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Welcome to the Pubget Medical Subject Headings (MESH) browser. Click on a topic or subtopic below to explore related papers. In the gold box is the most recent paper about the current MESH term, and below are 20 related papers.
Mechanotransduction, Cellular (0):
Recent article
Mechanotransduction, Cellular
Developmental Cell (21)4 2011
Abstract
We show that Fgf8 and Sema3f, produced by early dental epithelium, respectively, attract and repulse mesenchymal cells, which cause them to pack tightly together during mouse tooth development. Resulting mechanical compaction-induced changes in cell shape induce odontogenic transcription factors (Pa...
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PMID: 21924961
PDF is available here.
PDF is available here.
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Biochimica et Biophysica Acta (1812)10 2011
Abstract
We will discuss several well-accepted signaling pathways toward calcium-mediated mechanisms of cystic expansion. The second messenger calcium ion has contributed to a vast diversity of signal transduction pathways. We will dissect calcium signaling as a possible mechanism that contributes to renal c...
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PMID: 20932898
PDF is available here.
PDF is available here.
Biochimica et Biophysica Acta (1812)10 2011
Abstract
We will discuss several well-accepted signaling pathways toward calcium-mediated mechanisms of cystic expansion. The second messenger calcium ion has contributed to a vast diversity of signal transduction pathways. We will dissect calcium signaling as a possible mechanism that contributes to renal c...
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PMID: 20932898
PDF is available here.
PDF is available here.
Abstract
Inhomogeneous and uncontrolled cellular and tissue responses in bone tissue engineering constructs, as a result of heterogeneous oxygen delivery throughout the scaffold volume, is one of the hurdles hampering clinical transfer of cell-scaffold combinations. This study presents an acc...
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PMID: 21332298
PDF is available here.
PDF is available here.
Abstract
We are just beginning to harness that potential using stem cells in bone tissue engineering. ASC are the primary focus of this review due to their abundance and relative ease of accessibility for autologous procedures. This article outlines the current knowledge base in bone mechanobiology to invest...
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PMID: 21338267
PDF is available here.
PDF is available here.
Abstract
Stem cells reside within tissue, ensuring its natural ability to repair an injury. They are involved in the natural repair of damaged tissue, which encompasses a complex process requiring the modulation of cell survival, extracellular matrix turnover, angiogenesis, and reverse remode...
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PMID: 21034226
PDF is available here.
PDF is available here.
Development (138)8 2011
Abstract
We generated three mouse lines, each of which lacks one out of three prominent PCDH15 isoforms (CD1, CD2 and CD3). Surprisingly, mice lacking PCDH15-CD1 and PCDH15-CD3 form normal hair bundles and tip links and maintain hearing function. Tip links are also present in mice lacking PCDH15-CD2. However...
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PMID: 21427143
PDF is available here.
PDF is available here.
Biopolymers (95)5 2011
Abstract
Mechanical tension plays a large role in cell development ranging from morphology to gene expression. On the molecular level, the effects of tension can be seen in the dynamic arrangement of membrane proteins as well as the recruitment and activation of intracellular proteins. Forces applied to biopo...
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PMID: 21267988
PDF is available here.
PDF is available here.
Abstract
We report the identification of the Yorkie-homologues YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif, also known as WWTR1) as nuclear relays of mechanical signals exerted by ECM rigidity and cell shape. This regulation requires Rho GTPase activity and tensio...
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PMID: 21654799
PDF is available here.
PDF is available here.
Science Signaling (4)177 2011
Abstract
The ability to coordinate membrane trafficking events in space and time is of fundamental importance in biology. Polarized trafficking is essential for processes as diverse as cytokinesis, regulated endocytosis, cell motility, and morphogenesis, yet the interface between cellular sig...
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PMID: 21673314
PDF is available here.
PDF is available here.
Abstract
We have shown that interstitial flow upregulates matrix metalloproteinase (MMP) expression in rat vascular smooth muscle cells (SMCs) and fibroblasts/myofibroblasts via activation of an ERK1/2-c-Jun pathway, which in turn promotes cell migration in collagen. Herein, we focused on uncovering the flow...
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PMID: 21246051
PDF is available here.
PDF is available here.
Abstract
We have shown that interstitial flow upregulates matrix metalloproteinase (MMP) expression in rat vascular smooth muscle cells (SMCs) and fibroblasts/myofibroblasts via activation of an ERK1/2-c-Jun pathway, which in turn promotes cell migration in collagen. Herein, we focused on uncovering the flow...
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PMID: 21246051
PDF is available here.
PDF is available here.
Abstract
We have accomplished thermodynamic analysis of mouse TREK-1 gating and functional testing of several deletion mutants. The predicted increase of the channel in-plane area (ΔA) of ~5 nm(2) in models was supported by the experimental ΔA of ~4 nm(2) derived from the slope of open probability versus m...
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PMID: 21057213
PDF is available here.
PDF is available here.
Abstract
We briefly review how hMSCs respond to fluid flow stimuli and focus on the signal molecules involved in this mechanotransduction....
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PMID: 20309603
PDF is available here.
PDF is available here.
Abstract
Our carotid MRI data show that ESS is an important determinant of arterial remodeling and arterial stiffness in humans. The data warrant further studies to evaluate use of carotid ESS as a noninvasive tool to improve the understanding of individual cardiovascular disease risk and to assess novel dru...
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PMID: 20576811
PDF is available here.
PDF is available here.
Thrombosis and Haemostasis (104)3 2010
Abstract
Shear stress has an established effect on mature endothelial cells, but less is known about how shear stress regulates endothelial progenitor cells (EPCs). In vitro expanded EPCs isolated from adult human blood represent a novel tool in regenerative vessel therapy. However, in vitro culturing may ge...
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PMID: 20664910
PDF is available here.
PDF is available here.
Abstract
Atheroprone regions of the arterial circulation are characterized by time-varying, reversing, and oscillatory wall shear stress. Several in vivo and in vitro studies have demonstrated that flow reversal (retrograde flow) is atherogenic and proinflammatory. The molecular and structural basis for the...
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PMID: 20554908
PDF is available here.
PDF is available here.
Biophysical Journal (99)4 2010
Abstract
We found that series connection does not lead to a single minimum of stiffness with respect to hair bundle displacement unless the minimum is above a certain positive value. Thus, negative stiffness must appear in pairs in the displacement axis. In contrast, parallel connection of the two channels p...
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PMID: 20712985
PDF is available here.
PDF is available here.
Biophysical Journal (99)4 2010
Abstract
We have carried out molecular dynamics simulations of the SNARE complex in the oxidized and reduced states. Indeed, marked conformational differences and a reduction of helical content in SNAP-25B upon oxidation are seen. Further differences are found for hydrophobic interactions at three locations,...
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PMID: 20713006
PDF is available here.
PDF is available here.
Abstract
These results may help explain plaque stability, as cells in shoulder regions near an atherosclerotic plaque had a cobblestone morphology indicating that they may be more permeable to subendothelial transport and express prothrombotic factors, which would increase the risk of atherothrombosis....
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PMID: 20670062
PDF is available here.
PDF is available here.
Abstract
Biomaterials (31)19 2010
Abstract
Cells are known to sense and respond to the physical properties of their environment and those of tissue scaffolds. Optimizing these cell-material interactions is critical in tissue engineering. In this work, a simple and inexpensive combinatorial platform was developed to rapidly screen three-dimen...
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PMID: 20378163
PDF is available here.
PDF is available here.
Biomaterials (31)19 2010
Abstract
Cardiac tissue engineering requires finely-tuned manipulation of the extracellular matrix (ECM) microenvironment to optimize internal myocardial organization. The myocyte nucleus is mechanically connected to the cell membrane via cytoskeletal elements, making it a target for the cellular response to...
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PMID: 20382423
PDF is available here.
PDF is available here.
Nature Neuroscience (13)7 2010
Specific roles for DEG/ENaC and TRP channels in touch and thermosensation in C. elegans nociceptors.
Abstract
We found that the C. elegans PVD neurons are mulitidendritic nociceptors that respond to harsh touch and cold temperatures. The harsh touch modality specifically required the DEG/ENaC proteins MEC-10 and DEGT-1, which represent putative components of a harsh touch mechanotransduction complex. In con...
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PMID: 20512132
PDF is available here.
PDF is available here.
Abstract
We introduce an integrative three-dimensional electromechanical model of the left ventricle of the human heart. Electrical activity is represented by the ionic TP06 model for human cardiac cells, and mechanical activity is represented by the Niederer-Hunter-Smith active contractile tension model and...
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PMID: 20400690
PDF is available here.
PDF is available here.
Cardiovascular Research (86)3 2010
Abstract
These findings demonstrate a critical role for the mTOR complex, downstream from FAK, in mediating the activation of cardiac fibroblasts in response to mechanical stress....
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PMID: 20038548
PDF is available here.
PDF is available here.
Abstract
Abstract
We adapted a system of microfabricated force sensors to quantitatively report cell-cell tugging force and AJ size. We observed that AJ size was modulated by endothelial cell-cell tugging forces: AJs and tugging force grew or decayed with myosin activation or inhibition, respectively. Myosin-dependen...
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PMID: 20463286
PDF is available here.
PDF is available here.
Biomedical Microdevices (12)3 2010
Abstract
Despite the importance of cell adhesion in numerous physiological, pathological, and biomaterial-related responses, our understanding of adhesion strength at the cell-substrate interface and its relationship to cell function remains incomplete. One reason for this deficit is a lack of accessible exp...
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PMID: 20213215
PDF is available here.
PDF is available here.
Abstract
Although mechanical ventilation (MV) is a life-saving intervention for patients with acute respiratory distress syndrome (ARDS), it can aggravate or cause lung injury, known as ventilator-induced lung injury (VILI). The biophysical characteristics of heterogeneously injured ARDS lungs increase the p...
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PMID: 20524920
PDF is available here.
PDF is available here.
Optics Express (18)10 2010
Abstract
We compute the stress re-distribution on the deformed cell and its subsequent deformations recursively until a final equilibrium state solution is achieved. The experiment is done with the red blood cells in suspension swollen to spherical shape. The cell membrane elasticity coefficient is obtained...
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PMID: 20588900
PDF is available here.
PDF is available here.
Abstract
We investigated the changes in bone mass and strength induced by 6 weeks of mechanical loading and compared them to changes induced by 6 weeks of iPTH treatment. Loading and iPTH both increased ulnar bone accrual, as measured by bone mineral density and content, and fluorochrome-derived bone formati...
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PMID: 20306026
PDF is available here.
PDF is available here.
Abstract
We therefore propose that control of primary cilia length is an adaptive signalling mechanism in response to varying levels and duration of mechanical loads during joint activity....
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PMID: 20100169
PDF is available here.
PDF is available here.
Abstract
We investigated CCF (cyclic compressive force) responsive gene expression patterns at different time-points using Mouse genome-wide oligonucleotide microarrays with an osteocyte-like MLO-Y4 cell model. We performed a SOM (self-organizing maps) clustering algorithm based on pattern similarity to orga...
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PMID: 20047561
PDF is available here.
PDF is available here.
Development (137)10 2010
Abstract
We devised a simple method to gather dynamic morphometric information about axonal terminals in toto by four-dimensional imaging. Applying this strategy to the zebrafish allowed us to correlate hair cell orientation to single afferent neurons at subcellular resolution. Here we show that in zebrafish...
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PMID: 20430744
PDF is available here.
PDF is available here.
Abstract
A model of cochlear mechanics is described in which force-producing outer hair cells (OHC) are embedded in a passive cochlear partition. The OHC mechanoelectrical transduction current is nonlinearly modulated by reticular-lamina (RL) motion, and the resulting change in OHC membrane voltage produces...
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PMID: 20370025
PDF is available here.
PDF is available here.
Abstract
The meatus (auditory canal) plays a role in altering the waveform of incident sound, distorting time- and frequency-domain characteristics. Often in transient-evoked otoacoustic emission (TEOAE) recording protocols, a 75 mus click is utilized to elicit a click-evoked response. TEOAEs are recorded by...
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PMID: 20370024
PDF is available here.
PDF is available here.
Abstract
Previous studies show that phonation onset occurs as two eigenmodes of the vocal folds are synchronized by the interaction between the vocal folds and the glottal flow. This study examines the influence of the geometrical and biomechanical properties of the vocal folds on this eigenmode-synchronizat...
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PMID: 20370037
PDF is available here.
PDF is available here.
Abstract
These results support the notion that SFOAE delays provide a noninvasive measure of the sharpness of cochlear tuning....
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PMID: 20370023
PDF is available here.
PDF is available here.
Abstract
We describe the recent progress in understanding these missing components of the mechanism of chemomechanical transduction by myosin motors. These insights come from a combination of kinetic and single-molecule studies on multiple classes of myosins, with additional insights from contracting muscle...
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PMID: 20192767
PDF is available here.
PDF is available here.
Abstract
Mechanosensitive ion channels are gated directly by physical stimuli and transduce these stimuli into electrical signals. Several criteria must apply for a channel to be considered mechanically gated. Mechanosensitive channels from bacterial systems have met these criteria, but few eukaryotic channe...
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PMID: 20192782
PDF is available here.
PDF is available here.
Abstract
The process of chondrocyte mechanotransduction is poorly understood. However, recent studies suggest the involvement of a purinergic calcium signaling pathway although the mechanism of ATP release has not been identified. The present study tests the hypothesis that cyclic compression...
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PMID: 19890993
PDF is available here.
PDF is available here.
Microcirculation (17)3 2010
Abstract
We begun to understand the effects of hemodynamic force on embryonic development. In this review, we will discuss specific examples illustrating the role of hemodynamic force during the development of the embryo, with particular focus on the development of the vascular system and the morphogenesis o...
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PMID: 20374481
PDF is available here.
PDF is available here.
Clinical calcium (20)4 2010
Abstract
We previously reported that applying a cyclic, uni-axial strain to cells induced tyrosine phosphorylation of focal adhesion kinase and stimulated mitogen-activated protein kinase. However, it is difficult to quantify and analyze the spatial distribution of tyrosine phosphorylation in these cells, as...
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PMID: 20354324
PDF is available here.
PDF is available here.
Abstract
Abstract
We reconstituted this intermembrane signaling geometry between live EphA2-expressing human breast cancer cells and supported membranes displaying laterally mobile ephrin-A1. Receptor-ligand binding, clustering, and subsequent lateral transport within this junction were observed. EphA2 transport can...
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PMID: 20223987
PDF is available here.
PDF is available here.
Current Biology (20)5 2010
Abstract
We report that the pickpocket (ppk) gene, which encodes a Degenerin/Epithelial Sodium Channel (DEG/ENaC) subunit, is required for mechanical nociception but not thermal nociception in these sensory cells. Larvae mutant for pickpocket show greatly reduced nociception behaviors in response to harsh me...
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PMID: 20171104
PDF is available here.
PDF is available here.
Abstract
To identify mechanotransductive signals for combating musculoskeletal deterioration, it is essential to determine the components and mechanisms critical to the anabolic processes of musculoskeletal tissues. It is hypothesized that the interaction between bone and muscle may depend on...
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PMID: 20190376
PDF is available here.
PDF is available here.
Abstract
We address the influence of biomechanical factors on the arterial circulation. The first part presents our current understanding of the impact of blood flow on the arterial wall at the cellular level and the relationship between flow-induced stresses and the etiology of atherosclerosis. The second p...
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PMID: 20336826
PDF is available here.
PDF is available here.
Abstract
The critical discovery in the past two decades of the transient receptor potential (TRP) superfamily of ion channels has revealed the potential mechanisms by which cells sense diverse stimuli beyond the prototypical "five senses," identifying ion channels that are gated by heat, cold, mechanical loa...
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PMID: 20392266
PDF is available here.
PDF is available here.
Abstract
I presented as the recipient of the 2009 Pritzker Distinguished Lecturer Award at the Biomedical Engineering Society annual meeting in October 2009. Here, I review more than thirty years of research from my laboratory, beginning with studies designed to test the theory that cells use tensegrity (ten...
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PMID: 20140519
PDF is available here.
PDF is available here.
Health Physics (98)2 2010
Abstract
Exposure of fingernails and toenails to ionizing radiation creates radicals that are stable over a relatively long period (days to weeks) and characterized by an isotropic EPR signal at g = 2.003 (so-called radiation-induced signal, RIS). This signal in readily obtained fingernail parings has the po...
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PMID: 20065699
PDF is available here.
PDF is available here.
Abstract
Abstract
We compared recombinant R1623Q and WT currents in control vs. stretched membrane of cell-attached patches of Xenopus oocytes. Macroscopic current was monitored before, during, and after stretch induced by pipette suction. In either mutant Na(+) channel, peak current at small depolarizations could be...
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PMID: 20090423
PDF is available here.
PDF is available here.
Abstract
We highlight the relevance of TRPV channels in vascular regulation and focus on TRPV4 in the vascular system of the lung, which is constantly exposed to a unique combination of circumferential and longitudinal strains. In light of our observation in intact pulmonary microvessels that mechanical stre...
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PMID: 19842065
PDF is available here.
PDF is available here.
Abstract
We created by combining normal (5%) and reduced (1%) stretch with high shear (6 +/- 3 dynes/cm(2)) and oscillatory shear (0.3 +/- 3 dynes/cm(2)) stress while maintaining a pulse pressure of 80 +/- 10 mm Hg. Oscillatory flow and reduced stretch both proved detrimental to endothelial function, whereas...
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PMID: 20016207
PDF is available here.
PDF is available here.
Abstract
Abstract
Abstract
Abstract
Aging and a sedentary lifestyle conspire to reduce bone quantity and quality, decrease muscle mass and strength, and undermine postural stability, culminating in an elevated risk of skeletal fracture. Concurrently, a marked reduction in the available bone-marrow-derived population of mesenchymal ste...
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PMID: 20046206
PDF is available here.
PDF is available here.