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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Central Nervous System Depressants (4):
Recent article
Central Nervous System Depressants
Abstract
I (IGF-1) levels are closely associated with cardiac performance although the role of IGF-1 in alcoholic cardiac dysfunction is unknown. This study was designed to evaluate the impact of severe liver IGF-1 deficiency (LID) on chronic alcohol-induced cardiomyocyte contractile and intracellular Ca(2+)...
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PMID: 20731752
PDF is available here.
PDF is available here.
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Abstract
OVERVIEW: For a chronic drinker, sudden alcohol withdrawal because of an unexpected hospitalization can lead to escalating withdrawal symptoms and even death if unrecognized and untreated. Nurses need to be aware of the prevalence of alcohol abuse in the United States and consider the possibility of...
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PMID: 21191232
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
In 2005, approximately half of all alcohol consumption in Ukraine was unrecorded. This paper investigates the chemical composition of unrecorded and low-cost alcohol, including a toxicological evaluation. A sample of alcohol products (n=78) from both recorded and unrecorded sources was obtained main...
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PMID: 20638436
PDF is available here.
PDF is available here.
Ugeskrift for laeger (172)36 2010
Abstract
Abstract
Prescription drug abuse is a significant and growing health and socio-economical problem in the US and the world. According to the 2008 UN World Drug Report, the number of people who have consumed an illicit drug at least once in 2006/2007 reached 240 million, roughly 6% of the world...
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PMID: 21054261
PDF is available here.
PDF is available here.
Abstract
An obviously inebriated 36-year-old man was found in a helpless condition on a pavement. When he was brought to a police station, a doctor certified the individual to be fit to be held in custody. He was unresponsive when the officers tried to wake him the next morning but was allowed to sleep on un...
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PMID: 20473142
PDF is available here.
PDF is available here.
Behavioural Brain Research (211)2 2010
Abstract
Previous studies have shown that combined exposure to ethanol (EtOH) and methylmercury (MeHg) in rats during central nervous system development produces several behavioural impairments. This present study was done to investigate inhibitory avoidance acquisition and panic-like disorders in rats in an...
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PMID: 20346984
PDF is available here.
PDF is available here.
Neuropsychopharmacology (35)9 2010
Abstract
We report here that in acute midbrain slices from rats, clinically relevant concentrations of ethanol applied both in vitro and in vivo prevents LTP(GABA), which is reversed, respectively, by in vitro and in vivo administration of naloxone, a mu-opioid receptor (MOR) antagonist. Furthermore, the blo...
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PMID: 20393452
PDF is available here.
PDF is available here.
Abstract
We have previously demonstrated that fetal ethanol exposure deranges the function and viability of the neonatal alveolar macrophage. Although altered differentiation of the alveolar macrophage contributes to pulmonary disease states within the adult lung, the effects of fetal ethanol exposure on the...
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PMID: 20382747
PDF is available here.
PDF is available here.
Abstract
We determined the time course of ethanol's effect on plasma adrenocorticotropin and corticosterone levels in male and female AC7 transgenic (Adcy7(huTG)) mice (in which AC7 is overexpressed in neural tissue) and AC7 heterozygous knockdown [Adcy7(+/-)] mice (in which AC7 is underexpressed in neural t...
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PMID: 20363852
PDF is available here.
PDF is available here.
Abstract
We addressed this issue by examining the effect of chronic alcohol feeding of rats with liquid diet on physiological and molecular parameters of renal thiamin transport. Chronic alcohol feeding caused a significant inhibition in carrier-mediated thiamin transport across the renal brush-border membra...
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PMID: 20427470
PDF is available here.
PDF is available here.
Abstract
Abstract
We used rats fed an alcohol-liquid diet and human intestinal epithelial HuTu-80 cells chronically exposed to ethanol as model systems. The results showed that chronic alcohol feeding to rats led to a significant inhibition in carrier-mediated thiamin transport across both the jejunal brush-border me...
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PMID: 20448146
PDF is available here.
PDF is available here.
La Revue du praticien (60)6 2010
Abstract
Abstract
Drugs of abuse comprise several pharmacological classes, including psychomotor stimulants, such as amphetamine and cocaine, and CNS depressants, such as morphine and alcohol. Few studies have examined the effects of those drugs systematically on human sexual behavior, although substantial clinical a...
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PMID: 19837072
PDF is available here.
PDF is available here.
Abstract
Sexual assault is a form of interpersonal violence with significant consequential health problems. The purpose of this study was to describe the characteristics of the victims, assaults, and associated physical and psychologic trauma of sexual assault cases in Taipei.
Data were retrospectively colle...
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PMID: 20708522
PDF is available here.
PDF is available here.
Abstract
We examined human 5-HT(3A)(QDA) receptors expressed in human embryonic kidney 293 cells. The agonist sensitivity, macroscopic kinetics, and modulation by ethanol were similar between mutant and wild-type channels, suggesting the substitutions had not altered these channel structure-function properti...
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PMID: 20200118
PDF is available here.
PDF is available here.
Abstract
Though melatonin and melatonin receptor agonists are in clinical use and under development for treating insomnia, the role of endogenous melatonin in the regulation of the sleep-wake cycle remains uncertain. Some clinical case reports suggest that reduced nocturnal melatonin secretion is linked to sl...
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PMID: 20550025
PDF is available here.
PDF is available here.
Neurological Research (32)5 2010
Abstract
Decreased 5-HT content (p<0.05 and p<0.001) and decreased (p<0.001) 5-HT(2A) receptor binding in cerebral cortex and liver of ethanol-treated rats were observed when compared with control. 5-HT(2A) receptor mRNA in the cerebral cortex and liver showed an increase in crossing threshold value showing...
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PMID: 20501057
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the protective action of methyl donors is mediated by an effect on the oxidative metabolism of alcohol in the liver. Male C57BL/6J mice were administered a control high-fat diet or diet enriched in methyl donors with or without alcohol for 4 weeks using the enteral alcohol feedi...
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PMID: 20118189
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We investigated the effect of alcohol exposure on the internalization of two widely used endocytic markers, albumin and transferrin, in developing hippocampal neurons in primary culture. The effect of this treatment on the levels of several representative proteins involved in the endocytic process w...
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PMID: 20133374
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the protective action of methyl donors is mediated by an effect on the oxidative metabolism of alcohol in the liver. Male C57BL/6J mice were administered a control high-fat diet or diet enriched in methyl donors with or without alcohol for 4 weeks using the enteral alcohol feedi...
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PMID: 20118189
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We investigated the effect of alcohol exposure on the internalization of two widely used endocytic markers, albumin and transferrin, in developing hippocampal neurons in primary culture. The effect of this treatment on the levels of several representative proteins involved in the endocytic process w...
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PMID: 20133374
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the protective action of methyl donors is mediated by an effect on the oxidative metabolism of alcohol in the liver. Male C57BL/6J mice were administered a control high-fat diet or diet enriched in methyl donors with or without alcohol for 4 weeks using the enteral alcohol feedi...
|
PMID: 20118189
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We investigated the effect of alcohol exposure on the internalization of two widely used endocytic markers, albumin and transferrin, in developing hippocampal neurons in primary culture. The effect of this treatment on the levels of several representative proteins involved in the endocytic process w...
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PMID: 20133374
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the protective action of methyl donors is mediated by an effect on the oxidative metabolism of alcohol in the liver. Male C57BL/6J mice were administered a control high-fat diet or diet enriched in methyl donors with or without alcohol for 4 weeks using the enteral alcohol feedi...
|
PMID: 20118189
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We investigated the effect of alcohol exposure on the internalization of two widely used endocytic markers, albumin and transferrin, in developing hippocampal neurons in primary culture. The effect of this treatment on the levels of several representative proteins involved in the endocytic process w...
|
PMID: 20133374
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the protective action of methyl donors is mediated by an effect on the oxidative metabolism of alcohol in the liver. Male C57BL/6J mice were administered a control high-fat diet or diet enriched in methyl donors with or without alcohol for 4 weeks using the enteral alcohol feedi...
|
PMID: 20118189
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the protective action of methyl donors is mediated by an effect on the oxidative metabolism of alcohol in the liver. Male C57BL/6J mice were administered a control high-fat diet or diet enriched in methyl donors with or without alcohol for 4 weeks using the enteral alcohol feedi...
|
PMID: 20118189
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We investigated the effect of alcohol exposure on the internalization of two widely used endocytic markers, albumin and transferrin, in developing hippocampal neurons in primary culture. The effect of this treatment on the levels of several representative proteins involved in the endocytic process w...
|
PMID: 20133374
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We investigated the effect of alcohol exposure on the internalization of two widely used endocytic markers, albumin and transferrin, in developing hippocampal neurons in primary culture. The effect of this treatment on the levels of several representative proteins involved in the endocytic process w...
|
PMID: 20133374
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the protective action of methyl donors is mediated by an effect on the oxidative metabolism of alcohol in the liver. Male C57BL/6J mice were administered a control high-fat diet or diet enriched in methyl donors with or without alcohol for 4 weeks using the enteral alcohol feedi...
|
PMID: 20118189
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the protective action of methyl donors is mediated by an effect on the oxidative metabolism of alcohol in the liver. Male C57BL/6J mice were administered a control high-fat diet or diet enriched in methyl donors with or without alcohol for 4 weeks using the enteral alcohol feedi...
|
PMID: 20118189
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the protective action of methyl donors is mediated by an effect on the oxidative metabolism of alcohol in the liver. Male C57BL/6J mice were administered a control high-fat diet or diet enriched in methyl donors with or without alcohol for 4 weeks using the enteral alcohol feedi...
|
PMID: 20118189
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We investigated the effect of alcohol exposure on the internalization of two widely used endocytic markers, albumin and transferrin, in developing hippocampal neurons in primary culture. The effect of this treatment on the levels of several representative proteins involved in the endocytic process w...
|
PMID: 20133374
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We investigated the effect of alcohol exposure on the internalization of two widely used endocytic markers, albumin and transferrin, in developing hippocampal neurons in primary culture. The effect of this treatment on the levels of several representative proteins involved in the endocytic process w...
|
PMID: 20133374
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We investigated the effect of alcohol exposure on the internalization of two widely used endocytic markers, albumin and transferrin, in developing hippocampal neurons in primary culture. The effect of this treatment on the levels of several representative proteins involved in the endocytic process w...
|
PMID: 20133374
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the protective action of methyl donors is mediated by an effect on the oxidative metabolism of alcohol in the liver. Male C57BL/6J mice were administered a control high-fat diet or diet enriched in methyl donors with or without alcohol for 4 weeks using the enteral alcohol feedi...
|
PMID: 20118189
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We investigated the effect of alcohol exposure on the internalization of two widely used endocytic markers, albumin and transferrin, in developing hippocampal neurons in primary culture. The effect of this treatment on the levels of several representative proteins involved in the endocytic process w...
|
PMID: 20133374
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We hypothesized that the protective action of methyl donors is mediated by an effect on the oxidative metabolism of alcohol in the liver. Male C57BL/6J mice were administered a control high-fat diet or diet enriched in methyl donors with or without alcohol for 4 weeks using the enteral alcohol feedi...
|
PMID: 20118189
PDF is available here.
PDF is available here.
Toxicological Sciences (115)1 2010
Abstract
We investigated the effect of alcohol exposure on the internalization of two widely used endocytic markers, albumin and transferrin, in developing hippocampal neurons in primary culture. The effect of this treatment on the levels of several representative proteins involved in the endocytic process w...
|
PMID: 20133374
PDF is available here.
PDF is available here.
Abstract
Medical-forensic examination of sexual assault victims and alleged offenders is a common task of many forensic institutes. In the current study, the results from samples taken at the Institute of Legal Medicine, Hanover Medical School, during a period from 2005 to 2007 were retrospectively evaluated...
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PMID: 20182738
PDF is available here.
PDF is available here.
Biological Psychiatry (67)9 2010
Abstract
Ethanol-elicited nuclear GAPDH augments TIEG2-mediated MAO B, which might play a role in brain damage in subjects with alcoholism. Compounds that block this cascade are potential candidates for therapeutic strategies.
Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All ri...
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PMID: 20022592
PDF is available here.
PDF is available here.
Abstract
We review data demonstrating altered HPA function and increased depression/anxiety in FASD. In the context of the stress-diathesis model, we discuss the hypothesis that fetal programming of the HPA axis by PAE alters neuroadaptive mechanisms that mediate the stress response, thus sensitizing the org...
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PMID: 19545588
PDF is available here.
PDF is available here.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine (6)2 2010
Abstract
Forensic Science International (197)1-3 2010
Abstract
We describe two cases of human consumption of seeds from Argyreia nervosa (Hawaiian Baby Woodrose), which resulted in one fatality due to falling from a building and one surviving witness. The principal psychoactive constituent of the seeds, lysergamide (LSA), was recovered from blood and urine samp...
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PMID: 20018470
PDF is available here.
PDF is available here.
Abstract
The joint 30th Annual Meeting of the Australian Neuroscience Society and the 50th Anniversary Meeting of the Australian Physiological Society, held in Sydney, included topics covering new developments in the fields of neuroscience and physiology. This conference report highlights selected presentati...
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PMID: 20373243
PDF is available here.
PDF is available here.
Pediatric Emergency Care (26)4 2010
Abstract
Droperidol is a safe and effective medication in the adolescent and young adult population....
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PMID: 20401969
PDF is available here.
PDF is available here.
Abstract
We provide an update of current knowledge in the field of ALD....
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PMID: 20238395
PDF is available here.
PDF is available here.
Abstract
Chronic inflammation is often associated with alcohol-related medical conditions. The key inducer of such inflammation, and also the best understood, is gut microflora-derived lipopolysaccharide (LPS). Alcohol can significantly increase the translocation of LPS from the gut. In healthy individuals,...
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PMID: 20238396
PDF is available here.
PDF is available here.
Abstract
We may be able to apply much of the knowledge that we have gained regarding the effects of alcohol on the liver to the pancreas.
2010 Baishideng. All rights reserved....
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PMID: 20238397
PDF is available here.
PDF is available here.
Abstract
We discuss the mechanisms by which alcohol contributes to increased gut permeability, the activation of Kupffer cells, and the inflammatory cascade by LPS. The role of the Toll-like receptor 4 (TLR4) complex in LPS recognition and the importance of the TLR4-induced signaling pathways are evaluated i...
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PMID: 20238398
PDF is available here.
PDF is available here.
Abstract
We hypothesize that the development of therapeutic agents to regulate HO-1 and its downstream targets could be useful in enhancing the resolution of inflammation during ALD and preventing progression of early stages of liver injury.
2010 Baishideng. All rights reserved....
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PMID: 20238399
PDF is available here.
PDF is available here.
Abstract
Hepatitis C virus (HCV) is one of the main etiological factors responsible for liver disease worldwide. It has been estimated that there are over 170 million people infected with HCV worldwide. Of these infected individuals, approximately 75% will go on to develop a life long necroinflammatory liver...
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PMID: 20238400
PDF is available here.
PDF is available here.
Abstract
This article reviews the evidence that ties the development of hepatocellular carcinoma (HCC) to the natural immune pro-inflammatory response to chronic liver disease, with a focus on the role of Toll-like receptor (TLR) signaling as the mechanism of liver stem cell/progenitor transformation to HCC....
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PMID: 20238401
PDF is available here.
PDF is available here.
Abstract
Proteasome dysfunction has been repeatedly reported in alcoholic liver disease. Ethanol metabolism end-products affect the structure of the proteasome, and, therefore, change the proteasome interaction with its regulatory complexes 19S and PA28, as well as its interacting proteins. Chronic ethanol f...
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PMID: 20238402
PDF is available here.
PDF is available here.
Abstract
We will briefly discuss the hepatic organization of each cytoskeletal network and highlight some components of each system. We will also describe what is known about ethanol-induced changes in the dynamics and distributions of each cytoskeletal system and discuss what is known about changes in prote...
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PMID: 20238403
PDF is available here.
PDF is available here.
Abstract
S-adenosyl-L-methionine (SAM) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione. SAM is also a key metabolite that regulates hepatocyte growth, differentiation and death. Hepatic SAM levels are decreased in animal models of alcohol liver injury and in...
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PMID: 20238404
PDF is available here.
PDF is available here.
Abstract
We review changes in sex hormone metabolism resulting from alcohol ingestion, summarize research that points to estrogen as a cofactor in ALI, consider evidence that gut injury is linked to liver injury in the setting of alcohol, and briefly review the limited evidence regarding sex hormones and gut...
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PMID: 20238405
PDF is available here.
PDF is available here.
Abstract
We used the extracellular single-unit recording technique to examine the response properties of neurons in primary visual cortex (A17) of adult cats. We found that alcohol reduces spontaneous activity, visual evoked unit responses, the signal-to-noise ratio, and orientation selectivity of A17 cells....
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PMID: 20004679
PDF is available here.
PDF is available here.