These results demonstrate that P. gingivalis induces the MIP-3alpha/CCL20 mRNA in a NF-kappaB-, PLC-, and MAPK-dependent manner.... | PMID: 19710093

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We investigated the immunopharmacological aspects of innate immune responses via Toll-like receptors (TLRs), NOD1 and NOD2, in terms of induction of the histamine-forming enzyme, histidine decarboxylase (HDC), activity in mice. Intravenous injection of TLR4-agonistic synthetic lipid A definitely ind... | PMID: 19710098

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We compared the cytotoxicity of SPs of various sizes (30-1000 nm) and surface properties against differentiated THP-1 human macrophage-like cells. We found that 300 and 1000 nm SPs showed cytotoxicity against THP-1 cells, whereas 30, 50, and 70 nm SPs did not induce cell death. We demonstrated that... | PMID: 20824960

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The present study aimed to develop a high-throughput screening strategy for predicting the phototoxic potential of pharmaceutical substances, using a derivatives-of-reactive-oxygen-metabolites (D-ROM) assay. The assay conditions of the D-ROM assay were optimized with... | PMID: 20422261

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We define a subset of signaling markers closely associated with albuminuria. Mammalian target of rapamycin complex 2 (mTORC2)::IRS complexes may play a role in the nuclear accumulation, and possible downstream transcriptional effects, of p-PKC. The activity and apparent safety of nephrilin in rodent... | PMID: 20545557

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We have shown that masking the carboxyl group of 3-carboxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl (nitroxide 1) as an esterase-labile acetoxymethyl ester yields 3-acetoxymethoxycarbonyl-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl (nitroxide 2). Nitroxide 2 can cross the blood-brain barrier and is then hy... | PMID: 20201101

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A series of oxazolidine-based compounds with a variety of substituents in positions 2 and 3 was synthesized and their stability studied. Ring opened intermediates formed on addition of limiting amounts of D(2)O to oxazolidine solutions, as observed by NMR. As the hydrolysis reactions... | PMID: 20229599

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Species differences in microsomal binding were evaluated for 43 drug molecules in human, monkey, dog and rat liver microsomes, using a fixed concentration of microsomal protein. The dataset included 32 named drugs and 11 proprietary compounds encompassing a broad spectrum of physicoc... | PMID: 20229604

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This work reports the immobilization of Fenbufen, a nonsteroidal anti-inflammatory drug, into two different hexagonal mesoporous silicas (MCM-41) which exhibit some differences in terms of morphology and pore size, and their behavior as systems for sustained release at pH 7.5. The dr... | PMID: 20232455

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Liposomal locked-in dendrimers (LLDs), the combination of liposomes and dendrimers in one formulation, represents a relatively new term in the drug carrier technology. LLDs undergone appropriate physicochemical investigation can merge the benefits of liposomal and dendrimeric nanocar... | PMID: 20564386

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Water-based colourimetric indicator films are shown to have increased operational lifetimes under ambient conditions compared to similar solvent-based counterparts. The response and sensitivity characteristics of a water-based, carbon dioxide-responsive ink are characterised and compared and contras... | PMID: 20532409

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The purpose of the present study was to prepare multivesicular liposomes (MVL) with a high drug loading capacity for intramuscular sustained release and to investigate their potential applicability towards tramadol, and to improve the stability of liposomes by coating PEG. The basic physiochemical p... | PMID: 20662312

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These results indicated that GoldMag nanoparticles loaded with doxorubicin combined with a permanent magnetic field are more cytotoxic and could be a potential targeted drug delivery system.... | PMID: 20662318

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Multi-wall carbon nanotubes (MWNTs) could be modified as water soluble MWNTs (it was called as MWNTs-A and MWNTs-B) by chemical methods. MWNTs-A and MWNTs-B could emit room temperature phosphorescence (RTP) signal on the surface of nitrocellulose membrane (NCM). A new solid substrate-room temperatur... | PMID: 20376694

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We accomplished efficient precipitation of ammonium from concentrated industrial waste stream by using magnesium oxide (MgO) both as a source of magnesium ions and as a base. Best results were obtained with technical-grade MgO, which provided 99% removal of ammonium. Moreover, ammonium removal occur... | PMID: 20669719

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PMID: 20571566

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This study investigates uranium and technetium sorption onto aluminum and iron hydroxides during titration of acidic groundwater. The contaminated groundwater exhibits oxic conditions with high concentrations of NO(3)(-), SO(4)(2-), U, Tc, and various metal cations. More than 90% of U and Tc was rem... | PMID: 20116923

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A bioleaching study aimed at recovering metals from hazardous spent hydroprocessing catalysts was carried out. The exhaust catalyst was rich in nickel (4.5 mg/g), vanadium (9.4 mg/g) and molybdenum (4.4 mg/g). Involved microorganisms were iron/sulphur oxidizing bacteria. Investigated factors were el... | PMID: 20167424

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p-tert-Butyl-calix[4]arene-SBA-15 mesoporous silica molecular sieves have been prepared and characterized by Fourier transform infrared (FT-IR) spectroscopy, powder X-ray diffraction (XRD) and nitrogen adsorption-desorption measurements. FT-IR spectra showed the presence of methylene (-CH(2)-), meth... | PMID: 20185235

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A mild and clean liquid nitration of benzene with 65% nitric acid as nitrating agent over silica supported ammonium salt of 12-molybdophosphoric acid catalysts has been investigated. These catalysts with different loadings were prepared by sol-gel method and characterized by X-ray diffraction (XRD)... | PMID: 20185228

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A novel manganese complex Mn(2)(DAT)(2)Cl(4)(H(2)O)(4), where DAT is 1,5-diaminotetrazole, was synthesized by the reaction of manganese(II) chloride tetrahydrate and 1,5-diaminotetrazole (DAT) in ethanol, and characterized by elemental analysis, FT-IR spectroscopy. The crystal structure was determin... | PMID: 20338686

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In our work, a new process, catalytic vacuum distillation (CVD) was utilized for purification of petroleum refinery wastewater that was characteristic of high chemical oxygen demand (COD) and salinity. Moreover, various common promoters, like FeCl(3), kaolin, H(2)SO(4) and NaOH were investigated to... | PMID: 20153580

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We investigated the synergetic effect of La and F on the visible light photocatalytic activity of TiO(2) catalysts. La(2)O(3)/TiO(2-x)F(x) photocatalysts were prepared by a simple sol-gel process using tetrabutyl titanate (TBT), La(NO(3))(3) and NH(4)F as precursors. XPS results revealed that La(2)O... | PMID: 20149531

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A simple and selective method of flow injection microcolumn separation/preconcentration on-line coupled with inductively coupled plasma-optical emission spectrometry (ICP-OES) was developed for the speciation of V(V)/(IV). Various factors affecting the separation/preconcentration of V(IV) and V(V) b... | PMID: 20133063

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