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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Neurotransmitter Agents (10):
Recent article
Neurotransmitter Agents
Abstract
We will review the data about the connections of POP with conventional neurotransmitter systems and provide an overview of the role of POP in neurotransmission....
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PMID: 21222629
PDF is available here.
PDF is available here.
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Abstract
Autism is a developmental disorder of the central nervous system characterized by impairments in social interaction, communication and restricted repetitive and stereotyped behavior. It is generally assumed that in most cases autism has a polygenic cause, but the pathogenesis is stil...
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PMID: 21375492
PDF is available here.
PDF is available here.
Abstract
The modem representations of wakefulness-sleep cycle evolution and the data about dynamics of reactivity of activating and inhibition neurotransmitter systems of the forebrain, converging in striatum, in cold- and warm-blooded vertebrates are considered. The data about dynamics of immune reactivity o...
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PMID: 21786640
PDF is available here.
PDF is available here.
Abstract
Nociceptin/Orphanin FQ (N/OFQ) is the endogenous ligand for the N/OFQ receptor. N/OFQ acts directly on blood vessels to elicit vasodilation. This review will describe the peripheral cardiovascular effects of N/OFQ observed in studies conducted in vitro and in vivo, along with those d...
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PMID: 21070618
PDF is available here.
PDF is available here.
Abstract
Pluripotent and multipotent stem cells with differentiation potential to neural phenotypes have been described and characterized in the last decades. Embryonic stem cells, as well as neural stem cells from developing and adult nervous system, can differentiate into different types of...
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PMID: 21463247
PDF is available here.
PDF is available here.
Abstract
Cerebral complications of liver failure either due to chronic or acute manifestations lead to a neurological disorder known as Hepatic encephalopathy (HE). Neurosteroids, synthesized in the brain mainly by astrocytes but also in other brain cells independently from peripheral steroid...
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PMID: 20825363
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)49 2010
Abstract
We found that K-252a incubation reduces ACh release (~50%) in a short time (1 h), but the p75(NTR) signaling inhibitor Pep5 does not have this effect. The specificity of the K-252a blocking effect on trkB was confirmed with the anti-trkB antibody 47/trkB, which reduces evoked ACh release, like K-252...
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PMID: 21147991
PDF is available here.
PDF is available here.
Anesthesiology (113)6 2010
Abstract
Abstract
Abstract
Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now rec...
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PMID: 21068832
PDF is available here.
PDF is available here.
Cellular Signalling (22)11 2010
Abstract
We propose a model, in which the Ca(2+) binding at the EEEE motif and the consequent conformational changes in the channel are the primary event in triggering secretion, while synaptotagmin acts as a vesicle docking protein. Thus, the channel serves as the molecular On/Off signaling switch, where th...
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PMID: 20388539
PDF is available here.
PDF is available here.
Abstract
Although the goal of treatment for major depressive disorder is full remission, for most patients, remission is the exception rather than the rule. Carefully choosing medications with synergistic mechanisms of action at treatment initiation may increase rates of response and remission and decrease t...
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PMID: 21114944
PDF is available here.
PDF is available here.
Abstract
We show that the ability of sybII to support exocytosis is inhibited by addition of one or two residues to the sybII C terminus depending on their energy of transfer from water to the membrane interface, following a Boltzmann distribution. These results suggest that following stimulation, the SNARE...
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PMID: 20937897
PDF is available here.
PDF is available here.
Abstract
We screened the recently sequenced genome of the parasitic wasp, Nasonia vitripennis, for the presence of these signaling molecules and annotated 30 precursor genes encoding 51 different mature neuropeptides or protein hormones. Twenty-four of the predicted mature Nasonia neuropeptides could be expe...
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PMID: 20695486
PDF is available here.
PDF is available here.
Abstract
Traumatic brain injury (TBI) is a frequent and clinically highly heterogeneous neurological disorder with large socioeconomic consequences. TBI severity classification, based on the hospital admission Glasgow Coma Scale (GCS) score, ranges from mild (GCS 13-15) and moderate (GCS 9-12...
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PMID: 20738443
PDF is available here.
PDF is available here.
Pain Medicine (11)10 2010
Abstract
We thus hypothesized that endogenous allopregnanolone and other neurosteroid levels may be negatively correlated with self-reported pain symptoms in humans.
We determined serum neurosteroid levels by gas chromatography/mass spectrometry (allopregnanolone, pregnenolone) or radioimmuno...
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PMID: 20735755
PDF is available here.
PDF is available here.
Abstract
The adequate functioning of the maternal thyroid gland plays an important role to ensure that the offspring develop normally. Thus, maternal hypo- and hyperthyroidism are used from the gestation day 1 to lactation day 21, in general, to recognize the alleged association of offspring abnormalities as...
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PMID: 20599606
PDF is available here.
PDF is available here.
Abstract
Due to a big amount of dopaminergic receptors set in the vertebrate central nervous system (CNS), endogenously freed dopamine determines motor and cognitive activities of an organism. It influences neurohormonal regulation of the body, among all, other catecholamines' production; it also regulates k...
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PMID: 20931821
PDF is available here.
PDF is available here.
Journal of traditional Chinese medicine = Chung i tsa chih ying wenpan / sponsored by All-China Association of Traditional Chinese Medicine,Academy of Traditional Chinese Medicine (30)3 2010
Abstract
To observe the effects of Bushen Huoxue Formula (Formula for reinforcing the kidney and activating blood circulation) on the learning and memory function and the cerebral neurotransmitters in diabetic mice.
Forty ICR mice were randomized into the normal control group, model group, Nimotop group and...
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PMID: 21053627
PDF is available here.
PDF is available here.
Abstract
We now report a direct interaction between V0 c-subunit and the v-SNARE synaptobrevin, constituting a molecular link between the V-ATPase and SNARE-mediated fusion. Interaction domains were mapped to the membrane-proximal domain of VAMP2 and the cytosolic 3.4 loop of c-subunit. Acute perturbation of...
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PMID: 20670834
PDF is available here.
PDF is available here.
Abstract
We found that NO-generating substances (SNP and SNAP) activated the buccal rhythm while slowing the endogenous rhythm of B2 bursters. The inhibitor of NO-synthase, L-NNA, the NO scavenger PTIO, or the inhibitor of soluble guanylyl cyclase, ODQ, each produced opposite, depolarising effects on the B2...
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PMID: 20559642
PDF is available here.
PDF is available here.
Abstract
We demonstrate that deletion of the filamentous protein Septin 5 imparts immature synapses with striking morphological and functional features reminiscent of mature synapses. This includes synaptic vesicles tightly localized to active zones, resistance to the slow Ca(2+) buffer EGTA and a reduced nu...
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PMID: 20624595
PDF is available here.
PDF is available here.
Drug Discovery Today (15)13-14 2010
Abstract
Extracellular nucleotides, such as ATP and UTP, have distinct signaling roles through a class of G-protein-coupled receptors, termed P2Y. The receptor ligands are typically charged molecules of low bioavailability and stability in vivo. Recent progress in the development of selective agonists and an...
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PMID: 20594935
PDF is available here.
PDF is available here.
Abstract
We present an overview of the current knowledge of the metabolism of D-serine in human brain at the molecular and cellular levels, with a specific emphasis on the brain localization and regulatory pathways of D-serine, serine racemase, and D-amino acid oxidase. Furthermore, we discuss how D-serine i...
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PMID: 20195697
PDF is available here.
PDF is available here.
Postgraduate Medicine (122)4 2010
Abstract
Mood disorders are a frequent psychiatric comorbidity in patients with epilepsy, affecting quality of life and prognosis. Classic neuropsychiatric literature focused on major depression with data on bipolar disorder (BD) remains limited. However, emerging evidence suggests that mood instability, mix...
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PMID: 20675967
PDF is available here.
PDF is available here.
Abstract
Gonadotrophin-releasing hormone-1 (GnRH-1) is essential for mammalian reproduction, controlling release of gonadotrophins from the anterior pituitary. GnRH-1 neurones migrate from the nasal placode into the forebrain during development. Although first located within the nasal placode, the embryonic...
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PMID: 20646175
PDF is available here.
PDF is available here.
Abstract
Cyanide is a potential suicidal, homicidal and chemical warfare agent. It produces histotoxic hypoxia following inhibition of cytochrome c oxidase, a terminal respiratory chain enzyme. The profound metabolic changes lead to neurotoxicity including alterations in the levels of neurotransmitters. The...
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PMID: 20929056
PDF is available here.
PDF is available here.
Abstract
We demonstrated a chronic neurosteroid-dependent inhibition of activity-dependent spinal reflex potentiation (SRP), but it remains unclear whether neurosteroids acutely modulate SRP induction. This study shows progesterone as well as two of its 3alpha,5alpha-derivatives, allopregnalonone and 3alpha,...
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PMID: 20357028
PDF is available here.
PDF is available here.
Abstract
We found that larval recovery showed progressive increase over the course of infection. Furthermore, the infected mice displayed increased expression of pro-inflammatory cytokines and iNOS, as well as significant disturbances in neurotransmitter profile. Astrocytic activation, evidenced by enhanced...
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PMID: 20302888
PDF is available here.
PDF is available here.
Abstract
We demonstrate, using direct approaches, that loss of the major SV2 isoform in a central nervous system nerve terminal is associated with an elevation in both resting and evoked presynaptic Ca(2+) signals. This increase is essential for the expression of the SV2B(-/-) secretory phenotype, characteri...
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PMID: 20620874
PDF is available here.
PDF is available here.
Abstract
We derived a double knockout (DKO) mouse lacking both synapsin II and Rab3a. We found that Rab3a deletion rescued epileptic-like seizures typical for synapsin II gene deleted animals (Syn II(-)). Furthermore, action potential evoked release was drastically reduced in DKO synapses, although spontaneo...
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PMID: 20338242
PDF is available here.
PDF is available here.
Neuroscientist (16)3 2010
Abstract
Noninvasive plasticity paradigms, both physiologically induced and artificially induced, have come into their own in the study of the effects of genetic variation on human cortical plasticity. These techniques have the singular advantage that they enable one to study the effects of g...
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PMID: 20103503
PDF is available here.
PDF is available here.
Neuroscientist (16)3 2010
Abstract
Noninvasive plasticity paradigms, both physiologically induced and artificially induced, have come into their own in the study of the effects of genetic variation on human cortical plasticity. These techniques have the singular advantage that they enable one to study the effects of g...
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PMID: 20103503
PDF is available here.
PDF is available here.
Neuroscientist (16)3 2010
Abstract
Noninvasive plasticity paradigms, both physiologically induced and artificially induced, have come into their own in the study of the effects of genetic variation on human cortical plasticity. These techniques have the singular advantage that they enable one to study the effects of g...
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PMID: 20103503
PDF is available here.
PDF is available here.
Lancet Oncology (11)6 2010
Abstract
We summarise recent findings related to the interactions between the nervous system and tumour cells and suggest further research into the role of the nervous system in the aetiopathogenesis of cancer. Data showing the transmission of signals between the brain and tumour tissue create a complex view...
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PMID: 20522385
PDF is available here.
PDF is available here.
Acta Physiologica (199)2 2010
Abstract
The presence of adenosine in all nervous system cells (neurones and glia) together with its intensive release following insults makes adenosine as a sort of 'regulator' of synaptic communication, leading to the homeostatic coordination of brain function. Besides the direct actions of...
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PMID: 20345418
PDF is available here.
PDF is available here.
Acta Physiologica (199)2 2010
Abstract
We present a detailed account of the early developments and current status of purinergic signalling. We summarize the current knowledge on purinoceptors, their distribution and role in signal transduction in various tissues in physiological and pathophysiological conditions....
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PMID: 20345419
PDF is available here.
PDF is available here.
Abstract
We summarize recent progress on this process, progress which holds the promise of providing a rational framework for their classification, as well as means to understand their role in cortical processing....
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PMID: 20529125
PDF is available here.
PDF is available here.
Neuropeptides (44)3 2010
Abstract
We aimed to clarify which amino acid of these peptides contributes to the induction of thermal hyperalgesia. When two chimera peptides between the N-terminal region of SP and the C-terminal region of HK-1, and vice versa, SP (1-5)/HK-1 and HK-1 (1-5)/SP, were intrathecally administered, SP (1-5)/HK-...
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PMID: 20176398
PDF is available here.
PDF is available here.
Neurological Research (32)5 2010
Abstract
Cerebral arteries constricted in response to graded increase in intraluminal pressure (20-100 mmHg, in 20 mmHg increments). In vitro C-fiber desensitization with capsaicin (1 micromol/l, 20 minutes) significantly suppressed myogenic constriction by over 50%, but did not affect 5-hydroxytryptamine (0...
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PMID: 19570322
PDF is available here.
PDF is available here.
Abstract
Our previous study has proven that hypothalamic paraventricular nucleus (PVN) plays a role in antinociception. The effects of studied classical neurotransmitter on PVN antinociceptive modulation were investigated in the rat. The results showed: (1) Pain stimulation increased norepinephrine (NE), but...
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PMID: 20504214
PDF is available here.
PDF is available here.
Abstract
We report a solid-state ion bipolar junction transistor (IBJT) based on conducting polymers and thin films of anion- and cation-selective membranes. The IBJT is the ionic analogue to the conventional semiconductor BJT and is manufactured using standard microfabrication techniques. Transistor charact...
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PMID: 20479274
PDF is available here.
PDF is available here.
Biological Cybernetics (102)6 2010
Abstract
Neurotransmitters in the terminal bouton of a presynaptic neuron are stored in vesicles, which diffuse in the cytoplasm and, after a stimulation signal is received, fuse with the membrane and release its contents into the synaptic cleft. It is commonly assumed that vesicles belong to three pools who...
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PMID: 20407909
PDF is available here.
PDF is available here.
Neurochemical Research (35)6 2010
Abstract
New cardioactive protein-hormone complexes (PHC) are identified in magnocellular nuclei of hypothalamus. It was proved that they are specific for nervous tissues and are involved in the regulation of metabolic processes of brain and visceral organs, including the heart. PHC dissociate into high-mole...
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PMID: 19921431
PDF is available here.
PDF is available here.
Psychiatria Danubina (22)2 2010
Abstract
We have identified much literature on how stress affects biological mechanisms within the brain, and how it relates to biological vulnerabilities carried by different individuals. CONCLUSION: We have identified communalities in how the interplay between stress and vulnerability occurs in different d...
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PMID: 20562747
PDF is available here.
PDF is available here.
Psychiatria Danubina (22)2 2010
Abstract
Pain is one of the most ubiquitous problems of today's world, its impact being far-reaching. Current conceptualizations of pain medicine adopt a bio-psycho-social perspective. In this model, pain is best described as an interactive, psycho-physiological behavioral pattern that cannot be divided into...
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PMID: 20562750
PDF is available here.
PDF is available here.
Journal of Physiology (588)Pt 11 2010
Abstract
Pain remains a major clinical challenge, severely afflicting around 6% of the population at any one time. Channelopathies that underlie monogenic human pain syndromes are of great clinical relevance, as cell surface ion channels are tractable drug targets. The recent discovery that loss-of-function...
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PMID: 20142270
PDF is available here.
PDF is available here.
Journal of Physiology (588)Pt 11 2010
Abstract
Analytica Chimica Acta (667)1-2 2010
Abstract
We found that interaction via the amino group is the common mode among the studied compounds and the results are in good agreement with the electrochemical measurements.
Copyright 2010 Elsevier B.V. All rights reserved....
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PMID: 20441867
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)19 2010
Abstract
We addressed this issue by examining the activation of enteric glia by distinct neuronal subpopulations in the enteric nervous system. Enteric glia are unique peripheral glia that surround enteric neurons and respond to neuronally released ATP with increases in intracellular calcium ([Ca2+]i). Auton...
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PMID: 20463242
PDF is available here.
PDF is available here.
Journal of Cell Science (123)Pt 9 2010
Abstract
We characterized twf-null mutants in a metazoan for the first time and found that Drosophila twf negatively regulates F-actin formation in subcellular regions of rapid actin turnover in three different systems, namely postsynaptic neuromuscular junction (NMJ) synapses, migratory border cells and epi...
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PMID: 20410372
PDF is available here.
PDF is available here.
Abstract
Two reactive metabolites were identified in vivo for the dual A(2A)/A(1) receptor antagonist 1. Two strategies were implemented to successfully mitigate the metabolic liabilities associated with 1. Optimization of the arylindenopyrimidines led to a number of amide, ether, and amino analogs having co...
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PMID: 20338760
PDF is available here.
PDF is available here.
Abstract
A novel series of arylindenopyrimidines were identified as A(2A) and A(1) receptor antagonists. The series was optimized for in vitro activity by substituting the 8- and 9-positions with methylene amine substituents. The compounds show excellent activity in mouse models of Parkinson's disease when d...
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PMID: 20347304
PDF is available here.
PDF is available here.
médecine/sciences (26)5 2010
Abstract
Attention deficit/hyperactivity disorder (ADHD) is a frequent and disabling condition in school children, with cognitive and behavioral symptoms persisting into adulthood in a majority of patients. Etiology of ADHD is considered multifactorial and heterogenous, with an important contribution of gene...
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PMID: 20510147
PDF is available here.
PDF is available here.
Abstract
Brain Research Reviews (63)1-2 2010
Abstract
We propose that neurotransmitters are master regulators of the different stages of neurogenesis. In favor of this idea, a description of selective neurotransmitter signaling and their functions in the largest neurogenic zone, the subventricular zone (SVZ), is provided. In particular, we emphasize th...
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PMID: 20188124
PDF is available here.
PDF is available here.
Neuropharmacology (58)6 2010
Abstract
We attempt to organize the current research by summarizing findings affecting early neurogenesis: during proliferation, fate commitment and migration, versus late neurogenesis: including dendritic development, synaptic integration, and survival. We discuss the roles of three different classes of fac...
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PMID: 20097213
PDF is available here.
PDF is available here.
Neuroscience (167)2 2010
Abstract
We investigate on the effect of amyloid-beta1-40 (A beta 1-40) on the oxotremorine (OXO)-induced release of [(3)H] dopamine (DA), [(3)H]GABA and [(3)H]acetylcholine (ACh) from synaptosomes in the rat nucleus accumbens (NAc). OXO in presence of himbacine (HIMBA) was able to increase the basal release...
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PMID: 20144691
PDF is available here.
PDF is available here.