Ahmed Klink,
Fabien Hyafil,
James Rudd,
Peter Faries,
Valentin Fuster,
Ziad Mallat,
Olivier Meilhac,
Willem J M Mulder,
Jean-Baptiste Michel,
Francesco Ramirez,
Gert Storm,
Robert Thompson,
Irene C Turnbull,
Jesus Egido,
Jose L Martín-Ventura,
Carlos Zaragoza,
Didier Letourneur and
Zahi A Fayad
Abstract
We explore the current diagnostic and therapeutic strategies for the management of AAA. We also describe the diagnostic potential of new imaging techniques and therapeutic potential of new treatments for the management of small AAA....
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PMID: 21304473
PDF is available here.
Scot Garg,
Patrick W Serruys,
Sigmund Silber,
Joanna Wykrzykowska,
Robert Jan van Geuns,
Gert Richardt,
Pawel E Buszman,
Henning Kelbæk,
Adrianus Johannes van Boven,
Sjoerd H Hofma,
Axel Linke,
Volker Klauss,
William Wijns,
Carlos Macaya,
Philippe Garot,
Carlo DiMario,
Ganesh Manoharan,
Ran Kornowski,
Thomas Ischinger,
Antonio Bartorelli,
Eric Van Remortel,
Jacintha Ronden and
Stephan Windecker
Abstract
This study assessed the ability of the SYNTAX score (SXscore) to stratify risk in patients treated with percutaneous coronary intervention (PCI) using zotarolimus-eluting or everolimus-eluting stents.
The SXscore can identify patients treated with PCI who are at highe...
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PMID: 21511223
PDF is available here.
Abstract
Information relating the outcome of percutaneous coronary intervention to diabetes mellitus or hypertension is limited. The study objective was to describe the outcome in patients undergoing percutaneous coronary intervention in relation to diabetes and hypertension.
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PMID: 21396511
PDF is available here.
Abstract
To examine the overall morbidity of patients who underwent surgery for congenital cardiac defect during childhood.
A congenital cardiac defect treated with surgery is seldom totally cured. The incidence of residua, sequelae, and comorbidity is quite high. The morbidity has not been thoroughly examin...
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PMID: 20723271
PDF is available here.
Abstract
We examined endothelium-dependent and endothelium-independent vasodilation/vasorelaxation of coronary arterioles and aortas in control mice, diabetic mice (Lepr(db)), and Lepr(db) treated with adiponectin or neutralizing antibody to TNF-α (anti-TNF-α). Endothelium-dependent vasodilation to acetylc...
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PMID: 20814014
PDF is available here.
Joo-Yong Hahn,
Young Bin Song,
Jin-Ho Choi,
Sung-Hyuk Choi,
Sung Yun Lee,
Hun Sik Park,
Seung Ho Hur,
Sahng Lee,
Kyoo-Rok Han,
Seung-Woon Rha,
Byung Ryul Cho,
Jong-Sun Park,
Junghan Yoon,
Do Sun Lim,
Sang Hoon Lee,
Hyeon-Cheol Gwon and
DATE Registry Investigators
Abstract
The optimal duration of dual antiplatelet therapy remains controversial.
Between December 2006 and March 2008, 823 patients were enrolled in a prospective multicenter registry for 3-month dual antiplatelet therapy (aspirin 100-200mg+clopidogrel 75 mg daily) followed by aspirin mono-therapy after zot...
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PMID: 20938098
PDF is available here.
Katsuhisa Waseda,
Takao Hasegawa,
Junya Ako,
Yasuhiro Honda,
Eberhard Grube,
Robert Whitbourn,
John Ormiston,
Charles D O'Shaughnessy,
Timothy D Henry,
Paul Overlie,
Lewis B Schwartz,
Krishnankutty Sudhir,
Bernard Chevalier,
William A Gray,
Alan C Yeung,
Peter J Fitzgerald and
ZoMaxx I and II Trial Investigators
Abstract
I and II trials were randomized controlled studies of the zotarolimus-eluting, phosphorylcholine-coated, TriMaxx stent for the treatment of de novo coronary lesions. The aim of this study was to compare the vessel response between zotarolimus- (ZES) and paclitaxel-eluting stents (PES) using intravas...
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PMID: 20890052
PDF is available here.
Abstract
Endothelial lipase (EL) is a phospholipase that belongs to the lipoprotein lipase (LPL) family, which includes LPL and hepatic lipase (HL). Similar to LPL and HL, EL regulates lipoprotein metabolism, mainly high-density lipoprotein (HDL) metabolism and HDL cholesterol (HDL-C) levels in humans and mi...
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PMID: 20962428
PDF is available here.
Abstract
Erythropoietin (EPO) enhances re-endothelialization and anti-apoptotic action. Larger clinical studies to examine the effects of high-dose EPO are in progress in patients with acute myocardial infarction (AMI).
The aim of this multi-center pilot study was to investigate the effect of `low-dose EPO'...
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PMID: 20834185
PDF is available here.
Abstract
To review relevant literature supporting the use of β-blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), diuretics, digoxin, aldosterone antagonists, and vasodilators in the management of heart failure in an elderly patient population aged ≥65 years.
P...
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PMID: 20841514
PDF is available here.
Abstract
Cardiovascular and cerebrovascular diseases share many pathophysiological traits, often impact one another and share several risk factors, though not always to the same magnitude. Therefore, it is not surprising that many classes of cardiovascular drugs have demonstrated effectiveness in the primary...
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PMID: 20730696
PDF is available here.
Abstract
One of the primary impediments to successful drug R&D is the frequent failure of successfully translating positive results obtained in animal models to human disease. To a large degree, this discrepancy is secondary to the substantial biological differences between species. Non-human primate models...
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PMID: 20730697
PDF is available here.
Abstract
We present a case of a patient with IST, who was successfully treated with ivabradine after various ineffective therapeutic approaches....
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PMID: 20730728
PDF is available here.
Abstract
We have reason to believe that new pharmacological measurements or experimental interventions, such as ischaemic preconditioning, aimed at counteracting the drop in NO levels beyond the normal range of NO homeostasis during early reperfusion can represent an efficient strategy to reduce the extent o...
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PMID: 20508903
PDF is available here.
Abstract
We describe a 42-year-old man with chronic venous insufficiency, without DVT, caused by congenital absence of renal segment of the IVC....
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PMID: 20671659
PDF is available here.
Abstract
We trust that this addition to our journals will prove enlightening and, perhaps, entertaining.
Copyright (c) 2010 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved....
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PMID: 20670781
PDF is available here.
Abstract
We investigated the effects of lovastatin on vascular smooth muscle phenotype. We have previously shown that mammalian target of rapamycin complex 1 (mTORC1) inhibition with rapamycin induces vascular smooth muscle cell (VSMC) differentiation. We found that lovastatin also inhibits mTORC1 signaling...
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PMID: 20375271
PDF is available here.
Abstract
Babies are frequently exposed to cerebral hypoxia and ischemia (H/I) during the perinatal period as a result of stroke, problems with delivery, or postdelivery respiratory management. The sole approved treatment for acute stroke is tissue type plasminogen activator. H/I impairs pial artery dilation...
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PMID: 20435843
PDF is available here.
Abstract
To investigate the possibility of reconstituted protein-free high-density lipoprotein (HDL) being a carrier for delivering a lipophilic cardiovascular drug, Tanshinone IIA-loaded HDL-like nanostructured lipid carriers (TA-NLC) were prepared by a nanoprecipitation/solvent diffusion method. The physic...
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PMID: 20214958
PDF is available here.
Abstract
Advances in hemodynamic analysis and imaging the complex three-dimensional right ventricular shape continue to be reported. Additionally, several advances have occurred in our understanding of the pathophysiology of right ventricular adaptation to pressure overload. SUMMARY: Imaging and hemodynamic...
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PMID: 20179591
PDF is available here.
Abstract
The concordance between physician and patient report was assessed on 2702 patient-physician pairs. Agreement was excellent overall (kappa = 0.83, 95% confidence interval (CI): 0.81-0.85). Prevalences of exposure were very close between PS and PP for all classes of prescription CVDs. CONCLUSION: Usin...
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PMID: 20535758
PDF is available here.
Manoela Braga,
Amparo Casanova,
Hwee Teoh,
Keith C Dawson,
Hertzel C Gerstein,
David H Fitchett,
Stewart B Harris,
George Honos,
Philip A McFarlane,
Andrew Steele,
Ehud Ur,
Jean-François Yale,
Anatoly Langer,
Shaun G Goodman,
Lawrence A Leiter and
Diabetes Registry to Improve Vascular Events (DRIVE) Investigators
Abstract
Overall, 46% of individuals had a BP that was above the Canadian Diabetes Association's recommended target. Of these, 11% were untreated, 28% were receiving monotherapy, 38% were not receiving an angiotensin-converting enzyme inhibitor and 16% were not receiving either an angiotensin-converting enzy...
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PMID: 20548975
PDF is available here.
Abstract
We report the case of a 22-year-old man who developed severe myocarditis following a presumed katipo spider bite. Katipo spiders are thought to be one of the most poisonous native creatures in New Zealand. No deaths from katipo spider bites have been reported since the 19th Century. A literature sea...
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PMID: 20581920
PDF is available here.
Christopher M O'Connor,
Alan B Miller,
John E A Blair,
Marvin A Konstam,
Patricia Wedge,
Maria C Bahit,
Peter Carson,
Markus Haass,
Paul J Hauptman,
Marco Metra,
Ron M Oren,
Richard Patten,
Ileana Piña,
Sherryn Roth,
Jonathan D Sackner-Bernstein,
Brian Traver,
Thomas Cook,
Mihai Gheorghiade and
Efficacy of Vasopressin Antagonism in heart Failure Outcome Study with Tolvaptan (EVEREST) investigators
Abstract
Despite close follow-up and evidence-based therapy within a clinical trial, rehospitalization and death remain high. Although most deaths were from HF, one quarter of patients had SCD. In addition, there were almost as many non-CV hospitalizations as HF hospitalizations. Knowledge of the causes of d...
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PMID: 20435194
PDF is available here.
Abstract
In-stent and in-segment late loss, intimal hyperplasia volume, and percentage volumetric obstruction were similar, but stented external elastic membrane cross-sectional area and reference/stented segment ratio were lower in diabetic than in nondiabetic patients. Incomplete stent apposition (ISA) was...
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PMID: 20305549
PDF is available here.
Abstract
Insulin increased PAI-1 promoter activity, PAI-1 mRNA, and accumulation of PAI-1 protein in the conditioned media. Insulin-inducible PAI-1 promoter activity was attenuated by simvastatin. Experiments performed with luciferase reporters containing the 3'-UTR showed that insulin increased luciferase a...
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PMID: 20299979
PDF is available here.
Abstract
Awareness of the most frequent drug classes associated with ADRs and pADRs in a psychiatric hospital allows opportunity for education, medication management system changes, and improved patient safety. Lithium, followed by phenytoin and anxiolytics, were the most common drugs associated with pADRs....
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PMID: 20371749
PDF is available here.
Abstract
We could conclude that the use of dexrazoxane was effective cardioprotectant to allow a high-dose of anthracycline therapy. A randomized study is necessary to consolidate this asseveration....
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PMID: 20404753
PDF is available here.
Abstract
Technical success was achieved in 99.06%. Minor complications (hematoma, distal emboli, and vessel dissection) were documented in 8.77% of the patients. The 6, 12, and 18 months primary patency rate as controlled by Duplex sonography was 89.8, 84.2 and 83.3%, respectively; 77.6% of the lesions heale...
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PMID: 20354488
PDF is available here.
Abstract
The study was designed as a feasibility trial to evaluate the use of GP IIb/IIIa blockade in connection with drug eluting stents, bare stents and PTA only. Sixty patients with current ulcers were randomly assigned to receive abciximab plus a sirolimus coated stent (N.=14), abciximab plus a bare sten...
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PMID: 20354490
PDF is available here.
Abstract
Mean age was 63 +/- 13 years with 71% men.The prevalence of reduced GFR was 35% and the adjusted odds ratio for I-year mortality of patients in group 2 compared to those in group I was 1.86 (95% CI 1.54-2.25, P < 0.001). Compared with patients with no medication, the adjusted odds ratio for 1-year m...
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PMID: 20458829
PDF is available here.
Abstract
Data on outpatient drug utilization were obtained from the Zagreb Municipal Pharmacy to calculate the number of defined daily dose (DDD), and DDD per 1000 inhabitants per day (DDD/1000/day). The drug utilization 90% (DU90%) method was used on drug prescribing quality assessment. Data on hospital adm...
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PMID: 20458827
PDF is available here.
Abstract
This review examines how the sympathetic nervous system plays a major role in the regulation of cardiovascular function over multiple time scales. This is achieved through differential regulation of sympathetic outflow to a variety of organs. This differential control is a product of...
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PMID: 20393193
PDF is available here.
Abstract
This review examines how the sympathetic nervous system plays a major role in the regulation of cardiovascular function over multiple time scales. This is achieved through differential regulation of sympathetic outflow to a variety of organs. This differential control is a product of...
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PMID: 20393193
PDF is available here.
Abstract
This review examines how the sympathetic nervous system plays a major role in the regulation of cardiovascular function over multiple time scales. This is achieved through differential regulation of sympathetic outflow to a variety of organs. This differential control is a product of...
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PMID: 20393193
PDF is available here.
Abstract
This review examines how the sympathetic nervous system plays a major role in the regulation of cardiovascular function over multiple time scales. This is achieved through differential regulation of sympathetic outflow to a variety of organs. This differential control is a product of...
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PMID: 20393193
PDF is available here.
H Shigematsu,
T Nishibe,
Y Obitsu,
K Matsuzaki,
A Ishida,
T Miyata,
S Shindo,
K Hida,
T Ohta,
M Ando,
T Kawasaki,
T Yasugi and
T Matsumoto
Abstract
Three drugs, i.e., beraprost sodium, cilostazol, and aspirin, were most frequently used. The patients who had undergone vascular reconstruction of the lower limbs before enrollment showed significant improvement in ABI. Among the patients who had not undergone vascular reconstruction before enrollme...
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PMID: 20357743
PDF is available here.
T Isaji,
T Takayama,
A Endo,
A Akai,
M Kudo,
H Kagaya,
J Suzuki,
T Hashimoto,
K Hoshina,
H Kimura,
H Okamoto,
K Shigematsu and
T Miyata
Abstract
The average monthly costs for outpatient treatment and pharmacological agents were yen 168,002 in conservative cases, yen 149,871 in preoperation cases, and yen 128,527 in postoperation cases. The mean total costs were yen 5,407,950 in conservative cases, yen 7,375,290 in surgical cases, and yen 2,6...
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PMID: 20357751
PDF is available here.
Abstract
In Group A, RT(40) decreased from 9.5 +/- 5.8 min at the baseline to 6.4 +/- 3.5 min after 6 months (P=0.0002). In Group B, it decreased from 9.7+/-5.2 min at the baseline to 6.3+/-4.2 min after 3 weeks (P<0.0001). In Group A, ACD increased from 249+/-177 m at the baseline to 317+/-168 m after 6 mon...
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PMID: 20357750
PDF is available here.
Abstract
Two new cerebrosides, 1-O-(beta-d-glucopyranosyloxy)-(2S,3S,4R,8Z)-2-[(2'R)-2'-hydroxytricosanoylamino]-8-nonadecene-3,4-diol (1) and 1-O-(beta-D-glucopyranosyloxy)-(2S,3R,4E,8Z)-2-[(2'R)-2'-hydroxynonadecanoylamino]-4,13-nonadecene-3-diol (2), were isolated from the pollen of Typha angustifolia. Th...
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PMID: 19720118
PDF is available here.
Abstract
Transplant coronary artery disease (TCAD) remains the most significant cause of morbidity and mortality after orthotopic heart transplantation. Transplant coronary artery disease is largely an immunologic phenomenon, driven by an inflammatory milieu consisting of multiple cell types...
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PMID: 20398862
PDF is available here.
Abstract
Transplant coronary artery disease (TCAD) remains the most significant cause of morbidity and mortality after orthotopic heart transplantation. Transplant coronary artery disease is largely an immunologic phenomenon, driven by an inflammatory milieu consisting of multiple cell types...
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PMID: 20398862
PDF is available here.
Abstract
Transplant coronary artery disease (TCAD) remains the most significant cause of morbidity and mortality after orthotopic heart transplantation. Transplant coronary artery disease is largely an immunologic phenomenon, driven by an inflammatory milieu consisting of multiple cell types...
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PMID: 20398862
PDF is available here.
Abstract
The aim of this study was to compare outcomes after percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in the treatment of cardiac allograft vasculopathy (CAV).
PCI in patients with CAV is associated with i...
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PMID: 20398863
PDF is available here.
Abstract
The aim of this study was to compare outcomes after percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in the treatment of cardiac allograft vasculopathy (CAV).
PCI in patients with CAV is associated with i...
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PMID: 20398863
PDF is available here.