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Adrenergic Antagonists (2):
Recent article
Adrenergic Antagonists
Hypertension Research (33)10 2010
Abstract
To test the hypothesis that nonselective blockade of adrenergic receptor (AR) subtypes is superior to selective blockade of AR subtypes in suppressing left ventricular (LV) remodeling induced by hypertension. Sixty-four spontaneously hypertensive rats (SHR) were randomly divided into four groups: bi...
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PMID: 20668454
PDF is available here.
PDF is available here.
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Hypertension Research (33)10 2010
Abstract
Abstract
The extant data do not support the use of SSRIs as first-line treatments for PTSD in children and adolescents. There is limited evidence that the brief use of antiadrenergic agents, second-generation antipsychotics, and several mood stabilizers may attenuate some PTSD symptoms in youth. However, con...
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PMID: 20441729
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of NE on EGF-induced cell proliferation and TG2 activity using hepatocytes isolated in periportal and perivenous regions of the liver, which differ in proliferative capacity. Periportal hepatocytes (PPH) and perivenous hepatocytes (PVH) were isolated by the digitonin-colla...
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PMID: 20448147
PDF is available here.
PDF is available here.
Neuroscience Letters (476)2 2010
Abstract
We tried to investigate the role of swimming exercise in combined stress and whether its biological mechanism was related to the HSP70 and iNOS in hippocampus and prefrontal cortex. 32 Wistar rats were enrolled and divided into four groups: control, CUMS, labetalol and exercise. After the animal mod...
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PMID: 20398736
PDF is available here.
PDF is available here.
Abstract
Our results indicate that although treatments with ACEIs and ARBs are associated with low incidence of postoperative AF in patients with mild and moderate left ventricular systolic dysfunction, treatment with spironolactone is not....
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PMID: 20382613
PDF is available here.
PDF is available here.
Abstract
We investigated the relative contribution of these subtypes to beta-feedforward coronary vasodilation during exercise as well as to infusion of the beta(1)-agonist norepinephrine and the beta(1)- and beta(2)-agonist isoproterenol. Chronically instrumented swine were studied at rest and during graded...
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PMID: 20035031
PDF is available here.
PDF is available here.
Abstract
A six new analogs of MG-1(S), 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one, with adrenolytic properties were tested for electrocardiographic and antiarrhythmic activity in model ventricular arrhythmias associated with coronary artery occlusion and reperfusion in the non-working is...
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PMID: 20873423
PDF is available here.
PDF is available here.
Abstract
The sympathetic nervous system (SNS) modulates several functions in skeletal muscle fibers, including metabolism, ionic transport across the membrane, and contractility. These actions, together with the sympathetic control of other organ systems, support intense motor activity. However, some SNS act...
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PMID: 20016297
PDF is available here.
PDF is available here.
Abstract
We found that adrenaline increases COX-1 levels in the gastric tissue of both intact and adrenalectomized rats by stimulating alpha-2 receptors. Adrenaline decreases COX-2 levels by stimulating beta-2 adrenergic receptors. Prednisolone inhibits both COX-1 and COX-2 in the gastric tissue of intact ra...
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PMID: 20065506
PDF is available here.
PDF is available here.
Experimental Neurology (218)1 2009
Abstract
These results demonstrate that circulating blood borne catecholamines regulate the splenic response to stroke through the activation of both alpha and beta adrenergic receptors....
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PMID: 19371742
PDF is available here.
PDF is available here.
Abstract
Inhibition of the C-fiber reflex by the conditioning stimuli was reduced from 77.1 +/- 22.6% to 26.6 +/- 38.2% with continuous administration of DEX, and restored to 58.3 +/- 29.2% by intramuscular injection of atipamezole hydrochloride(APZ), a selective alpha 2-adrenoceptor antagonist. Inhibition o...
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PMID: 19697515
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of the intravenous infusion of a small dose of 0.97-9.7% NaCl solutions in anesthetized rats. Intravenous infusion of HTS at a rate of 0.3 ml/kg/min for 1 min produced the transient hypotension lasting for several minutes. The depressor response to HTS was not abolished by...
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PMID: 19764348
PDF is available here.
PDF is available here.
Abstract
Adrenaline is effective for the stimulation of intestinal absorption of Rg1 and the enhanced absorption is mediated mainly by the interaction of adrenaline with beta2-adrenoceptors....
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PMID: 19222907
PDF is available here.
PDF is available here.
Abstract
Patients who were receiving systemic medications seemed to be more susceptible to the development of BP. Should we consider drug exposure as one of the reasons for the increased prevalence of BP in the elderly? It is important to be more vigilant with this category of patients in order to provide an...
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PMID: 19200186
PDF is available here.
PDF is available here.
Abstract
Retention prediction models for reversed-phase liquid chromatography (RPLC) have been extensively studied owing to the fact that RPLC remains the most widely used chromatographic technique especially in the field of pharmaceutical and biomedical analyses. However, RPLC is not always the method of ch...
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PMID: 18777020
PDF is available here.
PDF is available here.
Abstract
This review discusses evidence-based pharmacotherapies for post-traumatic stress disorder (PTSD). The epidemiology of PTSD and its phenomenological characteristics are summarized. Focus is placed on the major classes of drugs for which at least a minimum of evidence-based outcome data are available...
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PMID: 19127485
PDF is available here.
PDF is available here.
Kardiologiia (49)3 2009
Abstract
Neuropharmacology (55)7 2008
Abstract
We evaluated the effects of intra-periaqueductal grey (PAG) N-arachidonoyl-serotonin (AA-5-HT), a compound with a "dual" ability to inhibit the fatty acid amide hydrolase (FAAH) and to antagonize transient receptor vanilloid type 1 (TRPV1) receptors, on endocannabinoid levels, rostral ventromedial m...
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PMID: 18616956
PDF is available here.
PDF is available here.
Abstract
Peripheral beta-adrenergic blockade and activation of central alpha2-adrenergic receptors have parasympathomimetic effects. The impact of activation of central imidazoline I1-receptors on vagal activity is not yet clear, but there is some evidence that imidazoline I1-receptors agonists may inhibit t...
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PMID: 19034032
PDF is available here.
PDF is available here.
Giornale italiano di cardiologia (2006) (9)10 Suppl 1 2008
Abstract
Diabetes mellitus is a worldwide epidemic whose incidence and prevalence have significantly increased in recent decades. Diabetic patients have an increased mortality and morbidity related to ischemic heart disease and are more likely to develop multivessel coronary artery disease than non-diabetic...
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PMID: 19195307
PDF is available here.
PDF is available here.
Abstract
Stress generally demonstrates the maximum stress of an organism at a specific moment, which is frequently important in evaluating the body's condition. The stress is generally accepted to be determined by the activity of adrenaline and the higher excitation of alpha- than beta-adrenoceptors. The pre...
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PMID: 19069447
PDF is available here.
PDF is available here.
Abstract
L-659,066 did not affect the quality of dexmedetomidine-induced sedation whilst it attenuated the reduction in PR. Thus, L-659,066 could prove a useful adjunct to reduce the peripheral cardiovascular effects attributed to dexmedetomidine in dogs. CLINICAL RELEVANCE: The clinical safety of alpha2-adr...
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PMID: 18466161
PDF is available here.
PDF is available here.
American Heart Journal (156)2 2008
Abstract
Increasing BP response to PE infusion suggests improvement in vascular alpha(1)-AR signal transduction with chronic carvedilol therapy. This effect is evident despite no detectable tolerance to preinfusion BP reductions. The varying affinities of alpha(1)-AR subtypes for carvedilol and PE may have c...
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PMID: 18657662
PDF is available here.
PDF is available here.
Abstract
We have investigated adrenoceptor-mediated responses of muscularis mucosae from the proximal, mid and distal regions of the rat colon. Noradrenaline-induced relaxations of the muscularis mucosae in each region were unaffected by atenolol, butoxamine or propranolol, but they were attenuated by the se...
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PMID: 18644202
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (100)1 2008
Abstract
We report that salsolinol can enhance agonist-induced platelet aggregation and granular secretion, which is essential in the thrombus formation. In rat and human platelets, agonist-induced platelet aggregation was significantly increased by salsolinol in a concentration-dependent manner. Agonist-ind...
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PMID: 18612538
PDF is available here.
PDF is available here.
Abstract
Administration of spinal analgesics around the spinal cord requires safety assessment due to the possibility of inflicting neurotoxic damage. Thus, neurotoxicologic evaluation should be performed for effective, safer spinal antinociception. Every potential agent for spinal administration should be s...
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PMID: 18580348
PDF is available here.
PDF is available here.
Abstract
Given the long-term health consequences and increasing incidence of type 2 diabetes, there is great interest to potentially prevent or delay its onset. Primary prevention studies have demonstrated that intensive exercise and weight reduction, and to a lesser extent certain antidiabetic agents, can r...
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PMID: 18248492
PDF is available here.
PDF is available here.
Abstract
An enantioselective high-performance liquid chromatographic method for the analysis of carvedilol in plasma and urine was developed and validated using (-)-menthyl chloroformate (MCF) as a derivatizing reagent. Chloroform was used for extraction, and analysis was performed by HPLC on a C18 column wi...
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PMID: 18551504
PDF is available here.
PDF is available here.
Cancer Investigation (26)6 2008
Abstract
We describe a 20-year-old man with an apparently sporadic pheochromocytoma associated with a novel, relatively conservative germline Gly104Val VHL gene mutation, which is localized within exon 1 of the VHL gene corresponding to the beta -domain of the VHL protein (pVHL). The nearly asymptomatic pati...
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PMID: 18584357
PDF is available here.
PDF is available here.
Brain Research Bulletin (76)3 2008
Abstract
We have been able to chart the passage of memory from acquisition to consolidation in the chick and to dissect out the multiple roles for noradrenaline in consolidating this memory. Fortunately only a small fraction of sensory input is remembered and it is clear that modulatory neurotransmitters pla...
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PMID: 18498929
PDF is available here.
PDF is available here.
Abstract
After pretreatment in the L and LG groups, heart rate, cardiac index, and partial pressure of oxygen in mixed-venous blood (PvO2) values were higher than those in the saline group. After medetomidine administration, heart rate, cardiac index, and PvO2 were higher and systemic vascular resistance, me...
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PMID: 18518652
PDF is available here.
PDF is available here.
Abstract
In the present study, the intracellular regulatory pathways involved in the adrenalin-stimulated chloride secretion across T84 cells were investigated. Biphasic characteristics were observed in the Isc response to the basolateral addition of adrenalin (0.25 nM-100 microM). The biphasic response was...
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PMID: 18343693
PDF is available here.
PDF is available here.
Abstract
We present here the in vivo and in vitro antiarrhythmic activity of compounds 1-10, as well as their electrocardiographic properties. Only compounds 4, 7, 8 and 10 demonstrated strong antiarrhythmic activity in adrenaline induced arrhythmia after intravenous and oral administration. In addition, com...
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PMID: 18604994
PDF is available here.
PDF is available here.
Neuroscience (152)3 2008
Abstract
These results suggest that VCS releases oxytocin in the olfactory bulb to enhance the social recognition memory and that this may be due to modulatory actions on noradrenaline release. The vagus and pelvic nerves are responsible for carrying the information from the pelvic area to the CNS....
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PMID: 18304743
PDF is available here.
PDF is available here.
Abstract
We have found that the hemodynamic changes can be precisely curve-fitted with a logistic function giving non-linear curve. The four parameters of the logistic function present the first asymptote, the last asymptote, the slope at the inflection point, and the time to the inflection point. Moreover,...
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PMID: 18341002
PDF is available here.
PDF is available here.
Abstract
We evaluated the role of norepinephrine at the DMV in mediating a vagovagal reflex controlling the fundus. A strain gauge was sutured onto the fundus of isoflurane-anesthetized rats to monitor changes in tone evoked by esophageal distension (ED). ED produced a decrease in fundus tone of 0.31 +/- 0.0...
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PMID: 18199591
PDF is available here.
PDF is available here.
Abstract
We tested the role of noradrenergic modulation in the olfactory bulb of cannulated rats by bilateral injections of vehicle (6 microL saline), the alpha noradrenergic receptor antagonist phentolamine (3.15 or 10 mM), the beta noradrenergic receptor antagonist alprenolol (12 or 120 mM), the alpha1 nor...
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PMID: 18364038
PDF is available here.
PDF is available here.
Hypertension Research (31)3 2008
Abstract
We evaluated our present treatment of hypertension and sought a way to improve it. We studied 164 of outpatients we treated in 2002. Mean systolic blood pressure (SBP)+/-SD was 142.0+/-11.3, and 56% of patients had SBP over 140 mmHg. We used more diuretics in patients with good control of SBP (19% v...
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PMID: 18497464
PDF is available here.
PDF is available here.
Abstract
Thyroid storm or thyrotoxic crisis is a rare but life-threatening condition requiring immediate treatment, preferably in an intensive care unit. Its incidence is about 1-2% among patients with overt hyperthyroidism. A thyrotoxic crisis occurs predominantly in the elderly and is three to five times m...
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PMID: 18302101
PDF is available here.
PDF is available here.
Abstract
Treatment with an ARB, but not ACEI, may be associated with a modest decrease in hemoglobin levels in diabetic patients with CKD....
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PMID: 18202667
PDF is available here.
PDF is available here.
Should we target the sympathetic nervous system in the treatment of obesity-associated hypertension?
Abstract
Physiology & Behavior (93)1-2 2008
Abstract
The effect of alpha(1)- and beta-adrenergic blockade on daily rhythms of urinary adrenalin (ADR) and cortisol (CORT) under basal conditions were evaluated. Voles acclimated to a 12:12 h light/dark cycle at 26+/-2 degrees C received a single dose of either propranolol (PROP; 4.5 mg/kg) or prazosin (P...
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PMID: 17910962
PDF is available here.
PDF is available here.
Nutrition Research (28)2 2008
Abstract
Fifty-four juvenile male New Zealand white rabbits were randomly allocated to 9 groups including chow-fed rabbits without mineral supplementation, HC diet fed rabbits without mineral supplementation, HC + Cu, HC + Zn, HC + FeO, HC + Cu + Zn, HC + FeO + Cu, HC + FeO + Zn, and HC + FeO + Cu + Zn. Feed...
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PMID: 19083395
PDF is available here.
PDF is available here.
Orvosi Hetilap (149)3 2008
Abstract
The beneficial effect achieved by the treatment of endothelial dysfunction in chronic cardiovascular diseases is already an evidence belonging to the basic treatment of the disease. Given the fact that the vascular system is uniform and consubstantial both physiologically, pathophysiologically and i...
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PMID: 18194920
PDF is available here.
PDF is available here.
Immunology Letters (115)1 2008
Abstract
These results suggest that alpha-stimulus is one of the important factors in the stress-induced phenomenon and that it eventually produces hypothermia, hyperglycemia and innate-immunity activation seen during stress....
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PMID: 17996950
PDF is available here.
PDF is available here.
Terapevticheskii arkhiv (80)4 2008
Abstract
We achieved positive effects of 12-week combined somatotropic and psychotropic therapy on carbohydrate metabolism: a significant decrease of fasting blood glucose from 6.6 +/- 1.4 to 6.2 +/- 0.7 mmol and postprandial (2 hours after meal) glucose from 8.6 +/- 1.5 to 7.8 +/- 0.8 mmol/l, of waist circu...
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PMID: 18491585
PDF is available here.
PDF is available here.
Abstract
We review studies of central noreadrenergic hyperactivity under both basal and challenge conditions and explore the evidence for these derangements as potential psychopharmacologic targets in patients with PTSD. Given the significant involvement of CNS norepinephrine hyperactivity in PTSD, and its l...
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PMID: 17354267
PDF is available here.
PDF is available here.
Abstract
We also analysed the findings of randomized studies aimed at comparing the efficacy of primary balloon dilatation and stenting of the infarction-associated coronary artery, and came to a conclusion that primary stenting makes it possible to more efficiently, than balloon angioplasty, revascularize t...
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PMID: 19156043
PDF is available here.
PDF is available here.
Abstract
We now demonstrate that dox-treatment inhibits proliferation and induces apoptosis in breast cancer cells in vitro by mechanisms that do not wholly involve the alpha1-adrenergic receptor. Intriguingly, dox-treatment reduced phosphorylated EGFR expression, decreased pERK1/2 levels and decreased NF-ka...
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PMID: 18042375
PDF is available here.
PDF is available here.
Abstract
We review the evidence for a role of the adrenergic system in the regulation of bone metabolism in vitro and in vivo and provide some new evidence for a dual role of beta-adrenergic receptors 1 and 2 on bone turnover. Furthermore, we will examine the similarities and disparities that may exist in th...
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PMID: 18622078
PDF is available here.
PDF is available here.
Drugs & Aging (25)7 2008
Abstract
Physiological urinary continence depends on many factors that are potentially vulnerable to adverse drug effects, which may lead to incontinence. In principle, drugs could cause incontinence by lowering bladder outlet resistance and/or by increasing intravesical pressure, which disrupts the normal p...
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PMID: 18582143
PDF is available here.
PDF is available here.
AAPS PharmSciTech (9)2 2008
Abstract
FEBS Letters (581)30 2007
Abstract
We found that the addition of scorpion venom (SV) elicited neurite activation via intracellular Ca2+ mobilization and, after a lag period, osteoblastic Ca2+ mobilization. SV did not have any direct effect on the osteoblastic cells in the absence of neurites. The addition of an alpha1-adrenergic rece...
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PMID: 18061580
PDF is available here.
PDF is available here.
Abstract
We could show that glucagon as well as IBMX and forskolin indeed significantly increased the frequency of the glucose-induced [Ca2+]i oscillations. These results support a cAMP mediated regulation and indicate that glucagon release from pancreatic alpha-cells acts in a paracrine fashion as a modulat...
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PMID: 17923116
PDF is available here.
PDF is available here.
Journal of Experimental Biology (210)Pt 23 2007
Abstract
The jeju is a teleost fish with bimodal respiration that utilizes a modified swim bladder as an air-breathing organ (ABO). Like all air-breathing fish studied to date, jeju exhibit pronounced changes in heart rate (fH) during air-breathing events, and it is believed that these may facilitate oxygen...
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PMID: 18025020
PDF is available here.
PDF is available here.
Biochemical Pharmacology (74)9 2007
Abstract
Alpha 1 adrenoceptor (alpha1-AR) regulation of DNA synthesis was studied in human neonatal foreskin fibroblast. Saturation assay with a specific radioligand for alpha1 adrenergic [3H]-prazosin revealed two saturated and specific binding sites with high or low affinity. Competitive binding assay with...
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PMID: 17714696
PDF is available here.
PDF is available here.
Abstract
Effects of specific and non-specific adrenoceptor agonists and antagonists were examined on the isolated scale melanophores of O. mossambica in physiological Ringer solution. The responses were recorded as melanophore size index. It was observed that adrenaline, nor-adrenaline, phenylpropanolamine,...
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PMID: 18072544
PDF is available here.
PDF is available here.
CJEM : Canadian journal of emergency medical care = JCMU : journal canadien de soins medicaux d'urgence (9)6 2007
Abstract
We recommend administering tamsulosin and a corticosteroid (deflazacort or prednisone) along with the standard therapy of analgesics, antibiotics and hydration....
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PMID: 18072994
PDF is available here.
PDF is available here.
Abstract
We investigated the influence of hypoxia (3% O(2)) on the ability of picomolar concentrations of phenylephrine (PHE), which are unable to induce any vascular contraction, to induce a trophic effect in human endothelial cells through stimulation of the alpha(1D)-subtype ARs. PHE, at picomolar concent...
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PMID: 17660397
PDF is available here.
PDF is available here.