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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Anticarcinogenic Agents (0):
Recent article
Anticarcinogenic Agents
Journal of Biological Chemistry (286)39 2011
Abstract
We have previously shown that two of the polyphenols from green tea (epigallocatechin gallate (EGCG) and epicatechin gallate (ECG)) inhibit GDH in vitro and that EGCG blocks GDH-mediated insulin secretion in wild type rat islets. Using structural and site-directed mutagenesis studies, we demonstrate...
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PMID: 21813650
PDF is available here.
PDF is available here.
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Abstract
We have analyzed differential miRNA expression in PCa cells treated with Res.
Using miRNA microarrays we found that 23 miRNAs were significantly down-regulated and 28 miRNAs were significantly up-regulated after Res treatment. The down-regulated miRs included miR-17-92 and miR-106ab...
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PMID: 21714127
PDF is available here.
PDF is available here.
Abstract
Abstract
We examined the impact of CR on a model of inflammation-associated pancreatitis and pancreatic dysplasia, with a focus on the mechanistic contribution of systemic IGF-1. Administration of a 30% CR diet for 14 weeks decreased serum IGF-1 levels and hindered pancreatic ductal lesion formation and dysp...
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PMID: 21593196
PDF is available here.
PDF is available here.
Ginekologia polska (82)6 2011
Abstract
We discuss the usefulness of various risk estimation models and their possible application for breast cancer prophylaxis....
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PMID: 21853936
PDF is available here.
PDF is available here.
Abstract
We hypothesized that activating NRF2-dependent cytoprotective gene expression with sulforaphane (SFN) affords protection against CS-induced lung damage by inhibiting chemokine production. Results indicate that in the human BEAS-2B epithelial cell line, 5 μM SFN activated NRF2-dependent gene express...
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PMID: 21401388
PDF is available here.
PDF is available here.
Abstract
The cancer preventive activities of tea (Camellia sinensis, Theaceae) have been demonstrated in animal models for cancers at different organ sites and suggested by some epidemiological studies. Many mechanisms for cancer prevention have been proposed based on studies in cell lines, w...
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PMID: 21538856
PDF is available here.
PDF is available here.
Cancer Epidemiology (35)3 2011
Abstract
We evaluated the effect of sulforaphane alone or in combination with gemcitabine on HeLa cells by cell viability assay and confirmed the results by apoptosis assay. Further we analyzed the effect of sulforaphane on the expression of Bcl-2, COX-2 and IL-1β by RT-PCR on HeLa cells.
In...
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PMID: 20956097
PDF is available here.
PDF is available here.
Abstract
We have employed two-dimensional electrophoresis to detect and quantitate gene expression effects of candidate chemoprevention compounds in the livers of treated rats. Oltipraz, an inducer of several phase II enzymes, affected a series of at least 26 proteins, most of which were slightly decreased b...
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PMID: 8538186
PDF is available here.
PDF is available here.
Abstract
The pathogenicity of staphylococcus aureus is dependent largely upon its ability to secrete a number of virulence factors, therefore, anti-virulence strategy to combat S. aureus-mediated infections is now gaining great interest. It is widely recognized that some plant essential oils could affect the...
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PMID: 21283822
PDF is available here.
PDF is available here.
Abstract
Abstract
We will discuss the current progress in the study of Nrf2 signaling, in particular, the mechanisms of Nrf2 activation by chemopreventive agents. We will also discuss some of the potential caveats of Nrf2 in cancer treatment and future opportunity and challenges on regulation of Nrf2-mediated antioxi...
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PMID: 20486765
PDF is available here.
PDF is available here.
Abstract
Journal of Biological Chemistry (285)45 2010
Abstract
We investigated a combinatorial approach using two natural dietary polyphenols, luteolin and EGCG, and found that their combination at low doses (at which single agents induce minimal apoptosis) synergistically increased apoptosis (3-5-fold more than the additive level of apoptosis) in both head and...
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PMID: 20826787
PDF is available here.
PDF is available here.
Abstract
Liver disease is the fifth commonest cause of death in the UK. Observational and case-controlled studies have suggested that coffee is beneficial in liver disease, but this evidence has yet to be evaluated or placed into the context of the natural history of liver disease. The aim of this study was...
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PMID: 20802342
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)7 2010
Abstract
Extracts of green tea and green tea polyphenols have exhibited inhibitory effects against the formation and development of tumors at different organ sites in animals. These include animal models for skin, lung, oral cavity, esophagus, stomach, intestine, colon, liver, pancreas, bladder, mammary glan...
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PMID: 20924968
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)7 2010
Abstract
We discuss merits of two such naturally occurring dietary agents-curcumin and resveratrol-for chemoprevention of CRC....
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PMID: 20924971
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)7 2010
Abstract
Head and neck squamous cell carcinoma (HNSCC) is one of the most fatal cancers worldwide. Despite advances in the management of HNSCC, the overall survival for patients has not improved significantly due to advanced stages at diagnosis, high recurrence rate after surgical removal, and second primary...
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PMID: 20924973
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)7 2010
Abstract
Nutrition and Cancer (62)7 2010
Abstract
We summarize the literature about TQ's molecular mechanism of action and its ability to induce apoptosis and inhibit tumor growth in preclinical models. TQ has anti-inflammatory effects, and it inhibits tumor cell proliferation through modulation of apoptosis signaling, inhibition of angiogenesis, a...
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PMID: 20924969
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)7 2010
Abstract
Curcumin (diferuloylmethane), the yellow pigment in Indian saffron (Curcuma longa; also called turmeric, haldi, or haridara in the East and curry powder in the West), has been consumed by people for centuries as a dietary component and for a variety of proinflammatory ailments. Extensive research wi...
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PMID: 20924967
PDF is available here.
PDF is available here.
Abstract
We performed (i) in vitro studies including luciferase reporter gene assays, MTS cell viability assays, and quantitative real-time PCR (qRT-PCR) in PC-3 AP-1 human PCa cells, (ii) in vivo temporal (3 h and 12 h) microarray studies in the prostate of Nrf2-deficient mice that was validated by qRT-PCR,...
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PMID: 20729872
PDF is available here.
PDF is available here.
Abstract
We summarize the recent findings of PEITC on prostate cancer prevention with an emphasis on epigenetic mechanisms. Studies have indicated that PEITC mediates gene regulation, such as downregulation of androgen receptor expression and induction of endogenous cyclin-dependent kinase inhibitors, p21 an...
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PMID: 20664922
PDF is available here.
PDF is available here.
Abstract
Inorganic selenium and oxo-sulfur compounds are widely available in dietary supplements and have been extensively studied for their antioxidant and anticancer properties. Although many in vivo and clinical trials have been conducted using these compounds, their biochemical and chemical mechanisms of...
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PMID: 20632128
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
The anticancer activity of sulforaphane is known to be mediated at least partly by apoptosis induction and associated with the presence of the -N=C=S moiety. The present study explored how oxidation of sulphur in the side chain of sulforaphane affected apoptosis induction to provide the chemical bas...
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PMID: 20944144
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
SFN dose- and time-dependently retarded the growth and induced cell death in MCF-7 and MDA-MB-231 human breast cancer cells. In MDA-MB-231 cells, 30 μM SFN caused S and G2/M cell-cycle arrest associated with increased p21WAF1 and p27KIP1 levels and decreased cyclin A, cyclin B1 and CDC2 levels. Cel...
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PMID: 20944112
PDF is available here.
PDF is available here.
Biochemical Pharmacology (80)4 2010
Abstract
We report that the type 1 ryanodine receptor (RyR1) is a molecular target that responds to nanomolar (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG). Single channel analyses demonstrate EGCG (5-10nM) increases channel open probability (Po) twofold, by lengthening open dwell...
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PMID: 20471964
PDF is available here.
PDF is available here.
Journal of Nutrition (140)8 2010
Abstract
We applied human lung cells in vitro to investigate the effects of several candidate phytopreventive agents, including green tea extracts (GTE), broccoli sprout extracts (BSE), epigallocatechin gallate (EGCG), sulforaphane (SFN), phenethyl isothiocyanate (PEITC), and benzyl isothiocyanate (BITC), on...
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PMID: 20554899
PDF is available here.
PDF is available here.
Abstract
We use small interfering RNA knockdown to study the role of individual PKC isoforms as regulators of keratinocyte differentiation induced by the potent differentiating stimulus, 12-O-tetradecanoylphorbol-13-acetate (TPA). PKC-delta knockdown reduces TPA-activated involucrin promoter activity, nuclea...
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PMID: 20445555
PDF is available here.
PDF is available here.
Abstract
We examined four cell lines for their sensitivity to MSC and SeMet in comparison with selenite. SeMet increased apoptotic cells in p53-positive A549 cells, whereas MSC increased apoptotic cells in p53-mutated HSC-3 cells. High activities of caspase-3, -8 and -9 were observed during apoptosis, and a...
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PMID: 19940991
PDF is available here.
PDF is available here.
Abstract
Our findings demonstrate that EGCG is effective for growth inhibition of a chondrosarcoma cell lines in vitro, and suggest that EGCG may be a new therapeutic option for patients with chondrosarcoma....
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PMID: 20127255
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of ellagic acid on colon cancer induced by 1,2-dimethylhydrazine in rats. Male Wistar albino rats were divided into four groups. Group 1 served as control, group 2 rats received ellagic acid 60 mg/kg bodyweight/every day p.o. throughout the experiment. Rats from groups 3 a...
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PMID: 20406206
PDF is available here.
PDF is available here.
Abstract
We demonstrated, using a murine colon cancer model, that yoghurt consumption inhibited tumour growth by decreasing the inflammatory response by increasing IL-10-secreting cells, cellular apoptosis and diminishing procarcinogenic enzymes. Milk fermented with Lactobacillus helveticus R389 delayed brea...
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PMID: 20550747
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (49)8 2010
Abstract
The HGF/c-Met pathway is an important regulator of signaling pathways responsible for invasion and metastasis of most human cancers, including prostate cancer. Exposure of DU145 prostate tumor cells to HGF stimulates the PI3-kinase and MAPK pathways, leading to increased scattering, motility, and in...
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PMID: 20623641
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)6 2010
Abstract
Gum Arabic (GA), a nutrient from dried exudate of Acacia senegal, is widely used as emulsifier and stabilizer. It stimulates sodium and water absorption in diarrhea. This study explored the effects of GA in colonic tissue. Mice were treated with GA (10% wt/vol) in drinking water and gene array was p...
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PMID: 20661830
PDF is available here.
PDF is available here.
Nutrition and Cancer (62)6 2010
Abstract
We report the efficacy of a mixed-tocotrienol diet against prostate tumorigenesis in the transgenic adenocarcinoma mouse prostate (TRAMP) mouse model. Male TRAMP mice, 8 wk old, were fed 0.1%, 0.3%, or 1% mixed tocotrienols in AIN-76A diet up to 24 wk old. Likewise, a positive control group consisti...
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PMID: 20661828
PDF is available here.
PDF is available here.
Biochemical Journal (429)2 2010
Abstract
We tested the ability of resveratrol and its metabolites to modulate the function of some known targets in vitro. In the present study, we have shown that COX-1, COX-2 and QR2 are potently inhibited by resveratrol, and that COX-1 and COX-2 are also inhibited by the resveratrol 4'-O-sulfate metabolit...
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PMID: 20450491
PDF is available here.
PDF is available here.
Abstract
We have performed pelvic magnetic resonance imaging (MRI) in patients undergoing breast cancer surgery before and after adjuvant drug therapy. Our purpose was to detect any radiographic uterine changes induced by various types of adjuvant therapy on pre- and postmenopausal patients by evaluating pro...
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PMID: 20661693
PDF is available here.
PDF is available here.
Abstract
The omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) has anticolorectal cancer activity in vitro and in preclinical models. The present study tested whether a novel, enteric-coated formulation of EPA, as the free fatty acid (EPA-FFA), has chemopreventative efficacy in p...
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PMID: 20348368
PDF is available here.
PDF is available here.
Abstract
Homeopathy (99)3 2010
Abstract
Chronic feeding of p-dimethyl amino azo benzene (p-DAB) and phenobarbital (PB) elevated the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT), lactate dehydrogenase (LDH), triglyceride, cholesterol, creatinine and bilirubin and lowered the l...
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PMID: 20674840
PDF is available here.
PDF is available here.
Abstract
This study represents a multiplex cytokine analysis of serum from a 10-month randomized, controlled trial of 238 subjects that investigated the effects of selenomethionine and/or celecoxib in subjects with mild or moderate esophageal squamous dysplasia. The original chemoprevention s...
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PMID: 20587703
PDF is available here.
PDF is available here.
Epidemiology (21)Supplement 2010
Abstract
We illustrate our model on calibration data for fat-soluble vitamins, focusing particularly on beta-cryptoxanthin. Prediction intervals for values above the LOQ are wide, and the width increases with the measured value. Prediction intervals below the LOQ provide more information than the statement t...
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PMID: 20526201
PDF is available here.
PDF is available here.
Molecular Carcinogenesis (49)7 2010
Abstract
Chemoprevention by dietary agents/supplements has emerged as a novel approach to control various malignancies, including colorectal cancer (CRC). This study assessed dietary grape seed extract (GSE) effectiveness in preventing azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation and associ...
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PMID: 20564341
PDF is available here.
PDF is available here.
Abstract
We have compared tumor progression in the LPB-Tag model of prostate in VDR knock out (VDRKO) and wild type (VDRWT) mice. On the C57BL/6 background LPB-Tag tumors progress significantly more rapidly in the VDRKO mice. VDRKO tumors show significantly higher levels of cell proliferation than VDRWT tumo...
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PMID: 20347977
PDF is available here.
PDF is available here.
Abstract
Gold compounds are well known for their neurological and nephrotoxic implications. However, haematological toxicity is one of the most serious toxic and less studied effects. The lack of information on these aspects of Au(III) prompted us to study the structural effects induced on cell membranes, pa...
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PMID: 20580689
PDF is available here.
PDF is available here.
Abstract
We report structure-activity relationships of 25 dithiolethiones. Several compounds show exceedingly potent and bladder specific activity in phase 2 enzyme induction. Structural features responsible for such activity, as well as those inhibiting the activity, are discussed. Moreover, the compounds a...
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PMID: 20481594
PDF is available here.
PDF is available here.
Toxicology (273)1-3 2010
Abstract
2,2,5,7,8-Pentamethyl-6-chromanol (PMCol) was administered by gavage in rats for 28 days at dose levels of 0, 100, 500, and 2000mg/kg/day. PMCol administration induced decreases in body weight gains and food consumption, hepatotoxicity (increased TBILI, ALB, ALT, TP; increased relative liver weights...
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PMID: 20430063
PDF is available here.
PDF is available here.
Neurochemical Research (35)6 2010
Abstract
Our researches with use of fluorescing antibodies to AFP, CEA and Ca-19-9 have shown that they are intensively besieged on a surface of cultivated malignant cells. It is the basic mechanism of tolerance and immunological escape, which is similar to pregnancy when "the maximal immunological most favo...
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PMID: 20119639
PDF is available here.
PDF is available here.
Abstract
Protein tyrosine phosphatases (PTPs) are a diverse family of enzymes encoded by 107 genes in the human genome. Together with protein tyrosine kinases (PTKs), PTPs regulate various cellular activities essential for the initiation and maintenance of malignant phenotypes. While PTK inhibitors are now u...
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PMID: 20337577
PDF is available here.
PDF is available here.
Abstract
Epidemiological studies have clearly shown that whole-grain cereals can protect against obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety, reduced transit time and glycaemic response), fibre (improved faecal bulking and satiety, viscosity and SCFA producti...
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PMID: 20565994
PDF is available here.
PDF is available here.
Abstract
Defects in epigenetic regulation of gene transcription play an important role in carcinogenesis of the breast and other tissues. The two most widely studied epigenetic changes are DNA methylation and acetylation of histone proteins and inhibition of these processes inhibits growth in breast cancer c...
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PMID: 20399854
PDF is available here.
PDF is available here.
Anticancer Research (30)6 2010
AKT and p21 WAF1/CIP1 as potential genistein targets in BRCA1-mutant human breast cancer cell lines.
Abstract
We showed that genistein inhibits proliferation and induces apoptosis more efficiently in BRCA1-mutant cells than in cells expressing wild-type BRCA1 protein. Increased AKT and decreased p21(WAF1/CIP1) protein levels could explain the relative resistance to genistein elicited by cells with wild-type...
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PMID: 20651350
PDF is available here.
PDF is available here.
Anticancer Research (30)6 2010
Abstract
We report that in addition to its function as an anticancer agent, and PEITC can inhibit migration and invasion through the extracellular signal-regulated kinases 1/2 (ERK1/2), protein kinase C (PKC) and nuclear factor-kappaB (NF-kappaB) signaling pathways in human gastric cells. The results from wo...
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PMID: 20651362
PDF is available here.
PDF is available here.
Abstract
This meta-analysis indicated that regular use of aspirin may be associated with reduced risk of noncardia gastric cancer, especially among Caucasians; for H. pylori-infected subjects the result was similar....
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PMID: 19672710
PDF is available here.
PDF is available here.
Abstract
Aminosalicylate and folic acid use may decrease the risk of CRC among IBD patients....
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PMID: 19705280
PDF is available here.
PDF is available here.
Gastroenterology (138)6 2010
Abstract
Colorectal cancer has been strongly associated with a Western lifestyle. In the past several decades, much has been learned about the dietary, lifestyle, and medication risk factors for this malignancy. Although there is controversy about the role of specific nutritional factors, consideration of di...
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PMID: 20420944
PDF is available here.
PDF is available here.
Gastroenterology (138)6 2010
Abstract
The connection between inflammation and tumorigenesis is well-established and in the last decade has received a great deal of supporting evidence from genetic, pharmacological, and epidemiological data. Inflammatory bowel disease is an important risk factor for the development of colon cancer. Infla...
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PMID: 20420949
PDF is available here.
PDF is available here.
Abstract
These results suggest that the trans,trans-CLA inhibits MNU-induced rat mammary tumorigenesis through the induction of apoptosis in conjunction with the reduction of arachidonic acid metabolites and that the efficacy of trans,trans-CLA is superior to cis-9,trans-11-CLA and trans-10,cis-12-CLA....
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PMID: 20373764
PDF is available here.
PDF is available here.