Find your PDFs fast.
Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Adrenergic Agents (3):
Recent article
Adrenergic Agents
Abstract
We previously showed that neurotoxin-induced dopaminergic (DA) cell loss is decreased by inhibition of angiotensin receptors, but the location and functional effects of prorenin receptor (PRR) in the brain, including the DA system, are unknown. In the substantia nigra of Macaca fascicularis and in r...
|
PMID: 20940627
PDF is available here.
PDF is available here.
| < More recent | Older article > |
Movement Disorders (25)11 2010
Abstract
We investigated whether elevation of N/OFQ expression in 6-hydroxydopamine-hemilesioned rats selectively occurs in substantia nigra and whether hypomotility following acute haloperidol administration is accompanied by a rise in nigral N/OFQ levels. Moreover, to prove a link between N/OFQ and idiopat...
|
PMID: 20589874
PDF is available here.
PDF is available here.
Abstract
We investigated whether annexin-A2-induced lipid microdomains might be linked to the SNAREs present at the plasma membrane. Stimulation of adrenergic chromaffin cells induces the translocation of cytosolic annexin-A2 to the plasma membrane, where it colocalizes with SNAP-25 and S100A10. Cross-linkin...
|
PMID: 20374557
PDF is available here.
PDF is available here.
Abstract
We investigated whether annexin-A2-induced lipid microdomains might be linked to the SNAREs present at the plasma membrane. Stimulation of adrenergic chromaffin cells induces the translocation of cytosolic annexin-A2 to the plasma membrane, where it colocalizes with SNAP-25 and S100A10. Cross-linkin...
|
PMID: 20374557
PDF is available here.
PDF is available here.
Abstract
We investigated whether annexin-A2-induced lipid microdomains might be linked to the SNAREs present at the plasma membrane. Stimulation of adrenergic chromaffin cells induces the translocation of cytosolic annexin-A2 to the plasma membrane, where it colocalizes with SNAP-25 and S100A10. Cross-linkin...
|
PMID: 20374557
PDF is available here.
PDF is available here.
Abstract
We investigated whether annexin-A2-induced lipid microdomains might be linked to the SNAREs present at the plasma membrane. Stimulation of adrenergic chromaffin cells induces the translocation of cytosolic annexin-A2 to the plasma membrane, where it colocalizes with SNAP-25 and S100A10. Cross-linkin...
|
PMID: 20374557
PDF is available here.
PDF is available here.
Abstract
We investigated whether annexin-A2-induced lipid microdomains might be linked to the SNAREs present at the plasma membrane. Stimulation of adrenergic chromaffin cells induces the translocation of cytosolic annexin-A2 to the plasma membrane, where it colocalizes with SNAP-25 and S100A10. Cross-linkin...
|
PMID: 20374557
PDF is available here.
PDF is available here.
Abstract
We investigated whether annexin-A2-induced lipid microdomains might be linked to the SNAREs present at the plasma membrane. Stimulation of adrenergic chromaffin cells induces the translocation of cytosolic annexin-A2 to the plasma membrane, where it colocalizes with SNAP-25 and S100A10. Cross-linkin...
|
PMID: 20374557
PDF is available here.
PDF is available here.
Abstract
We investigated whether annexin-A2-induced lipid microdomains might be linked to the SNAREs present at the plasma membrane. Stimulation of adrenergic chromaffin cells induces the translocation of cytosolic annexin-A2 to the plasma membrane, where it colocalizes with SNAP-25 and S100A10. Cross-linkin...
|
PMID: 20374557
PDF is available here.
PDF is available here.
Abstract
We investigated whether annexin-A2-induced lipid microdomains might be linked to the SNAREs present at the plasma membrane. Stimulation of adrenergic chromaffin cells induces the translocation of cytosolic annexin-A2 to the plasma membrane, where it colocalizes with SNAP-25 and S100A10. Cross-linkin...
|
PMID: 20374557
PDF is available here.
PDF is available here.
Abstract
We investigated whether annexin-A2-induced lipid microdomains might be linked to the SNAREs present at the plasma membrane. Stimulation of adrenergic chromaffin cells induces the translocation of cytosolic annexin-A2 to the plasma membrane, where it colocalizes with SNAP-25 and S100A10. Cross-linkin...
|
PMID: 20374557
PDF is available here.
PDF is available here.
Abstract
We investigated the involvement of basal sympathetic tone in brown adipose tissue (BAT) recruitment and gene expression profile induced by peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation. Innervated and surgically denervated BAT pads of rats treated or not with rosiglitazone...
|
PMID: 20393157
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)23 2010
Abstract
We used a recently developed NET antibody and the presence of large presynaptic boutons in sympathetic neurons to examine basal and AMPH-modulated NET trafficking. Specifically, we establish a role for Rab11 in AMPH-induced NET trafficking. First, we found that, in cortical slices, AMPH induces a re...
|
PMID: 20534835
PDF is available here.
PDF is available here.
Abstract
Wistar rats were submitted to bilateral ventral hippocampal injection of 6-hydroxydopamine on 32nd day after birth. Latent inhibition was measured in passive or active avoidance tasks when the rats received 20 and 100 pre-exposures of conditioned stimulus. Prepubertal and adult lesioned rats showed...
|
PMID: 20583569
PDF is available here.
PDF is available here.
Abstract
Parkinson's disease is the second most common neurodegenerative disorder and remains incurable. Many potential compensatory mechanisms have now been proposed; these are both dopaminergic, focused on enhancing effects or exposure to existing dopamine, and non-dopaminergic, being focused on reducing a...
|
PMID: 19578995
PDF is available here.
PDF is available here.
Abstract
Adrenergic (alpha1 and alpha2) and cholinergic muscarinic (M1-M5) receptor binding in rat forebrain was quantified after 4 wk of twice-daily subcutaneous administration of asenapine or vehicle. Asenapine (0.03, 0.1, and 0.3 mg/kg) produced increases in [3H]prazosin binding to alpha1-adrenergic recep...
|
PMID: 19835670
PDF is available here.
PDF is available here.
Abstract
Hospital practice (1995) (38)1 2010
Abstract
The definition of septic shock includes sepsis-induced hypotension despite adequate fluid resuscitation, along with the presence of organ perfusion abnormalities, and ultimately cell dysfunction. To restore adequate organ perfusion and cell homeostasis, cardiac output should be restored with volume...
|
PMID: 20469626
PDF is available here.
PDF is available here.
Abstract
The use of animal models to study human pathology has proved valuable in a number of fields. Animal models of neurological disease have successfully and accurately recreated many aspects of human illness allowing for in-depth study ofneuropathophysiology. These models have been the source of a pleth...
|
PMID: 20455493
PDF is available here.
PDF is available here.
Neuroreport (20)14 2009
Abstract
Dopamine replacement therapy for the treatment of Parkinson's disease leads to deleterious abnormal involuntary movements (AIMs), known as L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia, which parallels enhanced striatal dopamine D1 receptor-mediated signaling. Recent evidence suggests sti...
|
PMID: 19633584
PDF is available here.
PDF is available here.
Neurological Research (31)7 2009
Abstract
The PD + LIF group showed a statistically significant improvement in the number and density of NPCs compared with PD group, and NPCs are rarely seen in CON and CON + LIF groups. CONCLUSION: LIF may be a useful treatment for PD by up-regulating the re-expression of NPCs, which may represent the neuro...
|
PMID: 19108756
PDF is available here.
PDF is available here.
Abstract
Brain Research (1286) 2009
Abstract
We examined whether KD protected dopaminergic neurons of substantia nigra (SN) against 6-hydroxydopamine (6-OHDA) neurotoxicity in a rat model of Parkinson's disease (PD) using Nissl staining and tyrosine hydroxylase (TH) immunohistochemistry. At the same time we measured dopamine (DA) and its metab...
|
PMID: 19559687
PDF is available here.
PDF is available here.
Abstract
We conducted a reanalysis of Meston (2004)'s 8-week, double-blind, cross-over, placebo-controlled study of the effects of ephedrine (50 mg taken 1 h prior to sexual activity) on self-reported sexual functioning of women taking paroxetine (N = 5), sertraline (N = 7), or fluoxetine (N = 7). As predict...
|
PMID: 19466669
PDF is available here.
PDF is available here.
Journal of Neurophysiology (102)2 2009
Abstract
We examined in vivo network dynamics in the external globus pallidus (GPe) of rats before and after chronic dopamine depletion. Dopamine depletion led to decreases in the firing rates of GPe neurons and increases in synchronized network oscillations in the beta frequency (13-30 Hz) band. Using logis...
|
PMID: 19535481
PDF is available here.
PDF is available here.
Abstract
Analysis of a previously published data set revealed that VNS increased not only the spontaneous firing rates of NE neurons, but also the percentage of neurons firing in bursts. The enhancement of the 5-HT neuron firing rate by VNS was abolished by lesioning NE neurons. We found that VNS increased t...
|
PMID: 19568478
PDF is available here.
PDF is available here.
Neurobiology of Disease (35)1 2009
Abstract
We study the impact of graft- versus host-derived serotonin innervation. All experiments were performed in l-DOPA treated rats with unilateral 6-hydroxydopamine lesions. As expected, following intrastriatal transplantation of embryonic ventral mesencephalon all the transplanted rats exhibited pronou...
|
PMID: 19361557
PDF is available here.
PDF is available here.
Abstract
We found that 6-OHDA can cause neuronal death by regulating the activity of STAT3. Pretreatment of SH-SY5Y cells with EGCG (0.1-10 microM) significantly attenuated cell death induced by 6-OHDA. In addition, STAT3 activity decline induced by 6-OHDA in SH-SY5Y cells can be completely prevented by the...
|
PMID: 19221405
PDF is available here.
PDF is available here.
Neurotoxicity Research (15)4 2009
Abstract
We investigated whether nicotine can sensitize parkinsonian animals to the effect of dopaminergic drugs. Testing this hypothesis is important because nicotine has been shown to present neuroprotective and acute symptomatic effects on PD, but few studies have addressed the question of whether it may...
|
PMID: 19384569
PDF is available here.
PDF is available here.
Brain Research Bulletin (79)2 2009
Abstract
Early developmental abnormalities affecting mesocortical dopamine (DA) neurons may result in later functional deficits that play a role in the emergence of psychiatric illness in adolescence/early adulthood. Little is known about the functional maturation of these neurons under either normal or abno...
|
PMID: 19320060
PDF is available here.
PDF is available here.
Neurotoxicity Research (15)3 2009
Abstract
We confirmed that 6-OHDA significantly reduced contents of DA and its metabolites in the brain in adulthood. Histamine content was significantly increased in the hypothalamus, hipocampus, and medulla oblongata. Moreover, in 6-OHDA-lesioned rats behavioral response was altered mainly by thioperamide...
|
PMID: 19384597
PDF is available here.
PDF is available here.
Abstract
Adrenergic agonists have different modulatory effects on excitatory synaptic transmission depending on the receptor subtypes involved. The present study examined the loci of alpha(1)- and beta-adrenoceptor agonists, which have opposite effects on excitatory neural transmission, involved in modulatio...
|
PMID: 19116948
PDF is available here.
PDF is available here.
Abstract
One hundred and thirteen parturients were managed for the present study. The number of parturients and the anaesthetic care were similar between the two periods. In contrast, 155 ampoules were used for P1 versus 45 prefilled syringes for P2 (p<0.0001). The cost per parturient was 3.1 euro for P1 ver...
|
PMID: 19278808
PDF is available here.
PDF is available here.
Abstract
To determine if the preanesthetic administration of ephedrine would prevent anesthesia-induced hypotension in dogs and cats, 10 cats were anesthetized with acepromazine, butorphanol, ketamine, and isoflurane, and 8 dogs were anesthetized with acepromazine, morphine, propofol, and halothane. Cats rec...
|
PMID: 19412398
PDF is available here.
PDF is available here.
Abstract
Urticaria is defined as wheals consisting of three features: (i) central swelling of various sizes, with or without surrounding erythema; (ii) pruritus or occasional burning sensations; and (iii) the skin returning to normal appearance, usually within 1-24 hours. Angioedema is defined as: (i) abrupt...
|
PMID: 19489657
PDF is available here.
PDF is available here.
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.] (Chapter 1) 2009
Abstract
In the 1950s, the discovery of anti-nerve growth factor, an immunotoxin stunting sympathetic neural development, signaled the advent of neurotoxins as research modalities. Other selective neurotoxins were discovered in rapid succession. In the 1960s, 6-hydroxydopamine and 6-hydroxydopa were shown to...
|
PMID: 19170022
PDF is available here.
PDF is available here.
Neurological Research (30)10 2008
Abstract
The ultrastructural analysis shows increased diameter of the synaptic ending in ipsilateral (since the third day) and contralateral striata (since day 30) and an increase in perforated synaptic contacts. CONCLUSION: Our data suggest that the contralateral striatum should not be taken as control stru...
|
PMID: 18826753
PDF is available here.
PDF is available here.
Journal of Neurochemistry (107)6 2008
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of dopaminergic neurons in the substantia nigra pars compacta. Although understanding of the pathogenesis of PD remains incomplete, increasing evidence from human and animal studies has suggested that oxidative...
|
PMID: 19014378
PDF is available here.
PDF is available here.
Brain Research (1240) 2008
Abstract
The aim of the present study was to investigate changes in the firing activity of thalamic parafascicular nucleus (PF) neurons at different time periods after 6-hydroxydopamine (6-OHDA) lesions of the substantia nigra pars compacta (SNc) and the role of the pedunculopontine nucleus (PPN) in these ch...
|
PMID: 18823953
PDF is available here.
PDF is available here.
Brain Research (1240) 2008
Abstract
Clinical evidence has shown a correlation between Parkinson's disease (PD) and Type 2 Diabetes (T2D), as abnormal glucose tolerance has been reported in >50% of PD patients. The development of insulin resistance and the degeneration of nigrostriatal dopamine (DA) neurons are both mediated by oxidati...
|
PMID: 18805403
PDF is available here.
PDF is available here.
Behavioural Brain Research (193)1 2008
Abstract
These results demonstrate the importance of the visual and circadian systems in PD and are consistent with reports that identify impaired circadian involvement as a major component in a wide range of neurological and neuropsychiatric conditions....
|
PMID: 18547659
PDF is available here.
PDF is available here.
Neurobiology of Disease (32)2 2008
Abstract
We examined levodopa-induced dyskinesias (LIDs), GID-like behaviors, and synaptic ultrastructure in levodopa-treated, grafted, parkinsonian rats with mild (sham), moderate (allografts) or high (allografts plus peripheral spleen cell injections) immune activation. Grafts attenuated amphetamine-induce...
|
PMID: 18672063
PDF is available here.
PDF is available here.
Neurobiology of Disease (32)2 2008
Abstract
We addressed the hypothesis that inflammatory responses within and around an intrastriatal graft containing dopamine neurons can trigger dyskinetic behaviors. We subjected rats to unilateral nigrostriatal lesions with 6-hydroxydopamine (6-OHDA) and treated them with L-DOPA for 21 days in order to in...
|
PMID: 18675359
PDF is available here.
PDF is available here.
Brain Research (1238) 2008
Abstract
We investigated the influence of dopaminergic nigrostriatal denervation, obtained by intrastriatal injection of 6-hydroxydopamine (6-OHDA), on this response in Sprague-Dawley rats. We also explored the effects on the NTG-induced hyperalgesic response to painful stimuli (formalin and tail-flick tests...
|
PMID: 18761334
PDF is available here.
PDF is available here.
Neuropharmacology (55)5 2008
Abstract
Ethanol exerts effects on the brain noradrenergic system, and these are thought to contribute to the sedative/hypnotic (depressant) effects of ethanol. Recent studies suggest that the norepinephrine transporter (NET) plays an important role in modulating ethanol's depressant effects. The aim of the...
|
PMID: 18625256
PDF is available here.
PDF is available here.
Abstract
Previous work has demonstrated that 6-hydroxydopamine (6-OHDA) induces apoptosis in PC12 cells. The goal of the present study was to investigate the mechanisms underlying the protection by neurotrophin-3 (NT-3) against 6-OHDA-induced apoptosis in PC12 cells. Treatment of PC12 cells with 6-OHDA resul...
|
PMID: 18462913
PDF is available here.
PDF is available here.
Abstract
We hypothesized that OXY may exert neuroprotective effects against parkinsonian mimetic 6-hydroxydopamine (6-OHDA) neurotoxicity. Neuroblastoma SH-SY5Y cells have long been used as dopaminergic neurons in PD research. We found that both pretreatment and posttreatment with OXY on SH-SY5Y cells signif...
|
PMID: 18675900
PDF is available here.
PDF is available here.
Abstract
Stress generally demonstrates the maximum stress of an organism at a specific moment, which is frequently important in evaluating the body's condition. The stress is generally accepted to be determined by the activity of adrenaline and the higher excitation of alpha- than beta-adrenoceptors. The pre...
|
PMID: 19069447
PDF is available here.
PDF is available here.
Abstract
Abstract
We examine what has been gained and what can be learned. METHODS: Information available from various medical database resources: MEDLINE, EMBASE, Cochrane Database, ClinicalTrials.gov (a registry of federally and privately supported clinical trials) and schizophreniaforum.org--Drugs in Clinical Tria...
|
PMID: 18764724
PDF is available here.
PDF is available here.
Abstract
Rectal distension (RD) is known to induce upper gastrointestinal (GI) symptoms. The aim of this study was to investigate the effects and underlying mechanisms of RD on gastric slow waves (GSW) and motor activity and furthermore to investigate the effects and mechanisms of electroacupuncture (EA) on...
|
PMID: 18653722
PDF is available here.
PDF is available here.
Abstract
We report the case of a 51-year-old woman receiving endobronchial treatment with neodymium:yttrium garnet laser After 30 minutes of stable anaesthesia and laser treatment, sudden inferior myocardial ischaemia developed followed by haemodynamic collapse. Resuscitation with fluids, pressors, atropine...
|
PMID: 18853597
PDF is available here.
PDF is available here.
Neuroscience Letters (441)1 2008
Abstract
We investigated if and how EP2 activation might alter the survival of dopaminergic neurons following selective low-level oxidative injury evoked by the neurotoxin 6-hydroxydopamine (6-OHDA) in primary neuronal cultures prepared from embryonic rat midbrain. We found that cultured dopaminergic neurons...
|
PMID: 18597941
PDF is available here.
PDF is available here.
Medical Journal of Australia (189)3 2008
Abstract
Abstract
Differential characteristic of the reaction of pial arteries of various generations to intravenous administration of norepinephrine was obtained in experiments on rats under artificially stabilized systemic blood pressure.
|
PMID: 19145312
PDF is available here.
PDF is available here.
Neuroscience Research (61)4 2008
Abstract
These results suggest that NCAM is involved in the promotive effect of GDNF on the neurite outgrowth in lesioned DA neurons, but not involved in the promotive effect of GDNF on TH expression in these neurons....
|
PMID: 18524405
PDF is available here.
PDF is available here.
Brain Research (1218) 2008
Abstract
We investigated the survival and functional capacity of in vitro expanded, primary VM precursor cells after intrastriatal grafting to a rat model of PD. Embryonic day 12 rat VM tissue was mechanically dissociated and cultured for 4 or 8 days in vitro (DIV) in the presence of FGF2 (20 ng/ml), FGF8 (2...
|
PMID: 18513704
PDF is available here.
PDF is available here.
Neuroscience Letters (439)2 2008
Abstract
We have exploited the nematode Caenorhabditis elegans as a model system by which the neuroprotective capacity of acetaminophen could be rapidly evaluated for efficacy in attenuating dopamine (DA) neurodegeneration. Using three independent and established neurodegenerative models in C. elegans, we as...
|
PMID: 18514411
PDF is available here.
PDF is available here.
Journal of Neurophysiology (100)1 2008
Abstract
It is well established that parkinsonian syndrome is associated with alterations in the temporal pattern of neuronal activity and local field potentials in the basal ganglia (BG). An increase in synchronized oscillations has been observed in different BG nuclei in parkinsonian patients and animal mo...
|
PMID: 18497362
PDF is available here.
PDF is available here.