Abstract
We detected no increased risk for perinatal events with fluoxetine therapy compared to the short half-life antidepressants.
clinicaltrials.gov Identifier: NCT00279370.
© Copyright 2011 Physicians Postgraduate Press, Inc....
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PMID: 21824458
PDF is available here.
Abstract
In cases of agitation and aggressive behavior after severe traumatic brain injury (TBI), the benefits/risks ratio of pharmacological treatments remains unclear. A qualitative analysis of clinical situations could highlight the relevance of psychotherapy care.
In Janua...
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PMID: 21596642
PDF is available here.
Abstract
We report a case of serotonin syndrome that occurred during postoperative period in a patient who underwent coronary artery bypass grafting. The patient was receiving 60 mg/day fluoxetine since the last four years which she and her attendants concealed during the preoperative evaluation. To our know...
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PMID: 21991742
PDF is available here.
Abstract
We present an overview of the current knowledge concerning BDNF actions and associated intracellular signaling in hippocampus, prefrontal cortex, nucleus accumbens (NAc) and amygdala as their relation to depression....
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PMID: 21131999
PDF is available here.
Abstract
We previously established a mouse model of FM-like pain, induced by intermittent cold stress (ICS).
In this study, we find that ICS exposure causes a transient increase in plasma corticosterone concentration, but not in anxiety or depression-like behaviors. A single intrathecal injec...
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PMID: 21933442
PDF is available here.
Abstract
A rapid, sensitive and automated in-tube solid-phase microextraction-liquid chromatography-mass spectrometry (in-tube SPME/LC-MS) method was developed for the analysis of ten antidepressants in urine and plasma. A hybrid organic-inorganic silica monolith with cyanoethyl functional groups was prepare...
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PMID: 20980013
PDF is available here.
Abstract
Achieving remission in late-life depressive disorder is difficult; it is far better to prevent depression. In the last ten years there have been a number of clinical studies of the feasibility of prevention.
A limited literature review was undertaken of studies from 2000 specifically concerning the...
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PMID: 20594389
PDF is available here.
Abstract
Although prescriptions for psychotropic medications for children are at an all-time high, medication adherence rates for children are often low. In Part 1 of this article set, literature regarding adherence to psychotropic medications for children was reviewed. Important issues related to adherence...
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PMID: 21117522
PDF is available here.
Abstract
Disturbances in some endocrine hormones have been implicated in the pathophysiology of depression. Some of these hormones (and drugs that affect hormone function) have been used as therapeutic agents for the treatment of depression, especially adrenal, thyroid, and gonadal axis hormones. Open-label...
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PMID: 21117521
PDF is available here.
Abstract
To develop an individualized treatment plan that addresses both psychotic and affective symptoms in patients with schizoaffective disorder, clinicians can take several steps. First, clinicians can confirm the diagnosis. In the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Te...
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PMID: 21190648
PDF is available here.
Abstract
We examined the effects of a single dose of ketamine on suicidal ideation in subjects with treatment-resistant major depressive disorder (MDD).
Thirty-three subjects with DSM-IV-diagnosed MDD received a single open-label infusion of ketamine (0.5 mg/kg) and were rated at baseline and at 40, 80, 120,...
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PMID: 20673547
PDF is available here.
Abstract
Pharmacogenetic testing is used to uncover genetic causes for variations in drug response. Documentation of the method's usefulness in a clinical setting is scarce. The aim of the study was to systematically categorize the experience from routine CYP2D6 genotyping in a diagnostic laboratory.
All sam...
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PMID: 21109842
PDF is available here.
Abstract
A large proportion of patients admitted to psychological departments and wards suffer from depression. Knowledge is limited about the clinical aspects and treatment of depression at admission and discharge, as well as about the differences between psychiatric hospitals. The purpose of this study was...
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PMID: 21073833
PDF is available here.
Abstract
We included 4958 respondents in our study after excluding those with severe depressive symptoms or use of antidepressants at baseline.
Compared to employees doing non-person-related work, the use of antidepressants was increased statistically significantly for healthcare workers and statistically no...
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PMID: 20517584
PDF is available here.
Abstract
The FDA suicidality warning was associated with an overall decrease in antidepressant treatment for youth with a clinician-reported diagnosis of depression, but not for those with MDD. Also, following the warning, psychotherapy without medication increased....
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PMID: 20856141
PDF is available here.
Abstract
The aim of this study was to examine long-term changes in symptoms of post-traumatic stress disorder, depression, anxiety, and in health-related quality of life in traumatized refugees 23 months after admission to multidisciplinary treatment. The study group comprised 45 persons admitted to the Reha...
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PMID: 21048474
PDF is available here.
Abstract
The number of safe and effective medication treatments for psychiatric illness has expanded substantially over the past 10 to 15 years. Knowing when and how to prescribe psychotropics--and knowing which medication to prescribe--can be challenging, but with knowledge of some basic principles, this ta...
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PMID: 20951275
PDF is available here.
Abstract
This work identifies which psychosocial, clinical and perceived health status factors predict health-resource use in Fibromyalgia (FM), considering the patients' assistance level. Participants were 315 FM patients from Primary Care (PC: n=101) and Rheumatology Services (RS: n=214). Stepwise regressi...
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PMID: 21044477
PDF is available here.
Abstract
Biological treatment procedures are based on evidence-based guidelines. According to all of them, a correct diagnosis of depression is required before starting therapy. Within recent years many different types of antidepressants have been introduced to the pharmacotherapeutic armamentarium. The "new...
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PMID: 21043020
PDF is available here.
Abstract
Postpartum depressive disorders, except for the brief and common postpartum blues, are serious mental disorders which can result in adversities for the mother, her infant and the whole family. Information and prevention should be topics of major concern. Because of its numerous psychosocial implicat...
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PMID: 21043018
PDF is available here.
Abstract
About 11% of pregnant women suffer from a major depression requiring treatment. If left untreated, there are specific risks such as preterm delivery or low birth weight. The initial difficulty lies in diagnosing the depression itself, since many depressive symptoms are falsely ascribed to the pregna...
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PMID: 21043017
PDF is available here.
Abstract
The present review is a critical examination of the most recent published work on the role of zinc in the development and treatment of mood disorders.
Clinical studies and experimental work using animal models have both revealed a link between zinc status and neuropsychological disorders such as dep...
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PMID: 20689416
PDF is available here.
Abstract
Nocturnal sleep disturbances, including insomnia and recurrent nightmares, represent common distressing sleep complaints that might have important prognostic and therapeutic implications in psychiatric patients. The present study aimed at investigating nocturnal sleep disturbances in relation to the...
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PMID: 21114949
PDF is available here.
Abstract
The development of geriatric psychopharmacology was built on advances in geriatric psychiatry nosology and clinical pharmacology and on increased investment in aging research by the National Institute of Mental Health and by academic institutions. Application of the US Food and Drug Administration's...
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PMID: 21114947
PDF is available here.
Florian Seemüller,
Hans-Jürgen Möller,
Michael Obermeier,
Mazda Adli,
Michael Bauer,
Klaus Kronmüller,
Florian Holsboer,
Peter Brieger,
Gerd Laux,
Wolfram Bender,
Isabella Heuser,
Joachim Zeiler,
Wolfgang Gaebel,
Rebecca Schennach-Wolff,
Verena Henkel and
Michael Riedel
Abstract
Because of strict inclusion and exclusion criteria, results drawn from placebo-controlled randomized antidepressant efficacy trials may not be transferable to real-world patients.
This study was performed from March 2000 to September 2005 as a prospective, multicenter follow-up. Patients were recrui...
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PMID: 20816028
PDF is available here.
Abstract
Although the goal of treatment for major depressive disorder is full remission, for most patients, remission is the exception rather than the rule. Carefully choosing medications with synergistic mechanisms of action at treatment initiation may increase rates of response and remission and decrease t...
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PMID: 21114944
PDF is available here.
Abstract
We summarize the clinical evidence regarding somatic interventions associated with switching, with a particular focus on the biologic underpinnings presumably involved in the switch process.
Literature for this review was obtained through a search of the MEDLINE database (1966-2008) using the follow...
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PMID: 20492846
PDF is available here.
Abstract
Hot flashes are very common in women in menopause and can have a detrimental effect on quality of life. Women on risk reduction therapy are particularly prone because treatments, such as tamoxifen, raloxifene, or oophorectomy, have the potential to exacerbate these symptoms. Hormonal...
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PMID: 20971841
PDF is available here.
Abstract
Hot flashes are very common in women in menopause and can have a detrimental effect on quality of life. Women on risk reduction therapy are particularly prone because treatments, such as tamoxifen, raloxifene, or oophorectomy, have the potential to exacerbate these symptoms. Hormonal...
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PMID: 20971841
PDF is available here.
Abstract
We note how we then sought to manage such patients clinically.
The test may have some capacity to identify patients with a rapid metabolizing profile. Any further advantages were not identified by this study, whether reflecting methodological and/or assay limitations....
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PMID: 20863179
PDF is available here.
Abstract
These results indicate that postpartum female rats, compared to virgin controls, show a reduction in some "active coping behaviors" but no significant increase in immobility when tested during the early postpartum period, unlike ovariectomized females that have undergone hormone-simulated pregnancy...
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PMID: 20600244
PDF is available here.
Abstract
The diagnosis and management of chronic vulvovaginal disease requires attention to several issues. Psychological factors are usually important, because women worry about malignancy, impaired sexuality and self-image, fertility, and sexually transmitted diseases. Multifactorial processes are common d...
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PMID: 20883909
PDF is available here.
Abstract
Vulvodynia is a multifactorial chronic pain disorder that is distressing to the patient and exigent to the physician. Although the condition is common, it remains little understood, so patients remain undiagnosed and untreated or undertreated for many years. Although multiple therapies exist in the...
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PMID: 20883912
PDF is available here.
Abstract
Concerns have been expressed about possible adverse effects of the use of antidepressant medication during pregnancy, including risk for neonatal pathology and the presence of congenital malformations.
Data from the Swedish Medical Birth Register (MBR) from 1 July 1995 up to 2007 were used to identi...
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PMID: 20047705
PDF is available here.
Abstract
Depression is often a chronic illness that requires a methodical, long-term approach to manage it optimally. A single antidepressant trial is often insufficient for patients to achieve remission. Remission rates for selective serotonin reuptake inhibitors are about 30% to 35%. Using successive treat...
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PMID: 20977870
PDF is available here.
Abstract
The probability of achieving and sustaining symptomatic remission in major depressive disorder (MDD) with first-line pharmacotherapy is approximately 30%. Ample documentation shows that the maximal therapeutic effect obtained with antidepressant pharmacotherapy is approximately 4 to 6 weeks, perhaps...
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PMID: 20977871
PDF is available here.
Abstract
A majority of patients with major depression do not remit or adequately respond to initial antidepressant therapy. When response is insufficient, a diagnosis of depression and any comorbidities should be confirmed, treatment adherence should be established, and antidepressant dosages should be optim...
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PMID: 20977872
PDF is available here.
Abstract
Primary care clinicians need to move beyond first-line therapy for major depression. While initial treatment is ineffective in about two-thirds of patients, patients who have not responded to such initial treatments can be managed effectively. The severity of depression is as high in primary care as...
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PMID: 20977873
PDF is available here.
Abstract
We briefly consider the psychoemotional factors that might underlie the depression-diabetes relation. The effects (most of them deleterious) of the antidepressive therapy in glucometabolic control are also discussed....
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PMID: 20839171
PDF is available here.
Abstract
I AND postpartum depression', 'bipolar II AND postpartum depression', 'postpartum hypomania', and 'postpartum hypomania AND screening', was carried out. The reference lists of articles identified were also searched to select other relevant publications.
Brief hypomanic symptoms occur in the early pu...
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PMID: 19837461
PDF is available here.
Abstract
These results do not confirm the hypothesis of a general lack of Zn in depressive disorders, but Zn concentrations differed dependent on comorbid disorders and severity of depression. In depressive patients and control persons Zn concentration is associated with different FAs indicating diverging me...
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PMID: 20524151
PDF is available here.
Abstract
Estrogen is regulated through two intracellular receptors, estrogen receptor alpha and estrogen receptor beta, through a classic nuclear-initiated response. Recently, estrogen has also been shown to act more rapidly and it is proposed that these fast effects may be the consequence of membrane locali...
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PMID: 20661136
PDF is available here.