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Sensory System Agents (3):
Recent article
Sensory System Agents
Anesthesiology (114)1 2011
Abstract
We tested the hypothesis that that protein kinase A (PKA)-dependent AMPAR trafficking underlies the development of N-methyl-d-aspartate receptor-mediated cross-organ sensitization in vivo.
We recorded urethra reflex activity and analyzed immunoblotting of lumbosacral (L6-S2) dorsal horn (DH) tissue...
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PMID: 21169799
PDF is available here.
PDF is available here.
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Anesthesiology (114)1 2011
Abstract
Der Schmerz (24)4 2010
Abstract
The term "peripheral neuropathic pain syndromes" summarizes several chronic pain syndromes, which can occur focally or generalized in the peripheral nervous system in the course of an impairment of afferent neurons. Controlled clinical trials gave distinct indications for systemic treatments with an...
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PMID: 20628765
PDF is available here.
PDF is available here.
Abstract
Hyposecretion occurs in most patients early after submandibular gland autotransplantation for severe keratoconjunctivitis sicca. Endogenous transient receptor potential vanilloid subtype 1 (TRPV1) has been recently demonstrated in rabbit submandibular glands, and activation of TRPV1 by capsaicin inc...
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PMID: 20360133
PDF is available here.
PDF is available here.
Abstract
We determined the pressor and cardioaccelerator reflex responses to static contraction of hindlimb muscles whose femoral arteries were either occluded 72 h before contraction, occluded 3 min before contraction, or freely perfused. We found that the pressor reflex arising from the limb whose femoral...
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PMID: 20418475
PDF is available here.
PDF is available here.
Abstract
We studied whether activation of the CB1 receptor resulted in reduced TRPV1-mediated responses in cultured rat primary sensory neurons. We found that TRPV1-mediated whole-cell currents were significantly reduced respectively, by 50% and 25% by 10 nM and 30 nM of the endogenous CB1 receptor agonist,...
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PMID: 20511124
PDF is available here.
PDF is available here.
European Journal of Pain (14)5 2010
Abstract
Agonists of the TRPV1 receptor excite TRPV1-expressing polymodal nociceptors that is followed after higher doses by a state of diminished responsiveness called desensitization which ensues at two levels: (i) diminished responsiveness of the ion channel (TRPV1 receptor desensitization); (ii) diminish...
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PMID: 19800272
PDF is available here.
PDF is available here.
Circulation (121)16 2010
Abstract
Abstract
Pediatric Research (67)4 2010
Abstract
We compared skin plasma leakage in rats aged 2 and 8 wk, which was induced by topical capsaicin, topical formalin, and intracutaneous substance P, whose effects are mediated via tachykinin NK1 receptors. Evans blue dye extravasation served as an index of the increase in skin vascular permeability. C...
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PMID: 20035249
PDF is available here.
PDF is available here.
Methods in Molecular Biology (617)617 2010
Abstract
We describe the methodologies used to assay key mediators of MOR activation including cellular assays for cAMP, free Ca(2+), and NO, all of which have been implicated in the pharmacological effects of MOR agonists....
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PMID: 20336438
PDF is available here.
PDF is available here.
Methods in Molecular Biology (617)617 2010
Abstract
We describe some basic biophysical approaches used to study the properties of ion channels involved in pain and in analgesia....
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PMID: 20336426
PDF is available here.
PDF is available here.
Methods in Molecular Biology (617)617 2010
Abstract
The heat/capsaicin sensitization and intradermal capsaicin injection models are safe and noninvasive paradigms to generate stable, long-lasting, and reproducible injury capable of producing an area of both primary and secondary hyperalgesia. Risk of skin injury is substantially reduced since lower l...
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PMID: 20336422
PDF is available here.
PDF is available here.
Abstract
Journal of Neuroscience (30)4 2010
Abstract
We asked what combination of potencies in these three modes of TRPV1 activation corresponds to the lowest potency of a TRPV1 antagonist to cause hyperthermia. We studied hyperthermic responses of rats, mice, and guinea pigs to eight TRPV1 antagonists with different pharmacological profiles and used...
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PMID: 20107070
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that deafferentation of capsaicin-sensitive nerve induces oxidative destruction of proteins. NO has party to mediating oxidative modification of proteins....
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PMID: 20297694
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to investigate the effects of capsaicin (CAP) and resiniferatoxin (RTX) on substance P (SP) release and transient receptor potential vanilloid type 1 (TRPV1) expression of cultured rat dorsal root ganglion (DRG) neurons. Dissociated DRG cells of embryonic 15-day-old Wis...
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PMID: 20383340
PDF is available here.
PDF is available here.
Abstract
In healthy nonsmokers, inhalation of one single puff of cigarette smoke immediately evoked airway irritation and cough, which were either prevented or markedly diminished after premedication with hexamethonium. Single-fiber recording experiments performed in anesthetized animals showed that both C f...
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PMID: 19844757
PDF is available here.
PDF is available here.
Abstract
We discuss here the extensive research into the role of prostanoids in the airways and their modulation of the cough reflex....
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PMID: 19830488
PDF is available here.
PDF is available here.
Abstract
These results indicate that the rat proximal colon has two types of pacemaker cells. Myenteric pacemaker cells which receive predominantly nitrergic, but also cholinergic, peptidergic and NANCNN innervation, and submucosal pacemaker cells that are not markedly influenced by intramural nerves....
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PMID: 20093794
PDF is available here.
PDF is available here.
Abstract
We explored the urodynamic effect of primary afferent neurons modulation on detrusor activity in normal and OAB rats. Experiments were performed on 48 female rats. OAB was induced by intraperitoneal administration of cyclophosphamide. All the surgical procedures and urodynamic studies were performed...
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PMID: 20065501
PDF is available here.
PDF is available here.
Brain Research (1284) 2009
Abstract
We found that while BDNF treatment primarily increased the fraction of capsaicin-sensitive (TRPV1-expressing) neurons, GDNF exposure led to an increase in the allyl isothiocyanate (AITC)-responding (TRPA1-expressing) population. Moreover, BDNF treatment increased the amplitude of the response to bot...
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PMID: 19524560
PDF is available here.
PDF is available here.
Abstract
We confirmed the expression of TRPV1 in masseter afferents in rat trigeminal ganglia (TG), and provided new data that TRPA1 is also expressed in primary afferents innervating masticatory muscles in double-labeling immunohistochemistry experiments. We then examined whether the activation of each TRP...
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PMID: 19464796
PDF is available here.
PDF is available here.
Abstract
We developed and characterized an in vitro method that evaluates the responsiveness of isolated human nociceptors by measuring basal and stimulated release of neuropeptides from collected dental pulp biopsies. Informed consent was obtained from patients presenting for extraction of normal wisdom tee...
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PMID: 19428185
PDF is available here.
PDF is available here.
Neuroscience Letters (457)3 2009
Abstract
We tested this hypothesis by measuring concentrations of aspartate, glutamate and glycine in response to the first and second injection of acidic saline and compared to intramuscular injections of normal saline using microdialysis with HPLC analysis. We show a significant increase in aspartate and g...
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PMID: 19429181
PDF is available here.
PDF is available here.
Experimental Brain Research (195)3 2009
Abstract
We show that perceived pain intensity in secondary hyperalgesia is decreased when attention is distracted away from the painful pinprick stimulus with a visual task. Furthermore, it was found that the magnitude of attentional modulation in secondary hyperalgesia is very similar to that of capsaicin-...
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PMID: 19387625
PDF is available here.
PDF is available here.
Abstract
We concluded that the administration of RTX was more effective than CAP in facilitating voiding in the spinal cord-injured rats....
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PMID: 19764343
PDF is available here.
PDF is available here.
Abstract
We introduced recently (Trojan et al., Brain Res 2006;1120:106–113) is capable of tracking perceptual distortions in the somatotopic representation of heat-pain stimuli. Eleven healthy participants indicated the perceived positions of CO2 laser stimuli, repetitively presented to the dor...
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PMID: 19283552
PDF is available here.
PDF is available here.
Postgraduate Medicine (121)2 2009
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) have shown efficacy in patients with osteoarthritis (OA) pain but are also associated with a dose-dependent risk of gastrointestinal, cardiovascular, hematologic, hepatic, and renal adverse events (AEs). Topical NSAIDs were developed to provide analgesia...
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PMID: 19332972
PDF is available here.
PDF is available here.
ChemBioChem (10)3 2009
Abstract
Why are chilli peppers hot? The vanillyl amide, capsaicin, has long been known as the pungent principle of peppers, but only in their recent work have Tewksbury et al. addressed its ecological roles: to distract unsuitable seed dispensers and to protect the seeds against fungal infection by Fusarium...
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PMID: 19130454
PDF is available here.
PDF is available here.
Abstract
We had shown that TRPV1 stimulation inhibits hair shaft elongation and matrix keratinocyte proliferation, and induces premature hair follicle regression and keratinocyte apoptosis. In the current study, we have explored the role of TRPV1-mediated signaling in sebaceous gland (SG) biology, using a hu...
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PMID: 18769453
PDF is available here.
PDF is available here.
Abstract
We examined Glu levels released in the subcutaneous perfusate of the rat hind instep using a microdialysis catheter and the thermal withdrawal latency using the Plantar Test following injection of drugs associated with GluRs with/without capsaicin into the hindpaw. The injection of capsaicin into th...
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PMID: 19202316
PDF is available here.
PDF is available here.
Abstract
Nitrergic myenteric neurons co-innervating motor endplates were previously shown to inhibit vagally induced contractions of striated muscle in the rodent oesophagus. Immunohistochemical demonstration of putative co-transmitters, e.g. galanin, in enteric neurons prompted us to study a possible role o...
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PMID: 19077146
PDF is available here.
PDF is available here.
Recenti progressi in medicina (100)7-8 2009
Abstract
About 60 to 70 percent of people with diabetes have some neuropathy. Diabetic neuropathy can be classified as peripheral, autonomic, proximal, focal and multifocal or mixed. Peripheral neuropathy, the most common type of diabetic neuropathy, causes pain and/or loss of feeling in the toes, feet, legs...
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PMID: 19725472
PDF is available here.
PDF is available here.
Pharmacology (83)2 2009
Abstract
In order to further elucidate the mechanism(s) of action of analgesic and antihyperalgesic nefopam, its interactions with the transient receptor potential vanilloid subtype 1 (TRPV1) were investigated. In sensory neurons of rat embryos, dorsal root ganglion (DRG) in culture, nefopam (3-30 mumol/l) a...
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PMID: 19096234
PDF is available here.
PDF is available here.
Revista de Neurologia (48)7 2009
Abstract
The central role of TRPV1 in the physiology of pain will surely encourage the development of drugs aimed at this receptor which can be used in the treatment of several types of pain....
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PMID: 19319817
PDF is available here.
PDF is available here.
Abstract
We investigated the role of TRPV1 channels in the control of both excitatory and inhibitory transmission in the striatum. Pharmacological stimulation of TRPV1 channels with capsaicin (10 nM) selectively enhanced the frequency of glutamate-mediated spontaneous (sEPSCs) and miniature excitatory postsy...
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PMID: 18930149
PDF is available here.
PDF is available here.
Abstract
Compared to vehicle application, capsaicin elicited burning pain, increases in blood flow and temperature, but no change in mechanical sensitivity in the glabrous lips or tongue. Greater increases in blood flow and temperature paralleled more intense burning pain and larger areas of perceived pain f...
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PMID: 19639105
PDF is available here.
PDF is available here.
Journal of Physiology (586)Pt 23 2008
Abstract
Vagal pulmonary myelinated afferents are normally not activated by capsaicin, a selective agonist of transient receptor potential vanilloid type 1 (TRPV1) receptors. This study was carried out to investigate whether the expression of TRPV1 in these afferents is altered when chronic airway inflammati...
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PMID: 18832423
PDF is available here.
PDF is available here.
Lancet Neurology (7)12 2008
Abstract
Lancet Neurology (7)12 2008
Abstract
Patients who were randomly assigned to NGX-4010 (n=206) had a significantly greater reduction in pain during weeks two to eight than did patients who had the control patch (n=196). The mean changes in NPRS score were -29.6%vs -19.9% (difference -9.7%, 95% CI -15.47 to -3.95; p=0.001). 87 (42%) patie...
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PMID: 18977178
PDF is available here.
PDF is available here.
Abstract
We investigated the mechanism of capsaicin, the major pungent ingredient of red-chili pepper, in inducing apoptosis in pancreatic cancer cells. Treatment of AsPC-1 and BxPC-3 cells with capsaicin resulted in a dose-dependent inhibition of cell-viability and induction of apoptosis which was associate...
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PMID: 19002586
PDF is available here.
PDF is available here.
Neuron Glia Biology (4)4 2008
Abstract
Trigeminal nerve activation in response to inflammatory stimuli has been shown to increase neuron-glia communication via gap junctions in trigeminal ganglion. The goal of this study was to identify changes in the expression of gap junction proteins, connexins (Cxs), in trigeminal ganglia in response...
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PMID: 19674505
PDF is available here.
PDF is available here.
Abstract
The present study was conducted to compare the time-related cardiorespiratory changes occurring after the injection of Mesobuthus tamulus (BT; 1 mg/kg) venom and capsaicin (1.2 ng/kg) in the peripheral end of femoral artery in urethane anaesthetised rats. Blood pressure (BP), electrocardiogram (for...
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PMID: 19090345
PDF is available here.
PDF is available here.
Abstract
The results implicated that the morphological relationship between sensory nerve terminal and cardiac myocyte is much more close in vitro than it is in vivo. Cardiac myocytes may induce sensory neuropeptide synthesis and capsaicin-evoked neuropeptide release in neuromuscular co-cultures. Further exp...
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PMID: 18311519
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)41 2008
Abstract
Brain Research Bulletin (77)2-3 2008
Abstract
We studied the in vitro effect of capsaicin (1-10 microM) on homologous and heterologous competitive binding of opioid ligands, using unlabeled synthetic peptides and the following tritiated compounds: [(3)H]endomorphin-1, [(3)H]endomorphin-2, [(3)H]nociceptin((1-17)) and [(3)H]dynorphin((1-17)). Ca...
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PMID: 18588953
PDF is available here.
PDF is available here.
Abstract
We measured contraction of muscularis mucosae strips isolated from the human and guinea-pig oesophagus caused by cysteinyl leucotrienes, LTC(4), LTD(4) and LTE(4), as well as the dihydroxy leucotriene, LTB(4). Effects of leucotrienes in human were similar to those in guinea-pig oesophagus. LTC(4) an...
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PMID: 18651869
PDF is available here.
PDF is available here.
Abstract
A suggested explanation for airway symptoms induced by chemicals and scents is sensory hyperreactivity (SHR) of airway mucosal nerves. Patients with SHR have increased cough sensitivity to inhaled capsaicin, mediated by transient receptor potential (TRP) ion channels. In animal experiments, some TRP...
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PMID: 18621137
PDF is available here.
PDF is available here.
Abstract
We investigated the potential contribution of catecholamine metabolites to neuropathic pain in a model of alcoholic neuropathy. The presence of catecholamines in sensory neurons is supported by capsaicin-stimulated epinephrine release, an effect enhanced in ethanol-fed rats. mRNA for enzymes in dors...
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PMID: 18783367
PDF is available here.
PDF is available here.
Neuroscience Letters (442)1 2008
Abstract
In order to clarify the effect of age-related change in trigeminal nociception, phosphorylation of extracellular signal-regulated kinase (pERK) in trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord neurons were studied in the aged rats following subcutaneous capsaicin injectio...
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PMID: 18621095
PDF is available here.
PDF is available here.
Abstract
We address the hypothesis that 5-hydroxytryptamine (5-HT) differentially stimulates afferent nerve subtypes in the oesophagus. Extracellular recordings of single unit activity originating from nerve terminals were made in the isolated innervated guinea-pig oesophagus. Whole cell patch clamp recordin...
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PMID: 18482251
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (283)35 2008
Abstract
Venomous animals from distinct phyla such as spiders, scorpions, snakes, cone snails, or sea anemones produce small toxic proteins interacting with a variety of cell targets. Their bites often cause pain. One of the ways of pain generation is the activation of TRPV1 channels. Screening of 30 differe...
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PMID: 18579526
PDF is available here.
PDF is available here.
Neuroscience (155)2 2008
Abstract
I and II with TRPV1 in almost all (>90%) TRPV1 expressing neurons provides evidence consistent with a direct interaction on the same subpopulation of sensory neurons. In summary, our data demonstrate that TNFalpha directly enhances the sensitivity of rat trigeminal neurons to capsaicin via both rapi...
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PMID: 18582539
PDF is available here.
PDF is available here.
Abstract
It is postulated that Ara C treatment blocked insertion of TRPV1 in the cell membrane, resulting in accumulation of the receptors in the cytoplasm, loss of capsaicin sensitivity, and membrane-bound immunostaining, which was restored with a rebound on withdrawal of Ara C. The observed pattern of loss...
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PMID: 18414789
PDF is available here.
PDF is available here.
Abstract
We next investigated the mechanisms(s) responsible for the counteracting effect of papaverine, by analysing whether this effect was changed by pretreatment with N(G)-nitro-L-arginine methyl ester (L-NAME), dexamethasone, indomethacin or capsaicin. Papaverine, co-administered with morphine, counterac...
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PMID: 18363637
PDF is available here.
PDF is available here.
Abstract
We investigated its effect on sepsis-induced ileus and on cannabinoid receptor and FAAH expression in the mouse intestine. Sepsis was induced by treating mice with lipopolysaccharides for 18 h. Sepsis led to a decrease in gastric emptying and intestinal transit. Cannabidiol further reduced gastroint...
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PMID: 18373655
PDF is available here.
PDF is available here.
European Journal of Pain (12)6 2008
Abstract
We investigated isolated dorsal root ganglion neurons from a non-rodent species, the pig, Sus scrofa domesticus. Single labeling revealed capsaicin-induced cobalt-uptake in 54.3% and transient receptor potential V1 (TRPV1) immunoreactivity in 55.1% of all neurons. Ruthenium red and capsazepine suppr...
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PMID: 18218331
PDF is available here.
PDF is available here.
Journal of Neuroscience (28)28 2008
Abstract
We show that a model of acute inflammatory hyperalgesia is associated with an elevated density of GluR1-containing AMPA receptors, as well as an increased synaptic ratio of GluR1 to GluR2/3 subunits, at synapses established by C-fibers that lack the neuropeptide substance P. A more subtle increase i...
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PMID: 18614677
PDF is available here.
PDF is available here.
Journal of Neurophysiology (100)1 2008
Abstract
We have investigated the effects of anoxia and anoxic aglycemia on Ca2+ regulation in sensory neurons from rat dorsal root ganglia. Anoxia increased [Ca2+]i by evoking Ca2+ release from two distinct internal stores one sensitive to carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP) and one...
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PMID: 18417627
PDF is available here.
PDF is available here.