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Protective Agents (8):
Recent article
Protective Agents
Abstract
We here present genetic data showing that concomitant ablation of MMP9 (gelatinase B) and the serine protease plasmin results in lethal inflammatory mass lesions in the colon. These lesions possessed several histological attributes that are characteristic of mucosal prolapse seen in humans, and they...
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PMID: 21123624
PDF is available here.
PDF is available here.
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Abstract
Liver disease is the fifth commonest cause of death in the UK. Observational and case-controlled studies have suggested that coffee is beneficial in liver disease, but this evidence has yet to be evaluated or placed into the context of the natural history of liver disease. The aim of this study was...
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PMID: 20802342
PDF is available here.
PDF is available here.
Abstract
The intravascular administration of iodinated contrast media for diagnostic imaging is a common cause of acute kidney injury and a leading cause of iatrogenic renal disease. The purpose of this review is to describe the principal risk factors for contrast-induced acute kidney injury and to summarize...
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PMID: 20625289
PDF is available here.
PDF is available here.
Journal of Plant Physiology (167)15 2010
Abstract
We investigated the possible roles of ROS, NO and metallothionein in tomato plant responses to copper toxicity. We found that Cu(2+) stress caused the rapid release of H(2)O(2) and chlorotic leaves, and it stunted root growth and development. Cu treatment also caused an increase in NOS enzyme activi...
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PMID: 20627450
PDF is available here.
PDF is available here.
Abstract
We determined the effect of Radix Salviae Miltiorrhizae (Danshen) injection on apoptosis and NF-κB P65 protein expression in the intestinal mucosa of rats with SAP or OJ, and explored the protective mechanism of Danshen in their mucosa.
Sprague-Dawley rats were used in the SAP and OJ experiments. T...
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PMID: 20943465
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
We examined the effect of Etlingera elatior extract on lead-induced changes in the oxidative biomarkers and histology of bone marrow of rats. Sprague-Dawley rats were exposed to 500 ppm lead acetate in their drinking water for 14 days. E. elatior extract was treated orally (100mg/kg body weight) in...
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PMID: 20600524
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
We assessed the capability of hesperidin to prevent tert-butyl hydroperoxide (t-BuOOH)-induced cell damage by augmenting cellular antioxidant defense. Hesperidin significantly protected hepatocytes against t-BuOOH-induced cell cytotoxicity, such as mitochondrial membrane potential (MMP) deplete and...
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PMID: 20678535
PDF is available here.
PDF is available here.
Journal of Dentistry (38)10 2010
Abstract
To investigate the effect of an aqueous sodium fluoride solution of increasing concentration on erosion and attrition of enamel and dentine in vitro.
Enamel and dentine sections from caries-free human third molars were polished flat and taped (exposing a 3 mm x 3 mm area) before being randomly alloc...
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PMID: 20600557
PDF is available here.
PDF is available here.
Abstract
Remaxol is a new infusion hepatoprotector that contains succinic acid, inosine, methionine and methylglucamine. The hepatoprotective effect of remaxol on the liver function has been studied on the model of obstructive jaundice in rats, on the terms of one and two weeks after ligation of the common b...
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PMID: 21086649
PDF is available here.
PDF is available here.
Abstract
In recent years, the group of natural compounds called humic substances has drawn increasing interest of researchers both in, Russia and abroad. The properties of humic substances were studied and attempts of creating related medical preparations were undertaken. The article summarizes and reviews i...
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PMID: 21086653
PDF is available here.
PDF is available here.
Abstract
We investigated the antioxidant and hepatoprotective activities of M. bracteata methanol extract (MB). 2,2'-diphenyl-1-picrylhydrazyl radical scavenging activity, lipid peroxidation inhibition and trolox equivalent antioxidant capacity of MB were determined. The hepatoprotective activity of MB was s...
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PMID: 20869021
PDF is available here.
PDF is available here.
Abstract
Abstract
We performed cell viability assays, including MTS assay, colony formation assay and apoptotic cell sorting, to study MC-LR-induced cellular damage and the protective effects by SFN. The results showed that SFN protected MC-LR-induced damages at a nontoxic and physiological relevant dose in HepG2, BR...
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PMID: 20600217
PDF is available here.
PDF is available here.
Abstract
Picrorhiza (Picrorhiza kurrooa) is an endangered medicinal plant with well-known hepatoprotective activity attributed to monoterpenoid picrosides. The present article details on regulatory genes of terpenoid metabolism, 3-hydroxy-3-methylglutaryl coenzyme A reductase (pkhmgr) and 1-deoxy-D-xylulose-...
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PMID: 20076984
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of carnosine pretreatment on ethanol-induced oxidative stress and hepatotoxicity. Rats were given carnosine (2 g/L in drinking water) for 4 weeks and then ethanol was administered orally to rats at a dose of 5 g/kg every 12 hours for 3 doses totally (binge model). All rats...
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PMID: 20064906
PDF is available here.
PDF is available here.
Abstract
I (negative control) received intraperitoneal injections of isotonic saline (0.02 mL/g) for 6 consecutive days, Group II received intraperitoneal injections of DOX (2.5 mg/kg of body weight, six doses every other day; cumulative dosage, 15 mg/kg of body weight) for 6 consecutive days, Group III rece...
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PMID: 20553142
PDF is available here.
PDF is available here.
Abstract
In Mexican traditional medicine the orchid Prosthechea michuacana is highly valued as a food and in the treatment of various human diseases, including drug-related renal disease. Methanol, hexane, and chloroform extracts of bulbs of P. michuacana were studied in the cisplatin-induced renal injury mo...
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PMID: 20673060
PDF is available here.
PDF is available here.
Abstract
This study investigated the efficacy of terutroban, a specific thromboxane/prostaglandin endoperoxide receptor antagonist, on stroke incidence in spontaneously hypertensive stroke-prone rats (SHRSP). The effects of terutroban were compared with those of aspirin, another antiplatelet...
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PMID: 20332187
PDF is available here.
PDF is available here.
Abstract
A molecular hyperspectral imaging (MHI) system was developed to evaluate the protective effects of erythropoietin (EPO) on early diabetic retinopathy in rats. The system was used to capture hyperspectral images of rat retinal sections selected from three groups: normal control, diabe...
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PMID: 20172774
PDF is available here.
PDF is available here.
Abstract
The present article dwells in reviewing critically the patents published mainly on the new emerging trends and techniques for increasing the bioavailability of silymarin, the polyphenolic fraction obtained from the seeds of Silybum marianum. The use of this herb for treating various ailments like he...
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PMID: 20156178
PDF is available here.
PDF is available here.
Abstract
Liver fibrosis is one of the major health problems worldwide. Chronic alcohol abuse is one of the main causes of fibrosis. Ingestion of polyunsaturated fatty acids (PUFA) along with alcohol further aggravates the toxicity of alcohol. Fibrosis results due to increased deposition of extra cellular mat...
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PMID: 20465419
PDF is available here.
PDF is available here.
New Phytologist (186)4 2010
Abstract
Abstract
IMPORTANCE OF THE FIELD: To date, surgical dissection is based only on mechanical forces. The use of a chemical product that is able to ease tissue dissection represents an important advance. MESNA (sodium-2-mercaptoethanesulfonate) has recently been validated for chemically assisted tissue dissecti...
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PMID: 20433403
PDF is available here.
PDF is available here.
Abstract
OBJECTIVE: To describe a rare, but potential clinical manifestation of phenazopyridine (PAP) toxicity in a dog. CASE SUMMARY: A 6-year-old spayed female Chihuahua was evaluated for ataxia and dysphagia after ingestion of 200 mg (66 mg/kg) of PAP hydrochloride. The dog was presented to the hospital w...
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PMID: 20636989
PDF is available here.
PDF is available here.
Abstract
Obesity is associated with a complex systemic inflammatory state that has been implicated in the development of hepatic steatosis. This study was to test the efficacy of Yin-Chen-Hao-Tang (YCHT), an agent that improves hepatic triglyceride metabolism in its ability to modulate pathways implicated in...
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PMID: 20428786
PDF is available here.
PDF is available here.
Abstract
These results demonstrate FLNT is able to precondition rat hearts against myocardial ischemia/reperfusion damage to a similar level as that achieved via the late phase of ischemic preconditioning. The mechanism may involve the up-regulation of nitric oxide and the strengthening of anti-oxidant and a...
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PMID: 20607493
PDF is available here.
PDF is available here.
Abstract
We investigated the protective effect of resveratrol on hepatic injury induced by dimethylnitrosamine (DMN) in rats. Oral administration of resveratrol (20 mg/kg daily for 4 weeks) remarkably prevented the DMN-induced loss in body and liver weight, and inhibited the elevation of serum alanine transa...
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PMID: 20607498
PDF is available here.
PDF is available here.
Abstract
Topical used glucocorticoids (GC) represent an important class of steroid hormones for the treatment of a broad range of acute or chronic inflammatory diseases. Most interestingly, GC exert a pronounced anti-apoptotic effect in primary human fibroblasts whereas in variety of hematopoietic cells a pr...
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PMID: 20005955
PDF is available here.
PDF is available here.
Archives of Toxicology (84)5 2010
Abstract
Selenium is an oligoelement with essential biological functions. Diet is the most important selenium source, and intake of this element depends on its concentration in food and amount of food consumed. Among the essential human micronutrients, selenium is peculiar due to its beneficial physiological...
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PMID: 20033805
PDF is available here.
PDF is available here.
Abstract
Giving HES 130/0.4 attenuates rat liver IRI compared with no fluid, while giving HS does not. This suggests a role for HES in hepatoprotection associated with liver IRI....
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PMID: 20151340
PDF is available here.
PDF is available here.
Canadian Journal of Physiology and Pharmacology/Revue Canadienne de Physiologie et Pharmacologie (88)4 2010
Protective effects of polyphenolic compounds on oxidative stress-induced cytotoxicity in PC12 cells.
Abstract
We screened 12 polyphenols for their ability to increase the viability of PC12 cells subjected to oxidative stress via CoCl2 and H2O2. Cell viability data demonstrate that 50 micromol/L methyl gallate and 50 micromol/L fisetin significantly increase viability of H2O2-stressed cells. Further, viabili...
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PMID: 20555411
PDF is available here.
PDF is available here.
Abstract
The beneficial effects of beta blocking drugs in hypertension and heart failure are well known. However, this class of drugs is pharmacologically heterogeneous. In contrast to the non vasodilator betablockers like propranolol, atenolol or metoprolol which, in hypertension do not decrease intima medi...
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PMID: 20399940
PDF is available here.
PDF is available here.
Drug Discovery Today (15)7-8 2010
Abstract
We have used this model to screen for and identify multiple drugs that protect hair cells from aminoglycoside-induced death. The identification of multiple drugs and drug-like compounds that inhibit multiple hair cell death pathways might enable the development of protective cocktails to achieve com...
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PMID: 20096805
PDF is available here.
PDF is available here.
Amino Acids (38)4 2010
Abstract
The cellular stress response is a universal protective reaction to adverse environmental or microenvironmental conditions, such as heat and drugs, associated in part with the highly conserved heat shock proteins (HSPs). Histamine is a key inflammatory mediator derived from L: -histidine that governs...
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PMID: 19653065
PDF is available here.
PDF is available here.
Abstract
In the current review, we will discuss clinical studies that compare kidney transplant recipients with and without early graft dysfunction in order to elucidate the pathophysiology of ischemic acute allograft injury. We will specifically review the mechanisms leading to depression of the glomerular...
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PMID: 20009928
PDF is available here.
PDF is available here.
Abstract
Protective effects in human-liver transplantation were shown by methylprednisolone treatment in decreased donors, and by inhalation of a nontoxic dose of nitric oxide in recipients. In addition, recent results showed rescue of pig livers, donated after cardiac death by application of a cocktail of s...
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PMID: 20125019
PDF is available here.
PDF is available here.
Abstract
The 16% CP cause a significant decrease in MDPC-23 cell viability and 10% SA was able to partially prevent the toxic effects of CP.
Copyright 2010 Mosby, Inc. All rights reserved....
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PMID: 20303050
PDF is available here.
PDF is available here.
European Journal of Pharmacology (630)1-3 2010
Abstract
We investigated whether therapeutic treatment with the free radical scavenger edaravone could protect rats against acute pancreatitis and the associated lung injury. Acute pancreatitis was induced by infusion of 1ml/kg of sodium taurocholate (3% solution) into the biliopancreatic duct. Edaravone (8m...
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PMID: 20035747
PDF is available here.
PDF is available here.
Abstract
The GGT xenobiotic metabolism pathway is postulated to be a major toxification pathway for cisplatin nephrotoxicity, and BNP7787 may play a novel and critical therapeutic role in the modulation of GGT activity. We further postulate that there are two general mechanisms for BNP7787-mediated nephropro...
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PMID: 19714332
PDF is available here.
PDF is available here.
Abstract
We have studied the effect of Cr(III)(phen)3 [(tris(1,10-phenanthroline) chromium(III) chloride)] on lymphocytes in order to find out if metallothioneins (MTs) are produced in the process. We also investigated whether zinc pretreatment is able to protect cells from apoptosis reported to occur for th...
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PMID: 20043934
PDF is available here.
PDF is available here.
Pharmaceutical Biology (48)3 2010
Abstract
Administration of commonly used anticancer drug cisplatin [cis-diamminedichloroplatinum (II)] at pharmacologically relevant concentrations (12 mg/kg body weight) resulted in severe renal toxicity as evidenced from histopathological observations and biochemical alterations in the renal tissue. The ex...
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PMID: 20645815
PDF is available here.
PDF is available here.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (21)2 2010
Abstract
We therefore investigated whether theophylline (adenosine antagonist) reduces the incidence of contrast media induced nephropathy. Two hundred and eighty patients were randomly assigned to prophylactic administration of hydration with sodium bicarbonate plus theophylline (either orally or intravenou...
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PMID: 20228513
PDF is available here.
PDF is available here.
Abstract
The protective effects of different concentrations of aqueous extract of Rhus coriaria L. fruit (75 and 100 microg/ml) and also gallic acid (100 microM) as one of its main components were examined against oxidative stress toxicity induced by cumene hydroperoxide (CHP) in isolated rat hepatocytes. Bo...
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PMID: 20036300
PDF is available here.
PDF is available here.
Abstract
To investigate the renoprotective effect of adiponectin in streptozotocin (STz)-induced diabetic rats and explore its association with oxidation stress.
Type 2 diabetes mellitus was induced in rats by high-lipids and high-sucrose feeding and intraperitoneal STZ inject...
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PMID: 20335101
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (127)3 2010
Abstract
Zanthoxylum armatum DC possesses significant protective effect against hepatotoxicity induced by CCl(4) which may be attributed to the individual or combined action of phytoconstituents present in it.
Copyright 2009 Elsevier Ireland Ltd. All rights reserved....
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PMID: 19874881
PDF is available here.
PDF is available here.
Toxicology (268)3 2010
Abstract
The present study investigated the preventive effect of eugenol, a naturally occurring food flavouring agent on thioacetamide (TA)-induced hepatic injury in rats. Adult male Wistar rats of body weight 150-180 g were used for the study. Eugenol (10.7 mg/kg b.w./day) was administered to rats by oral i...
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PMID: 20036707
PDF is available here.
PDF is available here.
Anesthesiology (112)2 2010
Abstract
In women, kidneys were protected from cardiac arrest through estrogen. Estradiol-mediated renoprotection was not affected by ER deletion or blockade. Estradiol is renoprotective after cardiac arrest. The results indicate that estradiol renoprotection is ER-[alpha] and ER-[beta] independent....
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PMID: 20068453
PDF is available here.
PDF is available here.
Pharmaceutical Biology (48)2 2010
Protective activity of Jiang-Zhi-Li-Gan against carbon tetrachloride-induced hepatic injury in mice.
Abstract
These results support the use of this prescription against chemical hepatic injury....
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PMID: 20645847
PDF is available here.
PDF is available here.
Pharmaceutical Biology (48)2 2010
Abstract
In the present study, the hepatoprotective effects of petroleum ether (FRPE) and methanol (FRME) extract of Ficus racemosa Linn. (Moraceae) stem bark were studied using the model of hepatotoxicity induced by carbon tetrachloride (CCl(4)) in rats. CCl(4) administration induced a significant decrease...
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PMID: 20645843
PDF is available here.
PDF is available here.
Nutritional Neuroscience (13)1 2010
Abstract
The purpose of this work was to study the area of the varicosities of nerve fibers of myenteric neurons immunoreactive to vasoactive intestinal peptide (VIP-IR) and of the cell bodies of VIP-IR submucosal neurons of the jejunum of diabetic rats supplemented with 2% L-glutamine. Twenty male rats were...
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PMID: 20132654
PDF is available here.
PDF is available here.
Abstract
To improve bioavailability of poorly water-soluble YH439, a thermal reversible microemulsion system was prepared using modified fatty acids such as capric acid and palmitic acid with PEG 400. A combination of Capric-PEG 400 and Palmitic-PEG 400 with a ratio of 1 : 3 used as a lipid matrix and Cremop...
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PMID: 20045958
PDF is available here.
PDF is available here.
Ukrainskij biokhimicheskij zhurnal/Ukrayins'kij biokhimichnij zhurnal/Ukrainian biochemical journal (82)2 2010
Abstract
These results suggested that NSE protected the structural integrity and functional ability of cell membranes under the acute ethanol intoxication....
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PMID: 20684244
PDF is available here.
PDF is available here.
Anesthesiology (112)1 2010
Abstract
Patients undergoing temporary clipping (n = 441) were assigned to intraoperative hypothermia (33.3 degrees +/- 0.8 degrees C, n = 208) or normothermia (36.7 degrees +/- 0.5 degrees C, n = 233), with 178 patients also receiving supplemental protective drug (thiopental or etomidate) during temporary c...
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PMID: 19952722
PDF is available here.
PDF is available here.
Abstract
We demonstrated that HMG-CoA reductase inhibition protects against IR-induced endothelial damage, an effect that was lost upon COX-2 inhibition. These observations may suggest a mechanistic explanation for the cardioprotection observed in clinical settings such as percutaneous coronary interventions...
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PMID: 20675896
PDF is available here.
PDF is available here.
Abstract
In this paper, the protective effects of the active fraction (SF-7) from Shaofu Zhuyu decoction (SFZYD) were tested on a hydrogen peroxide (H(2)O(2))-induced rat vascular smooth muscle cells (VSMCs) oxidative injury model. This active fraction (SF-7) shows potent antioxidant properties. The cell via...
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PMID: 20714285
PDF is available here.
PDF is available here.
Abstract
We obtained genetic evidence showing not only that HSPs are protective against irritant-induced gastric lesions but also that GGA achieves its anti-ulcer effect through induction of HSPs. We also obtained genetic evidence that HSPs are protective against inflammatory bowel disease (IBD)-related coli...
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PMID: 20166990
PDF is available here.
PDF is available here.
Abstract
We investigated whether EPO is able to protect human renal tubular epithelial cells (hTECs) from oxidative stress and if so which pathways are involved. EPO (epoetin delta) could protect hTECs against oxidative stress by a dose-dependent inhibition of reactive oxygen species formation. This protecti...
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PMID: 20454536
PDF is available here.
PDF is available here.
Abstract
We compare the activity of each single extract with a commercial mixture for antiproliferative, antiradical and protective effects against induced oxidant stress effect. In ABTS and DPPH tests, turmeric extract is the most active, followed by artichoke and dandelion. All samples exhibited antiprolif...
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PMID: 20646355
PDF is available here.
PDF is available here.
Cell Transplantation (19)6 2010
Abstract
We reexamined the conditions of tissue disorders resulting from temporary ischemia of the organs as well as changes in tissue function and the effects on the preservation of renal function over time by using rat models in order to clinically utilize erythropoietin, which has inhibitory effects on is...
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PMID: 20525439
PDF is available here.
PDF is available here.
Abstract
We investigated the protective effect of Withania somnifera root powder (used in ayurvedic medicine in India) on gentamicin (GEN) induced nephrotoxicity in male Wistar rats. The root powder was administered orally to rats for 14 days before GEN treatment and thereafter with GEN for 8 days. Nephrotox...
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PMID: 20506689
PDF is available here.
PDF is available here.