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Indicators and Reagents (10):
Recent article
Indicators and Reagents
Abstract
We report a patient who, during a 5-month hospitalization, had persistently low total carbon dioxide levels (12.4 ± 2.7 [standard deviation] mEq/L [12.4 ± 2.7 mmol/L]), measured using an enzymatic/photometric assay, and a high anion gap (19.2 ± 3.1 mEq/L [19.2 ± 3.1 mmol/L]), suggesting high-ani...
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PMID: 21849226
PDF is available here.
PDF is available here.
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Abstract
Copper complex with Curtis macrocyclic tetramine is offered as reagent for extraction-photometric determination of nonsteroidal anti-inflammatory drugs (NSAIDs), belonging to the class of aromatic carboxylic acids. The studies indicate that this method is suitable for quantitative determination of NS...
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PMID: 21928706
PDF is available here.
PDF is available here.
Abstract
A series of 1,2,4-trisubstituted-1H- imidazole derivatives (4a-o) was synthesized by reacting 2,4-disubstituted-1H-imidazoles (3a-o) with chlorobenzene in the presence of triethylamine. Phenylglyoxal (2) was reacted with different aromatic aldehydes in the presence of ammonium acetate and glacial ace...
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PMID: 21928710
PDF is available here.
PDF is available here.
Abstract
Some medicinal plants are the object of biotechnologists' special interest owing to their content of secondary metabolites, which have a strong pharmacological effect. Polyscias filicifolia is a plant known for long in traditional medicine of the Southeast Asia. Literature data suggest that it acts o...
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PMID: 21928715
PDF is available here.
PDF is available here.
Abstract
Sulfurous compounds: sodium sulfite Na2SO3 (E 221), sodium bisulfite NaHSO, (E 222), and sodium metabisulfite Na2S2O5 (E 223) are largely used as antioxidants in many pharmaceutical formulations. A method for determination of sodium metabisulfite in parenteral formulations containing tartrate ions wa...
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PMID: 21928707
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Indicator organisms are used to assess public health risk in recreational waters, to highlight periods of challenge to drinking water treatment plants, and to determine the effectiveness of treatment and the quality of distributed water. However, many have questioned their efficacy for indicating pat...
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PMID: 21942192
PDF is available here.
PDF is available here.
Abstract
Two new proanthocyanidins, epigallocatechin-3-O-p-hydroxybenzoate-(4beta-->8)-epigallocatechin (1) and epigallocatechin-3-O-p-hydroxybenzoate-(4beta-->8)-epigallocatechin-3-O-gallate (2) in addition to the known compound epigallocatechin-(4beta-->6)-epigallocatechin-3-O-gallate (3), were isolated fro...
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PMID: 21699087
PDF is available here.
PDF is available here.
Abstract
We propose a new series of 2-benzoxazolinone derivatives as potential cholinesterase inhibitors. These compounds were synthesized by condensation of 6-chloro acetyl-2-benzoxa zolinone with the corresponding amine and evaluated as acetylcholinesterase inhibitors using the colorimetric Ellman's method...
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PMID: 21699076
PDF is available here.
PDF is available here.
Abstract
We examined AMH and SCF expression in human granulosa cells (hGCs). GCs were isolated from follicular aspirates after oocyte removal from the patients undergoing assisted reproduction techniques. After pretreated with GnRH-a (triptorelin) or GnRH-ant (cetrorelix) for 48 h, mRNA and protein of AMH an...
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PMID: 21699083
PDF is available here.
PDF is available here.
Abstract
I annulations. With the assistance of Ag(2)O, Type II annulations were achieved via selective γ-substitution. In the absence of the PPh(3) catalyst, the reagent Cs(2)CO(3) promoted β-addition to realize Type III annulations....
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PMID: 21574631
PDF is available here.
PDF is available here.
Abstract
Regioselective, catalyst-controlled monoalkylations of cis-vicinal diol motifs in carbohydrate derivatives, using a diphenylborinic ester precatalyst, are described. Selective installation of benzyl, naphthylmethyl, 4-bromobenzyl and benzyloxymethyl protective groups at a single seco...
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PMID: 21591630
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
We describe here our experience with site-specific protein modification via a novel cysteine-containing fusion tag (Cys-tag), which is a 15-amino-acid (aa) N-terminal fragment of human ribonuclease I with the R4C substitution. Several Cys-tagged proteins and peptides with different numbers of native...
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PMID: 18726580
PDF is available here.
PDF is available here.
Xenobiotica (41)5 2011
Abstract
Tyrosine phosphorylation plays a major role in intracellular signal transduction pathways. Phosphorylated tyrosine residues initiate signaling pathways by recruiting proteins containing Src homology-2 (SH2) domains. Herein is described a high-throughput assay to detect interactions between phosphory...
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PMID: 18370317
PDF is available here.
PDF is available here.
Abstract
Abstract
All serotonin derivatives described here (1-9) inhibited BACE 1 in a dose dependent manner. The 50% Inhibition Concentration (IC50) of N-cinnamoyl serotonin (1) was 86.7 +/- 4.0 microM. The peptide conjugation of serotonin derivatives influenced the BACE 1 inhibitory activity. Among...
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PMID: 21612159
PDF is available here.
PDF is available here.
Abstract
A simple and rapid HPLC method with UV detection was developed for the separation of ciprofloxacin, levofloxacin and moxifloxacin. Chromatography was carried out using a BDS Hypersil C18 (100 x 4.6 mm, 2.4 microm) HPLC column and an isocratic mobile phase consisting of MeOH/25 mM pho...
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PMID: 21612150
PDF is available here.
PDF is available here.
Abstract
Sanguinarine liposomes were prepared by a remote loading method using three different ammonium salts. A series of studies, including in vitro release, in vitro and in vivo anti-tumor effects and pharmacokinetics in rats, were conducted. The three liposomes showed pH-sensitive release...
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PMID: 21612152
PDF is available here.
PDF is available here.
Abstract
House dust mite (HDM) allergen quantification in house dust samples before and after the allergen elimination is one means of convincing the target population about the health benefits of allergen removal from their environment.
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PMID: 21560492
PDF is available here.
PDF is available here.
Abstract
2,3,9,10-Tetramethoxy-12-oxo-12-H-indolo[2,1-a]isoquinolinium chloride 1 (compound X) and 13-(3,4-dimethoxyphenyl)-2,3,8,9-tetramethoxy-6a, 12a-diazadibenzo[a,g] fluorenylium chloride 2 (compound NF) are new papaverine oxidation products. A solution of compound 1 bleaches on addition...
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PMID: 21553644
PDF is available here.
PDF is available here.
Abstract
The volatile components of both peel and juice of Japanese citrus, Kabosu (Citrus sphaerocarpa Hort. ex Tanaka) were investigated using SAFE (Solvent Assisted Flavor Evaporation) technique after solvent extraction. In this study, wine lactone, rose oxide, (2E)-4,5-epoxy-2-decenal, mi...
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PMID: 21485282
PDF is available here.
PDF is available here.
Abstract
Sulfadimethoxine was subjected to different International Conference on Harmonisation prescribed stress conditions (hydrolysis, oxidation and photolysis). A stability-indicating high-performance liquid chromatography method was developed for analysis of the drug in the presence of its major degradati...
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PMID: 21440101
PDF is available here.
PDF is available here.
Abstract
These results indicate that there were marked ethnic differences in the mutant frequencies of CYP3A5*3 and MDR1 C3435T among Chinese ethnic groups. Frequencies of those variants observed in Uygur Chinese, Kazakh Chinese, Tibetan Chinese, Wa Chinese and Bai Chinese wereintermediate between those seen...
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PMID: 21434577
PDF is available here.
PDF is available here.
Abstract
We assessed the potential estrogenic activity of shikonin with dual-luciferase reporter assay and bioluminescent measurements, by using transient cotransfection with estrogen dependent plasmid pERE-TK-Luc and internal control plasmid pRL-TK in MCF-7 cells. Estrogenic activity of shikonin, even at hi...
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PMID: 21434578
PDF is available here.
PDF is available here.
Abstract
A series of thiazepines has been studied as new ligands for the benzodiazepine binding site of the GABAA receptor. Compounds with high affinity and weak selectivity regarding alpha beta3gamma2, alpha2beta3gamma2, alpha3beta3gamma2, and alpha5beta3gamma2 subtypes were found. The pharm...
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PMID: 21434570
PDF is available here.
PDF is available here.
Pediatric nursing (37)3 2011
Abstract
Recurrent aphthous ulcers (RAUs), also known as canker sores, aphthous stomatitis, or aphthae, are a very common and often painful condition presenting in primary care. The majority of aphthous ulcers are benign, time-limited (7 to 14 days), and in some cases, require pain management until healed. Ho...
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PMID: 21739742
PDF is available here.
PDF is available here.
Abstract
The heterogeneity of tumor cell populations according to binding of lectins from lentil (LcL), wheat germs (WGA), peanut (PNA) and concanavalin A was investigated on a model of murine Nemeth-Kellner lymphoma (NK/Ly) and leukemia L-1210. Bound lectins were detected by indirect immunochemical method us...
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PMID: 21574425
PDF is available here.
PDF is available here.
Abstract
The bromocresol green (BCG) and bromocresol purple (BCP) assays often yield discordant serum albumin results. This study seeks to test the hypothesis that bias in albumin results are influenced by the concentration of serum globulin subtypes. The concentrations of serum albumin, alpha1-globulin, alph...
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PMID: 21950203
PDF is available here.
PDF is available here.
Collegium Antropologicum (35 Suppl 1) 2011
Abstract
The cerebrospinal fluid (CSF) formation rate (Vf) has been extensively studied by the ventriculocisternal perfusion, a method still regarded as the most precise one. This method as well as the equation for the calculation of the CSF formation rate (Vf) was established by Heisey et al...
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PMID: 21648314
PDF is available here.
PDF is available here.
Abstract
We decided to investigate blood donors for evidence of XMRV/pMLV.
Testing of cDNA prepared from the whole blood of 80 random blood donors, generated gag PCR signals from two samples (7C and 9C). These had previously tested negative for XMRV by two other PCR based techniques. To test...
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PMID: 21647447
PDF is available here.
PDF is available here.
Abstract
Structure-based library design employs both structure-based drug design (SBDD) and combinatorial library design. Combinatorial library design concepts have evolved over the past decade, and this chapter covers several novel aspects of structure-based library design together with successful case stud...
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PMID: 20981524
PDF is available here.
PDF is available here.
Abstract
We describe a complementary technique in the library design process, termed ProSAR, to effectively cover the accessible pharmacophore space around a given scaffold. With this method reagents are selected such that each R-group on the scaffold has an optimal coverage of pharmacophoric features. This...
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PMID: 20981522
PDF is available here.
PDF is available here.
Abstract
Combinatorial chemistry with two or more diversity points often leads to an immense number of theoretical products. It is sensible to select the reagents based on the desired properties of the products in the hope of maximizing the usefulness of the synthesized molecules. The presented tool enables...
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PMID: 20981532
PDF is available here.
PDF is available here.
Abstract
We also present methods for the determination of compositions of constituent fatty acids, distribution of fatty acids between sn-1 and sn-2 positions, and determination of contents of individual lipid classes by gas-liquid chromatography. These methods are applicable to isolated chloroplasts or some...
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PMID: 20960124
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)6 2011
Abstract
These results will provide a basis on which to evaluate cardiovascular drug effects on ARG, ADMA, and SDMA levels in new drug development....
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PMID: 21827044
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)6 2011
Abstract
New 4-aminoquinoline-derived esters containing the redox-active ferrocene group brought in by either ferrocenyformic or 4-ferrocenylbutanoic acids were synthesized and tested in vitro for their antiplasmodial activity. The results revealed that only esters derived from ferrocenylformic acid were acti...
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PMID: 21827047
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)6 2011
Abstract
1-Aryl-3-dimethylamino-1-propanone hydrochlorides type mono Mannich bases, D series, and corresponding hydrazone derivatives, K series, were synthesized and their cytotoxicity was tested against Jurkat cells (transformed human T-lymphocytes). The aryl part was changed as phenyl in D1 and K1, 4-methyl...
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PMID: 21827048
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
A randomized, two-treatment and two-way crossover study on twelve healthy Indian male subjects was conducted to assess the bioequivalence of two tablet formulations containing 20 mg of rimonabant (CAS 158681-13-1). Both of the formulations were administered orally as a single dose wi...
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PMID: 21428241
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 77-10-1, PCP, I) and many of its analogues have been synthesized and their pharmacological properties studied. In this research, new methyl morpholine derivative of phencyclidine (1-[1-(4-methylphenyl) (cyclohexyl)]morpholine, Meth...
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PMID: 21428243
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)7 2011
Abstract
The present paper describes the synthesis of a series of substituted 6-amino (1a-c) and 8-aminoquinoline derivatives (2b-c) and the evaluation of their ability to prevent the memory decline using a behavioural model, i.e. the elevated plus maze test. The effect of the candidate drugs...
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PMID: 21899203
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)7 2011
Abstract
In view of their expected anticonvulsant activity, some new derivatives of quinonxaline (V1-7) were designed and synthesized by condensation of different aromatic aldehydes with 2-(2-oxo-3-phenylquinoxalin-1(2H)-yl)acetohydrazide (IV). All synthesized compounds were isolated and conf...
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PMID: 21899204
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)7 2011
Abstract
Mangiferin (1,3,6,7-tetrahydroxy-2-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] -xanthen-9-one, CAS 4773-96-0), a naturally occurring glucosylxanthone, is widely distributed in higher plants and a constituent of folk medicine. In the present study the effect of systemic administrati...
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PMID: 21899205
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)2 2011
Abstract
The present study has been designed to investigate the pharmacokinetic parameters of the novel trioxane antimalarial 97-78 (US Patent 6316493 B1, 2001) in male and female rats after single oral and intravenous administration. The pharmacokinetic profile of 97-78 was investigated in t...
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PMID: 21428247
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)3 2011
Abstract
It was reported Panax ginseng had diverse components and multifaceted pharmacological functions. This study aims to investigate the effect of 20(S)-protopanaxatriol (PT, CAS 179799-20-3) and its epimeric derivatives (20S, 24R-epoxy-dammarane-3beta, 6alpha, 12beta, 25-tetraol, PTD1 and 20S, 24S-epoxy-...
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PMID: 21528638
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)3 2011
Abstract
In an attempt to develop effective and safer analgesic anti-inflammatory agents, nine compounds belonging to 4-[1-oxo-3-(substituted aryl)-2-propenyl]-3-(4-methoxyphenyl) sydnones, containing the structural features of mesoionic sydnone and styrylketone, have been designed and synthesized by condensi...
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PMID: 21528643
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)3 2011
Abstract
In this study, 15 compounds bearing N,N-phthaloylacetamide structure designed by the molecular simplification approach based on thalidomide structure were synthesized and evaluated for inhibitory potencies against cyclooxgenase (COX) isoenzymes, namely COX-1 and COX-2. The results suggested that the...
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PMID: 21528644
PDF is available here.
PDF is available here.
Arzneimittel-Forschung (61)3 2011
Abstract
Existing methods to determine biapenem (CAS 120410-24-4), a carbapenem, either lacked sensitivity/reproducibility or had no internal standard as a control. Here an improved reversed-phase high-performance liquid chromatographic (RP-HPLC) method was established in human plasma and urine. After adding...
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PMID: 21528646
PDF is available here.
PDF is available here.
Lab On a Chip (10)22 2010
Abstract
We report a mechanistic study of how flow and recirculation in a microreactor can be used to optimize the capture and release of stimuli-responsive polymer-protein reagents on stimuli-responsive polymer-grafted channel surfaces. Poly(N-isopropylacrylamide) (PNIPAAm) was grafted to polydimethylsiloxa...
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PMID: 20882219
PDF is available here.
PDF is available here.
Abstract
A convergent synthesis of the proposed structure of (+)-pestalazine B has been achieved in 4 steps using the N-alkylation of an unprotected tryptophan diketopiperazine with a 3a-bromopyrrolidinoindoline as the key step. Although its structure was confirmed by X-ray analysis, the spectroscopic data d...
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PMID: 20848034
PDF is available here.
PDF is available here.
Abstract
An efficient protocol for the construction of C-6-(hetero)aryl-substituted uridine phosphonate analogues utilizing an aerobic, ligand-free Suzuki-Miyaura cross-coupling reaction of a 6-iodo-precursor in aqueous media has been established. The method presents a modular approach toward the target comp...
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PMID: 20856988
PDF is available here.
PDF is available here.
Chemical Communications (46)42 2010
Abstract
An iridium catalysed oxidation was coupled concurrently to an asymmetric biocatalytic reduction in one-pot; thus it was shown for the first time that iridium- and alcohol dehydrogenase-catalysed redox reactions are compatible. As a model system racemic chlorohydrins were transformed to enantioenrich...
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PMID: 20871888
PDF is available here.
PDF is available here.
Abstract
White petrolatums of Japanese Pharmacopoeia grade and Sun white marketed as a cosmetic were characterized by measuring their physical properties and drug-releasing characteristics. White petrolatums of Japanese Pharmacopoeia grade available commercially in Japan were Perfecta, White 1S, Ultima, Snow...
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PMID: 21155385
PDF is available here.
PDF is available here.
Abstract
Bucolome N-glucuronide (BCP-NG), a major metabolite of bucolome (BCP), is the first unique N-glucuronide of barbituric acid derivatives to be reported. The purpose of the present study was to identify the UGT isoform(s) responsible for BCP-NG formation in rats. A pharmacokinetic study of BCP and the...
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PMID: 21155392
PDF is available here.
PDF is available here.
Abstract
We report the synthesis and in vitro receptor binding assay of three benzopyrano[3,4-c]pyridin-5-ones as potential dopamine D4 receptor ligands. These new compounds have higher affinity and selectivity toward dopamine D4 receptor and their K(i) values for D4 receptor are in the nanomolar (nM) range....
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PMID: 21155383
PDF is available here.
PDF is available here.
Abstract
Two new series of pyrimidinone derivatives linked to arylpiperazine moieties and 2'-carbethoxy-biphenylmethyl moieties were designed, synthesized and biologically evaluated for their in vivo hypotensive activities. The design of arylpiperazine analogues (IIa-f, IIIa-c, VIIa.b, IX) was based upon str...
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PMID: 21155384
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
The present paper aimed to test the potential cardioprotective activity of four pentacyclic triterpenes, uvaol, erythrodiol, oleanolic acid and maslinic acid, widely distributed throughout the vegetable kingdom. For this purpose, their antioxidant and antithrombotic activities related to LDL particl...
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PMID: 20650302
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
We believe that metabonomic approach is helpful to further understanding and clinical diagnosis of traditional Chinese medicine (TCM) induced nephrotoxicity.
Copyright (c) 2010 Elsevier Ltd. All rights reserved....
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PMID: 20678537
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
Trace element levels in different types of cat and dog foods consumed in Turkey were determined by flame atomic absorption spectrometry after wet digestion method. Data, expressed on a dry weight basis, were analyzed according to food type (cat or dog, and dry or wet), predominant flavour (beef, fis...
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PMID: 20637252
PDF is available here.
PDF is available here.
Food and Chemical Toxicology (48)10 2010
Abstract
Leaf of Salvia miltiorrhiza Bunge, the waste part during the root harvest, is rich in health-promoting phenolics and is a novel resource of natural antioxidants. The acetone and methanol extracts of leaves (AL and ML, respectively) of S. miltiorrhiza were evaluated by various in vitro antioxidant as...
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PMID: 20600528
PDF is available here.
PDF is available here.