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Vasodilator Agents (1):
Recent article
Vasodilator Agents
Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences (11)3 2011
Abstract
Many pharmacological agents were investigated for the prevention of renal ischemic reperfusion (I/R) injury as well as the phosphodiesterase (PDE) inhibitors. The aim of the study was to examine the possible renoprotective effect of a member in this family, tadalafil (Td) on I/R inju...
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PMID: 21875417
PDF is available here.
PDF is available here.
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Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences (11)3 2011
Abstract
Many pharmacological agents were investigated for the prevention of renal ischemic reperfusion (I/R) injury as well as the phosphodiesterase (PDE) inhibitors. The aim of the study was to examine the possible renoprotective effect of a member in this family, tadalafil (Td) on I/R inju...
|
PMID: 21875417
PDF is available here.
PDF is available here.
Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences (11)3 2011
Abstract
Many pharmacological agents were investigated for the prevention of renal ischemic reperfusion (I/R) injury as well as the phosphodiesterase (PDE) inhibitors. The aim of the study was to examine the possible renoprotective effect of a member in this family, tadalafil (Td) on I/R inju...
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PMID: 21875417
PDF is available here.
PDF is available here.
Harvard Heart Letter (21)9 2011
Abstract
Abstract
We briefly discuss the pathophysiology of pulmonary hypertension and endothelial dysfunction, along with current treatments. We then present a focused review of recent animal studies and human trials examining the use of activators and stimulators of soluble guanylate cyclase for the treatment of pu...
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PMID: 21510726
PDF is available here.
PDF is available here.
Abstract
Sildenafil citrate therapy for severe early-onset intrauterine growth restriction. BJOG 2011;118:624-628. Currently, there is no effective therapy for severe early-onset intrauterine growth restriction (IUGR). Sildenafil citrate vasodilates the myometrial arteries isolated from women...
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PMID: 21392225
PDF is available here.
PDF is available here.
Abstract
Abstract
We analyzed the effect of sildenafil on endothelial cells in insulin resistance conditions in vitro....
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PMID: 21297971
PDF is available here.
PDF is available here.
Abstract
Hypertension frequently coexists with diabetes and the cardiometabolic syndrome. β-Blockers have been a mainstay for controlling blood pressure for nearly 4 decades. However, β-blockers are perceived to cause glucose and lipid metabolism dysregulation, including hypoglycemia masking, reduced glycem...
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PMID: 21214722
PDF is available here.
PDF is available here.
Abstract
We sought to determine whether referring asymptomatic diabetic patients for screening of silent ischemia decreases the risk of cardiovascular events compared with usual care.
DYNAMIT was a prospective, randomized, open, blinded end-point multicenter trial run between 2000 and 2005, w...
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PMID: 21269454
PDF is available here.
PDF is available here.
Deutsche Medizinische Wochenschrift (136)1-2 2011
Abstract
A 42- year old women with a long history of migraine presented with burning pain of the limbs and reduced walking distance. No risk factors for peripheral arterial occlusive disease were present. Her daily medication included an ergotamine-containing-combination (2 mg ergotamine tartrate, 100 mg caf...
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PMID: 21181611
PDF is available here.
PDF is available here.
Abstract
We hypothesized that PGI(2) has a dominant role in cathodal current-induced vasodilation (CIV) described in human skin. We thus aimed to study, in physiological conditions, the PGI(2) involvement in cathodal CIV in rats in order to use pharmacological blockers that could not be used in humans. CIV w...
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PMID: 20827283
PDF is available here.
PDF is available here.
Abstract
This subanalysis of the Study of the Effects of Nebivolol Intervention on Outcomes and Hospitalisation in Seniors with Heart Failure (SENIORS) investigates whether treatment with nebivolol, a β-blocker with nitric oxide-releasing properties, can provide additional benefits besides its effects on he...
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PMID: 21138861
PDF is available here.
PDF is available here.
Abstract
Continuous treatment with nitroglycerin (GTN) causes tolerance and endothelial dysfunction, both of which may involve endothelial nitric oxide synthase (eNOS) dysfunction. eNOS dysfunction may be linked to depletion of tetrahydrobiopterin, and folic acid may be involved in the regeneration of this c...
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PMID: 21076717
PDF is available here.
PDF is available here.
Orvosi Hetilap (151)43 2010
Abstract
These results highlight, once more, the unacceptable risks for the consumers of such adulterated dietary supplements....
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PMID: 20940118
PDF is available here.
PDF is available here.
Abstract
Our observations concur with the results of a report in a previous issue of World Journal of Gastroenterology (October 2008). Moreover, tadalafil adversely affected renal function in patients with decompensated liver disease....
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PMID: 20954291
PDF is available here.
PDF is available here.
Acta Cardiologica (65)5 2010
Abstract
Beta-blockers are a heterogeneous group of antihypertensive agents. What they have in common is competitive antagonistic action on beta-adrenoreceptors (B1, B2 and B3). They differ in their receptor selectivity, intrinsic sympathomimetic activity (ISA), vasodilating properties and metabolism. Antihy...
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PMID: 21125979
PDF is available here.
PDF is available here.
Abstract
A 54-year-old woman with a 20-year history of Raynaud phenomenon was admitted to our hospital complaining of progressive dyspnea on exertion since 5 years previously. Interstitial lung disease was diagnosed, accompanied by pulmonary arterial hypertension (PAH) associated with systemic sclerosis. Aft...
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PMID: 21066870
PDF is available here.
PDF is available here.
Annals of Pharmacotherapy (44)10 2010
Abstract
To review relevant literature supporting the use of β-blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), diuretics, digoxin, aldosterone antagonists, and vasodilators in the management of heart failure in an elderly patient population aged ≥65 years.
P...
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PMID: 20841514
PDF is available here.
PDF is available here.
Abstract
A relationship between the vasodilating activity of flavonoids under conditions of endothelial dysfunction in experimental diabetes and their antioxidant effect is established. Flavicin and quercetin show the maximum influence on the vasodilating function of endothelium and exhibit more pronounced a...
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PMID: 21254507
PDF is available here.
PDF is available here.
Abstract
Abstract
In patients without prior coronary artery disease, routine follow-up SPECT scans are performed infrequently but well before the end of the patient's warranty period. Routine follow-up scans are performed more commonly in patients with prior coronary artery disease but generally after the end of the...
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PMID: 20631033
PDF is available here.
PDF is available here.
Abstract
Abstract
The management of wounds is a specialty in its infancy. Success requires more than the use of dressings. All wounds require a diagnosis, a point well illustrated by the management of these cases which depended solely on stopping nicorandil.
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PMID: 20819329
PDF is available here.
PDF is available here.
Abstract
We report two patients with non-healing surgical wounds, which healed after the withdrawal of Nicorandil therapy. Nicorandil should be recognised as an aetiological factor for non-healing wounds or ulcers once other inflammatory and malignant causes have been excluded. This may avoid surgery for hig...
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PMID: 20566033
PDF is available here.
PDF is available here.
Abstract
We report a life-threatening complication of such ulceration - catastrophic per-rectal haemorrhage requiring emergency surgery with no prior symptoms. Whilst nicorandil should be considered in cases of chronic peri-anal and peristomal ulceration which fail to respond to conventional treatments, this...
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PMID: 20615301
PDF is available here.
PDF is available here.
Abstract
Nicorandil is associated with fistula formation in diverticular disease....
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PMID: 20819332
PDF is available here.
PDF is available here.
Pneumologie (64)9 2010
Abstract
This article provides a brief overview on the history of pulmonary hypertension, starting with the first descriptions of the accompanying pulmonary vascular lesions by Ernst von Romberg and Victor Eisenmenger at the end of the 19th century. Many of the histopathological changes in the pulmonary vasc...
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PMID: 20827642
PDF is available here.
PDF is available here.
Abstract
We aimed to review the therapeutic algorithms in pulmonary hypertension based on current guidelines....
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PMID: 20819752
PDF is available here.
PDF is available here.
Abstract
The pathology of pulmonary arterial hypertension (PAH) is characterized by vascular vasoconstriction, smooth muscle cell proliferation, and thrombosis. Experimental studies have shown the beneficial effect of phosphodiesterase type 5 (PDE-5) inhibitors on pulmonary vascular remodeling and vasodilata...
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PMID: 20819751
PDF is available here.
PDF is available here.
Abstract
Prostacyclin, endothelin-1, and nitric oxide pathways are involved in the pathogenesis of pulmonary arterial hypertension. This devastating disease of the pulmonary vasculature is associated with vasoconstriction, thrombosis and proliferation, and this may be partly due to lack of endogenous prostac...
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PMID: 20819749
PDF is available here.
PDF is available here.
Abstract
I and II clinical trials performed with cinaciguat so far, however, are insufficient to provide convincing evidence on the efficacy and safety of the drug. Thus, caution should be exerted before extrapolating the present preliminary data to the clinical practice....
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PMID: 20730699
PDF is available here.
PDF is available here.
Journal of Hypertension (28)9 2010
Abstract
We re-examined earlier data in Page hypertension.
Total peripheral resistance (TPR) and total peripheral conductance (TPC) responsiveness were compared in hypertensive and normotensive rabbits, 5 weeks after bilateral renal cellophane wrapping or sham operation. The rabbits were studied with effecto...
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PMID: 20543714
PDF is available here.
PDF is available here.
Anesthesia & Analgesia (111)3 2010
Abstract
We reviewed the current strategies to rescue patients with severe hypoxemia. Included in these strategies are high-frequency oscillatory ventilation, airway pressure release ventilation, inhaled vasodilators, and the use of extracorporeal life support. All of these strategies are targeted at improvi...
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PMID: 20624836
PDF is available here.
PDF is available here.
Fitoterapia (81)6 2010
Abstract
I phosphorylation via activation of PKA and CaMK II, which are mediated by cyclic AMP levels and Ca(2+) influx.
Copyright (c) 2010 Elsevier B.V. All rights reserved....
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PMID: 20080157
PDF is available here.
PDF is available here.
Experimental Cell Research (316)14 2010
Abstract
We tested the potential of 8,9-EET and derivatives to protect pulmonary artery smooth muscle cells (PASMCs) from starvation induced apoptosis. We found 8,9-epoxy-eicos-11(Z)-enoic acid (8,9-EET analog (214)), but not 8,9-EET, increased cell viability, decreased activation of caspase-3 and caspase-9,...
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PMID: 20493836
PDF is available here.
PDF is available here.
Abstract
The aim of the present study was to use ambulatory blood pressure (BP) monitoring (ABPM) to determine the efficacy of a fixed-dose combination of amlodipine (AML) and olmesartan medoxomil (OM) over the 24-hour dosing interval. This 12-week, titrate-to-goal study was conducted in 185...
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PMID: 20519261
PDF is available here.
PDF is available here.
Abstract
Right heart catheterization (RHC) is required for confirmation of the diagnosis of pulmonary hypertension (PH) and to asses the prognosis and etiology. Pulmonary vasoreactivity testing (PVT) is one of the most crucial parts of RHC especially in the suitable patient subsets of pulmonary arterial hype...
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PMID: 20819766
PDF is available here.
PDF is available here.
Abstract
Causes of pulmonary arterial hypertension (PAH) are similar in adults and children. The main difference is that PAH secondary to congenital heart diseases, is the predominant cause in pediatric patients. Persistent pulmonary hypertension of the newborn shows completely different clinical course and...
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PMID: 20819767
PDF is available here.
PDF is available here.
Circulation Journal (74)8 2010
Abstract
Abstract
Abstract
We performed this study to evaluate the incremental prognostic value of BHR during pharmacological stress SPECT MPI.
Consecutive patients who underwent dipyridamole stress Tc-99m sestamibi ECG-gated SPECT MPI (without exercise) were identified. The ratio of peak stress heart rate to baseline was not...
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PMID: 20490960
PDF is available here.
PDF is available here.
Abstract
To investigate the effect of l-Arginine on the retinal arteriolar diameter following acute branch retinal vein occlusion (BRVO) in minipigs. Under general anesthesia, 10 eyes of 10 minipigs were evaluated. Two hours after BRVO, an intravitreal juxta-arteriolar micro-injection of 30 microl l-Arginine...
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PMID: 20457153
PDF is available here.
PDF is available here.
Abstract
A decrease in environmental temperature can directly affect the contractility of cutaneous vasculature, mediated in part by alpha(2)-adrenoceptors. Most of the cellular mechanisms underlying the cooling-enhanced contractility to alpha(2)-adrenoceptor agonists have been reported in cu...
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PMID: 20360439
PDF is available here.
PDF is available here.
Abstract
Nitrates are used in the treatment of coronary heart disease and heart failure. The major drawback of their therapeutic use is the rapid development of tolerance.
To investigate the effect of different nitrates on isolated rabbit hearts and aortic strips and the mecha...
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PMID: 20414121
PDF is available here.
PDF is available here.
Heart and Vessels (25)4 2010
Abstract
We aimed to assess the acute cardiopulmonary effects of a 100-mg oral single dose of sildenafil in patients with idiopathic pulmonary hypertension (IPAH) using a well-validated but less-used noninvasive echocardiographic method for the measurement of both systolic and diastolic pulmonary artery pres...
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PMID: 20676840
PDF is available here.
PDF is available here.
Pharmaceutical Biology (48)7 2010
Abstract
This study demonstrated that the aqueous extracts of plants employed in Mexican traditional medicine for the treatment of cardiovascular diseases are able to modify the tone of arterial smooth muscle. Agastache mexicana (Kunth) Lint & Epling (Labiatae), Chenopodium murale L. (Chenopodiaceae), Chiran...
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PMID: 20645769
PDF is available here.
PDF is available here.
Abstract
Four papers in 2008-2009 addressed effusions after the Fontan procedure. Off-pump Fontan procedures did not decrease time until chest tube removal. Pulmonary vascular compliance, derived from an electrical circuit model, predicted chest tube indwelling time. A retrospective study identified mean pul...
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PMID: 20410822
PDF is available here.
PDF is available here.
Abstract
Our current findings uncover a novel mechanism by which AMPK protects against hypercholesterolemia-mediated endothelial dysfunction....
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PMID: 20395595
PDF is available here.
PDF is available here.
Abstract
Abstract
We report the case of a treatment-naive patient with pulmonary arterial hypertension who presented with decompensated right ventricular failure and cardiogenic shock. Unstable hemodynamics, hypoxia and end-organ hypoperfusion limited up-titration of pharmacotherapy. Mechanical circulatory support wi...
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PMID: 20417127
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Urologia Internationalis (85)1 2010
Abstract
We measured intracavernous pressure (ICP), mean arterial pressure (MAP), detumescence time and area under the curve (AUC). To evaluate the endothelial responses, acetylcholine (Ach) was applied cumulatively (1 nM to 1 microM) to thoracic aorta tissues contracted with 60 mM KCl.
In the HCD group tota...
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PMID: 20224261
PDF is available here.
PDF is available here.
Echocardiography (27)6 2010
Abstract
The presence of viable myocardium may predict response to cardiac resynchronization therapy (CRT). The aim of this study is to evaluate in patients with left ventricular (LV) dyssynchrony whether response to CRT is related to myocardial viability in the region of the pacing lead.
Forty-nine consecut...
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PMID: 20345438
PDF is available here.
PDF is available here.
Mayo Clinic Proceedings (85)7 2010
Abstract
Peripheral artery disease (PAD), which comprises atherosclerosis of the abdominal aorta, iliac, and lower-extremity arteries, is underdiagnosed, undertreated, and poorly understood by the medical community. Patients with PAD may experience a multitude of problems, such as claudicatio...
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PMID: 20592174
PDF is available here.
PDF is available here.
Annals of Internal Medicine (153)1 2010
Abstract
Annals of Internal Medicine (153)1 2010
Abstract
Annals of Internal Medicine (153)1 2010
Abstract
Users of ED drugs had higher rates of STDs than nonusers the year before initiating ED drug therapy (214 vs. 106 annually per 100,000 persons; P = 0.003) and the year after (105 vs. 65; P = 0.004). After adjustment for age and other comorbid conditions, users of ED drugs had an odds ratio (OR) for a...
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PMID: 20621899
PDF is available here.
PDF is available here.