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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Phagocytes (3):
Recent article
Phagocytes
Abstract
We show that in both RAW264.7 macrophage cells and primary bone marrow-derived macrophages, the production of IFN-β and IL-6, but not TNF, in response to cyclic-di-AMP and cyclic-di-GMP requires MPYS (also known as STING, MITA, and TMEM173). Furthermore, expression of MPYS was required for IFN resp...
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PMID: 21813776
PDF is available here.
PDF is available here.
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Abstract
Juvenile idiopathic arthritis (JIA) has had a long and difficult problem with classification. It is clearly a heterogeneous and multi-factorial autoimmune disease but all too often the distinctions among subtypes were unclear. In fact, there is now increasing evidence of a distinct p...
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PMID: 21320644
PDF is available here.
PDF is available here.
Abstract
Our results showed that T. stromaticum spores prevented the expression and production of inflammatory mediators in macrophages stimulated with interferon (IFN)-γ plus lipopolysaccharide (LPS) and neutrophils stimulated with phorbol myristate 13-acetate (PMA). Quantitative polymerase chain reaction...
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PMID: 21623538
PDF is available here.
PDF is available here.
Cell Host & Microbe (8)5 2010
Abstract
We uncovered a beneficial effect of statins on bacterial clearance by phagocytes, although, paradoxically, both phagocytosis and oxidative burst were inhibited. Probing instead for an extracellular mechanism of killing, we found that statins boosted the production of antibacterial DNA-based extracel...
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PMID: 21075355
PDF is available here.
PDF is available here.
Abstract
A microglial cell is both a glial cell of the central nervous system and a mononuclear phagocyte, which belongs to the haematopoietic system and is involved in inflammatory and immune responses. As such, microglia face a challenging task. The neurons of the central nervous system cannot divide and b...
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PMID: 21068834
PDF is available here.
PDF is available here.
Abstract
We identify the plasma membrane channel pannexin 1 (PANX1) as a mediator of find-me signal/nucleotide release from apoptotic cells. Pharmacological inhibition and siRNA-mediated knockdown of PANX1 led to decreased nucleotide release and monocyte recruitment by apoptotic cells. Conversely, PANX1 over...
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PMID: 20944749
PDF is available here.
PDF is available here.
Abstract
We identified the chemokine receptor cxcr3a as a marker of innate immune cells. Cells expressing cxcr3a were characterized in fish transgenic for a cxcr3a:gfp reporter. In embryos and larvae, cxcr3a-expressing cells are motile in healthy and damaged tissues, and phagocytic; the majority of these cel...
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PMID: 20921403
PDF is available here.
PDF is available here.
Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (16)10 2010
Abstract
Neutrophils are always present in the cytomorphologic process of leishmaniasis but their role is still not fully understood. Microscopic examination was done on smears from 56 cases of clinically diagnosed cutaneous leishmaniasis. Neutrophils were the predominant cells in the smear (> 35% of the tot...
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PMID: 21222422
PDF is available here.
PDF is available here.
Journal of Hypertension (28)9 2010
Abstract
We performed in-vitro experiments in human peripheral blood mononuclear cells and murine macrophages.
Phagocytic NADPH oxidase activity and leptin levels were enhanced (P < 0.05) in obese patients compared with controls. NADPH oxidase activity positively correlated with leptin in obese patients. Thi...
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PMID: 20577124
PDF is available here.
PDF is available here.
Abstract
We turnover billions of cells. The quick, efficient, and immunologically silent disposal of the dying cells requires a coordinated orchestration of multiple steps, through which phagocytes selectively recognize and engulf apoptotic cells. Recent studies have suggested an important role for soluble m...
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PMID: 20805564
PDF is available here.
PDF is available here.
Infection and Immunity (78)8 2010
Abstract
We have tested the integrity of Staphylococcus-containing phagosomes in 293 (HEK-293), HeLa, and EA.hy926 cells over time. Rapid acidification of S. aureus-containing phagosomes occurred and was sustained for up to 24 h. All S. aureus strains tested displayed equally sustained intraphagosomal pH lev...
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PMID: 20530231
PDF is available here.
PDF is available here.
Abstract
We have generated an allele of Noxa1 suitable for conditional inactivation. Moreover, by crossing Noxa1 conditional allele carriers to B6.129S4-Meox2(tm1(Cre)Sor)/J mice, we have generated first, Noxa1-null heterozygotes, and ultimately, Noxa1-null homozygotes. Through the thoughtful use of tissue-s...
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PMID: 20645308
PDF is available here.
PDF is available here.
Experimental oncology (32)2 2010
Abstract
Ukrain (NSC-631570) is a cytostatic and immunomodulating semisynthetic compound of thiophosphate-modified alkaloids of Chelidonium majus L. It has selective cytotoxicity against cancer cells without healthy cells damaging. Dosage range, methods of introduction and duration of administration of the d...
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PMID: 20693973
PDF is available here.
PDF is available here.
Abstract
We show evidence that corals possess immunological repertoires that extend well beyond simple innate defenses. The extent to which corals have developed such an adaptive-like immune repertoire will determine whether corals will survive climate change and other anthropogenic disturbances....
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PMID: 20662364
PDF is available here.
PDF is available here.
Journal of Infectious Diseases (201)12 2010
Abstract
C. albicans within biofilms are more resistant to phagocytic host defenses but are susceptible to additive effects between phagocytes and an echinocandin....
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PMID: 20415537
PDF is available here.
PDF is available here.
Abstract
We describe how tissue-resident macrophages recognize tissue damage to promote the recruitment of neutrophils and the mechanisms by which infiltrating neutrophils can then promote monocyte recruitment. Furthermore, we discuss the phagocyte-derived signals that abrogate neutrophil recruitment and how...
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PMID: 20498669
PDF is available here.
PDF is available here.
Abstract
We review the origins and functions of the mononuclear phagocytes found in the intestinal lamina propria, highlighting the problems that have arisen from their classification. Understanding these cells in their physiological context will be important for developing new therapies for IBDs....
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PMID: 20498668
PDF is available here.
PDF is available here.
Neuromolecular Medicine (12)2 2010
Abstract
Neurologic disease promoted by microbial pathogens, sterile injury, or neurodegeneration rapidly induces innate immunity in adjacent healthy tissue, which in turn contributes extensively to neurologic injury. With more recent focus on innate immune processes, it appears that necrotic...
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PMID: 19830599
PDF is available here.
PDF is available here.
Abstract
We revealed that minute cholesterol crystals are present in early diet-induced atherosclerotic lesions and that their appearance in mice coincides with the first appearance of inflammatory cells. Other crystalline substances can induce inflammation by stimulating the caspase-1-activating NLRP3 (NALP...
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PMID: 20428172
PDF is available here.
PDF is available here.
Abstract
We sought to determine the biological activity of one such MAb, A7 (a human PPS3-specific IgM), and the mechanism by which it mediates protection. In vitro studies demonstrated that coincubation of A7 with ST3 in the absence of phagocytes or a complement source resulted in a reduction in CFU on bloo...
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PMID: 20200186
PDF is available here.
PDF is available here.
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Biology Letters (6)2 2010
Abstract
Evidence for a developmental relationship between B cells and macrophages has led to the hypothesis that B cells evolved from a phagocytic predecessor. The recent identification of phagocytic IgM+ cells in fishes and amphibians supports this hypothesis, but raises the question of whe...
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PMID: 19846448
PDF is available here.
PDF is available here.
Georgian medical news ()181 2010
Abstract
Tumor cells lose their capability of self-destruction at the hazard of their transformation; they are actually immortal. The macrophages phagocyting the oncogenous cell (its nucleus or fragment) may not manage to destroy it. Under such conditions, the transformation of the macrophage itself into the...
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PMID: 20495230
PDF is available here.
PDF is available here.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia (145)2 2010
Abstract
We hope that this effort will help specialists to facilitate the recognition of primary immunodeficiencies and therefore early diagnosis and management....
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PMID: 20467400
PDF is available here.
PDF is available here.
Autoimmunity (43)3 2010
Abstract
We show that MSU is taken up by eosinophils, neutrophils and monocytes in a process involving (a) heat-labile serum factor(s) and divalent cations. The uptake induces the release of the pro-inflammatory cytokines IL-1beta/IL-18/TNFalpha and IL-6/IL-8 by monocytes and PMN, respectively....
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PMID: 20187703
PDF is available here.
PDF is available here.
Hypertension (55)3 2010
Abstract
We showed recently that mononuclear phagocyte system (MPS) cells provide a buffering mechanism for salt-sensitive hypertension by driving interstitial lymphangiogenesis, modulating interstitial Na(+) clearance, and increasing endothelial NO synthase protein expression in response to very high dietar...
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PMID: 20142563
PDF is available here.
PDF is available here.
Abstract
The voltage-gated proton channel bears surprising resemblance to the voltage-sensing domain (S1-S4) of other voltage-gated ion channels but is a dimer with two conduction pathways. The proton channel seems designed for efficient proton extrusion from cells. In phagocytes, it facilitates the producti...
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PMID: 20134026
PDF is available here.
PDF is available here.
Abstract
We demonstrate that RvD1 actions on human polymorphonuclear leukocytes (PMNs) are pertussis toxin sensitive, decrease actin polymerization, and block LTB(4)-regulated adhesion molecules (beta2 integrins). Synthetic [(3)H]-RvD1 was prepared, which revealed specific RvD1 recognition sites on human leu...
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PMID: 20080636
PDF is available here.
PDF is available here.
Abstract
We monitored autophagosome formation in living nonphagocytic cells by inducing autophagy around artificial micrometer-sized beads instead of bacteria. Beads conjugated with bio-reactive molecules provide a powerful tool for examining biochemical properties in vitro. However, this technique has not b...
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PMID: 19901555
PDF is available here.
PDF is available here.
Abstract
Phagocytes, like neutrophils and macrophages, are specialized cells evolved to clear infectious pathogens. This function resides at the core of innate immunity and requires a series of concerted events that lead first to migration to the infected tissue and then to the killing of the invading pathog...
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PMID: 20852826
PDF is available here.
PDF is available here.
Abstract
Phagocytes are the most important early components of the immune response, programmed to recognize, engulf, and destroy immune complexes (formed when antibodies recognize their specific antigens), foreign particles, bacteria, mycobacteria, apoptotic cells, etc. Neutrophils, monocytes, macrophages, a...
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PMID: 20069529
PDF is available here.
PDF is available here.
Abstract
Functional antibody assays can broadly be divided into three categories: neutralisation, serum bactericidal antibody (SBA) and opsonophagocytic assays (OPA). These biological assays are generally more complex than antibody-binding counterparts. They invariably involve multiple biological components,...
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PMID: 20099130
PDF is available here.
PDF is available here.
Mediators of Inflammation (2010) 2010
Abstract
The regulatory functions of glycosaminoglycan hyaluronan (HA) are suggested to be dependent on its molecular weight (MW). Proinflammatory and stimulatory effects are proposed mainly for the low MW HA. However, the complex response of blood phagocytes to HA of different MW is unclear....
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PMID: 21403830
PDF is available here.
PDF is available here.
Abstract
Red dye did not influence the weight of the studied nodes, but determined statistically significant modifications on non-specific immune system parameters. Blue and grena dyes determined modifications of weight especially of retroauricular nodes. Grena dye determined important effects of non-specifi...
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PMID: 20509316
PDF is available here.
PDF is available here.
Abstract
Retro auricular and later cervical nodes mass increases after administration of textile dyes, compared to control group. Basophiles percentages were increased after administration of two dyes (stronger after yellow dye). Peripheral neutrophils activity was increased after administration of two dyes,...
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PMID: 20700994
PDF is available here.
PDF is available here.
Abstract
Phagocytic indexes (at 15 and 39 minutes) are variable according to polysaharides concentration; phagocytosis increased at 15 minutes for 40 microg/mL and 60 microg/mL, while for 30 minutes the phagocytic index decreased. In lymphocytes transformation assay, Chenopodium bonus-henricus polysaharides,...
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PMID: 20701009
PDF is available here.
PDF is available here.
Fiziologiia cheloveka (36)3 2010
Abstract
Results of innate and adaptive immunity indicators research at 12 cosmonauts who took part in long (128-215 days) expeditions to the International space station (ISS) are presented. It is shown that a space flight can lead to deflection of deviations in human immune system. These shifts occurred in...
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PMID: 20586299
PDF is available here.
PDF is available here.
Abstract
We introduce an application of flow cytometry for the concurrent detection of phagocytotic cells and surface molecules involved in the phagocytic process. E. coli expressing green fluorescent protein (GFP) were applied as the phagocytosable particles. Blood samples were incubated with E. coli expres...
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PMID: 21038787
PDF is available here.
PDF is available here.
Abstract
SP-A and SP-D contribute to host defense against respiratory viral infection. The most extensive body of evidence relates to influenza A viruses (IAV), and evidence from gene-deleted mice also indicate a role for surfactant collectins in defense against respiratory syncytial virus (R...
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PMID: 20036966
PDF is available here.
PDF is available here.
BMC Biology (8)1 2010
Abstract
We survey mechanisms that enable a phagocyte to remodel actin organization in response to particles of complex shape.
Using particles that consist of two lobes separated by a neck, we found that Dictyostelium cells transmit signals concerning the curvature of a surface to the actin s...
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PMID: 21190565
PDF is available here.
PDF is available here.
Free Radical Research (43)12 2009
Abstract
The present study explores expression of NOS and pro-inflammatory cytokines, NOS catalysis and NO mediated modulation of oxidative response and apoptosis in neutrophils from spontaneously hypertensive rats (SHR). Neutrophils from SHR showed approximately 3-fold increments in iNOS expression, 1.5-fol...
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PMID: 19905982
PDF is available here.
PDF is available here.
Abstract
Insulin resistance, hyperglycemia, inflammatory disorders and immune dysfunction cause high morbidity and mortality in patients with severe trauma, burn injuries, or sepsis. Many studies have shown that intensive insulin therapy can combat insulin resistance, decrease blood glucose l...
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PMID: 19647101
PDF is available here.
PDF is available here.
Abstract
We observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also dramatically inhibited IL-1beta production by another FPRL1 agonist serum am...
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PMID: 19381066
PDF is available here.
PDF is available here.
Pediatric Research (66)3 2009
Abstract
We conclude that antagonism of IL-1-mediated effects can, in major part, protect against lung injury in a rat model of 60% O2-induced chronic neonatal lung injury....
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PMID: 19542903
PDF is available here.
PDF is available here.
Abstract
We extended to S. epidermidis strategies previously aimed at treatment of S. aureus biofilms using photodynamic treatment (PDT) combined with chemotherapy or phagocytosis. A significant reduction in bacterial survival was observed when structurally distinct biofilms were exposed to the cationic porp...
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PMID: 19856267
PDF is available here.
PDF is available here.
Abstract
Francisella tularensis is a highly infectious, Gram-negative bacterium responsible for the disease tularemia in a broad variety of animals, including humans. F. tularensis intracellular multiplication occurs mainly in macrophages. However, F. tularensis is able to infect many other cell types, inclu...
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PMID: 19659427
PDF is available here.
PDF is available here.
Abstract
We examined whether CCR2 was requisite for control of infection by the dimorphic fungus Histoplasma capsulatum. H. capsulatum-infected CCR2(-/-) mice manifested defects in inflammatory cell recruitment, increased IL-4, and progressive infection. Increased IL-4 in CCR2(-/-) mice primarily contributed...
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PMID: 19587014
PDF is available here.
PDF is available here.
Abstract
There has been an increase in our understanding of the complexity of the T cell response to mycobacterial infection recently. Improved tools have allowed the determination of the location and kinetics of naïve T cell activation in the mouse as well the variety of function of mycobacteria-specific c...
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PMID: 19646851
PDF is available here.
PDF is available here.