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Radiopharmaceuticals (0):
Recent article
Radiopharmaceuticals
Abstract
dal-PLAQUE is a placebo-controlled multicenter study designed to assess the effect of dalcetrapib on imaging measures of plaque inflammation and plaque burden. dal-PLAQUE is a multimodality imaging study in the context of the large dal-HEART Program. Decreased high-density lipoprotei...
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PMID: 21835280
PDF is available here.
PDF is available here.
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The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... (55)4 2011
Abstract
Bone metastases are responsible for most of the morbidity and mortality associated with solid malignant tumors, occurring in about 65-70% of the patients with advanced breast or prostate cancer. The pathophysiology of skeletal metastasis is a complex process that involves several bio...
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PMID: 21738116
PDF is available here.
PDF is available here.
Abstract
I clinical trials, to treat patients whose HCC is gallium-avid in a gallium scan. Because gallium absorbed from orally administered GaM is bound predominately to serum transferrin, which travels to all tissues in the body, GaM has the potential to treat even distant metastases. A patient with advanc...
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PMID: 21554205
PDF is available here.
PDF is available here.
American Journal of Roentgenology (196)6 Suppl 2011
Abstract
Abstract
Quantitative (99m)Tc-DMSA renal uptake was studied in different renal ischemia/reperfusion (I/R) mice models for the assessment of renal repair capacity. Mice models of nephrectomy, uni- and bi-lateral I/R together with sham-operated mice were established. At 1h, 1d, 4d, 1, 2 and 3 w...
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PMID: 21277288
PDF is available here.
PDF is available here.
Abstract
Quantitative (99m)Tc-DMSA renal uptake was studied in different renal ischemia/reperfusion (I/R) mice models for the assessment of renal repair capacity. Mice models of nephrectomy, uni- and bi-lateral I/R together with sham-operated mice were established. At 1h, 1d, 4d, 1, 2 and 3 w...
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PMID: 21277288
PDF is available here.
PDF is available here.
Abstract
Quantitative (99m)Tc-DMSA renal uptake was studied in different renal ischemia/reperfusion (I/R) mice models for the assessment of renal repair capacity. Mice models of nephrectomy, uni- and bi-lateral I/R together with sham-operated mice were established. At 1h, 1d, 4d, 1, 2 and 3 w...
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PMID: 21277288
PDF is available here.
PDF is available here.
Abstract
Myocardial perfusion imaging (MPI) is a powerful diagnostic and prognostic tool for evaluating coronary artery disease (CAD). Several studies have shown that it is increased in individuals with type 2 diabetes. Also, insulin resistance is generally considered to be of major importanc...
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PMID: 20730497
PDF is available here.
PDF is available here.
Abstract
We evaluated 343 diabetic and 618 nondiabetic subjects with New York Heart Association class II or III heart failure and a left ventricular ejection fraction ≤35% over a median follow-up of 17 months. A multivariable Cox proportional hazards model was used to examine the influence of clinical vari...
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PMID: 21193691
PDF is available here.
PDF is available here.
Abstract
The dramatic increase in use of cellular telephones has generated concern about possible negative effects of radiofrequency signals delivered to the brain. However, whether acute cell phone exposure affects the human brain is unclear.
To evaluate if acute cell phone e...
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PMID: 21343580
PDF is available here.
PDF is available here.
Abstract
We should understand its limitation and diagnose carefully....
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PMID: 21174665
PDF is available here.
PDF is available here.
Anesthesiology (113)6 2010
Abstract
We hypothesized that inhalation anesthesia influences the intrapulmonary distribution of ventilation (V) and perfusion (Q), leading to less advantageous V/Q matching.
Ten healthy volunteers were studied in supine position on two separate occasions, once awake and once during mild anesthesia (sevoflu...
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PMID: 21068662
PDF is available here.
PDF is available here.
Abstract
We report the case of an unexpected small bowel intussusception caused by primary non-small cell lung cancer, which was primarily detected by 18 fluorine ((18)F)-fluorodeoxyglucose (FDG) positron emission tomography (PET) and computed tomography (CT). A 74-year-old man underwent FDG PET-CT for the d...
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PMID: 21095361
PDF is available here.
PDF is available here.
Abstract
We describe a case of a 57-year-old man who had a sarcoid-like reaction develop during induction chemotherapy for a pathologically proven N2 lung cancer. Re-evaluation of the nodal status using fluorodeoxyglucose-positron emission tomography showed false-positive accumulation in the mediastinal and...
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PMID: 21095358
PDF is available here.
PDF is available here.
Abstract
We describe preoperative computed tomography (CT)-guided injection of radiotracer technetium (99m) macroaggregates ((99m)Tc-MAA) in challenging small lung nodules, intraoperative localization, and resection.
Between November 2007 and February 2010, 44 patients with 47 lung nodules which were detecte...
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PMID: 21095303
PDF is available here.
PDF is available here.
Abstract
Pediatric Annals (39)12 2010
Abstract
Abstract
Samarium-153 ethylenediamine tetramethylene phosphoric acid (153Sm-EDTMP) is a radiopharmaceutical that has been used to treat osteosarcoma. The authors conducted a phase 2 study to test safety and response of high-risk osteosarcoma to tandem doses of 153Sm-EDTMP and to determine cor...
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PMID: 20715156
PDF is available here.
PDF is available here.
Abstract
We investigated the value of (68)Ga-DOTATOC PET/CT for the diagnosis of primary pulmonary carcinoid tumors.
This was a retrospective analysis of patients with primary pulmonary tumors who underwent (68)Ga-DOTATOC PET/CT. All the patients had a histopathologic diagnosis of carcinoid. The rate of dete...
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PMID: 21179276
PDF is available here.
PDF is available here.
Abstract
High specific activity (188)Re required for nuclear medicine is mostly obtained from (188)W/(188)Re generators. As the parent radionuclide (188)W is of low specific activity (<185 GBq/g), a relatively large volume of 0.9% saline is required for the elution of (188)Re. Post-elution concentration is n...
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PMID: 20637645
PDF is available here.
PDF is available here.
Abstract
We herein describe the design and performance evaluation of single-use whole-sterile "plug & play" kits for routine automated production of [(11)C]methionine and [(11)C]choline for human use. Kits were designed for maximal simplicity and ease of using modules from Eckert & Ziegler Modular Lab System...
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PMID: 20685129
PDF is available here.
PDF is available here.
Abstract
Separation of (90)Y from a parent solution of (90)Sr-(90)Y in 0.5 M nitric acid by two-stage liquid-liquid extraction has been investigated using centrifugal extractors. The extraction agent used was 0.25 M di-(2-ethylhexyl)phosphoric acid (D2EHPA) in n-dodecane. Back-extraction used 5 M HCl. Evapor...
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PMID: 20692176
PDF is available here.
PDF is available here.
Abstract
We compared the SPECT images between the groups.
Significant hyperperfusion was found at the left superior temporal gyrus and the left supramarginal gyrus in the panic disorder patients when compared to the controls (family-wise error [FWE], P < .001). The somatoform disorder patients showed hyperpe...
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PMID: 20673555
PDF is available here.
PDF is available here.
Brain research (1360) 2010
Abstract
We synthesized the novel radioligand [(125)I]4-iodophenyl 1,4-diazaicyclo[3.2.2]nonane-4-carboxylate ([(125)I]CHIBA-1006), a iodine-derivative of the selective α7 nAChR agonist SSR180711, and studied the characterization of [(125)I]CHIBA-1006 binding to rat brain membranes. The assays of [(125)I]CH...
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PMID: 20816767
PDF is available here.
PDF is available here.
Acta Radiologica (51)9 2010
Abstract
Tuberculosis (TB) can produce positive signals during ¹⁸F-fluorodeoxyglucose positron emission/computed tomography (FDG PET/CT) scanning. Until now, there has been no better method than clinical assessment to evaluate the therapeutic response of non-respiratory TB (NRTB).
To retrospectively asses...
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PMID: 20942732
PDF is available here.
PDF is available here.
Abstract
Abstract
18F-FDG PET/CT is an immerging tool for follow-up a head and neck cancerpatients. Accurate PET/CT interpretation in a post therapy setting is crucial for proper management. However there are many limitations in post therapy settings. For example, variable degree of normal physiologic uptake is noted...
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PMID: 21114218
PDF is available here.
PDF is available here.
Nippon Shokakibyo Gakkai Zasshi (107)11 2010
Abstract
Abstract
A novel synthesis of 4-[(18)F]fluorobenzylamine ([(18)F]FBA) by means of transition metal-assisted sodium borohydride reduction of 4-[(18)F]fluorobenzonitrile ([(18)F]FBN) is described. This approach could successfully be extended to borohydride exchange resin (BER) enabling a viable option for use...
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PMID: 20740244
PDF is available here.
PDF is available here.
Abstract
A 64-year-old female patient had been receiving hemodialysis since June 2008. A left adrenal mass, 2.5 cm in diameter, was incidentally found by screening computed tomography at the initiation of hemodialysis. Plasma epinephrine and norepinephrine were increased to 1.21 ng/ml and 4.71 ng/ml, respect...
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PMID: 21063160
PDF is available here.
PDF is available here.
Biological Psychiatry (68)7 2010
Abstract
Animal models of psychosis propose that striatal hyperdopaminergia is driven by abnormalities in hippocampal glutamatergic neurotransmission, but this has never been tested in humans.
Sixteen individuals with an at-risk mental state for psychosis (ARMS) and 12 control subjects underwent proton magne...
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PMID: 20638047
PDF is available here.
PDF is available here.
Anticancer Research (30)10 2010
Abstract
These results indicated that BLI could be used to monitor the growth of tumour. High uptake of (177)Lu-AMBA in PC-3M-luc-C6 tumour-bearing mice by microSPECT/CT imaging can further evaluate the potential of (177)Lu-AMBA therapy for PC-3M-luc-C6 tumours....
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PMID: 21036718
PDF is available here.
PDF is available here.
Abstract
We observed 124 asymptomatic patients with a noncalcified single lung nodule highlighted by computerised tomography (CT) of the thorax. Patients were divided into 2 groups: Group A consisted of 57 patients with lesion diameters between 0.5 cm and 0.99 cm; Group B consisted of 67 patients with lesion...
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PMID: 20922626
PDF is available here.
PDF is available here.
Abstract
For determination of cross sections of alpha-particle induced reactions on 99.65% enriched (192)Os, the methods for electrolytic preparation of thin samples and radiochemical separation of radioplatinum were optimized. The excitation functions of the (192)Os(alpha,n)(195m)Pt and (192)Os(alpha,3n) (1...
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PMID: 20538474
PDF is available here.
PDF is available here.
Abstract
(123)I-MIBG H/M gives a reliable estimate of cardiac sympathetic innervation as measured by (11)C-HED PET. Furthermore, despite the close correlation in defect size, (11)C-HED PET appears to be more suitable for assessing regional abnormalities than does (123)I-MIBG SPECT....
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PMID: 20534790
PDF is available here.
PDF is available here.
Abstract
In patients without prior coronary artery disease, routine follow-up SPECT scans are performed infrequently but well before the end of the patient's warranty period. Routine follow-up scans are performed more commonly in patients with prior coronary artery disease but generally after the end of the...
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PMID: 20631033
PDF is available here.
PDF is available here.
Abstract
In this sample of recently symptomatic patients with carotid stenosis, an association was found between in vivo measures of plaque inflammation detected by FDG PET and the presence of transcranial Doppler MES. These findings strengthen the notion that embolic events distal to carotid stenoses are re...
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PMID: 20639303
PDF is available here.
PDF is available here.
Abstract
Anticancer Research (30)9 2010
Abstract
The aim of this study was to compare the utility of gamma camera using a coincidence detection system imaging (CDET) with 18-fluorodeoxyglucose to conventional imaging techniques in the detection of recurrence of non-small cell lung cancer. Sixty-nine patients were randomized into two groups for fol...
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PMID: 20944175
PDF is available here.
PDF is available here.
Anticancer Research (30)9 2010
Abstract
Of 21 patients examined, 13 patients were eligible to enter this pilot study. Only one patient had lymph node metastasis, which was preoperatively detected by FDG-PET scan. Additionally, another patient was considered to have lymph node metastasis according to increased focal FDG uptake; however, al...
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PMID: 20944170
PDF is available here.
PDF is available here.
Abstract
We investigated the relationship between high-energy phosphate (HEP) and cardiac function following CABG using cine magnetic resonance imaging (cine-MRI) and phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS). A retrospective study was approved by the institutional review board. MRI and (31)P...
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PMID: 20444565
PDF is available here.
PDF is available here.
Clinical Lung Cancer (11)5 2010
Abstract
The aim of this study was to compare glucose metabolism and hypoxia using 18F- fluorodeoxyglucose (18F-FDG) and 18F-fluoroerythronitroimidazole (18F-FETNIM) positron emission tomography (PET) and investigate their prognostic role on survival in patients with locally advanced non-smal...
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PMID: 20837459
PDF is available here.
PDF is available here.
Abstract
Functional imaging using positron emission tomography (PET) plays an important role in the diagnosis, staging, image-guided treatment planning and monitoring of malignant diseases. PET imaging complements conventional anatomical imaging such as computed tomography (CT) and magnetic resonance imaging...
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PMID: 20691025
PDF is available here.
PDF is available here.
Abstract
Positron emission tomography (PET) is a powerful and rapidly developing area of molecular imaging that is used to study and visualize human physiology by the detection of positron-emitting radiopharmaceuticals. Information about metabolism, receptor/enzyme function, and biochemical mechanisms in liv...
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PMID: 20497120
PDF is available here.
PDF is available here.
Abstract
Molecular imaging represents an extremely important advancement in patient care and numerous agents have been developed and are being studied. Hundreds of molecular imaging agents currently exist for use in multiple modalities such as magnetic resonance imaging (MRI), computed tomography (CT), ultra...
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PMID: 20420567
PDF is available here.
PDF is available here.
Abstract
Malignant melanoma represents a serious public health problem and is a deadly disease when it is diagnosed at late stage. Though (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) has been widely used clinically for melanoma imaging, other approaches to specifically identify, ch...
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PMID: 20497118
PDF is available here.
PDF is available here.
Abstract
The current way to increase efficacy of cancer therapy is the use of molecular recognition of aberrantly expressed gene products for selective treatment. However, only a fraction of the patients have tumors with a particular molecular target. Radionuclide imaging of molecular targets might help to s...
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PMID: 20497119
PDF is available here.
PDF is available here.
Abstract
Hyperpolarized (HP) (13)C labeled compounds can be used as MR contrast agents to investigate metabolic pathways in vivo in almost real time. To date, a high proportion of reported studies have utilized HP 1-(13)C pyruvate to investigate intracellular metabolism in tumors and other tissues. The long...
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PMID: 20497107
PDF is available here.
PDF is available here.
Abstract
We will introduce the current state of development of dual-targeted molecular imaging probes and summarize the various dual-targeted molecular probes for in vivo cancer imaging....
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PMID: 20497116
PDF is available here.
PDF is available here.
Abstract
The advancement of molecular imaging hardware and disease targets has driven the demand of novel probes for diagnosis of human diseases. The high-throughput property of phage-display techniques makes the fast developments of these probes possible. The antibody and peptide phage display libraries hav...
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PMID: 20497117
PDF is available here.
PDF is available here.
Academic Radiology (17)9 2010
Abstract
To determine if anatomically "nonmeasurable" disease in bone marrow (BM) is assessable for response to therapy by [(18)F]-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET)/computed tomography (CT).
FDG PET/CT images of 27 patients with lymphoma, FDG-avid bone marrow (BM) lesions, a...
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PMID: 20634105
PDF is available here.
PDF is available here.
Oncology Reports (24)3 2010
Abstract
We prospectively investigated 29 patients who underwent CT, FDG-PET, and surgery for IPMNs, followed by histopathological examination. The maximum standardized uptake value (SUVmax) was determined on FDG-PET, and differentiation of benign from malignant IPMN was tested using various SUVmax cut-off l...
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PMID: 20664965
PDF is available here.
PDF is available here.
Abstract
Abstract
We describe the in vitro and in vivo evaluation of DTPA-derivatized lipid-based NP (DTPA-NP) radiolabeled with different radiometals, including (111)In and (99m)Tc, for single-photon emission computed tomography (SPECT), (68)Ga for positron emission tomography (PET), and (177)Lu for therapeutic appl...
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PMID: 19863193
PDF is available here.
PDF is available here.
Movement Disorders (25)11 2010
Abstract
[(123)I]-Meta-iodobenzylguanidine (MIBG) myocardial scintigraphy is useful for distinguishing multiple system atrophy (MSA) from Parkinson disease. In this study, longitudinal observation using MIBG myocardial scintigraphy was carried out in patients with MSA to evaluate the association of myocardia...
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PMID: 20645402
PDF is available here.
PDF is available here.
Annals of Surgery (252)2 2010
Abstract
Journal of Neurosurgery (113)2 2010
Abstract
Imaging with FRP-170 PET can visualize hypoxic lesions in patients with glioma, as confirmed by histological examination. This new method can assess tumor hypoxia preoperatively and noninvasively....
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PMID: 19895196
PDF is available here.
PDF is available here.
British Journal of Radiology (83)992 2010
Abstract
A 42-year-old woman presented with local recurrence and distant lung and liver metastases 7 years after resection of a primary intracranial haemangiopericytoma. Whole-body (18)F-fluoro-2-deoxy-d-glucose (FDG)-positron emission tomography (PET)-CT scan showed no increased uptake in local recurrence o...
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PMID: 20675461
PDF is available here.
PDF is available here.
British Journal of Radiology (83)992 2010
Abstract
We present a case of a false-positive (123)I-MIBG scan in a case of a mast-cell infiltrated infantile haemangioma and discuss the possible uptake mechanism....
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PMID: 20675460
PDF is available here.
PDF is available here.
Obstetrics & Gynecology (116 Suppl 2)supplement 2010
Abstract
BACKGROUND: The diagnosis of peritoneal tuberculosis (TB) is difficult, and the condition is often misdiagnosed as advanced ovarian cancer. The clinical discrimination is important to avoid both unnecessary surgery and a delay in anti-TB treatment. CASE: A 66-year-old woman presented with abdominal...
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PMID: 20664441
PDF is available here.
PDF is available here.