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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Central Nervous System Agents (18):
- Narcotic Antagonists
- Muscle Relaxants, Central
- Anti-Dyskinesia Agents
- Psychotropic Drugs
- Hypnotics and Sedatives
- Antitussive Agents
- Anticonvulsants
- Antiemetics
- Adjuvants, Anesthesia
- Nootropic Agents
- Neuroprotective Agents
- Emetics
- Central Nervous System Stimulants
- Anti-Obesity Agents
- Analgesics
- Alcohol Deterrents
- Hallucinogens
- Central Nervous System Depressants
Recent article
Central Nervous System Agents
Abstract
Hypoxia/ischemia brain damage (HIBD) is one of the most common central nervous system insults in newborns. Brain repair following HIBD is closely associated with cellular processes such as cell survival, angiogenesis, and neurogenesis. In recent years, many studies have suggested tha...
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PMID: 20874696
PDF is available here.
PDF is available here.
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Abstract
Behavioural Pharmacology (21)5-6 2010
Abstract
Abstract
Abstract
The present findings suggest that the systemic administration of PRF induces a wide spectrum of behavioural alterations in rats, consistent with the putative existence of hypnosedative, anticonvulsant and anxiolytic compounds....
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PMID: 20663041
PDF is available here.
PDF is available here.
Abstract
We ask whether the trafficking of recycling vesicles (i.e., those fused to and then retrieved from the plasma membrane) and endosomes/lysosomes depends on IFs. Recycling vesicles were labeled by antibodies against vesicle glutamate transporter 1 (VGLUT1) and atrial natriuretic peptide (ANP), respect...
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PMID: 20544856
PDF is available here.
PDF is available here.
Abstract
We ask whether the trafficking of recycling vesicles (i.e., those fused to and then retrieved from the plasma membrane) and endosomes/lysosomes depends on IFs. Recycling vesicles were labeled by antibodies against vesicle glutamate transporter 1 (VGLUT1) and atrial natriuretic peptide (ANP), respect...
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PMID: 20544856
PDF is available here.
PDF is available here.
Abstract
We ask whether the trafficking of recycling vesicles (i.e., those fused to and then retrieved from the plasma membrane) and endosomes/lysosomes depends on IFs. Recycling vesicles were labeled by antibodies against vesicle glutamate transporter 1 (VGLUT1) and atrial natriuretic peptide (ANP), respect...
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PMID: 20544856
PDF is available here.
PDF is available here.
Journal of Neuroscience (30)26 2010
Abstract
We here report that ATP levels, the energy currency of brain cells, show a surge in the initial hours of spontaneous sleep in wake-active but not in sleep-active brain regions of rat. The surge is dependent on sleep but not time of day, since preventing sleep by gentle handling of rats for 3 or 6 h...
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PMID: 20592221
PDF is available here.
PDF is available here.
Abstract
We ask whether the trafficking of recycling vesicles (i.e., those fused to and then retrieved from the plasma membrane) and endosomes/lysosomes depends on IFs. Recycling vesicles were labeled by antibodies against vesicle glutamate transporter 1 (VGLUT1) and atrial natriuretic peptide (ANP), respect...
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PMID: 20544856
PDF is available here.
PDF is available here.
Neurobiology of Disease (38)3 2010
Abstract
We investigated the effect of Triflusal on brain Abeta accumulation, neuroinflammation, axonal curvature and cognition in an AD transgenic mouse model (Tg2576). Triflusal treatment did not alter the total brain Abeta accumulation but significantly reduced dense-cored plaque load and associated glial...
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PMID: 20149872
PDF is available here.
PDF is available here.
Neurobiology of Disease (38)3 2010
Abstract
We discuss the controversy over the role of COX-1 in AD, which has not been considered carefully in part due to the presumed adverse gastrointestinal effects of COX-1 antagonism. However, recent clinical data from this group as well as other groups challenges this assumption that COX-1 antagonism wi...
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PMID: 20206264
PDF is available here.
PDF is available here.
Brain research (1330) 2010
Abstract
These results suggest that P2X3 receptors in the lPAG play an inhibitory role in pain modulation and EA exerts a marked therapeutic effect in relieving neuropathic pain in CCI rats, which may be related to its regulative effect on the expression of P2X3 receptors in the lPAG. In conclusion, P2X3 rec...
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PMID: 20302849
PDF is available here.
PDF is available here.
Brain research (1330) 2010
Abstract
We demonstrated that DHA-induced neuronal differentiation, neurite growth and branching of adult rat stem cells is mediated at least in part through GPR40 and it remains effective even at low concentrations of DHA. Furthermore, we also revealed that DHA/GPR40 induced the PLC/IP3 signaling pathway an...
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PMID: 20211608
PDF is available here.
PDF is available here.
Brain research (1330) 2010
Abstract
We measured and compared infarction volumes to investigate the effect of GGA on cerebral infarction induced by permanent middle cerebral artery occlusion in rats. We evaluated the effects of pretreatment with 5-hydroxydecanoate (5HD), a specific mitochondrial ATP-sensitive potassium (mitoK(ATP)) cha...
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PMID: 20206146
PDF is available here.
PDF is available here.
Abstract
Administration of medication in food or drink and covert medication were common in this group of hospitalized patients with severe mental illness. Before administering medication covertly it is important to discuss the matter with the multidisciplinary team and, where appropriate, with the patient's...
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PMID: 20078907
PDF is available here.
PDF is available here.
CNS Spectrums (15)5 2010
Abstract
Abstract
We suggest that non-pharmacological interventions (including psychosocial/psychological counseling, interpersonal management and environmental management) should be attempted first, followed by the least harmful medication for the shortest time possible. Pharmacological treatment options, such as an...
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PMID: 20096151
PDF is available here.
PDF is available here.
Abstract
An in vitro inhibition study was performed to investigate potential drug-drug interactions on glucuronidation of buprenorphine (BUP) and norbuprenorphine (NBUP), which represents the major elimination pathway of the drug using cDNA-expressed uridine 5'-diphosphate glucuronosyltransferases (UGTs) and...
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PMID: 20111869
PDF is available here.
PDF is available here.
Journal of Ethnopharmacology (128)3 2010
Abstract
The four major Stemona alkaloids in Stemona tuberosa do not contribute equally to antitussive potency in guinea pigs. Neotuberostemonine, tuberostemonine and stemoninine target on peripheral cough reflex pathway. Croomine acts on central sites in the cough reflex pathway and demonstrates central res...
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PMID: 20219659
PDF is available here.
PDF is available here.
Brain research (1324) 2010
Abstract
We investigated the in vitro effects of leucine (Leu), alpha-ketoisocaproic acid (KIC) and alpha-hydroxyisovaleric acid (HIV), respectively, the branched-chain amino, keto and hydroxy acids that most accumulate in MSUD, on brain bioenergetic homeostasis, evaluating respiratory parameters obtained by...
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PMID: 20153737
PDF is available here.
PDF is available here.
Abstract
We exposed healthy test subjects (n = 41), as well as persons who were under the influence of drugs and/or medication (n = 105), to different light stimuli and tested the pupillary light reflex using infrared technology. The synoptic examination of numerous parameters, and the possibility of examina...
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PMID: 20593599
PDF is available here.
PDF is available here.
Fitoterapia (81)3 2010
Abstract
The effect of detoxification on Strychnos nux-vomica seeds by traditional processing with aloe and ginger juices (B), by frying in cow ghee (C), and by boiling in cow milk (D) was investigated. The ethanolic extracts of these samples were subjected to spontaneous motor activity (SMA), pentobarbitone...
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PMID: 19699784
PDF is available here.
PDF is available here.
Abstract
The empirical evidence for relevant medications having a confounding effect on task performance or CBF in relevant areas remains sparse for most psychotropic medications among patients with PTSD. However, considerable evidence is accumulating for 2 of the most commonly prescribed medication classes...
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PMID: 20184804
PDF is available here.
PDF is available here.
Brain Research (1308) 2010
Abstract
We investigated the effect of quercetin on sleep-wake regulation. Intraperitoneal administration of quercetin (200mg/kg) significantly increased non-rapid eye movement (non-REM) sleep during dark period in rats, while it significantly decreased REM sleep. The decrease in REM sleep induced by quercet...
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PMID: 20303338
PDF is available here.
PDF is available here.
Abstract
The purpose of this study was to evaluate the effectiveness of pain management after electrical injury. A retrospective hospital chart review was conducted among electrically injured patients discharged from the outpatient burn clinic of a rehabilitation hospital (July 1, 1999, to July 31, 2008). De...
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PMID: 20061840
PDF is available here.
PDF is available here.
Neuropsychobiology (61)1 2010
Abstract
We investigated whether common polymorphisms of the GC receptor (GR) gene (ER22/23EK, N363S, BclI, 9 beta A3669G) modulate the influence of cortisol administration on working memory. Working memory performance was investigated in 169 subjects on 10 mg hydrocortisone (cortisol) and placebo using an i...
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PMID: 19940520
PDF is available here.
PDF is available here.
Cerebrovascular Diseases (29)2 2010
Abstract
The present study suggests a possible effect of nicergoline to increase substance P level in ischaemic stroke patients with partial damage to basal ganglia, who have a decreased swallowing response and consequent risk of aspiration pneumonia. Further trials of nicergoline treatment in patients at ri...
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PMID: 20029189
PDF is available here.
PDF is available here.
Neuroendocrinology (91)1 2010
Abstract
We aimed to test the hypothesis that restoration of gonadotropic function is a result of an upregulation of central acetylated melanocortin production.
Lean ovariectomised (OVX) ewes received intracerebroventricular (i.c.v.) infusions of leptin (or vehicle) for 3 days, which upregulated proopiomelan...
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PMID: 19923792
PDF is available here.
PDF is available here.
médecine/sciences (26)1 2010
Abstract
In the brain of vertebrates, glutamate receptor ion channels (iGluR) mediate fast neurotransmission at excitatory synapses. They exist as distinct subfamilies (AMPA, Kainate and NMDA) differing in their functional properties. Yet, all iGluR are tetramers sharing a common molecular architecture, and...
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PMID: 20132777
PDF is available here.
PDF is available here.
Abstract
Climate change is an important issue for Australia. Climate change research forecasts that Australia will experience accelerated warming due to anthrogenic activities. Australia's aging society will face special challenges that demand current attention. This paper discusses two issues in relation to...
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PMID: 20815990
PDF is available here.
PDF is available here.
Abstract
BACKGROUND AND PURPOSE: Alzheimer disease (AD) is one of the leading causes of dependence in the elderly. Providing care for patients with AD is complex and the type of care required depends on the stage of the disease and varies over time. The aim of this article is to discuss available care strate...
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PMID: 20126960
PDF is available here.
PDF is available here.
Abstract
We demonstrated the beneficial effects of ginsenoside Rg1 on Abeta-induced neuronal insult. Therefore, in the present study, we examined the effects of long-term consumption of Rg1 on the cerebral Abeta content and PKA/CREB signaling molecules, as well as cognitive performance in senescence-accelera...
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PMID: 20157253
PDF is available here.
PDF is available here.
Neuroscience (165)2 2009
Abstract
We used high-speed electroencephalographic (EEG) and electromyographic (EMG) recordings (4-s resolution) in freely moving rats to characterize the central electrophysiological effects of i.v. COC at low doses within a self-administration range (0.25-1.0 mg/kg). We found that COC induces rapid, stron...
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PMID: 19861149
PDF is available here.
PDF is available here.
Scientific American (301)4 2009
Abstract
Abstract
Personality disorder is argued to be the most prevalent psychiatric disorder and is considered to be a significant public health burden, yet there is little evidence that the disorder occupies a commensurate place in public health service planning, appropriate to such a burden. This paper reviews th...
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PMID: 19742373
PDF is available here.
PDF is available here.
Abstract
BACKGROUND: The guanidine group defines chemical and physicochemical properties of many compounds of medical interest and guanidine-containing derivatives constitute a very important class of therapeutic agents suitable for the treatment of a wide spectrum of diseases. OBJECTIVE: To review the most...
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PMID: 19780701
PDF is available here.
PDF is available here.
European Heart Journal (30)18 2009
Abstract
Hundred patients with recurrent episodes of classical VVS underwent two tilt tests in a randomized sequence. One test included 20 min of tilt at 60 degrees with intravenous administration of 5 mg clomipramine (clomipramine tilt), whereas the other test included an initial 30 min period of passive 60...
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PMID: 19556259
PDF is available here.
PDF is available here.
Pharmacology & Therapeutics (123)2 2009
Abstract
We conclude with consideration of mutually beneficial future collaborations between field ethnobotanists and pharmacologists....
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PMID: 19422851
PDF is available here.
PDF is available here.
Journal of Neurophysiology (102)2 2009
Abstract
We recorded from mouse hippocampal neurons cultured on glial micro-islands. This recording configuration allowed us to stimulate and record excitatory postsynaptic currents (EPSCs) or inhibitory postsynaptic currents (IPSCs) in the same neuron or pairs of neurons. CBX irreversibly reduced evoked alp...
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PMID: 19535488
PDF is available here.
PDF is available here.
Abstract
Chirality, the concept of nonsuperimposable mirror images, is a fundamental property of biological systems and can be observed on a molecular, cellular, or organism level. Stereoisomer compounds possess the same molecular and structural formula, but they differ in their three-dimensional configurati...
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PMID: 19681517
PDF is available here.
PDF is available here.
Neuropsychopharmacology (34)9 2009
Abstract
It is firmly established that the hippocampus, a brain region implicated in spatial learning, episodic memory, and consolidation, contains a high concentration of CB(1) receptors. Moreover, systemic and intrahippocampal administration of cannabinoid agonists have been shown to impair hippocampal-dep...
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PMID: 19322169
PDF is available here.
PDF is available here.
Abstract
This study expands explicit criteria to more precisely define preferred medication use in older adults. This refinement of the Beers criteria will enable providers to select medications with the greatest benefit-to-risk ratio for older adults, thereby minimizing drug-related problems. These criteria...
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PMID: 19689175
PDF is available here.
PDF is available here.
Behavioural Brain Research (201)1 2009
Abstract
These results indicate that the ability of an adenosine antagonist to reverse the effort-related effects of a D(2) antagonist depends upon the subtype of adenosine receptor being blocked. Together with other recent results, these experiments indicate that there is a specific interaction between DA D...
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PMID: 19428636
PDF is available here.
PDF is available here.
Therapeutische Umschau (66)7 2009
Abstract
All patients should undergo surgical procedures in the most stable and favourable condition with a continuation of chronic medication. Accordingly, this medication should be continued until the day before surgery in most patients. The preoperative period should be used to evaluate the completeness a...
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PMID: 19565445
PDF is available here.
PDF is available here.
Pharmacopsychiatry (42)4 2009
Abstract
Abstract
Treatment strategies for herpes zoster infection include limiting viral replication with anti-infective agents as well as limiting associated acute and chronic neuropathic pain with a variety of analgesics. The author outlines currently available pharmacotherapeutic options, from first-line (eg, ant...
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PMID: 19553635
PDF is available here.
PDF is available here.
Abstract
Despite the lack of uniformity in the cut-off points used in the trials, the follow-up time after administration of therapy, and the amount of time within which treatment is initiated after onset of stroke symptoms, the MRS seems to be more sensitive and responsive as compared to the BI in measuring...
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PMID: 19419341
PDF is available here.
PDF is available here.
Behavioral Neuroscience (123)3 2009
Abstract
Previous studies show discrepancies concerning the effects of pretraining on spatial learning deficits induced by blockade of the N-methyl-D-aspartate (NMDA) receptor. These inconsistencies might be attributed to the differences in the nature of the pretraining tasks and the method of blocking NMDA...
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PMID: 19485557
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (30 Suppl 1) 2009
Abstract
We evaluated the use of ginkgolide B, a herbal constituent extract from Ginkgo biloba tree leaves, in the prophylactic treatment of migraine with aura (MA). Fifty women suffering from migraine with typical aura, or migraine aura without headache, diagnosed according to International Headache Society...
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PMID: 19415441
PDF is available here.
PDF is available here.
Audio, Transactions of the IRE Professional Group on (30 Suppl 1) 2009
Abstract
Fixed-site" approach and "follow-the-pain" approach briefly considered the techniques of local therapy that now generate more interest and discussion on headaches and, in particular, of migraine. Far from being a full discussion, the work aims only to stimulate further thought and interest in local...
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PMID: 19415429
PDF is available here.
PDF is available here.
médecine/sciences (25)5 2009
Abstract
Psychopharmacology (203)2 2009
Abstract
Abstract
Different methods of poisoning used by individuals with the diagnosis of parasuicide admitted to the Loghman Hospital, Tehran, from 2000 to 2004 were investigated, with particular focus on gender and age differences. Drugs, pesticides, and other agricultural chemicals (women: 12.7%, men: 9%) were th...
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PMID: 19527164
PDF is available here.
PDF is available here.
Abstract
Brain imaging tools such as positron emission tomography (PET) and functional magnetic resonance imaging have been successfully used to investigate in vivo human brain functions. In particular, PET has been widely used to visualize various molecules such as receptors, transporters, and amyloid prote...
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PMID: 19562942
PDF is available here.
PDF is available here.
Abstract
The utility and possibility of PET in the drug development of the neuropsychiatry field is discussed in this review. Positron emission tomography (PET) is a nuclear medicine imaging technique which visualizes and quantifies the distributions of various molecular targets in vivo. This technique has b...
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PMID: 19562943
PDF is available here.
PDF is available here.
Abstract
We have demonstrated that systemic administration of dipeptide Leu-Ile increases BDNF and GDNF production in the brain, and has a protective role in methamphetamine and morphine dependence. In this review, we discuss the potential role of BDNF, GDNF and their inducers in the treatment for neuropsych...
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PMID: 19562947
PDF is available here.
PDF is available here.
Neuropsychopharmacology (34)9 2009
Abstract
We investigated how fentanyl affects dendritic spines and synaptic AMPA receptors in cultured hippocampal neurons. Fentanyl at low concentrations (0.01 and 0.1 microM) caused the collapse of dendritic spines and decreased the number of AMPA receptor clusters. In contrast, fentanyl at high concentrat...
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PMID: 19295508
PDF is available here.
PDF is available here.
Neuropsychopharmacology (34)9 2009
Abstract
These results provide the first functional evidence that the activation of NOP receptors produces antinociception without reinforcing effects in primates. Non-peptidic NOP receptor agonists may have therapeutic value as novel analgesics without abuse liability in humans....
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PMID: 19279568
PDF is available here.
PDF is available here.
Abstract
We summarize the different approaches that have been described in current literature, including the possible difficulties for clinical application. Particularly, we focus on the possible impact of brain diseases on receptor-mediated transport to the BBB/brain and how this may affect various targetin...
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PMID: 19327042
PDF is available here.
PDF is available here.