PDF is available here.
Abstract
We define a role for VEGF as an inhibitor of neovascularization on the basis of its capacity to disrupt VSMC function. Specifically, under conditions of PDGF-mediated angiogenesis, VEGF ablates pericyte coverage of nascent vascular sprouts, leading to vessel destabilization. At the molecular level,...
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PMID: 18997771
PDF is available here.
PDF is available here.
Abstract
We provide direct evidence that the cell fusion process contributes to the formation of pericytes after stroke. We generated mouse bone marrow chimeras using a cre/lox system that allows the detection of fusion events by X-gal staining. In these mice, we detected X-gal-positive cells that expressed...
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PMID: 19066613
PDF is available here.
PDF is available here.
Abstract
We examined the origins of coll1a1-producing cells in the kidney. Here we show that in normal kidney, both podocytes and pericytes generate coll1a1 transcripts as detected by enhanced GFP, and that in fibrotic kidney, coll1a1-GFP expression accurately identifies myofibroblasts. To determine the cont...
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PMID: 19008372
PDF is available here.
PDF is available here.
Abstract
We have previously reported that breast cancer cells which overexpress HER2 produce higher levels of VEGF than cells with low levels of HER2. This study tested the hypothesis that dual targeting of the VEGF (with VEGF-Trap) and HER2 (with trastuzumab) pathways would result in greater growth inhibiti...
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PMID: 19029832
PDF is available here.
PDF is available here.
Abstract
We investigated the impact of astrocytes and pericytes on brain endothelial cell permeability and survival during different degrees of O2 deprivation. Prolonged exposure to 1% O2 caused barrier breakdown and exposure to 0.1% O2 dramatically accelerated disruption and induced cell death, mediated at...
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PMID: 19016245
PDF is available here.
PDF is available here.
Abstract
We used VEGF-A165 (which binds HS and NRP1), VEGF-A121 (binds neither HS nor NRP1), and parapoxvirus VEGF-E-NZ2 (binds NRP1 but not HS) to investigate the role of NRP1 in organization of endothelial cells into vascular structures. All 3 ligands induced similar level of VEGFR-2 tyrosine phosphorylati...
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PMID: 18664627
PDF is available here.
PDF is available here.
Abstract
We isolated peripheral nerve, brain, and lung pericytes from transgenic rats harboring the temperature-sensitive simian virus 40 large T-antigen gene. These cell lines expressed several pericyte markers such as alpha-smooth muscle actin, NG2, osteopontin, and desmin, whereas they did not express end...
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PMID: 18543246
PDF is available here.
PDF is available here.
Current Eye Research (33)11 2008
Abstract
Elevated glucose decreased HRP viability and modulated changes in TGFbeta2 and VEGF release. This suggests a novel mechanism for HRP dropout in diabetic retinopathy....
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PMID: 19085381
PDF is available here.
PDF is available here.