Abstract
This subanalysis of the Study of the Effects of Nebivolol Intervention on Outcomes and Hospitalisation in Seniors with Heart Failure (SENIORS) investigates whether treatment with nebivolol, a β-blocker with nitric oxide-releasing properties, can provide additional benefits besides its effects on he...
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PMID: 21138861
PDF is available here.
Abstract
Hypertension frequently coexists with diabetes and the cardiometabolic syndrome. β-Blockers have been a mainstay for controlling blood pressure for nearly 4 decades. However, β-blockers are perceived to cause glucose and lipid metabolism dysregulation, including hypoglycemia masking, reduced glycem...
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PMID: 21214722
PDF is available here.
Abstract
β-blockers improve the prognosis of patients with cardiac failure due to left ventricular systolic dysfunction. The aim of this study was to assess the efficacy of β-blockers in patients with dysfunctional systemic right ventricle.
Fourteen patients with systemic right ventricle following a Mustar...
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PMID: 20519056
PDF is available here.
Abstract
To determine if treatment with prostaglandin (PG) analogues affects keratocyte density as an indirect measure of extracellular matrix in the corneal stroma.
In this case control study, 129 eyes from 68 patients were examined: 52 eyes had only PG analogue therapy for at least 3 years, 37 eyes had onl...
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PMID: 20179630
PDF is available here.
Abstract
The pathogenesis of adult-onset Still's disease (AOSD), which is currently thought to be an autoimmune disorder, may share similarities with autoimmune hyperthyroidism. This report describes a middle-aged woman in whom hyperthyroidism and Still's disease developed concurrently. Durin...
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PMID: 20201625
PDF is available here.
Abstract
Hypertension is a risk factor for myocardial infarction (MI), stroke, and heart failure and precedes heart failure in 91% of cases. This becomes even more important considering that the number of Americans with hypertension increased from 65 million in 2005 to 72 million in 2007. If blood pressure i...
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PMID: 21035578
PDF is available here.
Abstract
We summarize present trends and controversies in the use of beta-blockers in cardiovascular diseases. Beta-blockers are catecolamine competitive inhibitors and act through alpha and beta adrenergic receptors blockade. Different agents have a dose-dependent affinity for different beta adrenergic rece...
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PMID: 21197763
PDF is available here.
Abstract
We investigated the effectiveness, safety and plasma concentration of long-acting carteolol hydrochloride 2% ophthalmic solution (LA) as compared with the original carteolol hydrochloride 2% ophthalmic solution(CA).
Patients with primary open angle glaucoma and ocular hypertension were randomized to...
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PMID: 21141077
PDF is available here.
Abstract
Angiotensin II and insulin resistance (IR) have clinical implications in the pathophysiology of chronic heart failure (CHF). However, it is still unclear whether the combination of an angiotensin-receptor blocker and angiotensin-converting enzyme inhibitor (ACEI) improves IR in CHF patients who do n...
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PMID: 20827028
PDF is available here.
Abstract
Beta-blockers are a heterogeneous group of antihypertensive agents. What they have in common is competitive antagonistic action on beta-adrenoreceptors (B1, B2 and B3). They differ in their receptor selectivity, intrinsic sympathomimetic activity (ISA), vasodilating properties and metabolism. Antihy...
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PMID: 21125979
PDF is available here.
Abstract
To review relevant literature supporting the use of β-blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), diuretics, digoxin, aldosterone antagonists, and vasodilators in the management of heart failure in an elderly patient population aged ≥65 years.
P...
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PMID: 20841514
PDF is available here.
Abstract
We want curative or near-curative therapy that will return patients to a normal state of health at a feasible cost, much better diagnostic and therapeutic technologies need to be developed. This review addresses the vexing group of heart failure etiologies that include cardiomyopathies and other ven...
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PMID: 20869655
PDF is available here.
Abstract
A total of 38,779 operations were performed between 1996 and 2008. In patients meeting Perioperative Cardiac Risk Reduction indications for perioperative β-blockade, Addition is associated with a reduction in 30-day (odds ratio [OR], 0.52; 95% confidence interval [CI], 0.33 to 0.83; P = 0.006) and...
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PMID: 20864832
PDF is available here.
Abstract
The objective of this study was to describe the pattern of pediatric carvedilol ingestions reported to poison centers.
Cases were all carvedilol ingestions by patients aged 0 to 5 years reported to Texas poison centers during 2000 to 2008. Multiple substance ingestions and patients not followed up t...
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PMID: 20881906
PDF is available here.
Abstract
Our patient responded quickly to propanolol, with a clinical response within few days. Literature describes reduced size and changes in the colour of hemangiomas within 24-48 hours. Our experience is in line with that reported in the literature. Propanolol treatment of this patient group has only be...
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PMID: 20882080
PDF is available here.
Abstract
Medical management of systolic heart failure is standardized and based on international guidelines. They promote the use of combination therapy based on neurohormonal blockade targeting both the renin-angiotensin system (with ACE inhibitors or ARB) and sympathetic nervous system (i.e., beta blockers...
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PMID: 21033491
PDF is available here.
Abstract
Heart failure is frequently associated with comorbidities, either because of the etiology of heart failure, either because the prevalence of this disease is high in older age groups, who are affected by various pathologies. Hypertension, diabetes and renal failure are the most frequent comorbidities...
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PMID: 21033494
PDF is available here.
Abstract
Use of combination therapy whether fixed dose or separate pill combinations is becoming more prevalent. Physicians are not routinely trained in using combinations of different antihypertensive medicines.
Recent outcome trials as well as smaller studies document that meaningful combinations of pharma...
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PMID: 20539227
PDF is available here.
Abstract
The simultaneous use of beta adrenergic receptor blockers (beta-blockers) and trimethoprim-sulfamethoxazole (TMP-SMX) may confer a high risk of hyperkalemia.
Two nested case-control studies were conducted to examine the association between hospitalization for hyperkal...
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PMID: 20595693
PDF is available here.
Abstract
The chromatographic evaluation divided the tested drugs into more hydrophobic ones containing nonselective beta-blockers and less hydrophobic ones containing selective beta1-blockers. Nonselective beta-blockers, but not selective beta1-blockers, fluidized liposomal membranes, with the potency being...
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PMID: 20601889
PDF is available here.
Abstract
Ventricular tachycardia (VT) may be monomorphic or polymorphic. Although commonly related to organic heart disease, a significant percentage of VTs are idiopathic (occurring in patients with otherwise normal hearts). Correctly identifying the substrate and mechanism of the tachycardia is essential f...
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PMID: 20887902
PDF is available here.
Abstract
An incremental cycle exercise protocol was applied to 1708 volunteers. Individuals with structural heart disease, echocardiographic or lung function pathologies were excluded. Age, height, weight, smoking, and beta blockers were analysed for their influencing power in each sex. Reference values of C...
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PMID: 20305565
PDF is available here.
Abstract
POCD has emerged as a new concern for anesthesiologists and their older patients. Several recent studies indicate that POCD is common after noncardiac surgery, with an incidence approaching 30-40% at discharge, although this incidence declines at 3 months. Some data suggest that POCD imparts risk fo...
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PMID: 20489604
PDF is available here.
Abstract
There is growing interest on how to best tailor blood pressure (BP)-lowering medications according to the circadian (24 h) BP pattern of individual patients, that is, chronotherapy. Significant and clinically meaningful treatment-time differences in the beneficial and/or adverse effects of at least...
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PMID: 20571367
PDF is available here.
Abstract
We demonstrated that carteolol exhibits an inhibitory action on the production of inflammatory cytokines from PBMCs because of its intrinsic sympathomimetic action. We also showed that CAI and PG drugs had almost no effect on inflammatory cytokine production....
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PMID: 20803986
PDF is available here.
Abstract
Asymmetric dimethylarginine (ADMA) is an endogenous methylated amino acid derived from arginine which can inhibit the activity of nitric oxide synthases. In various pathological states such as hypercholesterolemia, hyperglycemia, hyperhomocysteinemia, hypertension, coronary artery disease, heart fai...
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PMID: 20824955
PDF is available here.
Abstract
A very rare case of continuous hypertension and tachycardia after excision of a cerebellar hemangioblastoma at the dorsal medulla oblongata is presented. This 21-year-old man was admitted to the authors' hospital with a headache and dizziness. Radiological examination revealed a tumor located behind...
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PMID: 19911894
PDF is available here.
Abstract
An increasing number of patients in the community are being treated with angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs) and beta-blockers for hypertension, coronary disease or diabetic renal and vascular complications. Some of these patients will develop heart f...
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PMID: 20613629
PDF is available here.
Xu X Li,
Xing-peng XP Liu,
Xiao-hui XH Liu,
Xin X Du,
Jun-ping JP Kang,
Qiang Q Lü,
Hai-yun HY Wang,
Xia X Xu,
Cui C Liang,
Qian Q Yan,
Tao T Lei,
Li-li LL Geng,
Bai-qiu BQ Liu and
Chang-sheng CS Ma
Abstract
We found that the follow-up mortality was 17.2% in statin group and it was significantly lower than 37.4% of non-statin users (P = 0.003); in patients with worsening cardiac function NYHA III - IV, the mortality of statin group was 17.2% while a much higher mortality of 47.4% was found in non-statin...
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PMID: 20979862
PDF is available here.
Richard J McManus,
Jonathan Mant,
Emma P Bray,
Roger Holder,
Miren I Jones,
Sheila Greenfield,
Billingsley Kaambwa,
Miriam Banting,
Stirling Bryan,
Paul Little,
Bryan Williams and
F D Richard Hobbs
Abstract
527 participants were randomly assigned to self-management (n=263) or control (n=264), of whom 480 (91%; self-management, n=234; control, n=246) were included in the primary analysis. Mean systolic blood pressure decreased by 12.9 mm Hg (95% CI 10.4-15.5) from baseline to 6 months in the self-manage...
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PMID: 20619448
PDF is available here.
Abstract
We recently observed the enhanced serine and matrix metalloproteinase (MMP) activity in the spontaneously hypertensive rat (SHR) compared with its normotensive Wistar-Kyoto (WKY) rat and the cleavage of membrane receptors in the SHR by MMPs. We demonstrate in vivo that MMP-7 and MMP-9 injection lead...
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PMID: 20382857
PDF is available here.
Abstract
The case of woman with dysfunction of left ventricle (LV) possible due to Hodgkin's lymphoma treatment and following myocarditis is presented. Triple therapy with carvedilol, ramipril and spironolactone was continued to prevent further LV remodeling. During 3-years follow-up repeated echocardiograph...
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PMID: 20648444
PDF is available here.
Abstract
These results suggested that treatment of SHR with beta-blockers at low dose improved bone loss and bone fragility. This antiosteoporotic effect of beta-blockers seems to be caused by the blocking action of beta2-AR, regardless of the membrane-stabilizing action....
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PMID: 20404011
PDF is available here.
Abstract
Both nadolol and ligation have proved to be effective in the prophylaxis of first variceal bleeding. This study was conducted to evaluate the effects and safety of combining nadolol with ligation. Cirrhotic patients with high-risk esophageal varices but without a bleeding history wer...
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PMID: 20578138
PDF is available here.
Abstract
Both nadolol and ligation have proved to be effective in the prophylaxis of first variceal bleeding. This study was conducted to evaluate the effects and safety of combining nadolol with ligation. Cirrhotic patients with high-risk esophageal varices but without a bleeding history wer...
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PMID: 20578138
PDF is available here.
Abstract
Both nadolol and ligation have proved to be effective in the prophylaxis of first variceal bleeding. This study was conducted to evaluate the effects and safety of combining nadolol with ligation. Cirrhotic patients with high-risk esophageal varices but without a bleeding history wer...
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PMID: 20578138
PDF is available here.
Abstract
Both nadolol and ligation have proved to be effective in the prophylaxis of first variceal bleeding. This study was conducted to evaluate the effects and safety of combining nadolol with ligation. Cirrhotic patients with high-risk esophageal varices but without a bleeding history wer...
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PMID: 20578138
PDF is available here.
Abstract
Both nadolol and ligation have proved to be effective in the prophylaxis of first variceal bleeding. This study was conducted to evaluate the effects and safety of combining nadolol with ligation. Cirrhotic patients with high-risk esophageal varices but without a bleeding history wer...
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PMID: 20578138
PDF is available here.
Abstract
Both nadolol and ligation have proved to be effective in the prophylaxis of first variceal bleeding. This study was conducted to evaluate the effects and safety of combining nadolol with ligation. Cirrhotic patients with high-risk esophageal varices but without a bleeding history wer...
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PMID: 20578138
PDF is available here.
Abstract
Both nadolol and ligation have proved to be effective in the prophylaxis of first variceal bleeding. This study was conducted to evaluate the effects and safety of combining nadolol with ligation. Cirrhotic patients with high-risk esophageal varices but without a bleeding history wer...
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PMID: 20578138
PDF is available here.
Abstract
PURPOSE. To examine whether treatment with oral blood-pressure-lowering medication or statins influences the risk of glaucoma. METHODS. This study was a case-control investigation, nested within a computerized primary care database of 177 general practices across the United Kingdom; 8778 cases diagn...
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PMID: 20130286
PDF is available here.
Abstract
Adrenergic stimulation of isolated guinea pig distal colonic mucosa produced transient Cl(-) and sustained K(+) secretion. Transient short-circuit current (I(sc)) depended on beta(2)-adrenergic receptors (beta(2)-AdrR), and sustained I(sc) relies on a beta(1)-AdrR/beta(2)-AdrR complex. Epinephrine (...
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PMID: 20413718
PDF is available here.
Juan Carlos García-Pagán,
Karel Caca,
Christophe Bureau,
Wim Laleman,
Beate Appenrodt,
Angelo Luca,
Juan G Abraldes,
Frederik Nevens,
Jean Pierre Vinel,
Joachim Mössner,
Jaime Bosch and
Early TIPS (Transjugular Intrahepatic Portosystemic Shunt) Cooperative Study Group
Abstract
In these patients with cirrhosis who were hospitalized for acute variceal bleeding and at high risk for treatment failure, the early use of TIPS was associated with significant reductions in treatment failure and in mortality. (Current Controlled Trials number, ISRCTN58150114.)
2010 Massachusetts Me...
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PMID: 20573925
PDF is available here.
Piergiuseppe Agostoni,
Anna Apostolo,
Gaia Cattadori,
Elisabetta Salvioni,
Giovanni Berna,
Laura Antonioli,
Carlo Vignati,
Mauro Schina,
Susanna Sciomer,
Maurizio Bussotti,
Pietro Palermo,
Cesare Fiorentini and
Mauro Contini
Abstract
Reduction of hyperventilation, with improvement of VE efficiency during exercise (reduction of VE/Vco(2) slope and increase of maximum end-tidal CO(2) pressure), is specific to carvedilol (beta(1)-beta(2) unselective blocker) and not to bisoprolol (beta(1)-selective blocker).
Copyright 2010 Mosby, I...
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PMID: 20569721
PDF is available here.
Abstract
The aim of this study was to define the impact of percutaneous coronary intervention (PCI) including stenting in patients with stress-positive stable coronary artery disease on long-term prognosis and symptoms. A group of 1,018 patients were identified from the angiographic and single-photon emissio...
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PMID: 20494657
PDF is available here.
Abstract
Five patients (2.3%) were excluded from the analysis; mean HR was 59 +/- 3 beats/min in the prescan phase and 62 +/- 5 beats/min during acquisition. In the 321 stented coronary segments, CCA found 27 significant ISRs. MSCT correctly diagnosed 26 significant ISRs, with two false-positive and one fals...
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PMID: 19918190
PDF is available here.
Abstract
Thirty-three patients did well without disease progression. However, disease progression was noted despite well-controlled brachial blood pressure in 23 patients. In intergroup comparisons, central aortic systolic pressure (112.7 +/- 3.5 mm Hg vs. 104.3 +/- 7.5 mm Hg) and aortic augmentation index (...
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PMID: 20666268
PDF is available here.
Abstract
We report a case in which all three major coronary arteries emptied into the left ventricle through multiple microfistulas....
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PMID: 20666279
PDF is available here.
Abstract
This article evaluates the current literature concerning the use of perioperative beta-blockade to reduce cardiac events in hopes that it may provide direction to clinicians or demonstrate gaps in medical knowledge, thus revealing areas suitable for future study. The current standard of practice for...
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PMID: 20541069
PDF is available here.
Abstract
Our purpose was to evaluate the effect of continuous vs. interval exercise training on arterial stiffness and blood pressure in hypertensive patients. Sixty-five patients with hypertension were randomized to 16 weeks of continuous exercise training (n=26), interval training (n=26) or a sedentary rou...
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PMID: 20379194
PDF is available here.
Abstract
Cyanoacrylate injection is more effective than beta-blocker treatment for the prevention of gastric variceal rebleeding and improving survival....
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PMID: 20551457
PDF is available here.