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Endothelium-Dependent Relaxing Factors (0):
Recent article
Endothelium-Dependent Relaxing Factors
YAKUGAKU ZASSHI (130)6 2010
Abstract
Vascular tone is tightly regulated by endothelium-derived factors. These include relaxing factors (EDRFs) such as nitric oxide (NO), hyperpolarizing factors (EDHFs), and contracting factors (EDCFs). Although EDHF is a prominent vasodilator, particularly in smaller arteries, little attention has been...
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PMID: 20519855
PDF is available here.
PDF is available here.
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Abstract
Epoxyeicosatrienoic acids (EETs) are cytochrome P450 metabolites of arachidonic acid that are produced by the vascular endothelium in response to agonists such as bradykinin and acetylcholine or physical stimuli such as shear stress or cyclic stretch. In the vasculature, the EETs have biological act...
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PMID: 20224870
PDF is available here.
PDF is available here.
Abstract
The term endothelium-derived hyperpolarising factor (EDHF) was introduced in 1987 to describe the hypothetical factor responsible for myocyte hyperpolarisations not associated with nitric oxide (EDRF) or prostacyclin. Two broad categories of EDHF response exist. The classical EDHF pathway is blocked...
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PMID: 20383718
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that endothelium-derived hydrogen peroxide (H(2)O(2)) is an EDHF in animals and humans. For the synthesis of H(2)O(2)/EDHF, endothelial NO synthase system that is functionally coupled with Cu,Zn-superoxide dismutase plays a crucial role. Importantly, endothelium-derived H(2)O(2)...
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PMID: 20140449
PDF is available here.
PDF is available here.
Abstract
Endothelial dysfunction is a common feature of hypertension, and it results from the imbalanced release of endothelium-derived relaxing factors (EDRFs; in particular, nitric oxide) and endothelium-derived contracting factors (EDCFs; angiotensin II, endothelins, uridine adenosine tetraphosphate, and...
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PMID: 20127126
PDF is available here.
PDF is available here.
Abstract
Endothelium-dependent changes in vasomotor tone, whether evoked by vasoactive agents or physical forces, are recognized as essential for the local hemodynamic control in various normal and pathological circumstances. They are based on a complex signaling network within the vascular wall. In recent y...
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PMID: 20213495
PDF is available here.
PDF is available here.
Abstract
We will first focus on the current understanding of the caveolin/eNOS paradigm and will then detail the most recent findings on the role of caveolae in driving EDHF-signaling pathways....
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PMID: 20339866
PDF is available here.
PDF is available here.
Abstract
We discuss the mechanisms whereby hyperglycaemia, oxidative stress and dyslipidaemia can alter endothelial function and highlight their effects on endothelial nitric oxide synthase (eNOS), the endothelium-dependent hyperpolarising factor (EDHF) pathway(s), as well as on the role of endothelium-deriv...
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PMID: 20238124
PDF is available here.
PDF is available here.
Abstract
Since the detection of nitric oxide two and a half decades ago, there has been an incredible boost in endothelial function research, which is fascinating the research community. Physiologically, endothelial cells synthesize a number of vasoactive substances. In particular, several endothelium-derive...
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PMID: 20383717
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (130)5 2010
Abstract
It is widely accepted that vascular endothelium regulates vasoconstriction via release of endothelium-derived relaxing factors (EDRF). The mesenteric circulation, which is the largest vascular bed, influences regulation of systemic blood pressure. However, the role of EDRF in the modulation of vascu...
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PMID: 20460871
PDF is available here.
PDF is available here.
European Journal of Pharmacology (630)1-3 2010
Abstract
We have examined the relative contribution of EDHF/NO to the attenuated endothelium-dependent relaxation of pulmonary artery in sepsis, and the role of inducible nitric oxide synthase (iNOS)-derived NO in this mechanism. Sepsis was induced in male adult Wistar rats by caecal ligation and puncture. A...
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PMID: 20035746
PDF is available here.
PDF is available here.
Circulation Research (106)4 2010
Abstract
We review the basic biochemistry of S-nitrosylation (and denitrosylation), discuss the role of S-nitrosylation in the vascular and cardiac functions of NO, and identify current and potential clinical applications....
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PMID: 20203313
PDF is available here.
PDF is available here.
Zhonghua Yixue Zazhi (90)4 2010
Abstract
Plasma A-FABP/APN ratio was higher in early AS group than in low IMT control group [A-FABP/APN x 1000, 3.9(2.8 approximately 6.1) vs 2.9(1.8 approximately 5.7), P < 0.05]. FA-IMT correlated positively with plasma A-FABP/APN ratio (r = 0.216, P = 0.006) and negatively with APN (r = -0.179, P = 0.020)...
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PMID: 20356535
PDF is available here.
PDF is available here.
Abstract
A novel histamine receptor subtype, histamine H(3) receptor, mediates inhibition of peripheral autonomic neurotransmission. The present study was designed to examine vascular effects of histamine H(3) receptor by using a selective histamine H(3) receptor agonist, R-(-)-alpha methylhistamine (alpha-m...
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PMID: 20045936
PDF is available here.
PDF is available here.
Critical Care (14)2 2010
Abstract
The peroxynitrite-induced PARP activation is involved in renal hypoperfusion, impaired endothelium-dependent vasodilation and resultant dysfunction, and injury, in a model of lung injury....
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PMID: 20346119
PDF is available here.
PDF is available here.
Hypertension (54)2 2009
Abstract
We examined whether such cerebrovascular protection from Ang II is related to the estrous cycle. Cerebral blood flow was monitored by laser-Doppler flowmetry in anesthetized (urethane-chloralose) C57BL/6 female mice equipped with a cranial window. The phase of the estrous cycle was determined by vag...
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PMID: 19506098
PDF is available here.
PDF is available here.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (40)4 2009
Abstract
Acetylcholine (10(-8)-10(-4) mol/L) caused a concentration-dependent relaxation in all preconstricted aortic rings. Compared with the control group, the maximal endothelium dependent relaxation of the aortic rings in the obese rats was impaired (p<0.05). With Adiponectin, the relaxation response of...
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PMID: 19764555
PDF is available here.
PDF is available here.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (40)4 2009
Abstract
The ratio of celiac fat and body weight in the obese rats was higher than in the controls. The levels of serum triglyceride, total cholesterol, and free fat acid were elevated in the Obese Group compared with the Control Group. The Astragali Group had lower triglyceride and free fat acid levels than...
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PMID: 19764554
PDF is available here.
PDF is available here.
Abstract
Effluent from the right atrial appendage caused a relaxation of 58.4 +/- 10.1% and the left atrial appendage 74.9 +/- 8.5% from the initial prostagladin F2alpha contraction in coronary artery. No significant statistical difference was detected in effluent from the right and left atrial appendages. T...
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PMID: 19768303
PDF is available here.
PDF is available here.
Abstract
We investigated the mechanisms of the perivascular adipocyte-derived relaxation factor (PVRF) by using isolated rat's aortic rings and isometric contraction measurements. We found that contraction of the thoracic aorta induced by phenylephrine was significantly attenuated in the presence of PVAT fro...
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PMID: 19811363
PDF is available here.
PDF is available here.
Journal of Hypertension (27)4 2009
Abstract
Immunohistochemical staining showed abundant presence of Ang-(1-7) in aortic PVAT. In vessels with PVAT removed but intact endothelium (PVAT - E+), contraction induced by phenylephrine was attenuated by preincubation with Ang-(1-7). PVAT - E+ vessels precontracted with phenylephrine showed a concent...
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PMID: 19516177
PDF is available here.
PDF is available here.
Abstract
Wiener Medizinische Wochenschrift (159)7-8 2009
Abstract
Nebivolol (Nomexor) is a third generation, vasodilating beta-blocker with a high beta(1)-adrenoceptor selectivity. Nebivolol acts as an agonist at the beta(3) adrenoceptor as well as the estrogen receptor thereby releasing nitric oxide in blood vessels via eNOS. Pleiotropic effects of nebivolol furt...
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PMID: 19412697
PDF is available here.
PDF is available here.
Abstract
Since it was identified as the elusive endothelium-derived relaxing factor (EDRF) in the 1980s, nitric oxide (NO) has rapidly gained status as one of the most important signalling molecules in the cardiovascular system. Now, 20 years later, NO is regarded by most to be a ubiquitous mediator of cardi...
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PMID: 19907806
PDF is available here.
PDF is available here.
Abstract
We examined the effects of Psidium guajava Linn. leaf aqueous extract (PGE) on isolated, spontaneously-contracting portal veins, as well as on endothelium-intact and endothelium-denuded descending thoracic aortic ring preparations of healthy, normotensive rats. Graded concentrations of PGE (0.25-4.0...
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PMID: 19234376
PDF is available here.
PDF is available here.
Abstract
Taurine (20-80 mM) concentration-dependently relaxed precontractions induced by KCl (30 mM) and phenylephrine (1 microM) in NC rings, but enhanced the precontractions in IR rings. Denudation of the endothelium and pretreatment with N(G)-nitro-L-arginine methylester ester (0.1 mM) reversed the contra...
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PMID: 18612804
PDF is available here.
PDF is available here.
Bradykinin or acetylcholine as vasodilators to test endothelial venous function in healthy subjects.
Abstract
Changes in vein diameter after phenylephrine-induced venoconstriction were measured to compare venodilation induced by acetylcholine or bradykinin (linear variable differential transformer dorsal hand vein technique). We studied 23 healthy volunteers; 31% were male, and the subject had a mean age of...
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PMID: 18925329
PDF is available here.
PDF is available here.
Journal of Perinatology (28)10 2008
Abstract
Term and near-term infants with pulmonary hypertension are frequently treated with inhaled nitric oxide. This therapy can be delivered with high-frequency ventilation, but there has been limited study of the relative effectiveness of high-frequency jet ventilation and high-frequency oscillatory vent...
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PMID: 18580880
PDF is available here.
PDF is available here.
The Lancet (372)9643 2008
Abstract
Abstract
Plasma skin regeneration (PSR) is a novel method of resurfacing that uses plasma energy to create a thermal effect on the skin. PSR is different from lasers, light sources, and ablative lasers in that it is not chromophore dependent and does not vaporize tissue, but leaves a layer of intact, desicca...
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PMID: 18789051
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of nitrite on in vivo hemodynamics in rats and in vitro vasorelaxation in isolated rat aorta under aerobic conditions. Studies were performed to determine the mechanisms by which nitrite is converted to NO. In anesthetized rats, nitrite dose dependently decreased both sys...
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PMID: 18539756
PDF is available here.
PDF is available here.
Abstract
Abstract
Sirolimus causes marked vascular dysfunction and nitrate resistance after continuous treatment for 7 days. This impaired vasorelaxation may, in part, be induced by up-regulated mitochondrial superoxide release as well as by an up-regulation of NADPH oxidase-driven superoxide production. Both process...
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PMID: 18510959
PDF is available here.
PDF is available here.
Abstract
Abstract
Ultrasonic flowmetry following partial hepatectomy revealed a marked increase in portal venous inflow with a concomitant decrease in hepatic arterial inflow. Nitric oxide substitution counteracted the decline in hepatic arterial inflow and caused a significantly greater increase in cell proliferatio...
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PMID: 18412296
PDF is available here.
PDF is available here.
Abstract
Nitric oxide (NO) released by endothelial cells in response to hemodynamic shear stress is a key controller molecule of the vascular functions and antiatherogenic mechanisms. Endothelial dysfunction is associated with increased cardiovascular events. Therefore, several indirect techniques have been...
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PMID: 18347830
PDF is available here.
PDF is available here.
Orthopaedic Nursing (21)3 2008
Abstract
Abstract
Abstract
Perivascular tissue of ITA releases potent, soluble, nitric oxide and prostacyclin-independent anticontractile factor. The pleural adipose tissue does not influence ITA reactivity to vasoconstrictors. Preservation of perivascular tissue may protect against vasospasm of ITA graft in clinical settings...
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PMID: 18083040
PDF is available here.
PDF is available here.
Abstract
Vascular endothelial injury in systemic sclerosis (SSc) includes a spectrum of changes that involve predominantly the microcirculation and arterioles. The pathologic changes in the blood vessels adversely impact the physiology of many organ systems, with a reduction in the size of microvascular beds...
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PMID: 18329532
PDF is available here.
PDF is available here.
Abstract
Erectile dysfunction (ED) is defined as the consistent inability to obtain or maintain an erection for satisfactory sexual relations. The past 20 years of basic science research on erection physiology has been devoted to investigating the pathogenesis of ED and has led to the conclusion that ED is p...
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PMID: 18256677
PDF is available here.
PDF is available here.
Abstract
Cumulative addition of artesunate from 6 x 10(-4) to 6 x 10(-1) mg/ml resulted in relaxation of pre-contracted aortic rings. L-NAME significantly reduced the relaxation response to artesunate (P < 0.05). Vascular contraction response to NA was significantly reduced (P < 0.01) following the addition...
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PMID: 19068550
PDF is available here.
PDF is available here.
Abstract
Cardiovascular Research (77)1 2008
Abstract
Nitric oxide (NO) is a gaseous molecule that plays many key roles in the cardiovascular system. Each of the enzymes that generate NO--neuronal, inducible and endothelial NO synthase-has been genetically disrupted in mice. This review discusses the cardiovascular phenotypes of each of the NO synthase...
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PMID: 17658499
PDF is available here.
PDF is available here.
Abstract
We investigate rat mesenteric arterial strips stimulated with phenylephrine (PE). Our results show that the endothelium is not necessary for vasomotion. However, when the endothelium is removed, the PE concentration needed to induce vasomotion is lower and the rhythmic contractions occur for a narro...
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PMID: 18401180
PDF is available here.
PDF is available here.
Abstract
Pulmonary hypertension frequently complicates the postoperative management of patients after congenital cardiac surgery. Inhaled nitric oxide is an effective treatment option, but rebound pulmonary hypertension can occur upon its withdrawal. Sildenafil may facilitate its withdrawal by restoring cycl...
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PMID: 18701525
PDF is available here.
PDF is available here.
European Journal of Pharmacology (574)2-3 2007
Abstract
The aim of this study was to investigate the vasorelaxant effect induced by diosgenin in superior mesenteric rings. In rings pre-contracted with phenylephrine (10 microM), diosgenin caused concentration-dependent relaxations [EC(50) = (3.3 +/- 1.2) x 10(- 4)M, E(max) = 94.2 +/- 2.6 %]. Vascular rela...
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PMID: 17689524
PDF is available here.
PDF is available here.
Abstract
Asymmetric (N(G),N(G))-dimethylarginine (ADMA) inhibits nitric oxide (NO) synthases (NOS). ADMA is a risk factor for endothelial dysfunction, cardiovascular mortality, and progression of chronic kidney disease. Two isoforms of dimethylarginine dimethylaminohydrolase (DDAH) metabolize ADMA. DDAH-1 is...
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PMID: 17933965
PDF is available here.
PDF is available here.
Circulation Research (101)6 2007
Abstract
We tested whether DDAH-1 or -2 regulates serum ADMA (S(ADMA)) and/or endothelium-derived relaxing factor (EDRF)/NO. Small inhibitory (si)RNAs targeting DDAH-1 or -2, or an siRNA control were given intravenously to rats. After 72 hours, EDRF/NO was assessed from acetylcholine-induced, NO synthase-dep...
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PMID: 17673667
PDF is available here.
PDF is available here.
Abstract
We investigated whether the balance between endothelium-derived relaxing factors (EDRFs) and endothelium-derived contracting factors (EDCFs) might be altered in mesenteric arteries from aged Otsuka Long-Evans Tokushima Fatty (OLETF) rats (a Type 2 diabetic model) [vs. age-matched control Long-Evans...
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PMID: 17513496
PDF is available here.
PDF is available here.
Abstract
The aim of the investigation was to study the possible effects of in vivo infusion of nitric oxide (NO) blockers upon the in vitro endothelium-dependent femoral reactivity. The experimental model tested herein was the inferior canine hindlimb global ischemia induced by infrarenal abdominal aortic cr...
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PMID: 17823044
PDF is available here.
PDF is available here.
Abstract
Inhalation of NO just before and during coronary reperfusion significantly improves microvascular perfusion, reduces infarct size, and may offer an attractive and novel treatment of myocardial infarction....
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PMID: 17707188
PDF is available here.
PDF is available here.
Abstract
We focus in the effect of glucose and AII in the mesangial cells in causing the events related to the genesis of diabetic nephropathy. The alterations in the signal pathways discussed in this review give support to the observational studies and clinical assays, where metabolic and antihypertensive c...
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PMID: 17934656
PDF is available here.
PDF is available here.
Endocrinology (148)8 2007
Abstract
We conclude that ZG cells release EETs and this release is stimulated by ACTH. Interaction of endocrine and vascular cells represents a mechanism for regulating adrenal blood flow and couples steroidogenesis to increased blood flow....
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PMID: 17446179
PDF is available here.
PDF is available here.
Abstract
Remnant-like lipoprotein particles (RLPs) have been implicated as potentially atherogenic lipoproteins. Endothelial dysfunction is known to be an early event in atherosclerosis and an important contributor to the pathogenesis of coronary artery disease. Moreover, there is considerable evidence linki...
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PMID: 17496332
PDF is available here.
PDF is available here.
Abstract
We determined the contributions of various endothelium-derived relaxing factors to control of basal vascular tone and endothelium-dependent vasodilation in the mouse hindlimb in vivo. Under anesthesia, catheters were placed in a carotid artery, jugular vein, and femoral artery (for local hindlimb ci...
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PMID: 17468338
PDF is available here.
PDF is available here.
Abstract
The mechanisms underlying the impairment of endothelium-mediated vasorelaxation induced by dietary hypercholesterolemia and the mechanisms of restoration of endothelial function following reintroduction of low cholesterol diet were evaluated. Feeding rats with high cholesterol diet induced hyperchol...
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PMID: 17585684
PDF is available here.
PDF is available here.
Abstract
We hypothesized that these substances can mediate endothelium-dependent vasodilatory responses to acetylcholine (ACh) and vasoactive intestinal peptide (VIP) in the human submandibular artery. We evaluated the contributions of endothelial vasodilatory substances to vessel relaxation in response to A...
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PMID: 17525359
PDF is available here.
PDF is available here.
YAKUGAKU ZASSHI (127)4 2007
Abstract
We reported that vasodilator responses to various vasodilator agents were augmented by endothelium removal. To explain this mechanism, we hypothesized that endothelium removal eliminates the release of endothelium-derived contracting factor EDCF, which counteracts the vasodilation. However, the unde...
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PMID: 17409704
PDF is available here.
PDF is available here.
Cardiovascular Research (74)1 2007
Abstract
In our 24-h mouse model of sepsis, NO in skeletal muscle is primarily derived from nNOS. Sepsis impairs both EDRF- and EDHF-mediated dilation in response to ACh. Both genetic deletion and inhibition of nNOS protect against this impairment when the dilation occurs via the EDRF but not EDHF pathway....
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PMID: 17258180
PDF is available here.
PDF is available here.