Abstract
We combine cell-type-specific electrophysiological, pharmacological, and optogenetic techniques to dissect neural circuits and molecular pathways controlling synaptic plasticity onto AGRP neurons, a population that regulates feeding. We find that food deprivation elevates excitatory synaptic input,...
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PMID: 21925320
PDF is available here.
Abstract
We characterized the pharmacokinetics of fentanyl in 15 patients (American Society of Anesthesiologists Physical Status Classification 2 or 3) undergoing living-donor liver transplantation (LDLT). Fentanyl was continuously infused at the rate of 200-400 µg/h throughout the operation. The time cour...
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PMID: 21814196
PDF is available here.
Abstract
We conducted a retrospective case-note review of 37 patients undergoing removal of naltrexone implants in the period 2001 to 2008 at Sir Charles Gairdner Hospital. Indications for removal included infection at the insertion site, naltrexone intolerance or the requirement for effective opioid analges...
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PMID: 21970135
PDF is available here.
Abstract
We avoided both propofol and inhalational anesthetics and anesthetized her with benzodiazepine and opioid combined with regional anesthesia to minimize the stress response. Her metabolism was kept stable throughout the intraoperative period. However, on the second postoperative day, she developed rh...
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PMID: 21626870
PDF is available here.
Abstract
The rate of prescription opioid-related overdose death increased substantially in the United States over the past decade. Patterns of opioid prescribing may be related to risk of overdose mortality.
To examine the association of maximum prescribed daily opioid dose an...
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PMID: 21467284
PDF is available here.
Abstract
To highlight the significant impact breakthrough cancer pain (BTcP) can have on patients' quality of life and to discuss potential management strategies that could improve pain control in clinical practice as well as effective strategies to manage risk.
BTcP can place...
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PMID: 21325998
PDF is available here.
Abstract
The current study was planned to assess post-tonsillectomy analgesic efficacy of pre-emptive peritonsillar ketamine infiltration with or without bupivacaine in comparison to meperidine alone or in combination with bupivacaine.
The study included 100 patients with mean...
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PMID: 21991732
PDF is available here.
Abstract
The main problem in the postoperative period is pain relief. Adequate postoperative analgesia not only leads to patient's comfort but also decreases morbidity, nursing care and time of hospitalization. Determination of the effect of intraperitoneal pethidine on postoperative pain in...
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PMID: 21991731
PDF is available here.
Abstract
Herpes zoster (HZ) is a painful vesicular rash localized to one dermatome. Post-herpetic neuralgia (PHN) is persistent pain three months after the rash started. In recent years several Cochrane reviews and clinical studies on how to treat HZ and PHN have been published. These studies show that early...
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PMID: 21219842
PDF is available here.
Abstract
Drugs of abuse present numerous challenges to plastic surgeons, and detection remains difficult. With rates of drug abuse and misuse on the rise, clinicians must remain especially attentive to drug abusers' verbal and nonverbal cues, and be familiar with treating perioperative complications if they...
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PMID: 20871481
PDF is available here.
Abstract
Sedation for colonoscopy discomfort imposes a recovery-time burden on patients. The water method permitted 52% of patients accepting on-demand sedation to complete colonoscopy without sedation. On-site and at-home recovery times were not reported.
To confirm the benef...
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PMID: 21184876
PDF is available here.
Abstract
To compare the subjective effects of oxymorphone extended release (OM-ER) versus oxycodone controlled release (OC-CR).
Randomized, double-blind, crossover study.
Inpatient unit.
Healthy, nondependent recreational opioid users....
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PMID: 21823549
PDF is available here.
Abstract
Sensory neuron opioid receptors are targets for spinal, epidural, and peripheral opioid application. Although local nerve growth factor (NGF) has been identified as a mediator of sensory neuron μ-opioid receptor (MOR) up-regulation, the signaling pathways involved have not been yet identified.
Wist...
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PMID: 21169793
PDF is available here.
Abstract
To assess sedative and cardiopulmonary effects of premedication with a medetomidine-buprenorphine or acepromazine-buprenorphine combination in dogs anesthetized with propofol and isoflurane.
Randomized controlled clinical trial.
90 dogs undergoing routine surgical and diagnostic procedures.
Dogs wer...
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PMID: 21155682
PDF is available here.
Abstract
Performance Improvement CME (PI CME) is an educational activity in which clinicians retrospectively assess their current clinical practice, choose areas for improvement and implement interventions based on treatment guidelines and health care standards, and then re-evaluate their clinical practice t...
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PMID: 21190636
PDF is available here.
Abstract
Fentanyl pectin nasal spray (FPNS) is formulated as a solution utilizing PecSys®; pectin based enabling technology (Archimedes). On contact with the nasal mucosa the formulation will gel and modulate fentanyl absorption while limiting nasal drip or runoff. This single-dose volunteer study compared...
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PMID: 21084042
PDF is available here.
Abstract
We reviewed all critical incident reports at three tertiary care hospitals dated January 1, 2002, to February 28, 2009. In this longitudinal cohort study, critical incidents attributable to PCA errors were identified, and each incident was investigated. A safety intervention was implemented in Febru...
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PMID: 21068659
PDF is available here.
Abstract
Results from previous studies have shown favorable effects from the addition of buprenorphine to local anesthetics used for interscalene or axillary perivascular brachial plexus blocks. The main objective of the current study was to determine whether addition of buprenorphine could enhance bupivacai...
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PMID: 21042200
PDF is available here.
Abstract
To identify users and use of opioids in Denmark three databases were combined. The latest fifteen years an increase in users has been noted, and the costs of opioids have increased from 175 million DKK (1994) to 540 million DKK (2008). Oxycodone and transdermal fentanyl constitute 60% of the total a...
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PMID: 21073831
PDF is available here.
Abstract
To determine the effects of IM administration of acepromazine, hydromorphone, or the acepromazine-hydromorphone combination on degree of sedation in clinically normal dogs and to compare 2 sedation scoring techniques.
Prospective, randomized, blinded, controlled trial. Animals-46 random-source dogs....
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PMID: 21073386
PDF is available here.
Abstract
We thus conclude that a constant i.v. infusion of procaine should no longer be recommended for pain relief in patients with acute pancreatitis anymore.
© Georg Thieme Verlag KG Stuttgart · New York....
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PMID: 21064010
PDF is available here.
Abstract
Guidelines for pain management in adult sickle cell patients with vaso-occlusive crises suggest prompt, frequent administration of parenteral opioids. Neither the ability to implement these guidelines in a busy urban emergency department nor opioid dose requirements in uncomplicated vaso-occlusive c...
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PMID: 21141290
PDF is available here.
Abstract
The purpose of this investigation was to partially remove feedback from type III/IV skeletal muscle afferents and determine how this feedback influences the central and peripheral hemodynamic responses to passive leg movement. Heart rate (HR), stroke volume (SV), cardiac output (CO), mean arterial p...
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PMID: 20802133
PDF is available here.
Abstract
I and Pentazocine group II, with 20 cases each. The regimens of the three groups included: Sufentanil of 2 g/kg; Pentazocine group I of 3 mg/kg; Pentazocine group II of 5 mg/kg. All were diluted with saline into 100 ml and were continuously infused at the rate of 2 ml/h. Visual analogue scale (VAS),...
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PMID: 21254677
PDF is available here.
Abstract
These results persisted during the 1-year follow-up period or until death. Minor adverse effects (moderate diarrhea and mild hypotension) were frequent (n = 64 and n = 47, respectively), and severe complications occurred in 1 patient with a transient paraparesis (n = 1). No procedure-related mortali...
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PMID: 20975463
PDF is available here.
Abstract
We tested the hypothesis that patients who receive combined propofol/paravertebral anesthesia-analgesia (propofol/paravertebral) exhibited reduced levels of protumorigenic cytokines and matrix metalloproteinases (MMPs) and elevated levels of antitumorigenic cytokines compared with patients receiving...
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PMID: 20975461
PDF is available here.
Abstract
We present our experience with ultrasound-guided TAP perineural catheter insertion and subsequent management of ambulatory TAP local anesthetic infusions after inguinal hernia repair.
Three patients scheduled for unilateral open inguinal hernia repair underwent preoperative posterior TAP catheter pl...
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PMID: 20975474
PDF is available here.
Abstract
Acute postoperative pain and nerve injuries frequently lead to neuropathic chronic pain after anterior iliac crest (AIC) bone graft. This prospective study evaluated postoperative pain relief after preoperative ultrasound-guided transversus abdominis plane (TAP) block for orthopedic surgery with an...
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PMID: 20975466
PDF is available here.
J I Gómez-Arnau,
J L Aguilar,
P Bovaira,
F Bustos,
J De Andrés,
J C de la Pinta,
J García-Fernández,
S López-Alvarez,
L López-Olaondo,
F Neira,
A Planas,
J Pueyo,
P Vila,
L M Torres and
Grupo de Trabajo de NVPO de la Sociedad Española de Anestesiología y Reanimación
Abstract
Postoperative nausea and vomiting (PONV) causes patient discomfort, lowers patient satisfaction, and increases care requirements. Opioid-induced nausea and vomiting (OINV) may also occur if opioids are used to treat postoperative pain. These guidelines aim to provide recommendations for the preventi...
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PMID: 21033457
PDF is available here.
Abstract
In this paper a simple, selective and inexpensive kinetic method was developed for the determination of morphine based on its inhibitory effect on the Janus green-bromate system in sulfuric acid media. The reaction was monitored spectrophotometrically at 618 nm by a fixed time method. The effect of...
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PMID: 20634129
PDF is available here.
Abstract
Cigarette smoke, which serves as a nicotine delivery vehicle in humans, produces profound changes in physiology. Experimental studies suggest that nicotine has analgesic properties. However, epidemiologic evidence shows that smoking is a risk factor for chronic pain. The complex relationship between...
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PMID: 20864835
PDF is available here.
Abstract
Tramadol is an atypical, mixed-mechanism analgesic involving both opioid and catecholamine processes that appears to have low abuse potential and may be useful as a treatment for opioid dependence.
The current study assessed the level of physical dependence and opioid blockade efficacy produced by d...
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PMID: 20589494
PDF is available here.
Abstract
All treatments provided adequate postoperative analgesia. Significant increases in mean+/-SD blood glucose concentrations were detected in dogs receiving tramadol (96+/-14 mg/dL), codeine (120+/-66 mg/dL and 96+/-21 mg/dL), ketoprofen (105+/-22 mg/dL), and codeine+ketoprofen (104+/-16 mg/dL) at 5, 1...
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PMID: 20807140
PDF is available here.
Abstract
We use intra-articular injections delivered directly into the soft tissue of the knee. Our current intra-articular injection is 60 mL of 0.5% ropivacaine with 0.5 mg of epinephrine. In patients with a normal renal function, 30 mg of ketorolac is added. The injection is administered throughout all of...
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PMID: 20839683
PDF is available here.
Abstract
This study compared immobilization of gemsbok (Oryx gazella) using thiafentanil-xylazine (TX) versus carfentanil-xylazine (CX). Twelve adult gemsboks were divided into two groups, TX and CX. Each group received either 6 mg thiafentanil (0.036 microg/kg (0.032-0.040 microg/kg) and 20 mg xylazine (TX)...
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PMID: 20945664
PDF is available here.
Abstract
Captive Asian elephants (Elephas maximus) are susceptible to lameness resulting from foot and joint pain, including chronic arthritis. In the past, opioid analgesics, such as butorphanol, have been used clinically for pain management. However, dosages used in treating elephants were often extrapolat...
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PMID: 20945638
PDF is available here.
Abstract
The analyzed population included 1038 (56%) NDUs, 578 (31%) FDUs, and 244 (13%) ADUs. About 85% of ADUs were on opioid maintenance therapy and 25% used illicit drugs. Although ADUs had a more chaotic lifestyle and more psychiatric disorders, sustained virological response of ADUs (58%) did not diffe...
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PMID: 20351554
PDF is available here.
Abstract
We evaluated the effect of tianeptine, an antidepressant with prominent neuroprotective and neuroplastic properties, on the development of morphine antinociceptive tolerance and physical dependence. Male C57BL/6 mice were rendered tolerant to or dependent on morphine by subcutaneously injecting them...
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PMID: 20679893
PDF is available here.
Abstract
We compared the analgesic efficacy of dilute topical proparacaine with placebo in emergency department patients with acute corneal injuries.
We conducted a prospective randomized controlled trial of adults with corneal injuries presenting to one of 2 tertiary care emergency departments in London, On...
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PMID: 20880433
PDF is available here.
Abstract
Important questions remain regarding how best to monitor patients during procedural sedation and analgesia (PSA). Capnometry can detect hypoventilation and apnea, yet it is rarely used in emergency patients. Even the routine practice of performing preoxygenation in low-risk patients is controversial...
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PMID: 20880431
PDF is available here.
Abstract
Prescription drug abuse is a significant and growing health and socio-economical problem in the US and the world. According to the 2008 UN World Drug Report, the number of people who have consumed an illicit drug at least once in 2006/2007 reached 240 million, roughly 6% of the world...
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PMID: 21054261
PDF is available here.
Abstract
We describe an intrathecal granuloma that reoccur twice in the same patient after its surgical removal.
This case report highlights the incomplete knowledge about the mechanism of granuloma formation and discuss the alternatives in the management of catheter-tip granulomas. This is the first case re...
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PMID: 20639731
PDF is available here.