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MAP Kinase Signaling System (0):
Recent article
MAP Kinase Signaling System
Abstract
These results suggest that macrophage accumulation in adipose tissue has a central role in stimulating MMP1 and MMP3 production by preadipocytes, and this is partially mediated by IL-1β via activation of the MAPK and NF-κB signaling pathways. J. Cell. Physiol. 226: 2869-2880, 2011. © 2011 Wiley-L...
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PMID: 21935932
PDF is available here.
PDF is available here.
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Science Signaling (4)190 2011
Abstract
We show that protein arginine methylation limits the ERK1/2 signal elicited by particular growth factors in different cell types from various species. We found that this restriction in ERK1/2 phosphorylation depended on methylation of RAF proteins by protein arginine methyltransferase 5 (PRMT5). PRM...
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PMID: 21917714
PDF is available here.
PDF is available here.
Cancer Biology & Therapy (12)6 2011
Abstract
We show that pretreatment with IFN-α enhanced TRAIL-induced apoptosis of gastric cancer MGC803 cells. IFN-α up-regulated death receptor 5 (DR5) expression and down-regulated survivin expression. Furthermore, extracellular-regulated protein kinase (ERK1/2) activation was induced by IFN-α, and a co...
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PMID: 21725207
PDF is available here.
PDF is available here.
Abstract
Similar multicellular structures can evolve within the same organism that may have different evolutionary histories, be controlled by different regulatory pathways, and play similar but nonidentical roles. In the human fungal pathogen Candida albicans, a quite extraordinary example of this has occurr...
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PMID: 21829325
PDF is available here.
PDF is available here.
Abstract
Abstract
We report here the regulation of members of the NR4A family of nuclear receptors by the BRAF-MEK-ERK cascade in melanoma cells. Expression profiling of melanoma cells in which both the NR4A1 and NR4A2 family members have been down-regulated by siRNA revealed alterations in genes associated with prol...
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PMID: 21362156
PDF is available here.
PDF is available here.
Abstract
We generated mice with combined loss of IFN-γ and the β-common cytokines GM-CSF and IL-3. These immunodeficient mice develop chronic pulmonary inflammation and lung tumors at a high frequency. Examination of the relationship between these tumors and their inflammatory microenvironment revealed a d...
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PMID: 21537082
PDF is available here.
PDF is available here.
Abstract
We have identified a tight-junction-associated protein complex comprising Merlin, Angiomotin, Patj, and Pals1. We demonstrate that Angiomotin functions downstream of Merlin and upstream of Rich1, a small GTPase Activating Protein, as a positive regulator of Rac1. Merlin, through competitive binding...
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PMID: 21481793
PDF is available here.
PDF is available here.
Abstract
We investigated microbial and host mechanisms through which H. pylori regulates eosinophil migration. Our results indicate that H. pylori increases production of the chemokines CCL2, CCL5, and granulocyte-macrophage colony-stimulating factor by gastric epithelial cells and that these molecules induc...
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PMID: 21406172
PDF is available here.
PDF is available here.
Molecular Oncology (5)2 2011
Abstract
Activating mutations in BRAF, a constituent of the map kinase pathway, were first discovered as being most prevalent in melanoma in 2002. Only recently have potent and selective, orally available inhibitors of BRAF emerged for clinical testing and demonstrated clear evidence of tumor...
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PMID: 21393075
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of two different inhibitors of MAPK signaling in proliferative and invasive melanoma cell cultures with various mutations in the MAPK pathway. Proliferative melanoma cells were more susceptible to pathway inhibition than invasive phenotype cells, irrespective of BRAF muta...
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PMID: 21176117
PDF is available here.
PDF is available here.
Abstract
Abstract
We identify the PTPN12 tyrosine phosphatase as a tumor suppressor in TNBC. PTPN12 potently suppresses mammary epithelial cell proliferation and transformation. PTPN12 is frequently compromised in human TNBCs, and we identify an upstream tumor-suppressor network that posttranscriptionally controls PT...
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PMID: 21376233
PDF is available here.
PDF is available here.
Abstract
We investigated the effects of a novel small-molecule JAK inhibitor (AZD1480) on IL-6/JAK signal transduction and its biological consequences on the human myeloma-derived cell lines U266 and Kms.11. At low micromolar concentrations, AZD1480 blocks cell proliferation and induces apoptosis of myeloma...
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PMID: 21164517
PDF is available here.
PDF is available here.
Abstract
We carried out a genome-wide screen for genes that when overexpressed throughout the developing Drosophila eye enhance Ras(ACT)-driven hyperplasia. Ras(ACT)-cooperating genes identified were Rac1 Rho1, RhoGEF2, pbl, rib, and east, which encode cell morphology regulators. In a clonal setting, which r...
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PMID: 21368274
PDF is available here.
PDF is available here.
Abstract
Anti-Cancer Drugs (22)2 2011
Abstract
Ursolic acid (UA), a pentacyclic triterpenoid compound, is widely distributed in the plant kingdom and has a broad range of biological effects. This study was carried out for the first time to investigate the potential role of UA in the differentiation of human leukemia HL60 cells and the underlying...
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PMID: 20948428
PDF is available here.
PDF is available here.
Biomedical Materials (6)1 2011
Abstract
Intranasal delivery of liposome-encapsulated inactivated Newcastle Disease virus (NDV) is known to be an effective vaccine for inducing immunity in the respiratory tract from our previous reports. Four-week-old specific pathogen-free chickens were intranasally immunized with NDV entr...
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PMID: 21239850
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1809)3 2011
Abstract
We further demonstrated that conditioned medium derived from δEF1-overexpressing MDA-MB-231 cells significantly induces osteoclast maturation and concurrently represses osteoblast differentiation and mineralization. On the contrary, conditioned medium derived from δEF1-interfered MDA-MB-231 cells...
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PMID: 21241837
PDF is available here.
PDF is available here.
Abstract
We wished to discern the role of NEDD9 in breast cancer progression and to investigate the molecular mechanism by which NEDD9 regulates EMT and promotes invasion in triple-negative breast cancer. We showed that expression of NEDD9 was frequently upregulated in TNBC cell lines, and in aggressive brea...
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PMID: 21829474
PDF is available here.
PDF is available here.
Abstract
We reported that the yeast Sc (strain CNCM I-3856) modulates transcript and protein expressions involved in inflammation, recruitment and activation of immune cells in differentiated porcine intestinal epithelial IPEC-1 cells. We demonstrated that viable Sc inhibits the ETEC-induced expression of pr...
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PMID: 21483702
PDF is available here.
PDF is available here.
Abstract
We found that Mtb-infected monocytes preferentially express a proinflammatory cytokine profile, including IL-6, TNF-α, and IL-1β. Conversely, among the regulatory cytokines, Mtb elicited IL-10 and IL-23 release while no expression of IL-12p70, IL-27, and IFN-β was observed. The analysis of the si...
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PMID: 21197399
PDF is available here.
PDF is available here.
Abstract
We show that direct dsDNA stimulation of endothelial cells induces a potent proinflammatory response as demonstrated by increased expression of ICAM1, E-selectin and VCAM1, and enhanced leukocyte adhesion. This response was dependent on the stress kinases JNK and p38 MAPK, required the activation of...
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PMID: 21611132
PDF is available here.
PDF is available here.
Abstract
Journal of Biological Chemistry (285)45 2010
Abstract
We identified a receptor adaptor interacting specifically with one receptor complex but not others. NHERF1, an adaptor known for its role in desensitization, internalization, and regulation of the ERK signaling cascade for several GPCRs, interacts via its PDZ2 domain with the CCR5 homodimer but not...
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PMID: 20801883
PDF is available here.
PDF is available here.
Journal of Biological Chemistry (285)45 2010
Abstract
We have now investigated the possible involvement of PiT1 in TNF-induced apoptosis. We show that PiT1-depleted cells are more sensitive to the proapoptotic activity of TNF (i.e. when the antiapoptotic NFκB pathway is inactivated). These observations were made in the human HeLa cancer cell line eith...
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PMID: 20817733
PDF is available here.
PDF is available here.
Abstract
We have generated hexavalent antibodies (HexAbs) comprising 6 Fabs tethered to one Fc of human IgG1. Three such constructs, 20-20, a monospecific HexAb comprising 6 Fabs of veltuzumab (humanized anti-CD20 immunoglobulin G1κ [IgG1κ]), 20-22, a bispecific HexAb comprising veltuzumab and 4 Fabs of ep...
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PMID: 20628151
PDF is available here.
PDF is available here.
EMBO Reports (11)11 2010
Abstract
Mitogen-activated protein kinase (MAPK) signalling occurs in response to almost any change in the extracellular or intracellular milieu that affects the metabolism of the cell, organ or the entire organism. MAPK-dependent signal transduction is required for physiological metabolic adaptation, but in...
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PMID: 20930846
PDF is available here.
PDF is available here.
Cell Biology International (34)11 2010
Abstract
We investigated the effect of Sal B on H₂O₂-induced apoptosis in rat BMSCs, focusing on the survival signalling pathways. Results indicated that the MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase] inhibitor (PD98059) and 10 μM Sal B remarkably pr...
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PMID: 20629637
PDF is available here.
PDF is available here.
Cell Biology International (34)11 2010
Abstract
We have shown that mutation in Rab11 (a subfamily of the Ypt/Rab gene family) results in the activation of JNK signalling pathways in Drosophila eye. Here, we report that Rab11 regulates JNK and Raf/MAPK-ERK signalling pathways during Drosophila wing development. Using immunofluorescence and immunoh...
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PMID: 20642455
PDF is available here.
PDF is available here.
Abstract
We demonstrate that T cell-specific deletion of cell-division cycle 42 (Cdc42) GTPase causes a profound loss of mature T cells. Deletion of Cdc42 leads to a markedly increased expression of growth factor independence-1 (Gfi-1) and represses expression of IL-7Rα. In the absence of Cdc42, aberrant ER...
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PMID: 20937872
PDF is available here.
PDF is available here.
Abstract
We found that 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan photoproduct postulated as a candidate physiological ligand of the aryl hydrocarbon receptor (AhR), induces L1-RTP. Notably, RNA-interference experiments combined with back-transfection of siRNA-resistant cDNAs revealed that the induc...
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PMID: 20852066
PDF is available here.
PDF is available here.
Journal of Hepatology (54)6 2011
Abstract
Compared with WT mice, liver recovery was significantly accelerated in VDUP1 KO mice during the first day after PH, in association with increased DNA synthesis. Consistent with this observation, the expression levels of key cell-cycle regulatory proteins, including cyclin D, cyclin E, cyclin-depende...
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PMID: 21145821
PDF is available here.
PDF is available here.
Biochemical Journal (432)1 2010
Abstract
We investigated the role of the ERK (extracellular-signal-regulated kinase) and p38 MAPK (mitogen-activated protein kinase) signalling pathways in MEL (mouse erythroleukaemia) cell differentiation. We found that treatment of HMBA (hexamethylene bisacetamide)-induced MEL cells with the ERK pathway in...
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PMID: 20738258
PDF is available here.
PDF is available here.
Abstract
Clinical management of chronic pain after nerve injury (neuropathic pain) and tumor invasion (cancer pain) is a real challenge due to our limited understanding of the cellular mechanisms that initiate and maintain chronic pain. It has been increasingly recognized that glial cells, such as microglia...
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PMID: 20880510
PDF is available here.
PDF is available here.
Abstract
We report that TGF-β1-induced expression of fibronectin (FN) depends on the activity of aldose reductase (AR) in human mesangial cells (HMCs).The results show that TGF-β1 increased the expression of FN, which attenuated by pharmacological inhibition of AR or knockdown of the enzyme by small interf...
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PMID: 19847669
PDF is available here.
PDF is available here.
Abstract
These results demonstrate that the eNOS/NO system provides cardiac protection after MI injury through inhibition of inflammation and suppression of MAPK signaling....
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PMID: 19908164
PDF is available here.
PDF is available here.
Experimental Dermatology (19)10 2010
Abstract
We investigated whether resveratrol would activate p66Shc in human immortalised keratinocytes (HaCaT cells), a well known and largely used model for skin keratinocytes. HaCaT cells were treated with resveratrol (10-150 μm) for different times. The effect of resveratrol on the proliferation of HaCaT...
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PMID: 20626463
PDF is available here.
PDF is available here.
Abstract
We recently reported that PED is overexpressed in human cancers and mediates resistance to induced apoptosis. To better understand its role in cancer, we investigated on PED interactome in non-small cell lung cancer (NSCLC). By the Tandem Affinity Purification (TAP), we identified and characterized...
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PMID: 20648624
PDF is available here.
PDF is available here.
Abstract
We identify the redox-responsive molecular signals that drive senescence-associated (SA) matrix metalloproteinase-1 (MMP-1) expression. Precise biochemical monitoring revealed that senescent fibroblasts increase steady-state (H(2)O(2)) 3.5-fold (13.7-48.6 pM) relative to young cells. Restricting H(2...
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PMID: 20648623
PDF is available here.
PDF is available here.
Biochemical Journal (431)2 2010
Abstract
We investigated transcription of hHSS triggered by EGF (epidermal growth factor) and the role of C/EBPβ (CCAAT/enhancer-binding protein β) as a potential core factor responsible for hHSS transcription in HepG2 cells. The results show that EGF suppresses hHSS mRNA expression at early time points. U...
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PMID: 20690902
PDF is available here.
PDF is available here.
Abstract
We further provide evidence that TA leads to increases in phospho-p38 MAPK, JNK and ERK levels. Inhibition of these pathways using selective inhibitors and dominant negative constructs ameliorated TA-induced ATF3 expression and promoter activities. The current study shows that TA stimulates ATF3 exp...
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PMID: 20581861
PDF is available here.
PDF is available here.
Abstract
We explore this question by performing cell culture experiments in our self-developed periodic stress field and perfusion culture system. Under periodic mechanical stress, we find that both rat chondrocyte area and migration are significantly amplified. These changes are associated with increases in...
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PMID: 20537760
PDF is available here.
PDF is available here.
Molecular and Cellular Endocrinology (325)1-2 2010
Abstract
We previously showed the presence of the GLP-1 receptor in human coronary artery endothelial cells (HCAECs) and the ameliorative actions of GLP-1 on endothelial dysfunction in type 2 diabetic patients. Here, we have studied the effect of exendin-4 on cell proliferation and its underlying mechanisms...
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PMID: 20452396
PDF is available here.
PDF is available here.
Oncology Reports (24)3 2010
Abstract
Oridonin, the main active constituent of Isodon rubescen, has antihepatocarcinoma activity in experimental and clinical settings. The aims of the study were to explore the anticancer effect of oridonin in HepG2 cells and to investigate the underlying mechanisms. Results showed that oridonin treatmen...
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PMID: 20664969
PDF is available here.
PDF is available here.
Abstract
We used multicellular tumour spheroids (MTS) as an in vitro tumour model to investigate the molecular mechanisms underlying necrosis-linked drug resistance. MCF-7 cells formed tight and spherical shape of spheroids and started to form the necrotic core at 8 days of culture. We found that docetaxel (...
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PMID: 20664934
PDF is available here.
PDF is available here.
Abstract
We review advances in targeted strategies to treat different subgroups of patients with melanoma....
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PMID: 21157411
PDF is available here.
PDF is available here.
Abstract
We investigated the effect of cAMP on tumor necrosis factor (TNF)-alpha-induced MMP-1 expression and the molecular events involved in the processes in human skin fibroblasts. We showed that cAMP suppresses TNF-alpha-induced MMP-1 expression via protein kinase A (PKA) pathway. cAMP inhibited TNF-alph...
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PMID: 20357815
PDF is available here.
PDF is available here.
Abstract
We use small interfering RNA knockdown to study the role of individual PKC isoforms as regulators of keratinocyte differentiation induced by the potent differentiating stimulus, 12-O-tetradecanoylphorbol-13-acetate (TPA). PKC-delta knockdown reduces TPA-activated involucrin promoter activity, nuclea...
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PMID: 20445555
PDF is available here.
PDF is available here.
Abstract
The current results indicated that EGFR overexpression may play an important role in reducing sensitivity to progestin treatment in EC. An EGFR tyrosine kinase-specific inhibitor may be useful in the treatment of EC.
Copyright (c) 2010 American Cancer Society....
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PMID: 20564127
PDF is available here.
PDF is available here.
Developmental Biology (344)1 2010
Abstract
We investigate the interaction of Geminin with the Brm complex during Drosophila development. We demonstrate that Drosophila Geminin (Gem) interacts antagonistically with the Brm-BAP complex during wing development. Moreover, we show in vivo during wing development and biochemically that Brm acts to...
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PMID: 20416294
PDF is available here.
PDF is available here.
Biochemical Journal (429)3 2010
Abstract
We describe changes in gene expression patterns and transcriptional networks that respond to dietary PQQ restriction or pharmacological administration. Rats were fed diets either deficient in PQQ (PQQ-) or supplemented with PQQ (approx. 6 nmol of PQQ/g of food; PQQ+). In addition, groups of rats wer...
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PMID: 20491655
PDF is available here.
PDF is available here.
Cancer Letters (295)1 2010
Abstract
We found that NFD inhibited the nuclear translocation of NF-kappaB, likely accounting for the down-regulation of pro-survival Bcl-2 family. Furthermore, suppression of p38 MAPK activity by a specific inhibitor significantly rescued the cell proliferation inhibited by NFD. These findings suggest that...
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PMID: 20350781
PDF is available here.
PDF is available here.
Cancer Letters (295)1 2010
Abstract
We comparatively investigate the antitumor potential of novel small-molecule inhibitors targeting mTOR (RAD001), mTOR/PI(3)K (NVP-BEZ235) and Raf (Raf265) on human NET cell lines of heterogeneous origin. All inhibitors induced potent antitumor effects which involved the induction of apoptosis and G0...
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PMID: 20356670
PDF is available here.
PDF is available here.
Abstract
We identify the multifunctional protein Bag1-L as a coactivator of phosphorylated c-Jun. Bag1-L preferentially interacts with N-terminally phosphorylated c-Jun, and Bag1-L greatly augments transcriptional activation by phosphorylated c-Jun. Chromatin immunoprecipitation experiments revealed binding...
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PMID: 20516211
PDF is available here.
PDF is available here.
Experimental Hematology (38)8 2010
Abstract
Following CEACAM6 cross-linking in ALL cells, we detected Erk1/2, Akt, and p38 MAPK phosphorylation and integrin upregulation, as well as enhanced binding of integrin ligands (vascular cell adhesion molecule-1 [VCAM-1] and intercellular cell adhesion molecule-1 [ICAM-1]). However, CEACAM6 signaling...
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PMID: 20380867
PDF is available here.
PDF is available here.
Abstract
The internal hydrostatic pressure (turgor) of the filamentous fungus Neurospora crassa is regulated at about 400-500 kiloPascals, primarily by an osmotic MAP kinase cascade which activates ion uptake from the extracellular medium and glycerol synthesis. In the absence of hyperosmotic stress, the phe...
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PMID: 20546911
PDF is available here.
PDF is available here.
Abstract
We found that p38alpha and p38delta had similar effects. The in vivo part of the study showed that transfection of these two constructs significantly lowered general venular hyperpermeability and enhanced the survival of burned animals. Because the p38 MAPK pathway seems to play a crucial role in bu...
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PMID: 20023600
PDF is available here.
PDF is available here.
Abstract
We found no difference in the overall m- RNA expression between controls and IPF in both investigated pathways. However, Braf has been overexpressed in IPF samples (P = 0.01) in contrast with K-ras that has been found downregulated (P < 0.001) in comparison with controls.
These findings cannot exclu...
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PMID: 20536315
PDF is available here.
PDF is available here.
Abstract
We investigated potential synergism between IL-6 and IL-1 for the production of matrix metalloproteinases (MMPs) by the synovial cell line SW982. Cells were cultured with different combinations of IL-6, soluble IL-6 receptor (sIL-6R) and IL-1beta for 24h and production of MMPs was then measured. IL-...
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PMID: 20403707
PDF is available here.
PDF is available here.